OA10528A - A novel protein and process for preparing the same - Google Patents

A novel protein and process for preparing the same Download PDF

Info

Publication number: OA10528A
Authority: OA; OAPI
Prior art keywords: protein; bone; cartilage; amino acid; homodimer
Prior art date: 1995-04-19

Application number

OA70112A

Other languages

English (en)

Inventor

Fusao Makishima

Hiroyuki Takamatsu

Hideo Miki

Shinji Kawai

Michio Kimura

Tomoaki Matsumoto

Mieko Katsuura

Koichi Enomoto

Yusuke Satoh

Original Assignee

Hoechst Japan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-19

Filing date

1997-10-17

Publication date

2002-04-26

1997-10-17 Application filed by Hoechst Japan filed Critical Hoechst Japan

2002-04-26 Publication of OA10528A publication Critical patent/OA10528A/en

Links

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HKYTWJOWZTWBQB-AVGNSLFASA-N Tyr-Glu-Asp Chemical compound OC(=O)C[C@@H](C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 HKYTWJOWZTWBQB-AVGNSLFASA-N 0.000 description 1
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RLVTVHSDKHBFQP-ULQDDVLXSA-N Val-Tyr-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)CC1=CC=C(O)C=C1 RLVTVHSDKHBFQP-ULQDDVLXSA-N 0.000 description 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
102100029469 WD repeat and HMG-box DNA-binding protein 1 Human genes 0.000 description 1
101710097421 WD repeat and HMG-box DNA-binding protein 1 Proteins 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
208000005065 achondrogenesis Diseases 0.000 description 1
210000001789 adipocyte Anatomy 0.000 description 1
108010087924 alanylproline Proteins 0.000 description 1
238000000137 annealing Methods 0.000 description 1
238000013459 approach Methods 0.000 description 1
108010062796 arginyllysine Proteins 0.000 description 1
108010060035 arginylproline Proteins 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
229940112869 bone morphogenetic protein Drugs 0.000 description 1
230000037118 bone strength Effects 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
229910052927 chalcanthite Inorganic materials 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
208000017568 chondrodysplasia Diseases 0.000 description 1
238000002316 cosmetic surgery Methods 0.000 description 1
108010004073 cysteinylcysteine Proteins 0.000 description 1
230000002950 deficient Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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238000009547 dual-energy X-ray absorptiometry Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
229940011871 estrogen Drugs 0.000 description 1
239000000262 estrogen Substances 0.000 description 1
210000002744 extracellular matrix Anatomy 0.000 description 1
239000000835 fiber Substances 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
239000011521 glass Substances 0.000 description 1
YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 1
239000003102 growth factor Substances 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
108010092114 histidylphenylalanine Proteins 0.000 description 1
238000001802 infusion Methods 0.000 description 1
208000014674 injury Diseases 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
238000002955 isolation Methods 0.000 description 1
210000000281 joint capsule Anatomy 0.000 description 1
210000003127 knee Anatomy 0.000 description 1
239000008101 lactose Substances 0.000 description 1
238000011031 large-scale manufacturing process Methods 0.000 description 1
238000011068 loading method Methods 0.000 description 1
210000004962 mammalian cell Anatomy 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000002609 medium Substances 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
230000005499 meniscus Effects 0.000 description 1
244000005700 microbiome Species 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
210000000663 muscle cell Anatomy 0.000 description 1
238000002703 mutagenesis Methods 0.000 description 1
231100000350 mutagenesis Toxicity 0.000 description 1
230000035772 mutation Effects 0.000 description 1
238000011587 new zealand white rabbit Methods 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
230000003239 periodontal effect Effects 0.000 description 1
210000003460 periosteum Anatomy 0.000 description 1
239000002953 phosphate buffered saline Substances 0.000 description 1
239000013600 plasmid vector Substances 0.000 description 1
238000003752 polymerase chain reaction Methods 0.000 description 1
239000011148 porous material Substances 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
239000013587 production medium Substances 0.000 description 1
229940070376 protein Drugs 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000002601 radiography Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
230000000284 resting effect Effects 0.000 description 1
108091008146 restriction endonucleases Proteins 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
229940102127 rubidium chloride Drugs 0.000 description 1
238000007789 sealing Methods 0.000 description 1
108010048818 seryl-histidine Proteins 0.000 description 1
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
238000000527 sonication Methods 0.000 description 1
238000013222 sprague-dawley male rat Methods 0.000 description 1
238000007447 staining method Methods 0.000 description 1
239000010959 steel Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
229960003495 thiamine Drugs 0.000 description 1
DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
108010021724 tonin Proteins 0.000 description 1
210000000515 tooth Anatomy 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000011426 transformation method Methods 0.000 description 1
238000013519 translation Methods 0.000 description 1
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
235000005282 vitamin D3 Nutrition 0.000 description 1
239000011647 vitamin D3 Substances 0.000 description 1
229940021056 vitamin d3 Drugs 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
229910000368 zinc sulfate Inorganic materials 0.000 description 1
239000011686 zinc sulphate Substances 0.000 description 1
235000009529 zinc sulphate Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Rheumatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

