NZ551448A - Analysis of liquid chromotography eluates - Google Patents

Analysis of liquid chromotography eluates

Info

Publication number: NZ551448A
Authority: NZ; New Zealand
Prior art keywords: saccharide; bacterial capsular; column; analytes; neisseria meningitidis
Prior art date: 2004-05-20

Application number

NZ551448A

Other languages

English (en)

Inventor

Daniela Proietti

Angela Bardotti

Stefano Ricci

Original Assignee

Novartis Vaccines & Diagnostic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-20

Filing date

2005-05-20

Publication date

2011-02-25

2004-05-20 Priority claimed from GB0411283A external-priority patent/GB0411283D0/en

2004-09-16 Priority claimed from GB0420649A external-priority patent/GB0420649D0/en

2005-05-20 Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic

2011-02-25 Publication of NZ551448A publication Critical patent/NZ551448A/en

Links

238000004458 analytical method Methods 0.000 title claims abstract description 44
239000007788 liquid Substances 0.000 title 1
150000001720 carbohydrates Chemical class 0.000 claims abstract description 156
238000000034 method Methods 0.000 claims abstract description 59
238000005571 anion exchange chromatography Methods 0.000 claims abstract description 21
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims abstract description 13
229910002651 NO3 Inorganic materials 0.000 claims abstract description 11
150000001450 anions Chemical class 0.000 claims abstract description 9
238000004611 spectroscopical analysis Methods 0.000 claims abstract description 8
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims abstract description 6
238000004082 amperometric method Methods 0.000 claims abstract description 6
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract description 5
239000012149 elution buffer Substances 0.000 claims abstract 9
238000001514 detection method Methods 0.000 claims description 34
230000001580 bacterial effect Effects 0.000 claims description 28
150000002482 oligosaccharides Chemical class 0.000 claims description 22
150000004676 glycans Chemical class 0.000 claims description 20
229920001542 oligosaccharide Polymers 0.000 claims description 19
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239000005017 polysaccharide Substances 0.000 claims description 19
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 15
229960005486 vaccine Drugs 0.000 claims description 15
239000012634 fragment Substances 0.000 claims description 13
150000002772 monosaccharides Chemical class 0.000 claims description 12
241000606768 Haemophilus influenzae Species 0.000 claims description 10
230000007062 hydrolysis Effects 0.000 claims description 9
238000006460 hydrolysis reaction Methods 0.000 claims description 9
241000588650 Neisseria meningitidis Species 0.000 claims description 8
229940047650 haemophilus influenzae Drugs 0.000 claims description 5
241000947238 Neisseria meningitidis serogroup C Species 0.000 claims description 4
241000589517 Pseudomonas aeruginosa Species 0.000 claims description 4
241000191967 Staphylococcus aureus Species 0.000 claims description 4
241000193985 Streptococcus agalactiae Species 0.000 claims description 4
241000193998 Streptococcus pneumoniae Species 0.000 claims description 4
238000004847 absorption spectroscopy Methods 0.000 claims description 4
229940031000 streptococcus pneumoniae Drugs 0.000 claims description 4
241001174901 Neisseria meningitidis alpha275 Species 0.000 claims description 3
241000921898 Neisseria meningitidis serogroup A Species 0.000 claims description 3
241000588677 Neisseria meningitidis serogroup B Species 0.000 claims description 3
241001573069 Neisseria meningitidis serogroup Y Species 0.000 claims description 3
229940045808 haemophilus influenzae type b Drugs 0.000 claims description 3
230000031700 light absorption Effects 0.000 claims description 2
239000003480 eluent Substances 0.000 description 30
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 27
239000000203 mixture Substances 0.000 description 23
239000012491 analyte Substances 0.000 description 21
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
238000010828 elution Methods 0.000 description 15
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 12
230000021615 conjugation Effects 0.000 description 12
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238000004811 liquid chromatography Methods 0.000 description 11
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229910019142 PO4 Inorganic materials 0.000 description 5
238000005349 anion exchange Methods 0.000 description 5
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MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 4
108010060123 Conjugate Vaccines Proteins 0.000 description 4
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VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 4
230000001629 suppression Effects 0.000 description 4
238000000825 ultraviolet detection Methods 0.000 description 4
238000002835 absorbance Methods 0.000 description 3
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 3
239000002775 capsule Substances 0.000 description 3
238000012512 characterization method Methods 0.000 description 3
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238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
125000001453 quaternary ammonium group Chemical group 0.000 description 3
230000000717 retained effect Effects 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
229920001503 Glucan Polymers 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
238000013459 approach Methods 0.000 description 2
238000005277 cation exchange chromatography Methods 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
239000010931 gold Substances 0.000 description 2
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238000004128 high performance liquid chromatography Methods 0.000 description 2
239000011325 microbead Substances 0.000 description 2
229920000447 polyanionic polymer Polymers 0.000 description 2
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238000003908 quality control method Methods 0.000 description 2
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239000004317 sodium nitrate Substances 0.000 description 2
235000010344 sodium nitrate Nutrition 0.000 description 2
159000000000 sodium salts Chemical class 0.000 description 2
238000012306 spectroscopic technique Methods 0.000 description 2
238000003860 storage Methods 0.000 description 2
239000000758 substrate Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
101500000959 Bacillus anthracis Protective antigen PA-20 Proteins 0.000 description 1
241000222122 Candida albicans Species 0.000 description 1
201000007336 Cryptococcosis Diseases 0.000 description 1
241000221204 Cryptococcus neoformans Species 0.000 description 1
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
SQVRNKJHWKZAKO-LUWBGTNYSA-N N-acetylneuraminic acid Chemical class CC(=O)N[C@@H]1[C@@H](O)CC(O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-LUWBGTNYSA-N 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
JVWLUVNSQYXYBE-UHFFFAOYSA-N Ribitol Natural products OCC(C)C(O)C(O)CO JVWLUVNSQYXYBE-UHFFFAOYSA-N 0.000 description 1
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
229910021607 Silver chloride Inorganic materials 0.000 description 1
241000193990 Streptococcus sp. 'group B' Species 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
150000001242 acetic acid derivatives Chemical class 0.000 description 1
238000005903 acid hydrolysis reaction Methods 0.000 description 1
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239000004480 active ingredient Substances 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
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150000001413 amino acids Chemical class 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
MPMBRWOOISTHJV-UHFFFAOYSA-N but-1-enylbenzene Chemical compound CCC=CC1=CC=CC=C1 MPMBRWOOISTHJV-UHFFFAOYSA-N 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
229940095731 candida albicans Drugs 0.000 description 1
238000005251 capillar electrophoresis Methods 0.000 description 1
150000007942 carboxylates Chemical group 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
150000003841 chloride salts Chemical class 0.000 description 1
238000013375 chromatographic separation Methods 0.000 description 1
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125000000600 disaccharide group Chemical group 0.000 description 1
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238000002474 experimental method Methods 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
238000005227 gel permeation chromatography Methods 0.000 description 1
238000007429 general method Methods 0.000 description 1
239000008103 glucose Substances 0.000 description 1
229960004443 hemophilus influenzae b vaccines Drugs 0.000 description 1
229920000140 heteropolymer Polymers 0.000 description 1
150000004679 hydroxides Chemical class 0.000 description 1
230000036039 immunity Effects 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
238000010829 isocratic elution Methods 0.000 description 1
230000002045 lasting effect Effects 0.000 description 1
239000004816 latex Substances 0.000 description 1
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229920006008 lipopolysaccharide Polymers 0.000 description 1
230000007774 longterm Effects 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
238000005259 measurement Methods 0.000 description 1
239000012528 membrane Substances 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
238000002156 mixing Methods 0.000 description 1
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150000002823 nitrates Chemical class 0.000 description 1
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HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
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SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
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HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
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238000012360 testing method Methods 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/78—Detectors specially adapted therefor using more than one detector
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/64—Electrical detectors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8836—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving saccharides
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/4473—Arrangements for investigating the separated zones, e.g. localising zones by electric means
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography

