BG104009A - Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists - Google Patents

Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists

Info

Publication number: BG104009A
Authority: BG; Bulgaria
Prior art keywords: alkyl; optionally substituted; alkylamino; aryl; group
Prior art date: 1997-05-23

Application number

BG104009A

Other languages

Bulgarian (bg)

English (en)

Inventor

Giuseppe Giardina

Mario Grugni

Davide Graziani

Luca Raveglia

Original Assignee

Smithkline Beecham S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-23

Filing date

1999-12-14

Publication date

2000-07-31

1997-05-23 Priority claimed from GBGB9710750.2A external-priority patent/GB9710750D0/en

1997-10-17 Priority claimed from IT002354 external-priority patent/IT1295358B1/it

1997-12-16 Priority claimed from ITMI972775 external-priority patent/IT1296976B1/it

1999-12-14 Application filed by Smithkline Beecham S.P.A. filed Critical Smithkline Beecham S.P.A.

2000-07-31 Publication of BG104009A publication Critical patent/BG104009A/xx

Links

LEWDKQKVAFOMPI-UHFFFAOYSA-N quinoline-4-carboxamide Chemical class C1=CC=C2C(C(=O)N)=CC=NC2=C1 LEWDKQKVAFOMPI-UHFFFAOYSA-N 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 11
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
-1 cyano, carboxy Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 2
125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 2
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000003107 substituted aryl group Chemical group 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 1
125000004945 acylaminoalkyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000005518 carboxamido group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pulmonology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BG104009A 1997-05-23 1999-12-14 Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists BG104009A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9710750.2A GB9710750D0 (en)	1997-05-23	1997-05-23	Novel compounds
IT002354 IT1295358B1 (it)	1997-10-17	1997-10-17	Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
ITMI972775 IT1296976B1 (it)	1997-12-16	1997-12-16	Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
PCT/EP1998/003014 WO1998052942A1 (fr)	1997-05-23	1998-05-18	Nouveaux composes

Publications (1)

Publication Number	Publication Date
BG104009A true BG104009A (en)	2000-07-31

Family

ID=27268859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG104009A BG104009A (en)	1997-05-23	1999-12-14	Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists

Country Status (26)

Country	Link
EP (1)	EP0983262B1 (fr)
JP (1)	JP2002500645A (fr)
CN (1)	CN1264378A (fr)
AP (1)	AP9901695A0 (fr)
AR (1)	AR012732A1 (fr)
AT (1)	ATE244711T1 (fr)
AU (1)	AU8209898A (fr)
BG (1)	BG104009A (fr)
BR (1)	BR9809652A (fr)
CA (1)	CA2291111A1 (fr)
CO (1)	CO4950515A1 (fr)
DE (1)	DE69816290T2 (fr)
DZ (1)	DZ2498A1 (fr)
EA (1)	EA199901062A1 (fr)
ES (1)	ES2201509T3 (fr)
HU (1)	HUP0002300A3 (fr)
ID (1)	ID22876A (fr)
IL (1)	IL133036A0 (fr)
MA (1)	MA26501A1 (fr)
NO (1)	NO995711L (fr)
OA (1)	OA11515A (fr)
PE (1)	PE75199A1 (fr)
PL (1)	PL336942A1 (fr)
SK (1)	SK159299A3 (fr)
TR (1)	TR199902883T2 (fr)
WO (1)	WO1998052942A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6780875B2 (en) *	1998-11-20	2004-08-24	Smithkline Beecham S.P.A.	Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
GB9825554D0 (en) *	1998-11-20	1999-01-13	Smithkline Beecham Spa	Novel Compounds
CN1406225A (zh) *	1998-11-20	2003-03-26	葛兰素史密丝克莱恩有限公司	用作nk－3和nk－2受体拮抗剂的喹啉－4－甲酰胺衍生物
WO2000058313A1 (fr)	1999-03-29	2000-10-05	Neurogen Corporation	Derives de quinoline 4-substitues en tant que ligands des recepteurs de gaba
AU4802500A (en)	1999-04-26	2000-11-10	Neurogen Corporation	2-aminoquinolinecarboxamides: neurokinin receptor ligands
WO2002013825A1 (fr) *	2000-08-11	2002-02-21	Smithkline Beecham P.L.C.	Nouvelle utilisation pharmaceutique de dérivés quinnoliniques
US20040082589A1 (en) *	2000-11-13	2004-04-29	Carlo Farina	Quinoline derivatives as nk-3 and nk-2 antagonists
WO2002044165A1 (fr) *	2000-11-28	2002-06-06	Glaxosmithkline Spa	Derives de quinoline utilises comme antagonistes de nk-3
GB0028964D0 (en) *	2000-11-28	2001-01-10	Smithkline Beecham Spa	Novel compounds
US6540733B2 (en)	2000-12-29	2003-04-01	Corazon Technologies, Inc.	Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion
GB0109122D0 (en) *	2001-04-11	2001-05-30	Smithkline Beecham Spa	Novel compounds
US20040152726A1 (en) *	2001-04-11	2004-08-05	Carlo Farina	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
MY134211A (en) *	2001-05-18	2007-11-30	Smithkline Beecham Corp	Novel use
GB0425076D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
GB0425075D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
GB0425077D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
AU2006253054A1 (en) *	2005-06-03	2006-12-07	Astrazeneca Ab	Quinoline derivatives as NK3 anatgonists
GB0515580D0 (en)	2005-07-29	2005-09-07	Merck Sharp & Dohme	Therapeutic compounds
AR057130A1 (es)	2005-09-21	2007-11-14	Astrazeneca Ab	Quinolinas de alquilsulfoxido y una composicion farmaceutica
DE202007017299U1 (de) *	2007-12-12	2009-04-23	Drebo Werkzeugfabrik Gmbh	Bohrer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RO114445B1 (ro) *	1994-05-27	1999-04-30	Smithkline Beecham S.P.A.	Derivaţi de chinolină antagonişti ai receptorului nk3 tachichinină,procedeu de preparare,compoziţii farmaceutice pe baza acestora şi metodă de tratament
AR004735A1 (es) *	1995-11-24	1999-03-10	Smithkline Beecham Spa	Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.

