DK0954521T3 - 4-[(thien-3-yl)methyl]-imidazoler med alfa2-adrenoceptor-agonistisk aktivitet - Google Patents

4-[(thien-3-yl)methyl]-imidazoler med alfa2-adrenoceptor-agonistisk aktivitet

Info

Publication number
DK0954521T3
DK0954521T3 DK97919907T DK97919907T DK0954521T3 DK 0954521 T3 DK0954521 T3 DK 0954521T3 DK 97919907 T DK97919907 T DK 97919907T DK 97919907 T DK97919907 T DK 97919907T DK 0954521 T3 DK0954521 T3 DK 0954521T3
Authority
DK
Denmark
Prior art keywords
methyl
thien
imidazoles
alpha2
agonistic activity
Prior art date
Application number
DK97919907T
Other languages
English (en)
Inventor
Robert E Boyd
Chris Royce Rasmussen
Jeffrey B Press
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Application granted granted Critical
Publication of DK0954521T3 publication Critical patent/DK0954521T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK97919907T 1996-03-28 1997-03-26 4-[(thien-3-yl)methyl]-imidazoler med alfa2-adrenoceptor-agonistisk aktivitet DK0954521T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/625,442 US5750720A (en) 1996-03-28 1996-03-28 4- (thien-3-yl)methyl!-imidazole analgesics
PCT/US1997/004773 WO1997035858A1 (en) 1996-03-28 1997-03-26 4-[(THIEN-3-YL)METHYL] IMIDAZOLE DERIVATIVES HAVING α2-ADRENOCEPTOR AGONISTIC ACTIVITY

Publications (1)

Publication Number Publication Date
DK0954521T3 true DK0954521T3 (da) 2003-09-15

Family

ID=24506097

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97919907T DK0954521T3 (da) 1996-03-28 1997-03-26 4-[(thien-3-yl)methyl]-imidazoler med alfa2-adrenoceptor-agonistisk aktivitet

Country Status (14)

Country Link
US (1) US5750720A (da)
EP (1) EP0954521B1 (da)
JP (1) JP2000507549A (da)
AT (1) ATE240321T1 (da)
AU (1) AU721867B2 (da)
DE (1) DE69722031T2 (da)
DK (1) DK0954521T3 (da)
ES (1) ES2198567T3 (da)
NO (1) NO984481L (da)
NZ (1) NZ332012A (da)
PT (1) PT954521E (da)
TW (1) TW504512B (da)
WO (1) WO1997035858A1 (da)
ZA (1) ZA972778B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329369B1 (en) 1997-12-04 2001-12-11 Allergan Sales, Inc. Methods of treating pain and other conditions
US6841684B2 (en) 1997-12-04 2005-01-11 Allergan, Inc. Imidiazoles having reduced side effects
PL341009A1 (en) * 1997-12-04 2001-03-12 Allergan Sales Substitute derivatives of imidazole exhibiting agonist-like activity in respect to adrenergic alpha 2b or 2b/2c receptors
AU2002254265B2 (en) * 1997-12-04 2008-05-15 Allergan, Inc. Imidiazole derivatives and their use as agonists selective at alpha 2B or 2B/2C adrenergic receptors
US6426356B1 (en) 1998-11-18 2002-07-30 Ortho-Mcneil Pharmaceutical, Inc. Imidazoethyl thiophenes
US6465486B1 (en) 1999-03-12 2002-10-15 Ortho-Mcneil Pharmaceutical, Inc. Pyridyl/quinolinyl imidazoles
TWI283669B (en) * 1999-06-10 2007-07-11 Allergan Inc Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors
US7838623B2 (en) 2004-09-14 2010-11-23 Corning Incorporated Fused thiophenes, methods for making fused thiophenes, and uses thereof
US7893191B2 (en) 2007-02-28 2011-02-22 Corning Incorporated Fused thiophenes, methods for making fused thiophenes, and uses thereof
KR101206202B1 (ko) 2004-09-14 2012-11-29 코닝 인코포레이티드 융합 티오펜, 융합 티오펜의 제조방법 및 그 용도
CA2632565A1 (en) * 2005-12-19 2007-07-05 Syngenta Limited Substituted aromatic heterocyclic compounds as fungicides
RU2478631C2 (ru) * 2007-05-14 2013-04-10 Аллерган, Инк. Соединения ((фенил)имидазолил)метилгетероарила, их применение, фармацевтическая композиция, содержащая указанные соединения, и набор, включающий такую композицию
US8487114B2 (en) 2008-03-31 2013-07-16 Corning Incorporated Fused thiophenes and methods for making and using same
CN103003268A (zh) * 2010-07-19 2013-03-27 先正达参股股份有限公司 作为杀微生物剂的异噁唑、异噻唑、呋喃以及噻吩化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01242571A (ja) * 1988-03-22 1989-09-27 Mitsui Petrochem Ind Ltd イミダゾール誘導体の製造方法
FI894911A0 (fi) * 1989-10-17 1989-10-17 Farmos Oy En terapeutiskt vaerdefull foerening.
CA2104873C (en) * 1991-02-26 2000-05-23 James N. Campbell Compositions and methods of treatment of sympathetically maintained pain
US5621113A (en) * 1996-03-28 1997-04-15 Ortho Pharmaceutical Corporation 4-[(thien-2-yl)methyl]-imidazole analgesics

Also Published As

Publication number Publication date
US5750720A (en) 1998-05-12
ES2198567T3 (es) 2004-02-01
NO984481L (no) 1998-11-23
ATE240321T1 (de) 2003-05-15
JP2000507549A (ja) 2000-06-20
TW504512B (en) 2002-10-01
PT954521E (pt) 2003-09-30
ZA972778B (en) 1998-10-01
DE69722031T2 (de) 2004-01-29
DE69722031D1 (en) 2003-06-18
AU2422997A (en) 1997-10-17
NZ332012A (en) 2000-07-28
AU721867B2 (en) 2000-07-13
NO984481D0 (no) 1998-09-25
EP0954521B1 (en) 2003-05-14
WO1997035858A1 (en) 1997-10-02
EP0954521A1 (en) 1999-11-10

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