Landscapes

Physics & Mathematics (AREA)
Biochemistry (AREA)
General Physics & Mathematics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Immunology (AREA)
Spectroscopy & Molecular Physics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Materials By Optical Means (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)

NZ551448A 2004-05-20 2005-05-20 Analysis of liquid chromotography eluates NZ551448A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0411283A GB0411283D0 (en)	2004-05-20	2004-05-20	Analysis of liquid chromatography eluates
GB0420649A GB0420649D0 (en)	2004-09-16	2004-09-16	Analysis of liquid chromatography eluates
PCT/IB2005/001772 WO2005114171A2 (en)	2004-05-20	2005-05-20	Analysis of liquid chromatography eluates

Publications (1)

Publication Number	Publication Date
NZ551448A true NZ551448A (en)	2011-02-25

Family

ID=34979826

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NZ551448A NZ551448A (en)	2004-05-20	2005-05-20	Analysis of liquid chromotography eluates

Country Status (11)

Country	Link
US (1)	US7833803B2 (de)
EP (1)	EP1747457B1 (de)
JP (1)	JP4714739B2 (de)
AT (1)	ATE535804T1 (de)
AU (1)	AU2005246093B2 (de)
BR (1)	BRPI0511442A (de)
CA (1)	CA2567528A1 (de)
MX (1)	MXPA06013473A (de)
NZ (1)	NZ551448A (de)
RU (1)	RU2380700C2 (de)
WO (1)	WO2005114171A2 (de)

