NO995711L - Kinolin-4-karboksamid-derivater som NK-2 og NK-3- reseptorantagonister - Google Patents

Kinolin-4-karboksamid-derivater som NK-2 og NK-3- reseptorantagonister

Info

Publication number: NO995711L
Authority: NO; Norway
Prior art keywords: alkyl; optionally substituted; group; compound; aryl
Prior art date: 1997-05-23

Application number

NO995711A

Other languages

English (en)

Norwegian (no)

Other versions

NO995711D0 (no

Inventor

Giuseppe Arnaldo Mari Giardina

Mario Grugni

Davide Graziani

Luca Francesco Raveglia

Original Assignee

Smithkline Beecham Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-23

Filing date

1999-11-22

Publication date

2000-01-19

1997-05-23 Priority claimed from GBGB9710750.2A external-priority patent/GB9710750D0/en

1997-10-17 Priority claimed from IT002354 external-priority patent/IT1295358B1/it

1997-12-16 Priority claimed from ITMI972775 external-priority patent/IT1296976B1/it

1999-11-22 Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa

1999-11-22 Publication of NO995711D0 publication Critical patent/NO995711D0/no

2000-01-19 Publication of NO995711L publication Critical patent/NO995711L/no

Links

108010040722 Neurokinin-2 Receptors Proteins 0.000 title 1
108010040716 Neurokinin-3 Receptors Proteins 0.000 title 1
102100029409 Neuromedin-K receptor Human genes 0.000 title 1
102100037342 Substance-K receptor Human genes 0.000 title 1
LEWDKQKVAFOMPI-UHFFFAOYSA-N quinoline-4-carboxamide Chemical class C1=CC=C2C(C(=O)N)=CC=NC2=C1 LEWDKQKVAFOMPI-UHFFFAOYSA-N 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
150000001875 compounds Chemical class 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 2
-1 cyano, carboxy Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000003107 substituted aryl group Chemical group 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
125000004945 acylaminoalkyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000005518 carboxamido group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000005544 phthalimido group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pulmonology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO995711A 1997-05-23 1999-11-22 Kinolin-4-karboksamid-derivater som NK-2 og NK-3- reseptorantagonister NO995711L (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9710750.2A GB9710750D0 (en)	1997-05-23	1997-05-23	Novel compounds
IT002354 IT1295358B1 (it)	1997-10-17	1997-10-17	Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
ITMI972775 IT1296976B1 (it)	1997-12-16	1997-12-16	Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
PCT/EP1998/003014 WO1998052942A1 (fr)	1997-05-23	1998-05-18	Nouveaux composes

Publications (2)

Publication Number	Publication Date
NO995711D0 NO995711D0 (no)	1999-11-22
NO995711L true NO995711L (no)	2000-01-19

Family

ID=27268859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO995711A NO995711L (no)	1997-05-23	1999-11-22	Kinolin-4-karboksamid-derivater som NK-2 og NK-3- reseptorantagonister

Country Status (26)

