OA10359A - Activin receptors-like kinase (alk) belonging to the tgf receptor family and/or to the bmp receptor family - Google Patents

Activin receptors-like kinase (alk) belonging to the tgf receptor family and/or to the bmp receptor family Download PDF

Info

Publication number
OA10359A
OA10359A OA60798A OA60798A OA10359A OA 10359 A OA10359 A OA 10359A OA 60798 A OA60798 A OA 60798A OA 60798 A OA60798 A OA 60798A OA 10359 A OA10359 A OA 10359A
Authority
OA
OAPI
Prior art keywords
leu
bmp
val
ser
gly
Prior art date
Application number
OA60798A
Other languages
English (en)
Inventor
John M Wozney
Anthony J Celeste
R Scott Thies
Noboru Yamaji
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of OA10359A publication Critical patent/OA10359A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
OA60798A 1993-09-17 1996-03-15 Activin receptors-like kinase (alk) belonging to the tgf receptor family and/or to the bmp receptor family OA10359A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/123,934 US6291206B1 (en) 1993-09-17 1993-09-17 BMP receptor proteins

Publications (1)

Publication Number Publication Date
OA10359A true OA10359A (en) 2001-10-19

Family

ID=22411794

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60798A OA10359A (en) 1993-09-17 1996-03-15 Activin receptors-like kinase (alk) belonging to the tgf receptor family and/or to the bmp receptor family

Country Status (14)