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Publication number	Priority date	Publication date	Assignee	Title
GB0524782D0 (en) *	2005-12-05	2006-01-11	Chiron Srl	Analysis of samples
GB0612854D0 (en)	2006-06-28	2006-08-09	Novartis Ag	Saccharide analysis
HK1208528A1 (en)	2012-02-27	2016-03-04	德马医药	Improved analytical methods for analyzing and determining impurities in dianhydrogalactitol
CN102645504B (zh) *	2012-05-10	2014-04-30	江南大学	一种灵芝孢子粉多糖离子色谱指纹图谱的构建方法
EP2852414B9 (de)	2012-05-22	2020-12-09	GlaxoSmithKline Biologicals SA	Meningokokken-serogruppe-x-konjugat
JP6214999B2 (ja) *	2013-10-21	2017-10-18	住友ベークライト株式会社	電気化学的検出のための糖鎖試料の調製方法
MX2016006457A (es) *	2013-11-18	2017-01-06	Del Mar Pharmaceuticals	Analisis de cromatografia liquida de alto rendimiento (hplc) de impurezas en dianhidrogalactitol.
EP2944955A1 (de) *	2014-05-13	2015-11-18	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Bezugspunkt für LC-MS-Systeme
KR102204927B1 (ko) *	2016-07-25	2021-01-19	에스케이바이오사이언스(주)	피막 다당류-단백질 접합 백신의 품질 평가 방법
US10877005B2 (en) *	2016-12-20	2020-12-29	Dionex Corporation	Method of measuring an analyte with a reductive detection waveform

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Publication number	Priority date	Publication date	Assignee	Title
CA1220053A (en) *	1983-10-01	1987-04-07	Toyo Soda Manufacturing Co., Ltd.	Method for chromatographic analysis and apparatus therefor
FR2737730B1 (fr) *	1995-08-10	1997-09-05	Pasteur Merieux Serums Vacc	Procede de purification de virus par chromatographie
JPH0980039A (ja) *	1995-09-14	1997-03-28	Shiseido Co Ltd	電気化学検出器を有する液体クロマトグラフィ装置
JPH1151922A (ja) *	1997-08-04	1999-02-26	Hitachi Ltd	液体クロマトグラフ
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ES2616180T3 (es) *	2002-03-26	2017-06-09	Glaxosmithkline Biologicals Sa	Sacáridos modificados con estabilidad mejorada en agua para su uso como medicamento

2005
- 2005-05-20 WO PCT/IB2005/001772 patent/WO2005114171A2/en not_active Ceased
- 2005-05-20 NZ NZ551448A patent/NZ551448A/en not_active IP Right Cessation
- 2005-05-20 MX MXPA06013473A patent/MXPA06013473A/es active IP Right Grant
- 2005-05-20 AT AT05748363T patent/ATE535804T1/de active
- 2005-05-20 BR BRPI0511442-0A patent/BRPI0511442A/pt active Search and Examination
- 2005-05-20 RU RU2006144969/28A patent/RU2380700C2/ru not_active IP Right Cessation
- 2005-05-20 CA CA002567528A patent/CA2567528A1/en not_active Abandoned
- 2005-05-20 AU AU2005246093A patent/AU2005246093B2/en not_active Ceased
- 2005-05-20 US US11/597,254 patent/US7833803B2/en not_active Expired - Fee Related
- 2005-05-20 JP JP2007517520A patent/JP4714739B2/ja not_active Expired - Fee Related
- 2005-05-20 EP EP05748363A patent/EP1747457B1/de not_active Expired - Lifetime

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Publication number	Publication date
RU2380700C2 (ru)	2010-01-27
US20080258710A1 (en)	2008-10-23
BRPI0511442A (pt)	2007-12-26
EP1747457A2 (de)	2007-01-31
AU2005246093A1 (en)	2005-12-01
EP1747457B1 (de)	2011-11-30
WO2005114171A3 (en)	2006-04-13
CA2567528A1 (en)	2005-12-01
ATE535804T1 (de)	2011-12-15
US7833803B2 (en)	2010-11-16
WO2005114171A2 (en)	2005-12-01
MXPA06013473A (es)	2007-03-01
JP2007538251A (ja)	2007-12-27
AU2005246093B2 (en)	2011-09-29
RU2006144969A (ru)	2008-06-27
JP4714739B2 (ja)	2011-06-29

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2009-04-30	ASS	Change of ownership	Owner name: NOVARTIS VACCINES AND DIAGNOSTICS S.R.L., IT Free format text: OLD OWNER(S): CHIRON SRL
2009-07-31	RENW	Renewal (renewal fees accepted)
2011-06-30	PSEA	Patent sealed
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2015-04-24	RENW	Renewal (renewal fees accepted)	Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 MAY 2016 BY CPA GLOBAL Effective date: 20150403
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2017-11-24	LAPS	Patent lapsed

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