OA12899A - Synergistic combination of an alphan-2-delta ligand and a PDEV inhibitor for use in the treatment ofpain. - Google Patents

Synergistic combination of an alphan-2-delta ligand and a PDEV inhibitor for use in the treatment ofpain. Download PDF

Info

Publication number: OA12899A
Authority: OA; OAPI
Prior art keywords: methyl; acid; pain; combination; ethyl
Prior art date: 2002-08-15

Application number

OA1200500037A

Other languages

English (en)

Inventor

Mark John Field

Richard Griffith Williams

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-15

Filing date

2003-08-04

Publication date

2006-10-13

2003-08-04 Application filed by Pfizer filed Critical Pfizer

2006-10-13 Publication of OA12899A publication Critical patent/OA12899A/en

Links

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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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OA1200500037A 2002-08-15 2003-08-04 Synergistic combination of an alphan-2-delta ligand and a PDEV inhibitor for use in the treatment ofpain. OA12899A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0219024.7A GB0219024D0 (en)	2002-08-15	2002-08-15	Synergistic combinations

Publications (1)

Publication Number	Publication Date
OA12899A true OA12899A (en)	2006-10-13

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ID=9942388

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200500037A OA12899A (en)	2002-08-15	2003-08-04	Synergistic combination of an alphan-2-delta ligand and a PDEV inhibitor for use in the treatment ofpain.

Country Status (40)

Country	Link
EP (1)	EP1536782B1 (de)
JP (1)	JP2006502139A (de)
KR (2)	KR20070009746A (de)
CN (1)	CN1674884A (de)
AP (1)	AP2005003227A0 (de)
AR (1)	AR040871A1 (de)
AT (1)	ATE359775T1 (de)
AU (1)	AU2003249476B2 (de)
BR (1)	BR0313484A (de)
CA (1)	CA2495433A1 (de)
CR (1)	CR7687A (de)
DE (1)	DE60313330T2 (de)
DK (1)	DK1536782T3 (de)
EA (1)	EA007504B1 (de)
EC (1)	ECSP055593A (de)
ES (1)	ES2285230T3 (de)
GB (1)	GB0219024D0 (de)
GE (1)	GEP20084366B (de)
GT (1)	GT200300173A (de)
HN (1)	HN2003000247A (de)
HR (1)	HRP20050136A2 (de)
IL (1)	IL166415A0 (de)
IS (1)	IS7643A (de)
MA (1)	MA27381A1 (de)
MX (1)	MXPA05001835A (de)
NO (1)	NO20050782L (de)
NZ (1)	NZ537818A (de)
OA (1)	OA12899A (de)
PA (1)	PA8577301A1 (de)
PE (1)	PE20040992A1 (de)
PL (1)	PL375553A1 (de)
PT (1)	PT1536782E (de)
RS (1)	RS20050078A (de)
SI (1)	SI1536782T1 (de)
TN (1)	TNSN05042A1 (de)
TW (1)	TW200404531A (de)
UA (1)	UA77329C2 (de)
UY (1)	UY27936A1 (de)
WO (1)	WO2004016259A1 (de)
ZA (1)	ZA200500369B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NI200300043A (es)	2002-03-28	2003-11-05	Warner Lambert Co	AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
JP2007505095A (ja) *	2003-09-12	2007-03-08	ワーナー−ランバートカンパニーリミティドライアビリティーカンパニー	うつ病及び不安障害の治療のためのアルファ−２−デルタリガンド及びｓｓｒｉ及び／又はｓｎｒｉを含む組み合わせ
CA2539976A1 (en)	2003-09-25	2005-04-07	Warner-Lambert Company Llc	Therapeutic beta aminoacids
OA13258A (en) *	2003-09-25	2007-01-31	Warner Lambert Co	Amino acids with affinity for the alpha2delta-protein.
GB0405200D0 (en) *	2004-03-08	2004-04-21	Pfizer Ltd	Combinations comprising alpha-2-delta ligands
MXPA06014662A (es) *	2004-07-09	2007-02-12	Warner Lambert Co	Preparacion de beta-amino acidos que tienen afinidad por la proteina alfa-2-delta.
ITMI20041447A1 (it) *	2004-07-20	2004-10-20	Zambon Spa	Composizione farmaceutica comprendente gabapentina
US20090227562A1 (en) *	2004-08-10	2009-09-10	Pfizer Inc.	Combination of a Selective Noradrenaline Reuptake Unhibitor and a PDEV Inhibitor
EP1791599A1 (de) *	2004-09-07	2007-06-06	Pfizer Limited	Kombination aus einem 5-ht(1) rezeptor-agonisten und einem alpha-2-delta-liganden zur behandlung von migräne
WO2006092692A1 (en) *	2005-03-01	2006-09-08	Pfizer Limited	Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
CA2685395A1 (en) *	2007-04-30	2008-11-06	Adolor Corporation	Compositions of (-)-e-10-oh-nt and methods for their synthesis and use
WO2008132589A1 (en) *	2007-05-01	2008-11-06	Pfizer Limited	Combinations comprising pregabalin
US20090148532A1 (en) *	2007-12-06	2009-06-11	Venkatesh Gopi M	Preparation of controlled release skeletal muscle relaxant dosage forms
TWI531362B (zh)	2008-07-21	2016-05-01	艾爾康股份有限公司	具有治療劑遞送能力之眼科裝置
CA2805371C (en) *	2010-07-30	2017-10-31	Toray Industries, Inc.	Therapeutic agent or prophylactic agent for neuropathic pain
PL2710005T3 (pl)	2011-05-17	2017-07-31	Principia Biopharma Inc.	Inhibitory kinazy tyrozynowej
ES2770550T3 (es)	2011-05-17	2020-07-02	Univ California	Inhibidores de quinasa
WO2012158795A1 (en)	2011-05-17	2012-11-22	Principia Biopharma Inc.	Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
WO2013084182A1 (en) *	2011-12-08	2013-06-13	Glenmark Pharmaceuticals S.A.	Pharmaceutical composition that includes a pde4 enzyme inhibitor and an analgesic agent
SI2892900T1 (en)	2012-09-10	2018-01-31	Principia Biopharma Inc.	Pyrazolopyrimidine compounds as kinase inhibitors
US8957080B2 (en)	2013-04-09	2015-02-17	Principia Biopharma Inc.	Tyrosine kinase inhibitors
CN112353806A (zh)	2014-02-21	2021-02-12	普林斯匹亚生物制药公司	Btk抑制剂的盐和固体形式
SG11201704808VA (en)	2014-12-18	2017-07-28	Principia Biopharma Inc	Treatment of pemphigus
WO2016210165A1 (en)	2015-06-24	2016-12-29	Principia Biopharma Inc.	Tyrosine kinase inhibitors
CN115054586B (zh)	2016-06-29	2024-08-02	普林斯匹亚生物制药公司	改性的释放制剂
US20210106584A1 (en)	2019-10-14	2021-04-15	Principia Biopharma Inc.	Methods for treating immune thrombocytopenia by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
US11814390B2 (en)	2020-01-22	2023-11-14	Principia Biopharma Inc.	Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
CN114195661B (zh) *	2021-12-21	2023-12-22	苏州楚凯药业有限公司	一种苯磺酸米洛巴林的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL189872B1 (pl) *	1996-07-24	2005-10-31	Warner Lambert Co	Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu
US6518289B1 (en) *	1997-12-16	2003-02-11	Pfizer, Inc.	1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders
HN2000000224A (es) *	1999-10-20	2001-04-11	Warner Lambert Co	Aminoacidos biciclicos como agentes farmaceuticos
IL139073A0 (en) *	1999-10-21	2001-11-25	Pfizer	Treatment of neuropathy
MXPA03001717A (es) *	2000-08-30	2003-09-22	Lilly Icos Llc	METODO PARA EL TRATAMIENTO DE LA MIGRAnA.
BR0208922A (pt) *	2001-04-19	2004-04-20	Warner Lambert Co	Aminoácidos bicìclicos ou tricìclicos fundidos