OA70112A 1995-04-19 1997-10-17 A novel protein and process for preparing the same OA10528A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP9366495		1995-04-19
JP32240395		1995-11-17

Publications (1)

Publication Number	Publication Date
OA10528A true OA10528A (en)	2002-04-26

Family

ID=26434967

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA70112A OA10528A (en)	1995-04-19	1997-10-17	A novel protein and process for preparing the same

Country Status (18)

Country	Link
US (3)	US7235527B2 (de)
EP (1)	EP0955313B1 (de)
AT (1)	ATE325131T1 (de)
AU (1)	AU704515C (de)
BR (1)	BR9608019A (de)
CA (1)	CA2216741C (de)
DE (2)	DE69636728T4 (de)
DK (1)	DK0955313T3 (de)
EA (1)	EA000582B1 (de)
ES (1)	ES2258774T3 (de)
HU (1)	HU225424B1 (de)
NO (1)	NO321153B1 (de)
NZ (1)	NZ305472A (de)
OA (1)	OA10528A (de)
PL (1)	PL186518B1 (de)
PT (1)	PT955313E (de)
UA (1)	UA46767C2 (de)
WO (1)	WO1996033215A1 (de)

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US20070166353A1 (en) *	1988-04-08	2007-07-19	Stryker Corporation	Osteogenic proteins
US20080233170A1 (en) *	1992-02-21	2008-09-25	Stryker Corporation	Osteogenic Proteins
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AP983A (en) *	1997-01-30	2001-07-16	Biopharm Gmbh	Freeze-dried composition of bone morphogenetic protein human MP52.
DE69814352T3 (de) †	1997-02-07	2009-08-13	Stryker Corp., Kalamazoo	Matrixlose osteogene vorrichtungen und implantate und verfahren zu deren verwendung
US6727224B1 (en)	1999-02-01	2004-04-27	Genetics Institute, Llc.	Methods and compositions for healing and repair of articular cartilage
US20070105762A1 (en) *	2005-03-30	2007-05-10	Jung Kim	Non-activated polypeptides having a function of tissue regeneration and method for preparing the same
KR100775958B1 (ko)	2005-03-30	2007-11-13	김정문	조직재생 기능을 가지는 비활성 폴리펩티드 및 그 제조방법
US20060286144A1 (en) *	2005-06-17	2006-12-21	Chunlin Yang	Reinforced collagen scaffold
DK1948689T3 (da)	2005-11-18	2012-07-23	Bioph Biotech Entw Pharm Gmbh	Højaktivitetsvækstfaktormutanter
EP1880731A1 (de) *	2006-07-18	2008-01-23	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Menschlicher Wachstums und Differenzierungsfaktor GDF-5
AU2007234612B2 (en)	2006-12-14	2013-06-27	Johnson & Johnson Regenerative Therapeutics, Llc	Protein stabilization formulations