Country Link
US (3) US6291206B1 (fr)
EP (2) EP0723588B1 (fr)
JP (1) JPH09502611A (fr)
KR (1) KR100406299B1 (fr)
AT (1) ATE376590T1 (fr)
AU (1) AU686232B2 (fr)
CA (1) CA2170405A1 (fr)
DE (1) DE69435038T2 (fr)
DK (1) DK0723588T3 (fr)
ES (1) ES2296287T3 (fr)
FI (1) FI961196L (fr)
NO (1) NO961009L (fr)
OA (1) OA10359A (fr)
WO (1) WO1995007982A1 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
WO1993009229A1 (fr) 1991-11-04 1993-05-13 Genetics Institute, Inc. Proteines heterodimeres morphogenetiques d'os de recombinaison, compositions et procedes d'utilisation
CA2149441C (fr) 1992-11-17 2004-03-02 Kohei Miyazono Kinases apparentees au recepteur de l'activine, proteines a domaines de serine threonine kinase et leur utilisation
US6692925B1 (en) 1992-11-17 2004-02-17 Ludwig Institute For Cancer Research Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
AU689184B2 (en) 1993-12-07 1998-03-26 Genetics Institute, Llc BMP-12, BMP-13 and tendon-inducing compositions thereof
EP0756628B1 (fr) * 1994-04-29 2007-11-14 Curis, Inc. Recepteurs de surface de cellule morphogenes specifiques d'une proteine et leurs usages
US5614609A (en) * 1994-10-20 1997-03-25 Carlos F. Ibanez Serine threonine kinase receptor
US6306622B1 (en) 1994-11-04 2001-10-23 The Procter & Gamble Co. cDNA encoding a BMP type II receptor
US6210899B1 (en) 1994-11-04 2001-04-03 The Procter & Gamble Company Use of a BMP protein receptor complex for screening bone metabolism actives and cells co-transfected with a type II BMP receptor and type I BMP receptor
CA2229557A1 (fr) * 1995-08-14 1997-02-27 Creative Biomolecules, Inc. Liaison de la proteine oestrogene 1 (op-1) et de ses analogues avec le recepteur alk-1 de surface de cellule et ses analogues
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DK1223990T3 (da) 1999-10-15 2004-11-29 Inst Genetics Llc Formuleringer af hyaluronsyre til tilförsel af osteogene proteiner
AU2002218774A1 (en) * 2000-07-12 2002-01-21 The Trustees Of Columbia University In The City Of New York Role of pph1 gene in pulmonary hypertension
WO2002054940A2 (fr) * 2001-01-12 2002-07-18 University Of Medicine & Dentistry Of New Jersey Proteine morphogenetique osseuse 2 (bmp-2) utilisee dans le traitement et le diagnostic du cancer
WO2002087632A1 (fr) * 2001-05-02 2002-11-07 Metaprobe, Inc. Procedes de depistage a grande capacite utilisant des produits d'imagerie par resonance magnetique
US7226587B2 (en) 2001-06-01 2007-06-05 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US20030134790A1 (en) * 2002-01-11 2003-07-17 University Of Medicine And Dentistry Of New Jersey Bone Morphogenetic Protein-2 And Bone Morphogenetic Protein-4 In The Treatment And Diagnosis Of Cancer
AU2002318168B2 (en) 2002-02-25 2007-12-13 Vaxiion Therapeutics, Llc Minicell compositions and methods
GB0307640D0 (en) * 2003-04-02 2003-05-07 Cyclacel Ltd Markers
CA2521623C (fr) 2003-04-11 2015-03-17 Etex Corporation Matiere osseuse osteo-inductrice
JP5392981B2 (ja) 2003-09-12 2014-01-22 ワイス・エルエルシー 骨形成蛋白の送達のための注入可能なリン酸カルシウム固体ロッドおよびペースト
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
WO2006081379A1 (fr) * 2005-01-26 2006-08-03 Wyeth Utilisation de sfrps, en tant que marqueurs d'une activte bmp
EP1863518A2 (fr) * 2005-03-30 2007-12-12 Wyeth Methodes pour stimuler la pousse des cheveux par administration de proteines bmp
NZ566774A (en) 2005-09-07 2011-11-25 Pfizer Human monoclonal antibodies to activin receptor-like kinase-1
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
ES2443581T3 (es) 2006-02-09 2014-02-19 Biomimetic Therapeutics, Llc Composiciones y métodos para el tratamiento de hueso
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
AU2007269712B2 (en) 2006-06-30 2013-02-07 Biomimetic Therapeutics, Llc PDGF-biomatrix compositions and methods for treating rotator cuff injuries
US20090061002A1 (en) 2007-09-05 2009-03-05 Venbrocks Rudolf A Calcium phospate based delivery of growth and differentiation factors to compromised bone
BR122020000059B8 (pt) 2008-09-09 2021-06-22 Biomimetic Therapeutics Inc composição que compreende uma matriz biocompatível e um fator de crescimento derivado de plaqueta e kit
JP5755635B2 (ja) 2009-03-30 2015-07-29 アクセルロン ファーマ， インコーポレイテッド Ｂｍｐ−ａｌｋ３アンタゴニストおよび骨成長促進のためのその使用
BR112012020566B1 (pt) 2010-02-22 2021-09-21 Biomimetic Therapeutics, Llc Composição de fator de crescimento derivado de plaqueta
WO2011116212A2 (fr) * 2010-03-17 2011-09-22 Oncomed Pharmaceuticals, Inc. Agents de liaison de récepteur de protéine morphogénétique osseuse et procédés de leur utilisation
WO2014012101A1 (fr) 2012-07-13 2014-01-16 Trustees Of Tufts College Compactage de poudre de soie pour fabrication de constructions à résistance mécanique et rigidité élevées
WO2016117618A1 (fr) * 2015-01-20 2016-07-28 国立大学法人九州大学 Procédé, kit, et biomarqueur de diagnostic de polyneuropathie démyélinisante inflammatoire chronique
EP3821880A1 (fr) 2015-10-26 2021-05-19 President and Fellows of Harvard College Polysaccharides oxydés et leurs méthodes d'utilisation