2002
- 2002-08-15 GB GBGB0219024.7A patent/GB0219024D0/en not_active Ceased
2003
- 2003-04-08 UA UAA200501347A patent/UA77329C2/uk unknown
- 2003-07-11 PA PA20038577301A patent/PA8577301A1/es unknown
- 2003-08-04 AT AT03787957T patent/ATE359775T1/de not_active IP Right Cessation
- 2003-08-04 AU AU2003249476A patent/AU2003249476B2/en not_active Ceased
- 2003-08-04 GE GEAP8632A patent/GEP20084366B/en unknown
- 2003-08-04 JP JP2004528754A patent/JP2006502139A/ja not_active Withdrawn
- 2003-08-04 OA OA1200500037A patent/OA12899A/en unknown
- 2003-08-04 NZ NZ537818A patent/NZ537818A/en unknown
- 2003-08-04 EP EP03787957A patent/EP1536782B1/de not_active Expired - Lifetime
- 2003-08-04 KR KR1020077000033A patent/KR20070009746A/ko not_active Ceased
- 2003-08-04 MX MXPA05001835A patent/MXPA05001835A/es active IP Right Grant
- 2003-08-04 PL PL03375553A patent/PL375553A1/xx not_active Application Discontinuation
- 2003-08-04 DE DE60313330T patent/DE60313330T2/de not_active Expired - Fee Related
- 2003-08-04 KR KR1020057002450A patent/KR20050042154A/ko not_active Ceased
- 2003-08-04 IL IL16641503A patent/IL166415A0/xx unknown
- 2003-08-04 CA CA002495433A patent/CA2495433A1/en not_active Abandoned
- 2003-08-04 PT PT03787957T patent/PT1536782E/pt unknown
- 2003-08-04 SI SI200330810T patent/SI1536782T1/sl unknown
- 2003-08-04 WO PCT/IB2003/003476 patent/WO2004016259A1/en not_active Ceased
- 2003-08-04 EA EA200500207A patent/EA007504B1/ru not_active IP Right Cessation
- 2003-08-04 BR BR0313484-9A patent/BR0313484A/pt not_active IP Right Cessation
- 2003-08-04 CN CNA038190737A patent/CN1674884A/zh active Pending
- 2003-08-04 HR HR20050136A patent/HRP20050136A2/xx not_active Application Discontinuation
- 2003-08-04 AP AP2005003227A patent/AP2005003227A0/xx unknown
- 2003-08-04 RS RSP-2005/0078A patent/RS20050078A/sr unknown
- 2003-08-04 ES ES03787957T patent/ES2285230T3/es not_active Expired - Lifetime
- 2003-08-04 DK DK03787957T patent/DK1536782T3/da active
- 2003-08-12 UY UY27936A patent/UY27936A1/es not_active Application Discontinuation
- 2003-08-12 PE PE2003000806A patent/PE20040992A1/es not_active Application Discontinuation
- 2003-08-13 AR AR20030102933A patent/AR040871A1/es not_active Application Discontinuation
- 2003-08-14 TW TW092122363A patent/TW200404531A/zh unknown
- 2003-08-14 HN HN2003000247A patent/HN2003000247A/es unknown
- 2003-08-14 GT GT200300173A patent/GT200300173A/es unknown
2005
- 2005-01-12 IS IS7643A patent/IS7643A/is unknown
- 2005-01-14 ZA ZA200500369A patent/ZA200500369B/en unknown
- 2005-02-10 EC EC2005005593A patent/ECSP055593A/es unknown
- 2005-02-14 CR CR7687A patent/CR7687A/es not_active Application Discontinuation
- 2005-02-14 NO NO20050782A patent/NO20050782L/no not_active Application Discontinuation
- 2005-02-15 MA MA28104A patent/MA27381A1/fr unknown
- 2005-02-15 TN TNP2005000042A patent/TNSN05042A1/fr unknown

