NO984513L - Benzyl(iden)-laktam-derivater, deres fremstilling og deres anvendelse som selektive (ant)agonister for 5-HT1A- og 5-HT1D-reseptorer - Google Patents

Benzyl(iden)-laktam-derivater, deres fremstilling og deres anvendelse som selektive (ant)agonister for 5-HT1A- og 5-HT1D-reseptorer

Info

Publication number: NO984513L
Authority: NO; Norway
Prior art keywords: ht1a; iden; ant; agonists; benzyl
Prior art date: 1996-03-29

Application number

NO984513A

Other languages

English (en)

Other versions

NO984513D0 (no

NO312957B1 (no

Inventor

Harry R Howard

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-29

Filing date

1998-09-28

Publication date

1998-09-28

1998-09-28 Application filed by Pfizer filed Critical Pfizer

1998-09-28 Publication of NO984513D0 publication Critical patent/NO984513D0/no

1998-09-28 Publication of NO984513L publication Critical patent/NO984513L/no

2002-07-22 Publication of NO312957B1 publication Critical patent/NO312957B1/no

Links

102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 title 1
101150015707 HTR1A gene Proteins 0.000 title 1
101100321769 Takifugu rubripes htr1d gene Proteins 0.000 title 1
239000000556 agonist Substances 0.000 title 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Diabetes (AREA)
Psychology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Child & Adolescent Psychology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Quinoline Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO19984513A 1996-03-29 1998-09-28 Benzyl(iden)-laktamderivater, anvendelse derav og farmasöytisk sammensetning NO312957B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1513496P	1996-03-29	1996-03-29
PCT/IB1997/000076 WO1997036867A1 (en)	1996-03-29	1997-02-03	Benzyl(idene)-lactam derivatives, their preparation and their use as selective (ant)agonists of 5-ht1a- and/or 5-ht1d receptors

Publications (3)

Publication Number	Publication Date
NO984513D0 NO984513D0 (no)	1998-09-28
NO984513L true NO984513L (no)	1998-09-28
NO312957B1 NO312957B1 (no)	2002-07-22

Family

ID=21769713

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19984513A NO312957B1 (no)	1996-03-29	1998-09-28	Benzyl(iden)-laktamderivater, anvendelse derav og farmasöytisk sammensetning

Country Status (39)

Country	Link
US (2)	US6462048B2 (no)
EP (1)	EP0894085B1 (no)
JP (1)	JP3118467B2 (no)
KR (1)	KR100305071B1 (no)
CN (1)	CN1128788C (no)
AP (1)	AP824A (no)
AR (1)	AR006390A1 (no)
AT (1)	ATE302182T1 (no)
AU (1)	AU706839B2 (no)
BG (1)	BG64176B1 (no)
BR (1)	BR9708581A (no)
CA (1)	CA2249603A1 (no)
CO (1)	CO4650033A1 (no)
CZ (1)	CZ293628B6 (no)
DE (1)	DE69733996T2 (no)
DZ (1)	DZ2198A1 (no)
EA (1)	EA001485B1 (no)
ES (1)	ES2246058T3 (no)
HN (1)	HN1997000023A (no)
HR (1)	HRP970175A2 (no)
HU (1)	HUP9902160A3 (no)
ID (1)	ID17781A (no)
IL (1)	IL125377A (no)
IS (1)	IS4813A (no)
MA (1)	MA26425A1 (no)
MY (1)	MY118498A (no)
NO (1)	NO312957B1 (no)
NZ (1)	NZ325914A (no)
OA (1)	OA10879A (no)
PL (1)	PL329170A1 (no)
SK (1)	SK131498A3 (no)
TN (1)	TNSN97056A1 (no)
TR (1)	TR199801929T2 (no)
TW (1)	TW413679B (no)
UA (1)	UA70284C2 (no)
UY (1)	UY24498A1 (no)
WO (1)	WO1997036867A1 (no)
YU (1)	YU11997A (no)
ZA (1)	ZA972690B (no)