Country	Link
EP (1)	EP0983262B1 (fr)
JP (1)	JP2002500645A (fr)
CN (1)	CN1264378A (fr)
AP (1)	AP9901695A0 (fr)
AR (1)	AR012732A1 (fr)
AT (1)	ATE244711T1 (fr)
AU (1)	AU8209898A (fr)
BG (1)	BG104009A (fr)
BR (1)	BR9809652A (fr)
CA (1)	CA2291111A1 (fr)
CO (1)	CO4950515A1 (fr)
DE (1)	DE69816290T2 (fr)
DZ (1)	DZ2498A1 (fr)
EA (1)	EA199901062A1 (fr)
ES (1)	ES2201509T3 (fr)
HU (1)	HUP0002300A3 (fr)
ID (1)	ID22876A (fr)
IL (1)	IL133036A0 (fr)
MA (1)	MA26501A1 (fr)
NO (1)	NO995711L (fr)
OA (1)	OA11515A (fr)
PE (1)	PE75199A1 (fr)
PL (1)	PL336942A1 (fr)
SK (1)	SK159299A3 (fr)
TR (1)	TR199902883T2 (fr)
WO (1)	WO1998052942A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6780875B2 (en) *	1998-11-20	2004-08-24	Smithkline Beecham S.P.A.	Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
JP2002530377A (ja) *	1998-11-20	2002-09-17	スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ	Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしてのキノリン−４−カルボキシアミド誘導体
GB9825554D0 (en) *	1998-11-20	1999-01-13	Smithkline Beecham Spa	Novel Compounds
ATE247652T1 (de)	1999-03-29	2003-09-15	Neurogen Corp	4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden
WO2000064877A1 (fr) *	1999-04-26	2000-11-02	Neurogen Corporation	2-aminoquinolinecarboxamides: ligands de recepteurs de la neurokinine
WO2002013825A1 (fr) *	2000-08-11	2002-02-21	Smithkline Beecham P.L.C.	Nouvelle utilisation pharmaceutique de dérivés quinnoliniques
EP1334089A1 (fr) *	2000-11-13	2003-08-13	GlaxoSmithKline S.p.A.	Derives de la quinoline en tant qu'antagonistes de nk-3 et nk-2
WO2002044165A1 (fr) *	2000-11-28	2002-06-06	Glaxosmithkline Spa	Derives de quinoline utilises comme antagonistes de nk-3
GB0028964D0 (en) *	2000-11-28	2001-01-10	Smithkline Beecham Spa	Novel compounds
US6540733B2 (en)	2000-12-29	2003-04-01	Corazon Technologies, Inc.	Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion
EP1385839B1 (fr) *	2001-04-11	2006-02-22	GlaxoSmithKline S.p.A.	Derives de 3-substitue quinoline-4-carboxamide utilises comme antagonistes du recepteur nk3 et du recepteur nk2
GB0109122D0 (en) *	2001-04-11	2001-05-30	Smithkline Beecham Spa	Novel compounds
MY134211A (en) *	2001-05-18	2007-11-30	Smithkline Beecham Corp	Novel use
GB0425075D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
GB0425077D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
GB0425076D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
CA2611060A1 (fr) *	2005-06-03	2006-12-07	R. Thomas Simpson	Derives de quinoline utilises comme antagonistes de nk3
GB0515580D0 (en)	2005-07-29	2005-09-07	Merck Sharp & Dohme	Therapeutic compounds
AR057130A1 (es)	2005-09-21	2007-11-14	Astrazeneca Ab	Quinolinas de alquilsulfoxido y una composicion farmaceutica
DE202007017299U1 (de) *	2007-12-12	2009-04-23	Drebo Werkzeugfabrik Gmbh	Bohrer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69531458T2 (de) *	1994-05-27	2004-08-05	Glaxosmithkline S.P.A.	Chinolinderivate als tachykinin nk3 rezeptor antagonisten
AR004735A1 (es) *	1995-11-24	1999-03-10	Smithkline Beecham Spa	Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.

1998
- 1998-05-18 CN CN98807356A patent/CN1264378A/zh active Pending
- 1998-05-18 PL PL98336942A patent/PL336942A1/xx unknown
- 1998-05-18 WO PCT/EP1998/003014 patent/WO1998052942A1/fr not_active Ceased
- 1998-05-18 IL IL13303698A patent/IL133036A0/xx unknown
- 1998-05-18 CA CA002291111A patent/CA2291111A1/fr not_active Abandoned
- 1998-05-18 AU AU82098/98A patent/AU8209898A/en not_active Abandoned
- 1998-05-18 DE DE69816290T patent/DE69816290T2/de not_active Expired - Fee Related
- 1998-05-18 ID IDW991432A patent/ID22876A/id unknown
- 1998-05-18 ES ES98932069T patent/ES2201509T3/es not_active Expired - Lifetime
- 1998-05-18 SK SK1592-99A patent/SK159299A3/sk unknown
- 1998-05-18 JP JP54996798A patent/JP2002500645A/ja not_active Ceased
- 1998-05-18 AP APAP/P/1999/001695A patent/AP9901695A0/en unknown
- 1998-05-18 BR BR9809652-4A patent/BR9809652A/pt not_active IP Right Cessation
- 1998-05-18 TR TR1999/02883T patent/TR199902883T2/xx unknown
- 1998-05-18 EA EA199901062A patent/EA199901062A1/ru unknown
- 1998-05-18 AT AT98932069T patent/ATE244711T1/de not_active IP Right Cessation
- 1998-05-18 HU HU0002300A patent/HUP0002300A3/hu unknown
- 1998-05-18 EP EP98932069A patent/EP0983262B1/fr not_active Expired - Lifetime
- 1998-05-19 DZ DZ980108A patent/DZ2498A1/fr active
- 1998-05-20 PE PE1998000398A patent/PE75199A1/es not_active Application Discontinuation
- 1998-05-21 MA MA25086A patent/MA26501A1/fr unknown
- 1998-05-21 AR ARP980102363A patent/AR012732A1/es not_active Application Discontinuation
- 1998-05-22 CO CO98029024A patent/CO4950515A1/es unknown
1999
- 1999-11-22 NO NO995711A patent/NO995711L/no not_active Application Discontinuation
- 1999-11-23 OA OA9900253A patent/OA11515A/en unknown
- 1999-12-14 BG BG104009A patent/BG104009A/xx unknown