Family Cites Families (232)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2465357A (en) 1944-08-14 1949-03-29 Upjohn Co Therapeutic sponge and method of making
CH563767A5 (fr) 1973-01-30 1975-07-15 Pheulpin Jean
US4468464A (en) 1974-11-04 1984-08-28 The Board Of Trustees Of The Leland Stanford Junior University Biologically functional molecular chimeras
DE2657370C2 (de) 1976-12-17 1982-11-11 Hans Dr.med. Dr.med.dent. 8000 München Scheicher Mittel zum Bedecken und/oder Ausfüllen von Knochendefekten
DE2732848A1 (de) 1977-07-18 1979-02-08 Schering Ag Diurethane, herbizide mittel enthaltend diese verbindungen sowie verfahren zu ihrer herstellung
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4455256A (en) 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4294753A (en) 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4789732A (en) 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
US4761471A (en) 1980-08-04 1988-08-02 The Regents Of The University Of California Bone morphogenetic protein composition
US4619989A (en) 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
PH19942A (en) 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4727028A (en) 1981-06-22 1988-02-23 Eli Lilly And Company Recombinant DNA cloning vectors and the eukaryotic and prokaryotic transformants thereof
US4472840A (en) 1981-09-21 1984-09-25 Jefferies Steven R Method of inducing osseous formation by implanting bone graft material
US4394370A (en) 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4474181A (en) 1982-02-18 1984-10-02 Schenck Robert R Method and apparatus for anastomosing small blood vessels
DE3382562D1 (de) 1982-09-24 1992-06-25 Us Health Wiederherstellung von gewebe bei tieren.
IL68218A (en) 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US4434094A (en) 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
EP0128041A3 (fr) 1983-06-06 1986-12-03 David Jeston Baylink Polypeptides ayant une activité de facteur de croissance du squelette
US4795804A (en) 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4923805A (en) 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US4703008A (en) 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
GB8334498D0 (en) 1983-12-24 1984-02-01 Beecham Group Plc Compounds
US4804744A (en) 1984-01-04 1989-02-14 International Genetic Engineering, Inc. Osteogenic factors
NZ210699A (en) 1984-01-04 1989-06-28 Int Genetic Eng Isolation of an osteogenic protein of the p3 immunologically related family
ZA848495B (en) 1984-01-31 1985-09-25 Idaho Res Found Production of polypeptides in insect cells
US4608199A (en) 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
US4662884A (en) 1984-04-25 1987-05-05 University Of Utah Research Foundation Prostheses and methods for promoting nerve regeneration
US4596574A (en) 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
CA1341617C (fr) 1984-06-08 2011-06-28 Henry George Burger Inhibine extracte de liquide folliculaire ovarien
US4868161A (en) 1984-06-29 1989-09-19 City Of Hope Method for promoting nerve regeneration
UA39161C2 (uk) 1984-07-06 2001-06-15 Новартіс Аг Рекомбінантний білок gm-csf для збільшення продукції гранулоцитів і макрофагів у пацієнтів, вектор і кднк, що його кодують
WO1986000525A1 (fr) 1984-07-13 1986-01-30 Economix Közgazdász Egyetemi Kisszövetkezet Procede de preparation d'une composition pharmaceutique exerçant une influence sur le metabolisme des tissus ainsi qu'une action regeneratrice
US4843063A (en) 1984-07-16 1989-06-27 Collagen Corporation Polypeptide cartilage-inducing factors found in bone
EP0169016B2 (fr) 1984-07-16 2004-04-28 Celtrix Pharmaceuticals, Inc. Facteur polypeptidique issu des os induisant le cartilage
US4627982A (en) 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
EP0177343B1 (fr) 1984-10-05 1992-07-22 Genentech, Inc. ADN, cultures de cellules et méthodes pour sécréter des protéines hétérologiques et récupérer des protéines périplasmiques
US4769328A (en) 1984-10-12 1988-09-06 Zymogenetics Inc. Expression of biologically active PDGF analogs in yeast
US5187263A (en) 1984-10-12 1993-02-16 Zymogenetics, Inc. Expression of biologically active PDGE analogs in eucaryotic cells
US4563350A (en) 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
WO1986004067A1 (fr) 1984-12-27 1986-07-17 Suntory Limited Procede de purification d'un interferon
US4886747A (en) 1985-03-22 1989-12-12 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
US4766067A (en) 1985-05-31 1988-08-23 President And Fellows Of Harvard College Gene amplification
