OA11677A - Pharmaceutical composition for modified release ofan insulin sensitiser and another antidiabetic agent. - Google Patents

Pharmaceutical composition for modified release ofan insulin sensitiser and another antidiabetic agent. Download PDF

Info

Publication number: OA11677A
Authority: OA; OAPI
Prior art keywords: composition according; tablet; release; composition; insulin
Prior art date: 1998-11-12

Application number

OA1200100117A

Other languages

English (en)

Inventor

Karen Lewis

Nicola Jayne Lilliott

Donald Colin Mackenzie

Vincenzo Re

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-12

Filing date

1999-11-08

Publication date

2005-01-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27547326&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA11677(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-11-12 Priority claimed from GBGB9824867.7A external-priority patent/GB9824867D0/en

1998-11-12 Priority claimed from GBGB9824866.9A external-priority patent/GB9824866D0/en

1998-11-12 Priority claimed from GBGB9824869.3A external-priority patent/GB9824869D0/en

1999-05-25 Priority claimed from GBGB9912190.7A external-priority patent/GB9912190D0/en

1999-05-25 Priority claimed from GBGB9912191.5A external-priority patent/GB9912191D0/en

1999-05-25 Priority claimed from GBGB9912193.1A external-priority patent/GB9912193D0/en

1999-11-08 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2005-01-12 Publication of OA11677A publication Critical patent/OA11677A/en

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract description 90
102000004877 Insulin Human genes 0.000 title claims abstract description 45
108090001061 Insulin Proteins 0.000 title claims abstract description 45
229940125396 insulin Drugs 0.000 title claims abstract description 45
231100000489 sensitizer Toxicity 0.000 title claims abstract description 38
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229940125708 antidiabetic agent Drugs 0.000 title claims abstract description 19
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 7
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239000003826 tablet Substances 0.000 claims description 54
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GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 claims description 18
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HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims description 16
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XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical group O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 claims description 14
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FSXVSUSRJXIJHB-UHFFFAOYSA-M ethyl prop-2-enoate;methyl 2-methylprop-2-enoate;trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CCOC(=O)C=C.COC(=O)C(C)=C.CC(=C)C(=O)OCC[N+](C)(C)C FSXVSUSRJXIJHB-UHFFFAOYSA-M 0.000 claims description 13
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GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 claims description 6
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LLJFMFZYVVLQKT-UHFFFAOYSA-N 1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-2-isoquinolinyl)ethyl]phenyl]sulfonylurea Chemical compound C=1C(OC)=CC=C(C(C2=O)(C)C)C=1C(=O)N2CCC(C=C1)=CC=C1S(=O)(=O)NC(=O)NC1CCCCC1 LLJFMFZYVVLQKT-UHFFFAOYSA-N 0.000 claims description 3
RKWGIWYCVPQPMF-UHFFFAOYSA-N Chloropropamide Chemical compound CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1 RKWGIWYCVPQPMF-UHFFFAOYSA-N 0.000 claims description 3
FAEKWTJYAYMJKF-QHCPKHFHSA-N GlucoNorm Chemical group C1=C(C(O)=O)C(OCC)=CC(CC(=O)N[C@@H](CC(C)C)C=2C(=CC=CC=2)N2CCCCC2)=C1 FAEKWTJYAYMJKF-QHCPKHFHSA-N 0.000 claims description 3
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IBAQFPQHRJAVAV-ULAWRXDQSA-N Miglitol Chemical compound OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO IBAQFPQHRJAVAV-ULAWRXDQSA-N 0.000 claims description 3
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NWWORXYTJRPSMC-QKPAOTATSA-N ethyl 4-[2-[(2r,3r,4r,5s)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]ethoxy]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1OCCN1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C1 NWWORXYTJRPSMC-QKPAOTATSA-N 0.000 claims description 3
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Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
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Medicinal Chemistry (AREA)
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Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
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Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Organic Chemistry (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

OA1200100117A 1998-11-12 1999-11-08 Pharmaceutical composition for modified release ofan insulin sensitiser and another antidiabetic agent. OA11677A (en)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GBGB9824867.7A GB9824867D0 (en)	1998-11-12	1998-11-12	Novel composition and use
GBGB9824866.9A GB9824866D0 (en)	1998-11-12	1998-11-12	Novel composition and use
GBGB9824869.3A GB9824869D0 (en)	1998-11-12	1998-11-12	Novel composition and use
GBGB9912190.7A GB9912190D0 (en)	1999-05-25	1999-05-25	Novel composition and use
GBGB9912191.5A GB9912191D0 (en)	1999-05-25	1999-05-25	Novel composition and use
GBGB9912193.1A GB9912193D0 (en)	1999-05-25	1999-05-25	Novel composition and use

Publications (1)

Publication Number	Publication Date
OA11677A true OA11677A (en)	2005-01-12

Family

ID=27547326

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200100117A OA11677A (en)	1998-11-12	1999-11-08	Pharmaceutical composition for modified release ofan insulin sensitiser and another antidiabetic agent.