1998
- 1998-05-18 ES ES98932069T patent/ES2201509T3/es not_active Expired - Lifetime
- 1998-05-18 AU AU82098/98A patent/AU8209898A/en not_active Abandoned
- 1998-05-18 AP APAP/P/1999/001695A patent/AP9901695A0/en unknown
- 1998-05-18 HU HU0002300A patent/HUP0002300A3/hu unknown
- 1998-05-18 BR BR9809652-4A patent/BR9809652A/pt not_active IP Right Cessation
- 1998-05-18 WO PCT/EP1998/003014 patent/WO1998052942A1/fr not_active Ceased
- 1998-05-18 SK SK1592-99A patent/SK159299A3/sk unknown
- 1998-05-18 EP EP98932069A patent/EP0983262B1/fr not_active Expired - Lifetime
- 1998-05-18 CN CN98807356A patent/CN1264378A/zh active Pending
- 1998-05-18 PL PL98336942A patent/PL336942A1/xx unknown
- 1998-05-18 JP JP54996798A patent/JP2002500645A/ja not_active Ceased
- 1998-05-18 DE DE69816290T patent/DE69816290T2/de not_active Expired - Fee Related
- 1998-05-18 AT AT98932069T patent/ATE244711T1/de not_active IP Right Cessation
- 1998-05-18 ID IDW991432A patent/ID22876A/id unknown
- 1998-05-18 IL IL13303698A patent/IL133036A0/xx unknown
- 1998-05-18 EA EA199901062A patent/EA199901062A1/ru unknown
- 1998-05-18 CA CA002291111A patent/CA2291111A1/fr not_active Abandoned
- 1998-05-18 TR TR1999/02883T patent/TR199902883T2/xx unknown
- 1998-05-19 DZ DZ980108A patent/DZ2498A1/fr active
- 1998-05-20 PE PE1998000398A patent/PE75199A1/es not_active Application Discontinuation
- 1998-05-21 MA MA25086A patent/MA26501A1/fr unknown
- 1998-05-21 AR ARP980102363A patent/AR012732A1/es not_active Application Discontinuation
- 1998-05-22 CO CO98029024A patent/CO4950515A1/es unknown
1999
- 1999-11-22 NO NO995711A patent/NO995711L/no not_active Application Discontinuation
- 1999-11-23 OA OA9900253A patent/OA11515A/en unknown
- 1999-12-14 BG BG104009A patent/BG104009A/xx unknown