US5026538A (en) * 1985-06-07 1991-06-25 Cadema Medical Products, Inc. Method of treating arthritis, including rheumatoid arthritis, with 166 Holmium radionuclide
US4681763A (en) 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US4740587A (en) 1985-07-18 1988-04-26 The Salk Institute For Biological Studies Inhibin and method of purifying same
NZ217727A (en) 1985-10-03 1990-05-28 Genentech Inc Nucleic acid encoding alpha or b chain of inhibin, its production and compositions containing it
US4798885A (en) 1986-02-07 1989-01-17 Genentech, Inc. Compositions of hormonally active human and porcine inhibin containing an α chain and 62 chain
US5089396A (en) 1985-10-03 1992-02-18 Genentech, Inc. Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US5215893A (en) 1985-10-03 1993-06-01 Genentech, Inc. Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US4737578A (en) 1986-02-10 1988-04-12 The Salk Institute For Biological Studies Human inhibin
DE3764144D1 (de) 1986-04-16 1990-09-13 Asta Pharma Ag Synergistische kombination von amantadin und selegilin.
US4758233A (en) 1986-04-22 1988-07-19 N.J. Phillips TPY. Limited Cream applicator
NL8601328A (nl) 1986-05-23 1987-12-16 Langen Research Inrichting voor het met een massa, in het bijzonder pasteuze massa, injekteren van vlees.
US5459047A (en) 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US4877864A (en) 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5187076A (en) 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5108922A (en) 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5631142A (en) 1986-07-01 1997-05-20 Genetics Institute, Inc. Compositions comprising bone morphogenetic protein-2 (BMP-2)
IL83003A (en) 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US5939388A (en) 1986-07-01 1999-08-17 Rosen; Vicki A. Methods of administering BMP-5 compositions
US5543394A (en) 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5366875A (en) 1986-07-01 1994-11-22 Genetics Institute, Inc. Methods for producing BMP-7 proteins
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US5106748A (en) 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
ZA874681B (en) 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US5019087A (en) 1986-10-06 1991-05-28 American Biomaterials Corporation Nerve regeneration conduit
US5124316A (en) 1986-11-14 1992-06-23 President And Fellows Of Harvard College Method for periodontal regeneration
JPS63181770A (ja) 1987-01-21 1988-07-26 永瀬　守 リン酸三カルシウムと酸と蛋白質と水を混合する事により硬化生成した人工骨
US5457092A (en) 1987-07-30 1995-10-10 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) Methods of promoting bone growth in mammals comprising administration of modified parathyroid hormone
US5041538A (en) 1987-08-28 1991-08-20 The Salk Institute For Biological Studies Mammalian follistatin
US5202120A (en) 1987-09-11 1993-04-13 Case Western Reserve University Methods of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes
US5147399A (en) 1988-02-01 1992-09-15 Dellon Arnold L Method of treating nerve defects through use of a bioabsorbable surgical device
IT1215881B (it) 1988-02-16 1990-02-22 Giancarlo Foresti Sussidio chirurgico ad azione osteotropa.
IL89869A0 (en) 1988-04-06 1989-12-15 Collagen Corp Bone-inducing protein
US4968590A (en) 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5258494A (en) 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
WO1989009787A2 (fr) 1988-04-08 1989-10-19 Creative Biomolecules, Inc. Dispositifs osteogeniques
US5354557A (en) 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
AU645244B2 (en) 1988-04-08 1994-01-13 Genetics Institute, Llc Bone and cartilage inductive compositions
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5011691A (en) 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5108753A (en) 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
GB8809419D0 (en) 1988-04-21 1988-05-25 Pragnell I Stem cell inhibitors
US5024841A (en) 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
US5071834A (en) 1988-09-16 1991-12-10 Genentech, Inc. Purified activin B composition
US5284756A (en) 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US5106626A (en) 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
US4955892A (en) 1988-10-24 1990-09-11 Louisiana State University Neural cell adhesion protein nerve prosthesis
US5457038A (en) 1988-11-10 1995-10-10 Genetics Institute, Inc. Natural killer stimulatory factor
US5011486A (en) 1988-11-18 1991-04-30 Brown University Research Foundation Composite nerve guidance channels
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US4920962A (en) 1988-11-23 1990-05-01 Claude Proulx Splint-like element for use in end-to-end nerve suture
