SK159299A3 - Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists - Google Patents

Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists Download PDF

Info

Publication number: SK159299A3
Authority: SK; Slovakia
Prior art keywords: alkyl; formula; compound; quinoline; group
Prior art date: 1997-05-23

Application number

SK1592-99A

Other languages

English (en)

Slovak (sk)

Inventor

Maria Arnaldo Giusepp Giardina

Mario Grugni

Davide Graziani

Francesco Luca Raveglia

Original Assignee

Smithkline Beecham Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-23

Filing date

1998-05-18

Publication date

2000-06-12

1997-05-23 Priority claimed from GBGB9710750.2A external-priority patent/GB9710750D0/en

1997-10-17 Priority claimed from IT002354 external-priority patent/IT1295358B1/it

1997-12-16 Priority claimed from ITMI972775 external-priority patent/IT1296976B1/it

1998-05-18 Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa

2000-06-12 Publication of SK159299A3 publication Critical patent/SK159299A3/sk

Links

LEWDKQKVAFOMPI-UHFFFAOYSA-N quinoline-4-carboxamide Chemical class C1=CC=C2C(C(=O)N)=CC=NC2=C1 LEWDKQKVAFOMPI-UHFFFAOYSA-N 0.000 title claims description 20
108010040722 Neurokinin-2 Receptors Proteins 0.000 title claims description 7
108010040716 Neurokinin-3 Receptors Proteins 0.000 title claims description 7
102100029409 Neuromedin-K receptor Human genes 0.000 title description 3
102100037342 Substance-K receptor Human genes 0.000 title description 3
239000002464 receptor antagonist Substances 0.000 title description 2
229940044551 receptor antagonist Drugs 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 180
-1 cyano, carboxy Chemical group 0.000 claims abstract description 38
150000003839 salts Chemical class 0.000 claims abstract description 34
125000000623 heterocyclic group Chemical group 0.000 claims abstract description 27
239000012453 solvate Substances 0.000 claims abstract description 26
125000003118 aryl group Chemical group 0.000 claims abstract description 22
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 21
239000001257 hydrogen Substances 0.000 claims abstract description 14
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 14
125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 14
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 13
125000001424 substituent group Chemical group 0.000 claims abstract description 13
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 12
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 11
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 11
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 9
125000005842 heteroatom Chemical group 0.000 claims abstract description 9
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 8
239000003814 drug Substances 0.000 claims abstract description 8
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims abstract description 7
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims abstract description 7
125000006615 aromatic heterocyclic group Chemical group 0.000 claims abstract description 7
229910052736 halogen Inorganic materials 0.000 claims abstract description 7
150000002367 halogens Chemical class 0.000 claims abstract description 7
238000004519 manufacturing process Methods 0.000 claims abstract description 7
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 7
125000003107 substituted aryl group Chemical group 0.000 claims abstract description 7
125000000278 alkyl amino alkyl group Chemical group 0.000 claims abstract description 6
125000004457 alkyl amino carbonyl group Chemical group 0.000 claims abstract description 6
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims abstract description 6
229910052760 oxygen Inorganic materials 0.000 claims abstract description 6
125000003342 alkenyl group Chemical group 0.000 claims abstract description 5
229910052799 carbon Inorganic materials 0.000 claims abstract description 5
125000001072 heteroaryl group Chemical group 0.000 claims abstract description 4
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 4
125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims abstract description 3
125000004945 acylaminoalkyl group Chemical group 0.000 claims abstract description 3
125000004423 acyloxy group Chemical group 0.000 claims abstract description 3
125000004183 alkoxy alkyl group Chemical group 0.000 claims abstract description 3
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract description 3
125000005518 carboxamido group Chemical group 0.000 claims abstract description 3
125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 3
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125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 3
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125000000217 alkyl group Chemical group 0.000 claims description 46
238000000034 method Methods 0.000 claims description 22
230000000694 effects Effects 0.000 claims description 11
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208000037920 primary disease Diseases 0.000 claims description 7
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230000003247 decreasing effect Effects 0.000 claims description 3
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NHKJPPKXDNZFBJ-UHFFFAOYSA-N phenyllithium Chemical compound [Li]C1=CC=CC=C1 NHKJPPKXDNZFBJ-UHFFFAOYSA-N 0.000 description 1
YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical compound C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 description 1
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229920001296 polysiloxane Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
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239000004334 sorbic acid Substances 0.000 description 1
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239000002466 tachykinin receptor agonist Substances 0.000 description 1
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150000003512 tertiary amines Chemical class 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pulmonology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SK1592-99A 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists SK159299A3 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9710750.2A GB9710750D0 (en)	1997-05-23	1997-05-23	Novel compounds
IT002354 IT1295358B1 (it)	1997-10-17	1997-10-17	Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
ITMI972775 IT1296976B1 (it)	1997-12-16	1997-12-16	Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
PCT/EP1998/003014 WO1998052942A1 (fr)	1997-05-23	1998-05-18	Nouveaux composes

Publications (1)

