OA10242A - Sels de céphème cristallins d'addition avec des acides procédés pour leur préparation médicaments les contenant et leur utilisation - Google Patents

Sels de céphème cristallins d'addition avec des acides procédés pour leur préparation médicaments les contenant et leur utilisation Download PDF

Info

Publication number: OA10242A
Authority: OA; OAPI
Prior art keywords: acides; acide; formule; que; acid
Prior art date: 1994-11-10

Application number

OA60734A

Other languages

English (en)

French (fr)

Inventor

Rudolf Dr Lattrell

Walter Dr Duerckheimer

Peter Dr Schmid

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-10

Filing date

1995-11-10

Publication date

1997-09-19

1995-11-10 Application filed by Hoechst Ag filed Critical Hoechst Ag

1997-09-19 Publication of OA10242A publication Critical patent/OA10242A/fr

Links

150000003839 salts Chemical class 0.000 title abstract description 36
239000002253 acid Substances 0.000 title abstract description 20
238000000034 method Methods 0.000 title description 9
238000002360 preparation method Methods 0.000 title description 5
239000003814 drug Substances 0.000 title description 4
229940079593 drug Drugs 0.000 title description 3
239000000654 additive Substances 0.000 title 1
230000000996 additive effect Effects 0.000 title 1
-1 phenolic carboxylic acid Chemical class 0.000 claims abstract description 9
150000001450 anions Chemical group 0.000 claims abstract description 7
208000015181 infectious disease Diseases 0.000 claims description 2
101100536354 Drosophila melanogaster tant gene Proteins 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
239000000126 substance Substances 0.000 claims 1
150000001782 cephems Chemical class 0.000 abstract 1
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 19
150000001875 compounds Chemical class 0.000 description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 12
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
239000000243 solution Substances 0.000 description 11
241001465754 Metazoa Species 0.000 description 10
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
238000007792 addition Methods 0.000 description 9
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 8
229960003237 betaine Drugs 0.000 description 7
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
150000001735 carboxylic acids Chemical class 0.000 description 6
JCJUKCIXTRWAQY-UHFFFAOYSA-N 6-hydroxynaphthalene-1-carboxylic acid Chemical compound OC1=CC=C2C(C(=O)O)=CC=CC2=C1 JCJUKCIXTRWAQY-UHFFFAOYSA-N 0.000 description 5
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 5
150000007513 acids Chemical class 0.000 description 5
230000037396 body weight Effects 0.000 description 5
150000001732 carboxylic acid derivatives Chemical class 0.000 description 5
239000000047 product Substances 0.000 description 5
241000283690 Bos taurus Species 0.000 description 4
239000013543 active substance Substances 0.000 description 4
229910052739 hydrogen Inorganic materials 0.000 description 4
239000002244 precipitate Substances 0.000 description 4
UIAFKZKHHVMJGS-UHFFFAOYSA-M 2-carboxy-5-hydroxyphenolate Chemical compound OC1=CC=C(C([O-])=O)C(O)=C1 UIAFKZKHHVMJGS-UHFFFAOYSA-M 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 3
239000003960 organic solvent Substances 0.000 description 3
ONJSZLXSECQROL-UHFFFAOYSA-N salicyluric acid Chemical compound OC(=O)CNC(=O)C1=CC=CC=C1O ONJSZLXSECQROL-UHFFFAOYSA-N 0.000 description 3
229910021653 sulphate ion Inorganic materials 0.000 description 3
238000005160 1H NMR spectroscopy Methods 0.000 description 2
UPHOPMSGKZNELG-UHFFFAOYSA-N 2-hydroxynaphthalene-1-carboxylic acid Chemical class C1=CC=C2C(C(=O)O)=C(O)C=CC2=C1 UPHOPMSGKZNELG-UHFFFAOYSA-N 0.000 description 2
UYEMGAFJOZZIFP-UHFFFAOYSA-N 3,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC(O)=C1 UYEMGAFJOZZIFP-UHFFFAOYSA-N 0.000 description 2
BCEQKAQCUWUNML-UHFFFAOYSA-N 4-hydroxybenzene-1,3-dicarboxylic acid Chemical compound OC(=O)C1=CC=C(O)C(C(O)=O)=C1 BCEQKAQCUWUNML-UHFFFAOYSA-N 0.000 description 2
IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 2
QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
241000124008 Mammalia Species 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 2
GCWCVCCEIQXUQU-UHFFFAOYSA-N alpha-hydroxyhippuric acid Chemical compound OC(=O)C(O)NC(=O)C1=CC=CC=C1 GCWCVCCEIQXUQU-UHFFFAOYSA-N 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 2
HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 description 2
239000003085 diluting agent Substances 0.000 description 2
238000001914 filtration Methods 0.000 description 2
LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
239000005457 ice water Substances 0.000 description 2
IWYDHOAUDWTVEP-UHFFFAOYSA-N mandelic acid Chemical compound OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 2
238000002156 mixing Methods 0.000 description 2
239000000203 mixture Substances 0.000 description 2
150000002894 organic compounds Chemical class 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
230000002035 prolonged effect Effects 0.000 description 2
239000000725 suspension Substances 0.000 description 2
KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
HSKBGALULOFBAM-UHFFFAOYSA-N 2,3-dihydroxy-4-methylidene-3h-naphthalene-1-carboxylic acid Chemical class C1=CC=C2C(=C)C(O)C(O)=C(C(O)=O)C2=C1 HSKBGALULOFBAM-UHFFFAOYSA-N 0.000 description 1
KFJHIKRAIHSDKU-UHFFFAOYSA-N 2,3-dihydroxy-4-methylidenecyclohexa-1,5-diene-1-carboxylic acid Chemical class OC1C(=C)C=CC(C(O)=O)=C1O KFJHIKRAIHSDKU-UHFFFAOYSA-N 0.000 description 1
NCLKLKFWHLNSPF-UHFFFAOYSA-N 2,3-dihydroxy-5-methylbenzoic acid Chemical compound CC1=CC(O)=C(O)C(C(O)=O)=C1 NCLKLKFWHLNSPF-UHFFFAOYSA-N 0.000 description 1
229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
241000251468 Actinopterygii Species 0.000 description 1
241000271566 Aves Species 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
108020004256 Beta-lactamase Proteins 0.000 description 1
229930186147 Cephalosporin Natural products 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
108010087702 Penicillinase Proteins 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
101100073357 Streptomyces halstedii sch2 gene Proteins 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
229940126575 aminoglycoside Drugs 0.000 description 1
150000008064 anhydrides Chemical class 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
239000002246 antineoplastic agent Substances 0.000 description 1
238000009360 aquaculture Methods 0.000 description 1
244000144974 aquaculture Species 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical compound C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
229940124587 cephalosporin Drugs 0.000 description 1
150000001780 cephalosporins Chemical class 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000012043 crude product Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
229940127089 cytotoxic agent Drugs 0.000 description 1
239000012024 dehydrating agents‎ Substances 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
150000005169 dihydroxybenzoic acids Chemical class 0.000 description 1
238000001035 drying Methods 0.000 description 1
KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
235000001785 ferulic acid Nutrition 0.000 description 1
229940114124 ferulic acid Drugs 0.000 description 1
KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
229940074391 gallic acid Drugs 0.000 description 1
235000004515 gallic acid Nutrition 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
229930005346 hydroxycinnamic acid Natural products 0.000 description 1
DEDGUGJNLNLJSR-UHFFFAOYSA-N hydroxycinnamic acid group Chemical class OC(C(=O)O)=CC1=CC=CC=C1 DEDGUGJNLNLJSR-UHFFFAOYSA-N 0.000 description 1
235000010359 hydroxycinnamic acids Nutrition 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
125000000896 monocarboxylic acid group Chemical group 0.000 description 1
WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
229950009506 penicillinase Drugs 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
230000036470 plasma concentration Effects 0.000 description 1
229920000151 polyglycol Polymers 0.000 description 1
239000010695 polyglycol Substances 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000013558 reference substance Substances 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000027 toxicology Toxicity 0.000 description 1
QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
150000005170 trihydroxybenzoic acids Chemical class 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
239000003981 vehicle Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/48—Methylene radicals, substituted by hetero rings
- C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