Country Status (36)

Country	Link
EP (3)	EP1813273A1 (de)
JP (1)	JP2002529504A (de)
KR (1)	KR100643833B1 (de)
CN (1)	CN1230162C (de)
AR (1)	AR024228A1 (de)
AT (1)	ATE406889T1 (de)
AU (1)	AU768994B2 (de)
BG (2)	BG65351B1 (de)
BR (1)	BR9915285A (de)
CA (1)	CA2351058A1 (de)
CY (1)	CY1108587T1 (de)
CZ (1)	CZ20011629A3 (de)
DE (1)	DE69939485D1 (de)
DK (1)	DK1131070T3 (de)
DZ (1)	DZ2936A1 (de)
EA (2)	EA200601145A1 (de)
ES (1)	ES2312221T3 (de)
HK (1)	HK1040910B (de)
HR (1)	HRP20010343B1 (de)
HU (1)	HUP0104303A3 (de)
ID (1)	ID28783A (de)
IL (2)	IL143002A0 (de)
MY (1)	MY124695A (de)
NO (1)	NO20012303L (de)
NZ (1)	NZ511614A (de)
OA (1)	OA11677A (de)
PE (1)	PE20001238A1 (de)
PL (1)	PL347634A1 (de)
PT (1)	PT1131070E (de)
SI (1)	SI1131070T1 (de)
SK (1)	SK287038B6 (de)
TR (1)	TR200101333T2 (de)
TW (2)	TW592694B (de)
UY (1)	UY25799A1 (de)
WO (1)	WO2000028989A1 (de)
YU (1)	YU37301A (de)

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1999
- 1999-11-08 WO PCT/EP1999/008704 patent/WO2000028989A1/en not_active Ceased
- 1999-11-08 YU YU37301A patent/YU37301A/sh unknown
- 1999-11-08 DE DE69939485T patent/DE69939485D1/de not_active Expired - Lifetime
- 1999-11-08 DK DK99964483T patent/DK1131070T3/da active
- 1999-11-08 CZ CZ20011629A patent/CZ20011629A3/cs unknown
- 1999-11-08 ES ES99964483T patent/ES2312221T3/es not_active Expired - Lifetime
- 1999-11-08 EA EA200601145A patent/EA200601145A1/ru not_active IP Right Cessation
- 1999-11-08 EP EP07105992A patent/EP1813273A1/de not_active Withdrawn
- 1999-11-08 PL PL99347634A patent/PL347634A1/xx not_active Application Discontinuation
- 1999-11-08 EP EP08163249A patent/EP1992337A1/de not_active Withdrawn
- 1999-11-08 OA OA1200100117A patent/OA11677A/en unknown
- 1999-11-08 BR BR9915285-1A patent/BR9915285A/pt not_active Application Discontinuation
- 1999-11-08 PT PT99964483T patent/PT1131070E/pt unknown
- 1999-11-08 AT AT99964483T patent/ATE406889T1/de active
- 1999-11-08 HK HK02101023.7A patent/HK1040910B/en not_active IP Right Cessation
- 1999-11-08 HR HR20010343A patent/HRP20010343B1/xx not_active IP Right Cessation
- 1999-11-08 EP EP99964483A patent/EP1131070B1/de not_active Revoked
- 1999-11-08 KR KR1020017005967A patent/KR100643833B1/ko not_active Expired - Fee Related
- 1999-11-08 TR TR2001/01333T patent/TR200101333T2/xx unknown
- 1999-11-08 SI SI9931017T patent/SI1131070T1/sl unknown
- 1999-11-08 IL IL14300299A patent/IL143002A0/xx unknown
- 1999-11-08 EA EA200100541A patent/EA007610B1/ru not_active IP Right Cessation
- 1999-11-08 AU AU30338/00A patent/AU768994B2/en not_active Ceased
- 1999-11-08 CA CA002351058A patent/CA2351058A1/en not_active Abandoned
- 1999-11-08 NZ NZ511614A patent/NZ511614A/en not_active IP Right Cessation
- 1999-11-08 ID IDW00200101045A patent/ID28783A/id unknown
- 1999-11-08 SK SK644-2001A patent/SK287038B6/sk not_active IP Right Cessation
- 1999-11-08 CN CNB998154792A patent/CN1230162C/zh not_active Expired - Fee Related
- 1999-11-08 HU HU0104303A patent/HUP0104303A3/hu unknown
- 1999-11-08 JP JP2000582036A patent/JP2002529504A/ja not_active Ceased
- 1999-11-10 DZ DZ990236A patent/DZ2936A1/xx active
- 1999-11-10 AR ARP990105697A patent/AR024228A1/es unknown
- 1999-11-11 MY MYPI99004896A patent/MY124695A/en unknown
- 1999-11-12 PE PE1999001146A patent/PE20001238A1/es not_active Application Discontinuation
- 1999-11-12 UY UY25799A patent/UY25799A1/es not_active Application Discontinuation
- 1999-12-24 TW TW088122853A patent/TW592694B/zh not_active IP Right Cessation
- 1999-12-24 TW TW093109152A patent/TWI251487B/zh not_active IP Right Cessation
2001
- 2001-05-07 IL IL143002A patent/IL143002A/en not_active IP Right Cessation
- 2001-05-10 NO NO20012303A patent/NO20012303L/no not_active Application Discontinuation
- 2001-06-07 BG BG105568A patent/BG65351B1/bg unknown
- 2001-06-07 BG BG109852A patent/BG109852A/bg unknown
2008
- 2008-11-24 CY CY20081101346T patent/CY1108587T1/el unknown