ES2402672T3 (es) *	2007-01-25	2013-05-07	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Uso del GDF-5 para el mejoramiento o el mantenimiento del aspecto dérmico
US7678764B2 (en)	2007-06-29	2010-03-16	Johnson & Johnson Regenerative Therapeutics, Llc	Protein formulations for use at elevated temperatures
EP2019117A1 (de)	2007-07-27	2009-01-28	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Optimiertes Reinigungsverfahren für rekombinantes Wachstumsfaktorprotein
CA2695697A1 (en)	2007-08-07	2009-02-12	Advanced Technologies And Regenerative Medicine, Llc	Protein formulations comprising gdf-5 in aqueous acidic solution
JP2009106163A (ja) *	2007-10-26	2009-05-21	Kyushu Univ	核酸配列、ベクター、形質転換体、製造方法、及び、核酸配列プライマー
EP2276458A1 (de) *	2008-04-14	2011-01-26	Advanced Technologies and Regenerative Medicine, LLC	Flüssige gepufferte gdf-5-formulierungen
US11260110B2 (en)	2009-11-18	2022-03-01	Ptlnv, Llc, Series Four (4)	Nanoparticles for the therapeutic treatment of radiation-induced skin ulcers
US9226898B1 (en) *	2009-11-18	2016-01-05	Richard C. K. Yen	Submicron particles for the treatment of radiation damage in patients
EP2598177B1 (de)	2010-07-30	2015-06-17	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH	Wirkstofffreisetzungsvorrichtungen und wachstumsfaktorformulierungen für beschleunigte wundheilung
US8551525B2 (en)	2010-12-23	2013-10-08	Biostructures, Llc	Bone graft materials and methods
US8455436B2 (en)	2010-12-28	2013-06-04	Depuy Mitek, Llc	Compositions and methods for treating joints
US8524662B2 (en)	2010-12-28	2013-09-03	Depuy Mitek, Llc	Compositions and methods for treating joints
US8398611B2 (en)	2010-12-28	2013-03-19	Depuy Mitek, Inc.	Compositions and methods for treating joints
EP2537538A1 (de)	2011-06-22	2012-12-26	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH	Bioresorbierbarer Wundverband
US8623839B2 (en)	2011-06-30	2014-01-07	Depuy Mitek, Llc	Compositions and methods for stabilized polysaccharide formulations
EP2602264A1 (de)	2011-12-05	2013-06-12	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH	GDF-5-Mutant zur Induzierung der Knorpelbildung
US9682099B2 (en)	2015-01-20	2017-06-20	DePuy Synthes Products, Inc.	Compositions and methods for treating joints
CN114786707A (zh)	2019-12-18	2022-07-22	默克专利股份公司	Gdf-5突变体用于治疗疼痛和软骨破坏的用途
KR20240064367A (ko) *	2022-11-04	2024-05-13	주식회사 대웅제약	TGF-β3 단백질의 정제방법