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US5880141A (en) *	1995-06-07	1999-03-09	Sugen, Inc.	Benzylidene-Z-indoline compounds for the treatment of disease
US6696448B2 (en) *	1996-06-05	2004-02-24	Sugen, Inc.	3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
US6423708B1 (en) *	1996-09-30	2002-07-23	Pfizer Inc	Aralkyl and aralkylidene heterocyclic lactams and imides
UA56185C2 (uk)	1996-09-30	2003-05-15	Пфайзер Інк.	Аралкіл- та аралкіліденгетероциклічні лактами та іміди, фармацевтична композиція та спосіб лікування
GB9718913D0 (en)	1997-09-05	1997-11-12	Glaxo Group Ltd	Substituted oxindole derivatives
US6531502B1 (en)	1998-01-21	2003-03-11	Sugen, Inc.	3-Methylidenyl-2-indolinone modulators of protein kinase
DE19830201A1 (de) *	1998-07-07	2000-01-13	Boehringer Ingelheim Pharma	Mittel mit antidepressiver Wirkung
WO2000006162A1 (de) *	1998-07-27	2000-02-10	Boehringer Ingelheim Pharma Kg	Mittel mit antidepressiver wirkung, mit pramipexol und einem weiteren antidepressivum
GB9904933D0 (en)	1999-03-04	1999-04-28	Glaxo Group Ltd	Compounds
US6624171B1 (en)	1999-03-04	2003-09-23	Smithkline Beecham Corporation	Substituted aza-oxindole derivatives
US6492398B1 (en)	1999-03-04	2002-12-10	Smithkline Beechman Corporation	Thiazoloindolinone compounds
DE60013751T2 (de) *	1999-12-29	2005-09-29	Pfizer Products Inc., Groton	Optisch aktive 3-((2-piperazinyl-phenyl)methyl)-1-(4-(trifluoromethyl)-phenyl)-2-pyrrolidinone als selektive 5-HT1D Rezeptor Antagonisten
AR034118A1 (es)	2000-02-15	2004-02-04	Sugen Inc	Compuestos de 2-indolinonas sustituidas con pirroles inhibidoras de proteinquinasas; sus composiciones farmaceuticas e intermediarios de sintesis
US6620818B1 (en)	2000-03-01	2003-09-16	Smithkline Beecham Corporation	Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
AR042586A1 (es)	2001-02-15	2005-06-29	Sugen Inc	3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
MXPA04003385A (es)	2001-10-10	2005-04-11	Sugen Inc	Derivados de 3-?4-substituido con heterociclilo)-pirrol-2-ilmetilidene?-2-indolinona como inhibidores de cinasa.
EP1469850B1 (en)	2002-01-02	2013-01-02	Versi Group, LLC	Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
TWI263497B (en) *	2002-03-29	2006-10-11	Lilly Co Eli	Pyridinoylpiperidines as 5-HT1F agonists
US7671072B2 (en) *	2003-11-26	2010-03-02	Pfizer Inc.	Aminopyrazole derivatives as GSK-3 inhibitors
CA2553291A1 (en) *	2004-01-29	2005-09-09	Pfizer Products Inc.	Combination of .gamma.-aminobutyric acid modulators and 5-ht1b receptor antagonists