US5217867A (en) * 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
JPH03504201A (ja) 1989-02-23 1991-09-19 ゲゼルシャフト・フュア・ビオテクノロギッシェ・フォルシュンク・ミット・ベシュレンクテル・ハフツング　（ゲー・ベー・エフ） Ｐｔｈ変種をコードするｄｎａ配列、ｐｔｈ変種、発現ベクター、細菌宿主、利用と治療用組成物
DK0429570T3 (da) 1989-03-28 1998-04-27 Genetics Inst Osteoinducerende præparater
US5026381A (en) 1989-04-20 1991-06-25 Colla-Tec, Incorporated Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit
US4963146A (en) 1989-04-20 1990-10-16 Colla-Tec Incorporated Multi-layered, semi-permeable conduit for nerve regeneration
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
JPH03151877A (ja) 1989-06-02 1991-06-28 Chiron Corp 骨カルシウム沈着因子
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
AU5958090A (en) 1989-06-29 1991-01-17 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Method for protecting bone marrow against chemotherapeutic drugs and radiation therapy using transforming growth factor beta 1
CA2020729A1 (fr) 1989-07-19 1991-01-20 Michael C. Kiefer Proteine morphogenetique des os
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
WO1991002744A1 (fr) 1989-08-21 1991-03-07 Celtrix Laboratories, Inc. Proteine specifique aux os
US5422340A (en) 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
US5016809A (en) * 1989-09-05 1991-05-21 Ford Motor Company Thermal degreasing in reactive atmospheres and subsequent brazing of aluminum-based sheets or parts
EP0416578B1 (fr) 1989-09-06 1996-07-31 Takeda Chemical Industries, Ltd. Protéine, ADN et leur utilisation
CA2064558C (fr) 1989-09-25 2001-01-30 Ian B. Pragnell Methode d'inhibition de la croissance de cellules souches
WO1991005802A1 (fr) 1989-10-17 1991-05-02 Creative Biomolecules, Inc. Dispositifs osteogenes
US5236456A (en) 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5215895A (en) 1989-11-22 1993-06-01 Genetics Institute, Inc. Dna encoding a mammalian cytokine, interleukin-11
GB8927546D0 (en) 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5166190A (en) 1990-01-08 1992-11-24 Genentech, Inc. Method for increasing fertility in males
US5256418A (en) 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
US5290271A (en) 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
US5688678A (en) 1990-05-16 1997-11-18 Genetics Institute, Inc. DNA encoding and methods for producing BMP-8 proteins
WO1991018098A1 (fr) 1990-05-16 1991-11-28 Genetics Institute, Inc. Proteines d'induction osseuse et cartilagineuse
WO1991017777A2 (fr) 1990-05-22 1991-11-28 University Of Florida Compositions de verre bioactives injectables et procede de reconstitution de tissus
US5168050A (en) 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
US5218090A (en) * 1990-06-12 1993-06-08 Warner-Lambert Company EGF receptor truncates
US5364839A (en) 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
ATE177472T1 (de) 1990-09-14 1999-03-15 Chiron Corp Expression von makrophagen-induzierbaren proteinen (mips) in hefezellen
EP0550625B1 (fr) 1990-09-26 2003-11-05 Genetics Institute, LLC Derives bmp-5
JPH07500487A (ja) 1990-10-18 1995-01-19 ストライカー コーポレイション 骨形成ペプチド
AU8941791A (en) 1990-10-18 1992-05-20 Creative Biomolecules, Inc. Osteogenic protein
WO1992009697A1 (fr) 1990-11-30 1992-06-11 Celtrix Laboratories, Inc. UTILISATION EN OSTEOPATHIE D'UNE PROTEINE MORPHOGENETIQUE D'ORIGINE OSSEUSE ASSOCIEE DE MANIERE SYNERGIQUE AVEC DU BETA DE FACTEUR DE CROISSANCE DE TRANSFORMATION (β-FCT).
US5206028A (en) 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
US5208219A (en) 1991-02-14 1993-05-04 Celtrix Pharmaceuticals Inc. Method for inducing bone growth
DK0575555T3 (da) 1991-03-11 2001-11-05 Curis Inc Proteininduceret morfogenese
US5318898A (en) 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
US5118667A (en) 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
EP0542971A1 (fr) * 1991-05-10 1993-05-26 The Salk Institute For Biological Studies CLONAGE ET PRODUCTION PAR RECOMBINAISON D'UN OU DE PLUSIEURS RECEPTEUR(S) DE LA SUPERFAMILLE ACTIVINE/FTC-$g(b)
WO1992020371A1 (fr) 1991-05-10 1992-11-26 Celtrix Pharmaceuticals, Inc. Apport cible de facteurs de croissance osseuse
US5229495A (en) * 1991-06-18 1993-07-20 Ludwig Institute For Cancer Research Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
US5216126A (en) * 1991-06-19 1993-06-01 Genentech, Inc. Receptor polypeptides and their production and uses
DE69213739T2 (de) 1991-06-21 1997-02-20 Genetics Institute, Inc., Cambridge, Mass. Osteogene proteine enthaltende arzneimittel