Publication Number	Publication Date
SK159299A3 true SK159299A3 (en)	2000-06-12

Family

ID=27268859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1592-99A SK159299A3 (en)	1997-05-23	1998-05-18	Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists

Country Status (26)

Country	Link
EP (1)	EP0983262B1 (fr)
JP (1)	JP2002500645A (fr)
CN (1)	CN1264378A (fr)
AP (1)	AP9901695A0 (fr)
AR (1)	AR012732A1 (fr)
AT (1)	ATE244711T1 (fr)
AU (1)	AU8209898A (fr)
BG (1)	BG104009A (fr)
BR (1)	BR9809652A (fr)
CA (1)	CA2291111A1 (fr)
CO (1)	CO4950515A1 (fr)
DE (1)	DE69816290T2 (fr)
DZ (1)	DZ2498A1 (fr)
EA (1)	EA199901062A1 (fr)
ES (1)	ES2201509T3 (fr)
HU (1)	HUP0002300A3 (fr)
ID (1)	ID22876A (fr)
IL (1)	IL133036A0 (fr)
MA (1)	MA26501A1 (fr)
NO (1)	NO995711L (fr)
OA (1)	OA11515A (fr)
PE (1)	PE75199A1 (fr)
PL (1)	PL336942A1 (fr)
SK (1)	SK159299A3 (fr)
TR (1)	TR199902883T2 (fr)
WO (1)	WO1998052942A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6780875B2 (en) *	1998-11-20	2004-08-24	Smithkline Beecham S.P.A.	Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
GB9825554D0 (en)	1998-11-20	1999-01-13	Smithkline Beecham Spa	Novel Compounds
JP2002530377A (ja) *	1998-11-20	2002-09-17	スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ	Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしてのキノリン−４−カルボキシアミド誘導体
AU4038000A (en)	1999-03-29	2000-10-16	Neurogen Corporation	4-substituted quinoline derivatives as gaba receptor ligands
WO2000064877A1 (fr)	1999-04-26	2000-11-02	Neurogen Corporation	2-aminoquinolinecarboxamides: ligands de recepteurs de la neurokinine
WO2002013825A1 (fr) *	2000-08-11	2002-02-21	Smithkline Beecham P.L.C.	Nouvelle utilisation pharmaceutique de dérivés quinnoliniques
EP1334089A1 (fr) *	2000-11-13	2003-08-13	GlaxoSmithKline S.p.A.	Derives de la quinoline en tant qu'antagonistes de nk-3 et nk-2
AU2002226356A1 (en) *	2000-11-28	2002-06-11	Glaxosmithkline S.P.A.	Quinoline derivatives as nk-3 antagonists
GB0028964D0 (en) *	2000-11-28	2001-01-10	Smithkline Beecham Spa	Novel compounds
US6540733B2 (en)	2000-12-29	2003-04-01	Corazon Technologies, Inc.	Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion
GB0109122D0 (en) *	2001-04-11	2001-05-30	Smithkline Beecham Spa	Novel compounds
DE60209362T2 (de) *	2001-04-11	2006-10-26	Glaxosmithkline S.P.A.	3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten
MY134211A (en) *	2001-05-18	2007-11-30	Smithkline Beecham Corp	Novel use
GB0425077D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
GB0425075D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
GB0425076D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
MX2007014831A (es) *	2005-06-03	2008-02-15	Astrazeneca Ab	Derivados de quinolina como antagonistas de neurocinina-3.
GB0515580D0 (en)	2005-07-29	2005-09-07	Merck Sharp & Dohme	Therapeutic compounds
AR057130A1 (es)	2005-09-21	2007-11-14	Astrazeneca Ab	Quinolinas de alquilsulfoxido y una composicion farmaceutica
DE202007017299U1 (de) *	2007-12-12	2009-04-23	Drebo Werkzeugfabrik Gmbh	Bohrer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK282721B6 (sk) *	1994-05-27	2002-11-06	Smithkline Beecham S.P.A.	Nepeptidové NK3 antagonistické látky, spôsob ich výroby, farmaceutické prostriedky s ich obsahom a ich použitie
AR004735A1 (es) *	1995-11-24	1999-03-10	Smithkline Beecham Spa	Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.