ATE533745T1 (de) *	2004-03-17	2011-12-15	Pfizer Prod Inc	Neue benzyl(iden)-lactam-derivate
EP1753460A2 (en) *	2004-05-11	2007-02-21	Pfizer Products Inc.	Combination of atypical antipsychotics and 5-ht1b receptor antagonists
EP1753745A2 (en) *	2004-05-21	2007-02-21	Pfizer Products Inc.	Pyrazinylmethyl lactam derivatives
MXPA06014473A (es) *	2004-06-25	2007-03-01	Pfizer Prod Inc	Piridil piperazinas para el tratamiento de trastornos de sistema nervioso central.
ATE521591T1 (de)	2005-01-13	2011-09-15	Ge Healthcare Ltd	11c-markierte benzyl-lactam-verbindungen und deren verwendung als bildgebungsmittel
WO2006106416A1 (en) *	2005-04-08	2006-10-12	Pfizer Products Inc.	PYRIDIL-LACTAMS AND THEIR USE 5 -HTl RECEPTORS LIGAN
EP1891041A1 (en) *	2005-06-17	2008-02-27	Pfizer Products Incorporated	METABOLITES OF 1- [-6- (1-ETHYL-l-HYDROXY-PROPYL) -PYRIDIN-3-YL]-3- [2- (4-METHYL-PIPERAZIN-I-YL) -BENZYL]-PYRR0LIDIN-2-0NE AS SERATONIN RECEPTOR ANTAGONISTS
WO2007012964A1 (en) *	2005-07-25	2007-02-01	Pfizer Products Inc.	Preparation of alkylpiperazinylphenyl compounds by classical resolution
WO2007026224A2 (en) *	2005-08-31	2007-03-08	Pfizer Products Inc.	5-ht1b antagonist composition for depression, anxiety and cognition
WO2007026219A2 (en) *	2005-08-31	2007-03-08	Pfizer Products Inc.	Combinations of a 5-ht1b antagonist with a noradrenalin re-uptake inhibitor or a serotonin noradrenalin reutake inhibitor for treating cns conditions
US20070096411A1 (en) *	2005-11-02	2007-05-03	Rempe Gary L Ii	Device for retaining a kneeling rider on a gliding board
WO2014078568A1 (en)	2012-11-14	2014-05-22	The Johns Hopkins University	Methods and compositions for treating schizophrenia
CA3015702A1 (en)	2015-09-02	2017-03-09	Trevena, Inc.	6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
BR112019016827A2 (pt)	2017-02-17	2020-04-07	Trevena Inc	compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 5 membros, métodos de uso e produção dos mesmos
JP7185633B2 (ja)	2017-02-17	2022-12-07	トレベナ・インコーポレイテッド	７員アザ複素環を含有するデルタ－オピオイド受容体調節化合物、その使用方法及び製造方法
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HU221816B1 (hu)	1991-10-11	2003-01-28	Bristol-Myers Squibb Pharma Company	Gyűrűs karbonil vegyületek, és ezeket tartalmazó gyógyászati készítmények
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US6467084B1 (en) *	1999-12-16	2002-10-15	Emware, Inc.	Systems and methods for reprogramming an embedded device with program code using relocatable program code