EP0592562B1 (fr) 1991-06-25 1999-01-07 Genetics Institute, Inc. Compositions bmp-9
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
US5356629A (en) 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5306307A (en) 1991-07-22 1994-04-26 Calcitek, Inc. Spinal disk implant
DE69233559T2 (de) 1991-08-30 2006-08-31 Curis, Inc., Cambridge Osteogenische proteine in der behandlung von metabolischen knochenkrankheiten
JP3693338B2 (ja) 1991-08-30 2005-09-07 キュリス インコーポレイテッド 組織形成因子誘導による炎症反応の調節
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5171579A (en) 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
AU671606B2 (en) * 1991-10-31 1996-09-05 Whitehead Institute For Biomedical Research TGF-beta type receptor cDNAs and uses therefor
WO1993009229A1 (fr) 1991-11-04 1993-05-13 Genetics Institute, Inc. Proteines heterodimeres morphogenetiques d'os de recombinaison, compositions et procedes d'utilisation
EP0625050B1 (fr) 1991-11-22 1999-04-14 Genentech, Inc. Tgf-beta pour ameliorer la recuperation des neurones
US6057123A (en) 1991-12-23 2000-05-02 British Biotech Pharmaceuticals Limited Stem cell inhibiting proteins
SE469653B (sv) 1992-01-13 1993-08-16 Lucocer Ab Poroest implantat
DK0625989T3 (da) 1992-02-12 2000-06-26 Bioph Biotech Entw Pharm Gmbh DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
DE69331096T2 (de) 1992-02-28 2002-08-14 Cohesion Technologies, Inc. Injektierbare, keramische verbindungen sowie verfahren zur deren herstellung und anwendung
AU3920693A (en) * 1992-03-18 1993-10-21 General Hospital Corporation, The Four novel receptors of the TGF-beta receptor family
IT1259090B (it) 1992-04-17 1996-03-11 Fidia Spa Biomaterialli per protesi d'osso
IT1259100B (it) 1992-05-20 1996-03-11 Lanfranco Callegaro Uso di idrogeli per il bloccaggio di sistemi protesici
IL106278A0 (en) 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
PT653942E (pt) 1992-07-31 2003-11-28 Curis Inc Regeneracao e reparacao de nervos induzidos por morfogenios
TW242109B (fr) * 1992-08-20 1995-03-01 Ciba Geigy
CA2144514C (fr) 1992-09-16 2002-03-26 Thangavel Kuberasampath Regeneration hepatique induite par des morphogenes
CA2149441C (fr) * 1992-11-17 2004-03-02 Kohei Miyazono Kinases apparentees au recepteur de l'activine, proteines a domaines de serine threonine kinase et leur utilisation
CA2153653C (fr) 1993-01-12 2010-12-07 Se-Jin Lee Facteur 9 de differenciation de croissance
EP0690871A4 (fr) 1993-01-12 1999-10-20 Univ Johns Hopkins Med Facteur-5 de croissance et de differentiation
US5808007A (en) 1993-01-12 1998-09-15 The Johns Hopkins University School Of Medicine Growth differentiation factor-3
US5420243A (en) 1993-01-26 1995-05-30 Celtrix Pharmaceuticals, Inc. Biologically active TGF-β2 peptides
DK0690873T3 (da) 1993-03-19 2003-09-29 Univ Johns Hopkins Med Vækstdifferentieringsfaktor-8
ES2127389T3 (es) * 1993-03-26 1999-04-16 Du Pont Triazolinonas utilizadas como herbicidas.
GB9308060D0 (en) 1993-04-19 1993-06-02 Cancer Res Campaign Tech Stem cell inhibitor
JPH09501305A (ja) 1993-05-12 1997-02-10 ジェネティックス・インスティテュート・インコーポレイテッド Ｂｍｐ−１０組成物
WO1994026892A1 (fr) 1993-05-12 1994-11-24 Genetics Institute, Inc. Compositions de bmp-11
US5637480A (en) 1993-05-12 1997-06-10 Genetics Institute, Inc. DNA molecules encoding bone morphogenetic protein-10
EP0626451A3 (fr) 1993-05-27 1997-11-05 Takeda Chemical Industries, Ltd. Hétérodimères d'une superfamille de TGF-bêta
US5447725A (en) 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
AU688779B2 (en) 1993-07-09 1998-03-19 Johns Hopkins University School Of Medicine, The Growth differentiation factor-7
WO1995001801A1 (fr) 1993-07-09 1995-01-19 The Johns Hopkins University School Of Medicine Facteur 6 de croissance et de differenciation cellulaires
EP1716864A1 (fr) 1993-08-26 2006-11-02 Genetics Institute, LLC Régéneration nerveuse utilisant des protéines morphogénetiques osseuses chez l'homme
US5455041A (en) 1993-09-13 1995-10-03 Research Foundation Of State University Of New York At Buffalo Method for inducing periodontal tissue regeneration
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US6204047B1 (en) 1993-10-08 2001-03-20 The Johns Hopkins University School Of Medicine Growth differentiation factor-10
JPH09503673A (ja) 1993-10-14 1997-04-15 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ ニューロン細胞の誘導および維持法
AU8095694A (en) 1993-10-28 1995-05-22 Thm Biomedical, Inc. Improved process and device for treating and healing a bone void
USH1532H (en) 1993-11-03 1996-05-07 Genetics Institute, Inc. Adaption of mammalian cell lines to high cell densities