OA60734A 1994-11-10 1995-11-10 Sels de céphème cristallins d'addition avec des acides procédés pour leur préparation médicaments les contenant et leur utilisation OA10242A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4440141A DE4440141A1 (de)	1994-11-10	1994-11-10	Neue kristalline Cephem-Säureadditionssalze und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number	Publication Date
OA10242A true OA10242A (fr)	1997-09-19

Family

ID=6532953

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA60734A OA10242A (fr)	1994-11-10	1995-11-10	Sels de céphème cristallins d'addition avec des acides procédés pour leur préparation médicaments les contenant et leur utilisation

Country Status (28)

Country	Link
US (1)	US5747484A (pl)
EP (1)	EP0711774B1 (pl)
JP (1)	JP3920939B2 (pl)
KR (1)	KR100449191B1 (pl)
CN (1)	CN1066452C (pl)
AR (1)	AR002246A1 (pl)
AT (1)	ATE213248T1 (pl)
AU (1)	AU707730B2 (pl)
BR (1)	BR9505132A (pl)
CA (1)	CA2162530C (pl)
CZ (1)	CZ290936B6 (pl)
DE (2)	DE4440141A1 (pl)
DK (1)	DK0711774T3 (pl)
ES (1)	ES2172549T3 (pl)
FI (1)	FI120263B (pl)
HU (1)	HU219475B (pl)
IL (1)	IL115914A (pl)
MA (1)	MA23709A1 (pl)
NO (1)	NO311891B1 (pl)
NZ (1)	NZ280424A (pl)
OA (1)	OA10242A (pl)
PL (1)	PL182806B1 (pl)
PT (1)	PT711774E (pl)
RU (1)	RU2161619C2 (pl)
SK (1)	SK282545B6 (pl)
TR (1)	TR199501392A2 (pl)
TW (1)	TW422847B (pl)
ZA (1)	ZA959510B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998049130A2 (en) *	1997-04-29	1998-11-05	The University Of New Mexico	Hydroxynaphthoic acids and derivatives
ES2265590T3 (es) *	2002-10-25	2007-02-16	Intervet International Bv	Composicion farmaceutica de liberacion prolongada.
JP5322649B2 (ja) *	2005-10-29	2013-10-23	インターベツト・インターナシヨナル・ベー・ベー	セフキノム組成物およびその使用方法
AR077320A1 (es) *	2009-07-20	2011-08-17	Intervet Int Bv	Metodo para la preparacion de particulas de cefquinoma y formulaciones farmaceuticas que las comprenden.
MX352760B (es)	2011-09-09	2017-12-07	Merck Sharp & Dohme Corp Star	Metodos para tratar infecciones intrapulmonares.
US20140234365A1 (en) *	2011-09-29	2014-08-21	Alere San Diego, Inc.	2-hydroxyhippuric acid analogs, and methods for their synthesis and use
US8809314B1 (en)	2012-09-07	2014-08-19	Cubist Pharmacueticals, Inc.	Cephalosporin compound
US8476425B1 (en)	2012-09-27	2013-07-02	Cubist Pharmaceuticals, Inc.	Tazobactam arginine compositions
DK2893929T3 (da)	2013-03-15	2025-07-07	Merck Sharp & Dohme Llc	Antibiotisk ceftolozansammensætninger
US9872906B2 (en)	2013-03-15	2018-01-23	Merck Sharp & Dohme Corp.	Ceftolozane antibiotic compositions
US20140274993A1 (en)	2013-03-15	2014-09-18	Cubist Pharmaceuticals, Inc.	Ceftolozane-tazobactam pharmaceutical compositions
EP3043797B1 (en)	2013-09-09	2020-04-08	Merck Sharp & Dohme Corp.	Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en)	2013-09-27	2015-04-02	Calixa Therapeutics, Inc.	Solid forms of ceftolozane

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3118732A1 (de) *	1981-05-12	1982-12-02	Hoechst Ag, 6000 Frankfurt	Cephalosporinderivate und verfahren zu ihrer herstellung
DE3248281A1 (de) *	1982-12-28	1984-06-28	Hoechst Ag, 6230 Frankfurt	Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
DE3316797A1 (de) *	1983-05-07	1984-11-08	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von cephemverbindungen
JPH064643B2 (ja) *	1985-12-20	1994-01-19	ファイザー製薬株式会社	セフアロスポリン化合物
DE3706020A1 (de) *	1987-02-25	1988-09-08	Hoechst Ag	Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung

1994
- 1994-11-10 DE DE4440141A patent/DE4440141A1/de not_active Withdrawn
1995
- 1995-10-27 TW TW084111318A patent/TW422847B/zh not_active IP Right Cessation
- 1995-11-01 US US08/551,480 patent/US5747484A/en not_active Expired - Lifetime
- 1995-11-01 MA MA24054A patent/MA23709A1/fr unknown
- 1995-11-06 ES ES95117409T patent/ES2172549T3/es not_active Expired - Lifetime
- 1995-11-06 AT AT95117409T patent/ATE213248T1/de active
- 1995-11-06 EP EP95117409A patent/EP0711774B1/de not_active Expired - Lifetime
- 1995-11-06 DE DE59510048T patent/DE59510048D1/de not_active Expired - Lifetime
- 1995-11-06 DK DK95117409T patent/DK0711774T3/da active
- 1995-11-06 PT PT95117409T patent/PT711774E/pt unknown
- 1995-11-08 AR ARP950100095A patent/AR002246A1/es unknown
- 1995-11-08 CZ CZ19952933A patent/CZ290936B6/cs not_active IP Right Cessation
- 1995-11-08 NZ NZ280424A patent/NZ280424A/en not_active IP Right Cessation
- 1995-11-08 AU AU37728/95A patent/AU707730B2/en not_active Expired
- 1995-11-08 SK SK1397-95A patent/SK282545B6/sk not_active IP Right Cessation
- 1995-11-08 TR TR95/01392A patent/TR199501392A2/xx unknown
- 1995-11-08 IL IL11591495A patent/IL115914A/en not_active IP Right Cessation
- 1995-11-08 CN CN95118555A patent/CN1066452C/zh not_active Expired - Lifetime
- 1995-11-08 FI FI955382A patent/FI120263B/fi not_active IP Right Cessation
- 1995-11-09 CA CA002162530A patent/CA2162530C/en not_active Expired - Lifetime
- 1995-11-09 NO NO19954511A patent/NO311891B1/no not_active IP Right Cessation
- 1995-11-09 ZA ZA959510A patent/ZA959510B/xx unknown
- 1995-11-09 RU RU95119433/04A patent/RU2161619C2/ru active
- 1995-11-09 BR BR9505132A patent/BR9505132A/pt not_active IP Right Cessation
- 1995-11-09 HU HU9503213A patent/HU219475B/hu unknown
- 1995-11-09 KR KR1019950040388A patent/KR100449191B1/ko not_active Expired - Lifetime
- 1995-11-09 PL PL95311326A patent/PL182806B1/pl unknown
- 1995-11-09 JP JP29142795A patent/JP3920939B2/ja not_active Expired - Lifetime
- 1995-11-10 OA OA60734A patent/OA10242A/fr unknown

Also Published As

Publication number	Publication date
SK139795A3 (en)	1996-06-05
KR100449191B1 (ko)	2006-01-12
PL182806B1 (pl)	2002-03-29
NZ280424A (en)	1997-06-24
SK282545B6 (sk)	2002-10-08
TW422847B (en)	2001-02-21
DE4440141A1 (de)	1996-05-15
ES2172549T3 (es)	2002-10-01
PL311326A1 (en)	1996-05-13
CA2162530A1 (en)	1996-05-11
JP3920939B2 (ja)	2007-05-30
FI955382L (fi)	1996-05-11
DE59510048D1 (de)	2002-03-21
FI120263B (fi)	2009-08-31
HU9503213D0 (en)	1996-01-29
AR002246A1 (es)	1998-03-11
EP0711774B1 (de)	2002-02-13
ZA959510B (en)	1996-05-28
NO954511L (no)	1996-05-13
PT711774E (pt)	2002-07-31
EP0711774A1 (de)	1996-05-15
TR199501392A2 (tr)	1996-07-21
IL115914A (en)	2002-08-14
HUT74163A (en)	1996-11-28
MA23709A1 (fr)	1996-07-01
BR9505132A (pt)	1997-09-09
AU707730B2 (en)	1999-07-15
CZ293395A3 (en)	1996-05-15
CA2162530C (en)	2007-07-31
RU2161619C2 (ru)	2001-01-10
NO954511D0 (no)	1995-11-09
US5747484A (en)	1998-05-05
FI955382A0 (fi)	1995-11-08
IL115914A0 (en)	1996-01-31
ATE213248T1 (de)	2002-02-15
KR960017670A (ko)	1996-06-17
CZ290936B6 (cs)	2002-11-13
JPH08208662A (ja)	1996-08-13
NO311891B1 (no)	2002-02-11
DK0711774T3 (da)	2002-04-22
CN1066452C (zh)	2001-05-30
AU3772895A (en)	1996-05-16
CN1129220A (zh)	1996-08-21
HU219475B (hu)	2001-04-28

