ATE325131T1 - Neues protein und verfahren zu dessen herstellung - Google Patents

Neues protein und verfahren zu dessen herstellung

Info

Publication number
ATE325131T1
ATE325131T1 AT96910198T AT96910198T ATE325131T1 AT E325131 T1 ATE325131 T1 AT E325131T1 AT 96910198 T AT96910198 T AT 96910198T AT 96910198 T AT96910198 T AT 96910198T AT E325131 T1 ATE325131 T1 AT E325131T1
Authority
AT
Austria
Prior art keywords
protein
seq
purifying
amino acid
acid sequence
Prior art date
Application number
AT96910198T
Other languages
English (en)
Inventor
Fusao Makishima
Hiroyuki Takamatsu
Hideo Miki
Shinji Kawai
Michio Kimura
Tomoaki Matsumoto
Mieko Katsuura
Koichi Enomoto
Yusuke Satoh
Original Assignee
Bioph Biotech Entw Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioph Biotech Entw Pharm Gmbh filed Critical Bioph Biotech Entw Pharm Gmbh
Application granted granted Critical
Publication of ATE325131T1 publication Critical patent/ATE325131T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96910198T 1995-04-19 1996-04-19 Neues protein und verfahren zu dessen herstellung ATE325131T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9366495 1995-04-19
JP32240395 1995-11-17

Publications (1)

Publication Number Publication Date
ATE325131T1 true ATE325131T1 (de) 2006-06-15

Family

ID=26434967

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96910198T ATE325131T1 (de) 1995-04-19 1996-04-19 Neues protein und verfahren zu dessen herstellung

Country Status (18)

Country Link
US (3) US7235527B2 (de)
EP (1) EP0955313B1 (de)
AT (1) ATE325131T1 (de)
AU (1) AU704515C (de)
BR (1) BR9608019A (de)
CA (1) CA2216741C (de)
DE (2) DE69636728T4 (de)
DK (1) DK0955313T3 (de)
EA (1) EA000582B1 (de)
ES (1) ES2258774T3 (de)
HU (1) HU225424B1 (de)
NO (1) NO321153B1 (de)
NZ (1) NZ305472A (de)
OA (1) OA10528A (de)
PL (1) PL186518B1 (de)
PT (1) PT955313E (de)
UA (1) UA46767C2 (de)
WO (1) WO1996033215A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070166353A1 (en) * 1988-04-08 2007-07-19 Stryker Corporation Osteogenic proteins
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US20080233170A1 (en) * 1992-02-21 2008-09-25 Stryker Corporation Osteogenic Proteins
ZA9711580B (en) * 1996-12-25 1999-09-23 Hoechst Marion Roussel Ltd Process for the production of purified dimeric bone morphogenetic factors.
CA2278546C (en) * 1997-01-30 2008-04-01 Hoechst Marion Roussel Ltd. Freeze-dried composition of bone morphogenetic protein human mp52
JP4388602B2 (ja) † 1997-02-07 2009-12-24 ストライカー コーポレイション マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
WO2006104306A1 (en) * 2005-03-30 2006-10-05 Jung Moon Kim Non-activated polypeptides having a function of tissue regeneration and method for preparing the same
KR100775958B1 (ko) 2005-03-30 2007-11-13 김정문 조직재생 기능을 가지는 비활성 폴리펩티드 및 그 제조방법
US20060286144A1 (en) * 2005-06-17 2006-12-21 Chunlin Yang Reinforced collagen scaffold
WO2007057212A1 (en) 2005-11-18 2007-05-24 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh High activity growth factor mutants
EP1880731A1 (de) * 2006-07-18 2008-01-23 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Menschlicher Wachstums und Differenzierungsfaktor GDF-5
AU2007234612B2 (en) * 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
HRP20120698T1 (hr) * 2007-01-25 2013-09-30 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Uporaba dgf-5 za poboljšanje ili održavanje izgleda kože
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
EP2019117A1 (de) * 2007-07-27 2009-01-28 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Optimiertes Reinigungsverfahren für rekombinantes Wachstumsfaktorprotein
JP5323832B2 (ja) 2007-08-07 2013-10-23 アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー 酸性水溶液中にｇｄｆ−５を含むタンパク質製剤
JP2009106163A (ja) * 2007-10-26 2009-05-21 Kyushu Univ 核酸配列、ベクター、形質転換体、製造方法、及び、核酸配列プライマー
BRPI0911048A2 (pt) * 2008-04-14 2015-12-29 Atrm Llc formulações líquidas tamponadas de gdf-5
US11260110B2 (en) 2009-11-18 2022-03-01 Ptlnv, Llc, Series Four (4) Nanoparticles for the therapeutic treatment of radiation-induced skin ulcers
US9226898B1 (en) * 2009-11-18 2016-01-05 Richard C. K. Yen Submicron particles for the treatment of radiation damage in patients
US20130122066A1 (en) 2010-07-30 2013-05-16 Biopham Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Drug delivery devices and growth factor formulations for accelerated wound healing
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
EP2537538A1 (de) 2011-06-22 2012-12-26 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Bioresorbierbarer Wundverband
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
EP2602264A1 (de) 2011-12-05 2013-06-12 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH GDF-5-Mutant zur Induzierung der Knorpelbildung
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
IL293988A (en) 2019-12-18 2022-08-01 Merck Patent Gmbh Use of a gdf-5 mutant in the treatment of pain and cartilage destruction
KR20240064367A (ko) * 2022-11-04 2024-05-13 주식회사 대웅제약 TGF-β3 단백질의 정제방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725234A (en) * 1985-08-15 1988-02-16 Ethridge Edwin C Alveolar bone grafting process with controlled surface active ceramics
US5079352A (en) * 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5143829A (en) * 1990-03-29 1992-09-01 California Biotechnology Inc. High level expression of basic fibroblast growth factor having a homogeneous n-terminus
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
WO1993009229A1 (en) 1991-11-04 1993-05-13 Genetics Institute, Inc. Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
DK0625989T3 (da) 1992-02-12 2000-06-26 Bioph Biotech Entw Pharm Gmbh DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
EP0690871A4 (de) * 1993-01-12 1999-10-20 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-5
IL110589A0 (en) * 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
US6248554B1 (en) 1993-11-24 2001-06-19 The Procter & Gamble Company DNA sequence coding for a BMP receptor
AU689184B2 (en) * 1993-12-07 1998-03-26 Genetics Institute, Llc BMP-12, BMP-13 and tendon-inducing compositions thereof
US5399677A (en) 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
US5707962A (en) * 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof

Also Published As

Publication number Publication date
EA000582B1 (ru) 1999-12-29
NO974812D0 (no) 1997-10-17
US20090325864A1 (en) 2009-12-31
MX9708011A (es) 1998-03-31
EP0955313B1 (de) 2006-05-03
UA46767C2 (uk) 2002-06-17
EP0955313A1 (de) 1999-11-10
CA2216741C (en) 2008-01-15
US20020102633A1 (en) 2002-08-01
EA199700329A1 (ru) 1998-04-30
NO321153B1 (no) 2006-03-27
US7268114B2 (en) 2007-09-11
HU225424B1 (en) 2006-11-28
DK0955313T3 (da) 2006-08-21
BR9608019A (pt) 1999-11-30
AU704515B2 (en) 1999-04-22
PT955313E (pt) 2006-07-31
US20030181378A1 (en) 2003-09-25
HUP9801697A2 (hu) 1998-10-28
DE69636728D1 (de) 2007-01-04
NO974812L (no) 1997-12-19
OA10528A (en) 2002-04-26
EP0955313A4 (de) 2001-11-07
AU704515C (en) 2002-03-28
DE69636728T4 (de) 2007-06-28
US7816103B2 (en) 2010-10-19
PL186518B1 (pl) 2004-01-30
WO1996033215A1 (en) 1996-10-24
DE69636728T2 (de) 2007-02-22
US7235527B2 (en) 2007-06-26
CA2216741A1 (en) 1996-10-24
NZ305472A (en) 1999-09-29
AU5347096A (en) 1996-11-07
PL322945A1 (en) 1998-03-02
HUP9801697A3 (en) 2000-06-28
ES2258774T3 (es) 2006-09-01

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