AU689184B2 (en) 1993-12-07 1998-03-26 Genetics Institute, Llc BMP-12, BMP-13 and tendon-inducing compositions thereof
US6027919A (en) 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
US5439904A (en) 1993-12-07 1995-08-08 Synphar Laboratories, Inc. 2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents
US5399677A (en) 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
US5556767A (en) 1993-12-22 1996-09-17 Human Genome Sciences, Inc. Polynucleotide encoding macrophage inflammatory protein γ
US5723331A (en) 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
EP1574577A3 (fr) 1994-07-08 2006-06-14 The Johns Hopkins University School Of Medicine Facteur 11 de differentation de croissance
DK0770089T3 (da) 1994-07-13 2000-10-23 Univ Johns Hopkins Med Vækstdifferentieringsfaktor-12
US5520923A (en) 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5545616A (en) 1994-09-22 1996-08-13 Genentech, Inc. Method for predicting and/or preventing preterm labor
US5693779A (en) 1994-11-08 1997-12-02 The United States Of America As Represented By The Department Of Health And Human Services Production and use of anti-dorsalizing morphogenetic protein
ES2093593T1 (es) 1995-05-05 1997-01-01 Hoffmann La Roche Proteinas obesas (ob) recombinantes.
US5635372A (en) 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
US5760189A (en) 1995-06-02 1998-06-02 Genetics Institute, Inc. Protein recovery & purification methods
EP1364656B1 (fr) 1995-06-05 2013-11-20 Genetics Institute, LLC Utilisation de protéines morphogéniques osseuses pour soigner et réparer les insertions du tissu conjonctif
US5902785A (en) 1995-06-06 1999-05-11 Genetics Institute, Inc. Cartilage induction by bone morphogenetic proteins
MXPA97009909A (es) 1995-06-06 2004-08-23 Gensci Regeneration Lab Inc Materiales osteogenicos modificados.
US5714583A (en) 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
JP2000501966A (ja) 1995-12-18 2000-02-22 デグッサ アクチエンゲゼルシャフト 医療用インプラント
EP0894004B2 (fr) 1996-03-22 2007-02-21 Curis, Inc. Procede pour favoriser la recuperation fonctionnelle de la coordination motrice, de la parole ou de la perception sensorielle a la suite d'une ischemie ou d'un traumatisme du systeme nerveux central
US5700774A (en) 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
ATE439849T1 (de) 1996-04-19 2009-09-15 Osiris Therapeutics Inc Die wiederherstellung und verstärkung von knochen mittels mesenchymalen stammzellen
EP0907721A1 (fr) 1996-05-28 1999-04-14 Brown University Research Foundation Charpentes biodegradables a base de hyaluronan destinees a la reparation tissulaire
US6133232A (en) 1996-06-20 2000-10-17 The Regents Of The University Of California Endoderm, cardiac and neural inducing factors
IT1288290B1 (it) 1996-06-21 1998-09-11 Fidia Spa In Amministrazione S Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie
US5813411A (en) 1996-08-20 1998-09-29 Menlo Care, Inc. Method of deforming tissue with a swollen hydrogel
US5965403A (en) 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
AU4981797A (en) 1996-10-11 1998-05-11 Government Of The United States Of America, The Isolation and method of using tissue growth-inducing frzb protein
AU6245898A (en) 1997-01-21 1998-08-07 Genetics Institute Inc. Injectable formulations for treatment of osteoporotic bone
WO1998034951A1 (fr) 1997-02-11 1998-08-13 Amrad Operations Pty. Ltd. Nouvelle famille de cytokines et utilisations correspondantes
US20020098222A1 (en) 1997-03-13 2002-07-25 John F. Wironen Bone paste
US6034062A (en) 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses
US6001352A (en) 1997-03-31 1999-12-14 Osteobiologics, Inc. Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
US6610510B1 (en) 1997-04-29 2003-08-26 Regeneron Pharmaceuticals, Inc. Morphogenic proteins
US5972368A (en) 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
JP4371179B2 (ja) 1997-07-04 2009-11-25 ユニバーシティー オブ ユタ リサーチ ファンデーション 系列限定ニューロン前駆体
IT1296689B1 (it) 1997-11-06 1999-07-14 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico aventi proprieta viscoelastiche e loro uso in campo biomedico-sanitario
US20030036629A1 (en) 1997-12-12 2003-02-20 Barry Foster Novel tgf-beta protein purification methods
US20030170213A1 (en) 1998-01-23 2003-09-11 Marc F. Charette Methods and compositions for enhancing cognitive function using morphogenic proteins
US20020076429A1 (en) 1998-01-28 2002-06-20 John F. Wironen Bone paste subjected to irradiative and thermal treatment
US6004937A (en) 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
IT1302534B1 (it) 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per