Also Published As

Publication number	Publication date
EP0983262A1 (fr)	2000-03-08
HUP0002300A3 (en)	2002-01-28
BR9809652A (pt)	2001-09-11
TR199902883T2 (xx)	2000-05-22
IL133036A0 (en)	2001-03-19
EA199901062A1 (ru)	2000-08-28
CA2291111A1 (fr)	1998-11-26
DE69816290D1 (de)	2003-08-14
AP9901695A0 (en)	1999-12-31
HUP0002300A2 (hu)	2001-06-28
ES2201509T3 (es)	2004-03-16
CO4950515A1 (es)	2000-09-01
SK159299A3 (en)	2000-06-12
OA11515A (en)	2004-02-04
JP2002500645A (ja)	2002-01-08
MA26501A1 (fr)	2004-12-20
AR012732A1 (es)	2000-11-08
EP0983262B1 (fr)	2003-07-09
ID22876A (id)	1999-12-16
ATE244711T1 (de)	2003-07-15
NO995711D0 (no)	1999-11-22
AU8209898A (en)	1998-12-11
PE75199A1 (es)	1999-10-22
PL336942A1 (en)	2000-07-17
CN1264378A (zh)	2000-08-23
DE69816290T2 (de)	2004-05-27
DZ2498A1 (fr)	2003-01-25
BG104009A (en)	2000-07-31
WO1998052942A1 (fr)	1998-11-26

Legal Events

Date	Code	Title	Description
2003-01-27	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
AP9801238A0 (en)	1998-06-30	Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (NK-3)- and neurokinin 2 (NK-2) receptor antagonists.
HK1041257A1 (zh)	2002-07-05	作為nk-3受體拮抗劑的喹啉-4-酰胺衍生物
AR004972A1 (es)	1999-04-07	Compuesto quinolino 4-carboxamidas n-sustituidas, un procedimiento para su preparacion, el uso de los mismos para la fabricacion de un medicamento, una composicion farmaceutica y un antagonista nk-2/nk-3 combinado.
EA200200942A1 (ru)	2003-02-27	Фармацевтические композиции, содержащие производные 3-аминоазетидина, новые производные и способ их получения
EA200100428A1 (ru)	2001-10-22	Производные тетрагидробензазепина, полезные в качестве модуляторов допаминовых d3 рецепторов (антипсихотические агенты)
BG104248A (en)	2001-08-31	Benzamidoxim derivatives, intermediate products and methods for preparing and using them as fungicides
MX9504349A (es)	1997-03-29	Derivados de aroilpiperidina.
EA200602060A1 (ru)	2007-04-27	Производные пирролидин-2-она и пиперидин-2-она, используемые в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы
AR007077A1 (es)	1999-10-13	Derivados tetrahidroisoquinolina, un procedimiento para su preparacion, una composicion farmaceutica que los contiene, el uso de los mismos parala fabricacion de un medicamento
CO4950625A1 (es)	2000-09-01	Derivados de nicotinamida
CY1108313T1 (el)	2014-02-12	Παραγωγα της κινολινης και η χρηση τους ως προσδεματων 5-ht6
CO5040071A1 (es)	2001-05-29	Derivados de aminas biciclicas, procesos para su prepara- cion, y composiciones insecticidas que los comprenden
ES2091615T3 (es)	1996-11-01	Derivados de indol fungicidas.
BR9809652A (pt)	2001-09-11	Derivados de quinolina-4-carboxamida como antagonistas de receptor nk-2 e nk-3
CO5590895A2 (es)	2005-12-30	Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos
NO952208L (no)	1995-08-02	Amin-derivater
AR005338A1 (es)	1999-04-28	Derivados acetidinalquilicos de heterociclos con nitrogeno n-sustituido o sales farmaceuticamente aceptables de los mismos, un procedimiento paraprepararlos, composiciones farmaceuticas que los comprenden, uso de dichos derivados, sales y composiciones, y compuestos utilizables como intermedios
ATE348813T1 (de)	2007-01-15	Chinolinderivate als nk-2 und nk-3 rezeptor- liganden
NO964698D0 (no)	1996-11-06	Bicykliske aminderivater som inhibitorer av nitrogenoksid-syntetase
DK1034174T3 (da)	2003-09-22	Azaringetherderivater og disses anvendelse som nikotin-ACh-receptormodulatorer
HRP20030610B1 (en)	2006-02-28	Process for the preparation of mesylates of piperazine derivatives
AR023111A1 (es)	2002-09-04	Derivados de sulfonamida utiles como antagonistas del receptor 5-ht7, un procedimiento para su preparacion y composicion farmaceutica que los comprenden
EA200400469A1 (ru)	2004-08-26	Замещенные производные алкиламинопиридазинона, способ их получения и содержащие их фармацевтические композиции
DE69914803D1 (de)	2004-03-18	Benzoxazol-derivate zur verwendung als integrin-inhibitoren
DK0701551T3 (da)	1997-10-20	3-(Indol-3-yl)propensyrederivater som NMDA-antagonister