Also Published As

Publication number	Publication date
EP0983262B1 (fr)	2003-07-09
NO995711D0 (no)	1999-11-22
ES2201509T3 (es)	2004-03-16
DZ2498A1 (fr)	2003-01-25
DE69816290D1 (de)	2003-08-14
EA199901062A1 (ru)	2000-08-28
MA26501A1 (fr)	2004-12-20
ID22876A (id)	1999-12-16
HUP0002300A2 (hu)	2001-06-28
HUP0002300A3 (en)	2002-01-28
AP9901695A0 (en)	1999-12-31
TR199902883T2 (xx)	2000-05-22
ATE244711T1 (de)	2003-07-15
AR012732A1 (es)	2000-11-08
EP0983262A1 (fr)	2000-03-08
PL336942A1 (en)	2000-07-17
PE75199A1 (es)	1999-10-22
IL133036A0 (en)	2001-03-19
WO1998052942A1 (fr)	1998-11-26
CN1264378A (zh)	2000-08-23
AU8209898A (en)	1998-12-11
CO4950515A1 (es)	2000-09-01
OA11515A (en)	2004-02-04
BR9809652A (pt)	2001-09-11
CA2291111A1 (fr)	1998-11-26
NO995711L (no)	2000-01-19
SK159299A3 (en)	2000-06-12
DE69816290T2 (de)	2004-05-27
JP2002500645A (ja)	2002-01-08

Publication	Publication Date	Title
MX9804108A (es)	1998-09-30	Derivados de quinolina-4-carboxamida, su preparacion y uso como antagonistas receptores de neuroquinina 3 (nk-3)- y neuroquinina 2 (kn-2).
HK1041257A1 (zh)	2002-07-05	作為nk-3受體拮抗劑的喹啉-4-酰胺衍生物
AR004972A1 (es)	1999-04-07	Compuesto quinolino 4-carboxamidas n-sustituidas, un procedimiento para su preparacion, el uso de los mismos para la fabricacion de un medicamento, una composicion farmaceutica y un antagonista nk-2/nk-3 combinado.
AP9901695A0 (en)	1999-12-31	Quinoline-4-carbaoxamide derivatives as NK-2 and NK-3 receptor antagonists.
NO20004778L (no)	2000-11-27	Amidderivater og nociceptin antagonister
WO2003024967A3 (fr)	2003-09-04	Composes chimiques
DE69710319D1 (de)	2002-03-21	Para-substituierte phenylpropansäure derivate als integrin-antagonisten
DK1539700T3 (da)	2010-01-04	8-hydroxyquinolin-derivater
EE03446B1 (et)	2001-06-15	8-asabitsüklo[3.2.1]okt-2-eeni derivaadid, nende valmistamine ja kasutamine
UA72917C2 (en)	2005-05-16	Cyclic carbamates derivatives, pharmaceutical composition containing said derivatives of cyclic carbamates and active ingredients as modulators of the progesterone receptor
CA2238171A1 (fr)	1999-11-21	Derives de quinoleine en tant qu'antagonistes nk3
ATE463483T1 (de)	2010-04-15	6-substituierte isochinolinderivate als rock-1- inhibitoren
WO2001064645A3 (fr)	2001-12-27	Derives de quinoline utilises comme antagonistes alpha2
SE0101579D0 (sv)	2001-05-04	New compounds
EA200400994A1 (ru)	2005-06-30	Новые 1,2,3-замещенные производные индолизина, являющиеся ингибиторами факторов роста фибробластов, способ их получения и фармацевтические композиции, содержащие их
MY146599A (en)	2012-08-30	New azetidine compounds
CA2187309A1 (fr)	1995-10-26	Derives de tropane-2-aldoxime en tant qu'inhibiteurs de recaptage des neurotransmetteurs
ATE469157T1 (de)	2010-06-15	Tetrahydrofuroä3,4-düdioxolverbindungen und zusammensetzungen und verfahren zur inhibierung der trombozytenaggregation
ATE348813T1 (de)	2007-01-15	Chinolinderivate als nk-2 und nk-3 rezeptor- liganden
CA2278687A1 (fr)	1998-07-30	Derives de 5-aroylnaphthalene
EA200301171A1 (ru)	2004-04-29	Новые соединения трициклических дигидрохинолинов, способ их получения и фармацевтические композиции, содержащие их
AR035718A1 (es)	2004-07-07	Derivados de quinolina, procedimientos para su preparacion, composiciones farmaceuticas que lo comprenden, y el uso de tales compuestos en la fabricacion de medicamentos
NZ323388A (en)	2000-01-28	Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (NK-3) and neurokinin 2 (NK-2) receptor antagonists
BG106079A (en)	2002-05-31	Cyclocarbamate derivatives as progesterone receptor modulators
EA200200379A2 (ru)	2002-10-31	Новые соединения пиримидин-4-она, способ их получения и содержащие их фармацевтические композиции