Also Published As

Publication number Publication date
CA2170405A1 (fr) 1995-03-23
NO961009D0 (no) 1996-03-12
EP1903112A3 (fr) 2008-08-20
EP0723588B1 (fr) 2007-10-24
US7091007B2 (en) 2006-08-15
NO961009L (no) 1996-03-12
JPH09502611A (ja) 1997-03-18
WO1995007982A1 (fr) 1995-03-23
AU7722494A (en) 1995-04-03
ES2296287T3 (es) 2008-04-16
US20040142417A1 (en) 2004-07-22
EP0723588A1 (fr) 1996-07-31
US20020137133A1 (en) 2002-09-26
DE69435038D1 (de) 2007-12-06
ATE376590T1 (de) 2007-11-15
EP1903112A2 (fr) 2008-03-26
KR960705041A (ko) 1996-10-09
DE69435038T2 (de) 2008-08-07
FI961196A7 (fi) 1996-04-19
KR100406299B1 (ko) 2004-04-03
FI961196L (fi) 1996-04-19
US6291206B1 (en) 2001-09-18
DK0723588T3 (da) 2008-02-04
AU686232B2 (en) 1998-02-05
US6610513B2 (en) 2003-08-26
FI961196A0 (fi) 1996-03-14

Similar Documents

Publication Publication Date Title
OA10359A (en) Activin receptors-like kinase (alk) belonging to the tgf receptor family and/or to the bmp receptor family
JP3681069B2 (ja) Ｂｍｐ−１１組成物
US6835544B2 (en) Methods of screening for compounds that bind to activin receptor
EP0977861B1 (fr) Facteur 7 mammalien du type cytokine
OA10192A (en) Bmp-10 compositions
US20050186593A1 (en) Cloning and recombinant production of CRF receptor(s)
CA2220010A1 (fr) Compositions de proteines bmp-15
AU2022201603A1 (en) TGF-beta superfamily heteromultimers and uses thereof
US20020102639A1 (en) Evi27 gene sequences and protein encoded thereby
US7008781B1 (en) Method of enhancing the biological activity of ligands
JP2001522810A (ja) Ｂｍｐ−１１のニューロンにおける使用
JP2002540763A (ja) ３３個のヒト分泌タンパク質
US20100076179A1 (en) Antibodies to mammalian cytokine-like factor 7
US20040132661A1 (en) Therapeutic method for treating bone formation diseases
CA2319208A1 (fr) Recepteurs orphelins
AU9305298A (en) Estrogen receptor