Also Published As

Publication number	Publication date
CA2495433A1 (en)	2004-02-26
NZ537818A (en)	2007-07-27
UY27936A1 (es)	2004-03-31
NO20050782L (no)	2005-04-08
IS7643A (is)	2005-01-12
UA77329C2 (en)	2006-11-15
EA007504B1 (ru)	2006-10-27
PA8577301A1 (es)	2004-03-10
MA27381A1 (fr)	2005-06-01
RS20050078A (sr)	2007-09-21
AR040871A1 (es)	2005-04-20
AU2003249476B2 (en)	2008-06-26
MXPA05001835A (es)	2005-09-30
SI1536782T1 (sl)	2007-08-31
GEP20084366B (en)	2008-05-13
EA200500207A1 (ru)	2005-08-25
HRP20050136A2 (en)	2005-06-30
JP2006502139A (ja)	2006-01-19
CN1674884A (zh)	2005-09-28
AP2005003227A0 (en)	2005-03-31
EP1536782B1 (de)	2007-04-18
GB0219024D0 (en)	2002-09-25
HN2003000247A (es)	2007-12-14
BR0313484A (pt)	2005-06-21
ZA200500369B (en)	2006-10-25
DE60313330T2 (de)	2008-01-03
TNSN05042A1 (fr)	2007-05-14
GT200300173A (es)	2007-03-29
ECSP055593A (es)	2005-04-18
PE20040992A1 (es)	2004-12-29
KR20050042154A (ko)	2005-05-04
IL166415A0 (en)	2006-01-15
TW200404531A (en)	2004-04-01
WO2004016259A1 (en)	2004-02-26
EP1536782A1 (de)	2005-06-08
DE60313330D1 (de)	2007-05-31
KR20070009746A (ko)	2007-01-18
PT1536782E (pt)	2007-06-27
ATE359775T1 (de)	2007-05-15
PL375553A1 (en)	2005-11-28
AU2003249476A1 (en)	2004-03-03
DK1536782T3 (da)	2007-07-30
CR7687A (es)	2005-07-08
ES2285230T3 (es)	2007-11-16

Publication	Publication Date	Title
OA12899A (en)	2006-10-13	Synergistic combination of an alphan-2-delta ligand and a PDEV inhibitor for use in the treatment ofpain.
US7419981B2 (en)	2008-09-02	Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
US20090036487A1 (en)	2009-02-05	Combinations
AU2011200717A1 (en)	2011-03-10	Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
WO2005102390A2 (en)	2005-11-03	Combinations comprising alpha-2-delta ligands and nmda receptor antagonists
JP2007527905A (ja)	2007-10-04	アルファ−２−デルタリガンドを含む組合せ
CA2575980A1 (en)	2006-02-16	Combination of a selective noradrenaline reuptake inhibitor and a pdev inhibitor
US20040092522A1 (en)	2004-05-13	Synergistic combinations
HK1077754A (en)	2006-02-24	Synergistic combination of an alpha-2-delta ligand and a pdev inhibitor for use in the treatment of pain
CA2495108A1 (en)	2004-02-19	Therapeutic use of aryl amino acid derivatives