1997
- 1997-02-03 CN CN97193251A patent/CN1128788C/zh not_active Expired - Fee Related
- 1997-02-03 SK SK1314-98A patent/SK131498A3/sk unknown
- 1997-02-03 PL PL97329170A patent/PL329170A1/xx unknown
- 1997-02-03 BR BR9708581A patent/BR9708581A/pt not_active Application Discontinuation
- 1997-02-03 WO PCT/IB1997/000076 patent/WO1997036867A1/en not_active Ceased
- 1997-02-03 ES ES97900717T patent/ES2246058T3/es not_active Expired - Lifetime
- 1997-02-03 AT AT97900717T patent/ATE302182T1/de not_active IP Right Cessation
- 1997-02-03 KR KR1019980707713A patent/KR100305071B1/ko not_active Expired - Fee Related
- 1997-02-03 CZ CZ19983052A patent/CZ293628B6/cs not_active IP Right Cessation
- 1997-02-03 CA CA002249603A patent/CA2249603A1/en not_active Abandoned
- 1997-02-03 AU AU13170/97A patent/AU706839B2/en not_active Ceased
- 1997-02-03 NZ NZ325914A patent/NZ325914A/en unknown
- 1997-02-03 EA EA199800771A patent/EA001485B1/ru not_active IP Right Cessation
- 1997-02-03 US US09/155,215 patent/US6462048B2/en not_active Expired - Fee Related
- 1997-02-03 HU HU9902160A patent/HUP9902160A3/hu unknown
- 1997-02-03 TR TR1998/01929T patent/TR199801929T2/xx unknown
- 1997-02-03 DE DE69733996T patent/DE69733996T2/de not_active Expired - Fee Related
- 1997-02-03 IL IL12537797A patent/IL125377A/xx not_active IP Right Cessation
- 1997-02-03 JP JP09535074A patent/JP3118467B2/ja not_active Expired - Fee Related
- 1997-02-03 EP EP97900717A patent/EP0894085B1/en not_active Expired - Lifetime
- 1997-02-04 TW TW086101295A patent/TW413679B/zh active
- 1997-02-06 HN HN1997000023A patent/HN1997000023A/es unknown
- 1997-03-02 UA UA98095077A patent/UA70284C2/uk unknown
- 1997-03-13 CO CO97013714A patent/CO4650033A1/es unknown
- 1997-03-21 UY UY24498A patent/UY24498A1/es not_active IP Right Cessation
- 1997-03-25 AR ARP970101200A patent/AR006390A1/es not_active Application Discontinuation
- 1997-03-26 TN TNTNSN97056A patent/TNSN97056A1/fr unknown
- 1997-03-26 MA MA24535A patent/MA26425A1/fr unknown
- 1997-03-26 HR HR60/015,134A patent/HRP970175A2/hr not_active Application Discontinuation
- 1997-03-26 DZ DZ970045A patent/DZ2198A1/fr active
- 1997-03-27 ZA ZA972690A patent/ZA972690B/xx unknown
- 1997-03-27 AP APAP/P/1997/000955A patent/AP824A/en active
- 1997-03-27 YU YU11997A patent/YU11997A/sh unknown
- 1997-03-27 ID IDP971025A patent/ID17781A/id unknown
- 1997-03-28 MY MYPI97001340A patent/MY118498A/en unknown
1998
- 1998-07-29 IS IS4813A patent/IS4813A/is unknown
- 1998-09-16 OA OA9800170A patent/OA10879A/en unknown
- 1998-09-24 BG BG102791A patent/BG64176B1/bg unknown
- 1998-09-28 NO NO19984513A patent/NO312957B1/no unknown
2002
- 2002-08-15 US US10/219,692 patent/US6924289B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AR006390A1 (es)	1999-08-25
NO984513D0 (no)	1998-09-28
CA2249603A1 (en)	1997-10-09
IL125377A0 (en)	1999-03-12
ZA972690B (en)	1998-09-28
YU11997A (sh)	1999-09-27
US20020028821A1 (en)	2002-03-07
NO312957B1 (no)	2002-07-22
DE69733996D1 (de)	2005-09-22
BR9708581A (pt)	1999-08-03
JP3118467B2 (ja)	2000-12-18
TW413679B (en)	2000-12-01
BG102791A (en)	1999-11-30
IL125377A (en)	2005-07-25
US6462048B2 (en)	2002-10-08
TNSN97056A1 (fr)	2005-03-15
AU1317097A (en)	1997-10-22
DE69733996T2 (de)	2006-07-20
HUP9902160A3 (en)	2001-02-28
CN1128788C (zh)	2003-11-26
AP9700955A0 (en)	1997-04-30
IS4813A (is)	1998-07-29
ID17781A (id)	1998-01-29
UA70284C2 (en)	2004-10-15
BG64176B1 (bg)	2004-03-31
JPH11506472A (ja)	1999-06-08
MA26425A1 (fr)	2004-12-20
PL329170A1 (en)	1999-03-15
MY118498A (en)	2004-11-30
ATE302182T1 (de)	2005-09-15
EA001485B1 (ru)	2001-04-23
DZ2198A1 (fr)	2002-12-02
CZ305298A3 (cs)	1999-07-14
ES2246058T3 (es)	2006-02-01
CN1214043A (zh)	1999-04-14
EA199800771A1 (ru)	1999-06-24
EP0894085B1 (en)	2005-08-17
NZ325914A (en)	1999-09-29
KR100305071B1 (ko)	2001-12-12
AP824A (en)	2000-04-28
WO1997036867A1 (en)	1997-10-09
US20030027812A1 (en)	2003-02-06
AU706839B2 (en)	1999-06-24
HN1997000023A (es)	1997-06-05
UY24498A1 (es)	2000-09-29
HK1019446A1 (en)	2000-02-11
KR20000005083A (ko)	2000-01-25
TR199801929T2 (xx)	1998-12-21
EP0894085A1 (en)	1999-02-03
CZ293628B6 (cs)	2004-06-16
HUP9902160A2 (hu)	1999-11-29
HRP970175A2 (en)	1998-12-31
OA10879A (en)	2001-10-05
SK131498A3 (en)	2000-09-12
US6924289B2 (en)	2005-08-02
CO4650033A1 (es)	1998-09-03