Publication	Publication Date	Title
EP0606024B1 (fr)	1996-03-20	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments
OA10242A (fr)	1997-09-19	Sels de céphème cristallins d'addition avec des acides procédés pour leur préparation médicaments les contenant et leur utilisation
JPS6123192B2 (pl)	1986-06-04
FR2555584A1 (fr)	1985-05-31	Derives de l'acide fluoro-6-dihydro-1,4-oxo-4-piperazinyl substitue-7-quinoline-carboxylique-3 et procede pour leur preparation et compositions pharmaceutiques a action anti-bacteriennes a base desdits derives
FR2464956A1 (fr)	1981-03-20	Procede de production de 10-deazaminopterine et de ses derives 10-alkyliques, composes obtenus et composition pharmaceutique les contenant
SU805948A3 (ru)	1981-02-15	Способ получени -аминофосфонистыхКиСлОТ
EP0136198B1 (fr)	1988-02-10	Dérivés de triazolo pyrimidine, leur procédé de préparation et leur application thérapeutique en tant que toni-cardiaques
EP0043756B1 (fr)	1984-05-09	1,2,4-Triazinylthiométhyl-3-céphèmes sulfoxydes, procédé de préparation et compositions pharmaceutiques en contenant
FR2624856A1 (en)	1989-06-23	Tromethamine salt of 1-methyl-ss-oxo- alpha -(phenylcarbamoyl)-2-pyrrolepropionitrile
FR2502152A1 (fr)	1982-09-24	Nouveaux derives solubles n2 substitues de la diamino-2,4-benzyl-5-pyrimidines, leur procede de preparation et medicaments les contenant
WO1998025942A1 (fr)	1998-06-18	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2756825A1 (fr)	1998-06-12	Nouveaux derives [3h]-benzoxazole-2-thiones et [3h]- benzothiazole-2-thiones substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2612185A1 (fr)	1988-09-16	Derives oxo-isoindolinyliques optiquement actifs, leur preparation et leur utilisation comme medicaments
US4439363A (en)	1984-03-27	Acetylmethyl ester of hetacyllin and/or salts of this ester
WO1992007836A1 (fr)	1992-05-14	Nouveaux derives sulfamides, leur procede d'obtention et leur application comme medicament
US4035381A (en)	1977-07-12	Antibacterial agents
FR2485540A1 (fr)	1981-12-31	Nouveaux derives antibiotiques des cephalosporines, leur procede de preparation et les medicaments en contenant
FR2646350A1 (fr)	1990-11-02	Nouveaux derives benzothiazolinoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2651129A1 (fr)	1991-03-01	Nouveaux derives de cysteine; compositions pharmaceutiques ou cosmetiques en contenant.
BE876466A (fr)	1979-11-23	Derive de l'acide penicillanique et son procede de preparation
US3794678A (en)	1974-02-26	(1,4-cyclohexadien-1-yl)acetic acid
LU83775A1 (fr)	1983-09-01	Derives de naphtyridine,leur preparation et leur application en therapeutique
FR2621589A1 (fr)	1989-04-14	Derives des cephalosporines a pharmacocinetique amelioree, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2491927A1 (fr)	1982-04-16	Derives de cephalexine solubles dans l'eau, et procede pour leur preparation
FR2607135A1 (fr)	1988-05-27	Nouveaux derives des cephalosporines a pharmacocinetique amelioree, procede pour leur preparation et compositions pharmaceutiques les contenant