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US5079352A (en) *	1986-08-22	1992-01-07	Cetus Corporation	Purified thermostable enzyme
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US5143829A (en) *	1990-03-29	1992-09-01	California Biotechnology Inc.	High level expression of basic fibroblast growth factor having a homogeneous n-terminus
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1996
- 1996-04-19 PL PL96322945A patent/PL186518B1/pl not_active IP Right Cessation
- 1996-04-19 PT PT96910198T patent/PT955313E/pt unknown
- 1996-04-19 ES ES96910198T patent/ES2258774T3/es not_active Expired - Lifetime
- 1996-04-19 US US08/945,459 patent/US7235527B2/en not_active Expired - Fee Related
- 1996-04-19 UA UA97115563A patent/UA46767C2/uk unknown
- 1996-04-19 CA CA002216741A patent/CA2216741C/en not_active Expired - Fee Related
- 1996-04-19 HU HU9801697A patent/HU225424B1/hu not_active IP Right Cessation
- 1996-04-19 AU AU53470/96A patent/AU704515C/en not_active Ceased
- 1996-04-19 AT AT96910198T patent/ATE325131T1/de active
- 1996-04-19 WO PCT/JP1996/001062 patent/WO1996033215A1/ja not_active Ceased
- 1996-04-19 DK DK96910198T patent/DK0955313T3/da active
- 1996-04-19 DE DE69636728T patent/DE69636728T4/de not_active Expired - Lifetime
- 1996-04-19 EA EA199700329A patent/EA000582B1/ru not_active IP Right Cessation
- 1996-04-19 BR BR9608019-1A patent/BR9608019A/pt not_active IP Right Cessation
- 1996-04-19 EP EP96910198A patent/EP0955313B1/de not_active Expired - Lifetime
- 1996-04-19 DE DE69636728A patent/DE69636728D1/de not_active Expired - Lifetime
- 1996-04-19 NZ NZ305472A patent/NZ305472A/en not_active IP Right Cessation
1997
- 1997-10-17 NO NO19974812A patent/NO321153B1/no not_active IP Right Cessation
- 1997-10-17 OA OA70112A patent/OA10528A/en unknown
2003
- 2003-02-12 US US10/365,231 patent/US7268114B2/en not_active Expired - Fee Related
2007
- 2007-08-03 US US11/833,653 patent/US7816103B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PL322945A1 (en)	1998-03-02
EA199700329A1 (ru)	1998-04-30
US7816103B2 (en)	2010-10-19
DE69636728T2 (de)	2007-02-22
NO974812L (no)	1997-12-19
EP0955313A1 (de)	1999-11-10
HU225424B1 (en)	2006-11-28
DE69636728D1 (de)	2007-01-04
NZ305472A (en)	1999-09-29
DE69636728T4 (de)	2007-06-28
US20090325864A1 (en)	2009-12-31
US7268114B2 (en)	2007-09-11
CA2216741C (en)	2008-01-15
AU5347096A (en)	1996-11-07
NO321153B1 (no)	2006-03-27
EP0955313B1 (de)	2006-05-03
CA2216741A1 (en)	1996-10-24
EA000582B1 (ru)	1999-12-29
PL186518B1 (pl)	2004-01-30
HUP9801697A3 (en)	2000-06-28
ES2258774T3 (es)	2006-09-01
US20020102633A1 (en)	2002-08-01
US7235527B2 (en)	2007-06-26
ATE325131T1 (de)	2006-06-15
PT955313E (pt)	2006-07-31
US20030181378A1 (en)	2003-09-25
MX9708011A (es)	1998-03-31
AU704515C (en)	2002-03-28
NO974812D0 (no)	1997-10-17
UA46767C2 (uk)	2002-06-17
DK0955313T3 (da)	2006-08-21
WO1996033215A1 (en)	1996-10-24
HUP9801697A2 (hu)	1998-10-28
BR9608019A (pt)	1999-11-30
AU704515B2 (en)	1999-04-22
EP0955313A4 (de)	2001-11-07

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OA10528A (en)	2002-04-26	A novel protein and process for preparing the same
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AU645244B2 (en)	1994-01-13	Bone and cartilage inductive compositions
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IE75881B1 (en)	1997-09-24	Novel osteoinductive factors
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KR100490817B1 (ko)	2005-09-08	119아미노산으로구성된mp52유래의단백질및그제법
MXPA97008011A (en)	1998-10-15	New protein and process for your preparation
JP2997549B2 (ja)	2000-01-11	新規なタンパク質およびその製法
JPWO1996033215A1 (ja)	1997-08-26	新規なタンパク質およびその製法
MXPA98000686A (en)	1999-01-11	New human human protein mp