Also Published As

Publication number	Publication date
IL143002A0 (en)	2002-04-21
NZ511614A (en)	2003-12-19
TR200101333T2 (tr)	2001-10-22
ID28783A (id)	2001-07-05
AU768994B2 (en)	2004-01-15
NO20012303L (no)	2001-07-04
EA011633B1 (ru)	2009-04-28
EP1131070A1 (de)	2001-09-12
PT1131070E (pt)	2008-11-19
IL143002A (en)	2007-02-11
CA2351058A1 (en)	2000-05-25
EA007610B1 (ru)	2006-12-29
DK1131070T3 (da)	2008-11-17
DZ2936A1 (fr)	2004-03-15
EA200601145A1 (ru)	2009-04-28
WO2000028989A1 (en)	2000-05-25
CZ20011629A3 (cs)	2001-12-12
DE69939485D1 (de)	2008-10-16
EA200100541A1 (ru)	2001-10-22
PL347634A1 (en)	2002-04-22
YU37301A (sh)	2005-06-10
EP1813273A1 (de)	2007-08-01
KR20010080419A (ko)	2001-08-22
SK6442001A3 (en)	2001-12-03
AU3033800A (en)	2000-06-05
BG65351B1 (bg)	2008-03-31
SK287038B6 (sk)	2009-10-07
HRP20010343B1 (hr)	2010-11-30
PE20001238A1 (es)	2001-01-11
CN1230162C (zh)	2005-12-07
KR100643833B1 (ko)	2006-11-10
ATE406889T1 (de)	2008-09-15
HK1040910B (en)	2009-06-26
ES2312221T3 (es)	2009-02-16
NO20012303D0 (no)	2001-05-10
TW592694B (en)	2004-06-21
HK1040910A1 (en)	2002-06-28
CY1108587T1 (el)	2014-04-09
EP1131070B1 (de)	2008-09-03
BG105568A (en)	2002-01-31
HUP0104303A2 (hu)	2002-03-28
TW200418453A (en)	2004-10-01
CN1348369A (zh)	2002-05-08
EP1992337A1 (de)	2008-11-19
BR9915285A (pt)	2001-08-07
SI1131070T1 (sl)	2008-12-31
AR024228A1 (es)	2002-09-25
UY25799A1 (es)	2000-12-29
TWI251487B (en)	2006-03-21
HUP0104303A3 (en)	2003-12-29
MY124695A (en)	2006-06-30
HRP20010343A2 (en)	2002-06-30
BG109852A (bg)	2008-11-28
JP2002529504A (ja)	2002-09-10

Publication	Publication Date	Title
AU768994B2 (en)	2004-01-15	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
US20080014266A1 (en)	2008-01-17	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
EP1231918B1 (de)	2005-04-06	Neue zusammensetzung auf basis von einem thiazolidindion und metformin und verwendung
US20070281023A1 (en)	2007-12-06	Pharmaceutical composition for modified release insulin sensitiser
KR100732599B1 (ko)	2007-06-27	조절 방출형 인슐린 감작제용 제약 조성물
OA11279A (en)	2003-07-31	Treatment of diabetes with thiazolidinedione, insulin secretagogue and diguanide.
AU2757202A (en)	2002-05-16	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
HK1127277A (en)	2009-09-25	Novel modified release composition and use
HK1106135A (en)	2008-03-07	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
AU2008203540A1 (en)	2008-08-28	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
ZA200103843B (en)	2002-05-14	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent.
AU2005200704A1 (en)	2005-03-17	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
UA73927C2 (en)	2005-10-17	Pharmaceutical composition of thiasolidindion and metformin providing for pulsating or delayed release for one of ingredients