Publication	Publication Date	Title
NO984513D0 (no)	1998-09-28	Benzyl(iden)-laktam-derivater, deres fremstilling og deres anvendelse som selektive (ant)agonister for 5-HT1A- og 5-HT1D-reseptorer
NO993003D0 (no)	1999-06-18	Sulfonamid-derivater, fremgangsmÕte for deres fremstilling og deres anvendelse som medikamenter
AU4337699A (en)	1999-12-30	Multivalent agonists, partial agonists, inverse agonists and antagonists of the 5HT4 receptors
DK1119557T3 (da)	2004-04-13	Indeno-, naphto- og benzocyclohepta-dihydrothiazolderivater, fremstilling deraf og anvendelse deraf som anorektiske medikamenter
NO20006138L (no)	2001-02-01	Substituerte indolinoner, fremstilling og anvendelse derav som medikamenter
DK0847388T3 (da)	2003-08-18	Heterocyklisk substituerede biphenylamidderivater, fremstilling heraf og anvendelse heraf som fungicider
NO20012058D0 (no)	2001-04-26	2-ureido-tiazolderivater, fremgangsmåte for deres fremstilling og anvendelse som antitumormidler
NO20021719D0 (no)	2002-04-11	6-posisjon substituerte indoliner, fremstilling og anvendelse derav som medikament
DK1083171T3 (da)	2004-08-09	Pyrazolinderivater, deres fremstilling og anvendelse som medikamenter
DK0946512T3 (da)	2004-01-12	6-Phenylpyridyl-2-aminderivater, der er nyttige som NOS-inhibitorer
DK1095025T3 (da)	2003-04-07	Benzimidazoler, deres fremstilling og deres anvendelse som lægemidler
IS2458B (is)	2008-11-15	Indólín-2-ón afleiður, framleiðsla og notkun þeirra sem mjaltavaka (ocytocin) viðtakabindlar
NO20005146D0 (no)	2000-10-13	Tienylazolylalkoksyetanaminer, deres fremstilling og deres anvendelse som medikamenter
NO996115D0 (no)	1999-12-10	Azetidinylpropylpiperidin-derivater, intermediater og anvendelse som tachykinin-antagonister
NO20006460L (no)	2001-02-19	4, 5, 6 og 7-Indol og indolinderivater, deres fremstilling og anvendelse
NO963117D0 (no)	1996-07-25	Indol-derivater som 5-HT1-agonister
NO971136D0 (no)	1997-03-12	Aminoalkyl- og acylaminoaklyleter, fremgangsmåte for fremstilling derav og anvendelse som bradykinin-reseptor antagonister
NO20004144D0 (no)	2000-08-18	Heterocykliske forbindelser, deres fremstilling og anvendelse som takykinin reseptor antagonister
NO20001934D0 (no)	2000-04-13	3-Substituerte tetrahydropyridopyrimidinon-derivater, deres fremstilling og anvendelse
DK0912556T3 (da)	2001-01-22	Indolinderivater, der er anvendelige som 5-HT-2C-receptorantagonister
NO20002959D0 (no)	2000-06-09	Echinocandinderivater, fremgangsmÕte for fremstilling av slike og deres anvendelse som anti-soppmidler
AU2883397A (en)	1998-01-05	5-alkoxy-tryptamine derivatives, their preparation and their use as 5-ht1d receptor agonists
DK1076651T3 (da)	2005-08-15	Substituerede sulfonylcyanamider, fremgangsmåde til fremstilling heraf og anvendelsen heraf som lægemidler
NO307176B1 (no)	2000-02-21	Indol-derivater som CCK-reseptorantagonister, anvendelse derav og farmasoeytisk preparat
IL131157A0 (en)	2001-01-28	4-Aminoalkoxy-1,3-dihydrobenzoimidazol-2-thione derivatives their preparation and their use as dopamine autoreceptor (d2) agonists