1998
- 1998-05-18 EP EP98932069A patent/EP0983262B1/fr not_active Expired - Lifetime
- 1998-05-18 WO PCT/EP1998/003014 patent/WO1998052942A1/fr not_active Ceased
- 1998-05-18 AP APAP/P/1999/001695A patent/AP9901695A0/en unknown
- 1998-05-18 BR BR9809652-4A patent/BR9809652A/pt not_active IP Right Cessation
- 1998-05-18 IL IL13303698A patent/IL133036A0/xx unknown
- 1998-05-18 JP JP54996798A patent/JP2002500645A/ja not_active Ceased
- 1998-05-18 DE DE69816290T patent/DE69816290T2/de not_active Expired - Fee Related
- 1998-05-18 TR TR1999/02883T patent/TR199902883T2/xx unknown
- 1998-05-18 HU HU0002300A patent/HUP0002300A3/hu unknown
- 1998-05-18 ID IDW991432A patent/ID22876A/id unknown
- 1998-05-18 SK SK1592-99A patent/SK159299A3/sk unknown
- 1998-05-18 CN CN98807356A patent/CN1264378A/zh active Pending
- 1998-05-18 EA EA199901062A patent/EA199901062A1/ru unknown
- 1998-05-18 AT AT98932069T patent/ATE244711T1/de not_active IP Right Cessation
- 1998-05-18 ES ES98932069T patent/ES2201509T3/es not_active Expired - Lifetime
- 1998-05-18 CA CA002291111A patent/CA2291111A1/fr not_active Abandoned
- 1998-05-18 PL PL98336942A patent/PL336942A1/xx unknown
- 1998-05-18 AU AU82098/98A patent/AU8209898A/en not_active Abandoned
- 1998-05-19 DZ DZ980108A patent/DZ2498A1/fr active
- 1998-05-20 PE PE1998000398A patent/PE75199A1/es not_active Application Discontinuation
- 1998-05-21 MA MA25086A patent/MA26501A1/fr unknown
- 1998-05-21 AR ARP980102363A patent/AR012732A1/es not_active Application Discontinuation
- 1998-05-22 CO CO98029024A patent/CO4950515A1/es unknown
1999
- 1999-11-22 NO NO995711A patent/NO995711L/no not_active Application Discontinuation
- 1999-11-23 OA OA9900253A patent/OA11515A/en unknown
- 1999-12-14 BG BG104009A patent/BG104009A/xx unknown

Also Published As

Publication number	Publication date
TR199902883T2 (xx)	2000-05-22
DE69816290D1 (de)	2003-08-14
IL133036A0 (en)	2001-03-19
CA2291111A1 (fr)	1998-11-26
AU8209898A (en)	1998-12-11
CN1264378A (zh)	2000-08-23
MA26501A1 (fr)	2004-12-20
OA11515A (en)	2004-02-04
WO1998052942A1 (fr)	1998-11-26
ES2201509T3 (es)	2004-03-16
JP2002500645A (ja)	2002-01-08
CO4950515A1 (es)	2000-09-01
NO995711D0 (no)	1999-11-22
AR012732A1 (es)	2000-11-08
BG104009A (en)	2000-07-31
DZ2498A1 (fr)	2003-01-25
EA199901062A1 (ru)	2000-08-28
HUP0002300A3 (en)	2002-01-28
ID22876A (id)	1999-12-16
BR9809652A (pt)	2001-09-11
HUP0002300A2 (hu)	2001-06-28
PE75199A1 (es)	1999-10-22
EP0983262B1 (fr)	2003-07-09
DE69816290T2 (de)	2004-05-27
PL336942A1 (en)	2000-07-17
ATE244711T1 (de)	2003-07-15
EP0983262A1 (fr)	2000-03-08
AP9901695A0 (en)	1999-12-31
NO995711L (no)	2000-01-19

Publication	Publication Date	Title
US6277862B1 (en)	2001-08-21	Quinoline derivatives
SK159299A3 (en)	2000-06-12	Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists
US20020068827A1 (en)	2002-06-06	Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 ( NK-3 ) - and neurokinin 2 ( NK-3 ) receptor antagonists
EP1377555B1 (fr)	2007-01-24	Un derive de dioxino[2,3-g]quinoline-9-acide carboxylique en tant qu'antagoniste du recepteur nk3
MXPA01005095A (es)	2002-04-24	Derivados de quinolin-4-carboxamida como antagonistas de receptor de neurocinina-3 y neurocinina-2.
US20040152726A1 (en)	2004-08-05	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
US6613770B1 (en)	2003-09-02	Quinoline derivatives as NK-2 and NK-3 receptor ligands
US20040077658A1 (en)	2004-04-22	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
US20040082589A1 (en)	2004-04-29	Quinoline derivatives as nk-3 and nk-2 antagonists
US20040102633A1 (en)	2004-05-27	Novel compounds
EP1337253A1 (fr)	2003-08-27	Composes
US20070197546A1 (en)	2007-08-23	Quinoline-4-carboxamide as nk-2 and nk-3 receptor antagonists
AU757836B2 (en)	2003-03-06	Quinoline derivatives
MXPA99010841A (en)	2000-07-01	Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists
Luca et al.	0	PCT WORLD) INTELLECTUAL PROPERTY ORGANIZATION
KR20010012823A (ko)	2001-02-26	Ｎｋ-2 및 ｎｋ-3 수용체 길항제로서의퀴놀린-4-카르복스아미드 유도체
ITMI972352A1 (it)	1999-04-17	Derivati chinolinici, procedimento per la loro preparazione e uso come antagonisti del recettore nk3
AU1031797A (en)	1997-07-03	Quinoline derivatives
CZ416199A3 (cs)	2000-08-16	Chinolin-4-karboxamidové deriváty jako antagonisté receptoru pro NK-2 a NK-3
ITMI972354A1 (it)	1999-04-17	Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
ITMI972774A1 (it)	1999-06-16	Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
ITMI972775A1 (it)	1999-06-16	Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3