PE20040189A1 - Pirimidina y piridina biciclicos como inhibidores de p38 quinasa - Google Patents

Pirimidina y piridina biciclicos como inhibidores de p38 quinasa

Info

Publication number
PE20040189A1
PE20040189A1 PE2003000209A PE2003000209A PE20040189A1 PE 20040189 A1 PE20040189 A1 PE 20040189A1 PE 2003000209 A PE2003000209 A PE 2003000209A PE 2003000209 A PE2003000209 A PE 2003000209A PE 20040189 A1 PE20040189 A1 PE 20040189A1
Authority
PE
Peru
Prior art keywords
alkyl
pyrimidine
ilamino
tetrahydropyran
aryl
Prior art date
Application number
PE2003000209A
Other languages
English (en)
Inventor
Jian Jeffrey Chen
Christoph Martin Stahl
Nolan James Dewdney
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20040189A1 publication Critical patent/PE20040189A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE PIRIMIDINA Y PIRIDINA AMINO-BICICLICOS 2-SUSTITUIDOS DE FORMULA I DONDE A ES N O CH; R1 ES H, ALQUILO O ARILALQUILO; R2 ES ALQUILO, HIDROXIALQUILO, (R")2NCO-ALQUILENO, CICLOALQUILO, HETEROCICLILO, ARILO, HETEROARILO O HETEROALQUILO; R" ES H O ALQUILO; X ES O, NR3 O S, DONDE R3 ES H, ALQUILO O ARILO; Y ES ENLACE, O, NR', C(=O), CH(R'), CH(OR'), O S(O)n, DONDE n ES 0,1 O 2; R' ES H O ALQUILO; R ES ARILO O HETEROARILO. SON COMPUESTOS PREFERIDOS 2-(TETRAHIDROPIRAN-4-ILAMINO)-6-(2-CLOROBENZOIL)TIENO[2,3-d]PIRIMIDINA; 2-(TETRAHIDROPIRAN-4-ILAMINO)-6-(2-FLUOROBENZOIL)TIENO[2,3-d]PIRIMIDINA; 2-(TETRAHIDROPIRAN-4-ILAMINO)-6-(2-METOXIBENZOIL)-7-METIL-PIRROL[2,3-d]PIRIMIDINA; ENTRE OTROS.TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON INHIBIDORES DE LA PROTEINQUINASA p 38 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE UN TRASTORNO MEDIADO POR PROTEINQUINASA p38 TAL COMO ARTRITIS, ENFERMEDAD DE CROHN, ALZHEIMER, SINDORME DE INTESTINO IRRITABLE, SINDROME DE DISTRESS RESPIRATORIO DEL ADULTO Y ENFERMEDAD OBSTRUCTIVA PULMONAR CRONICA
PE2003000209A 2002-03-07 2003-03-04 Pirimidina y piridina biciclicos como inhibidores de p38 quinasa PE20040189A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36237302P 2002-03-07 2002-03-07
US43050802P 2002-12-03 2002-12-03

Publications (1)

Publication Number Publication Date
PE20040189A1 true PE20040189A1 (es) 2004-05-01

Family

ID=27791709

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000209A PE20040189A1 (es) 2002-03-07 2003-03-04 Pirimidina y piridina biciclicos como inhibidores de p38 quinasa

Country Status (19)

Country Link
US (3) US7091347B2 (es)
EP (1) EP1485390B1 (es)
JP (1) JP4187657B2 (es)
KR (1) KR100714519B1 (es)
CN (1) CN100386328C (es)
AR (1) AR038864A1 (es)
AT (1) ATE410429T1 (es)
AU (1) AU2003210388B2 (es)
BR (1) BR0308232A (es)
CA (1) CA2477721A1 (es)
DE (1) DE60323946D1 (es)
ES (1) ES2314224T3 (es)
MX (1) MXPA04008592A (es)
PA (1) PA8568401A1 (es)
PE (1) PE20040189A1 (es)
PL (1) PL372886A1 (es)
RU (1) RU2301233C2 (es)
TW (1) TW200306194A (es)
WO (1) WO2003074530A1 (es)

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CN103254194B (zh) * 2013-05-17 2015-07-08 浙江师范大学 一种8-硫杂黄嘌呤化合物的制备方法
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Also Published As

Publication number Publication date
US20050288312A1 (en) 2005-12-29
TW200306194A (en) 2003-11-16
KR20040091084A (ko) 2004-10-27
US7439247B2 (en) 2008-10-21
WO2003074530A1 (en) 2003-09-12
US7449472B2 (en) 2008-11-11
AR038864A1 (es) 2005-02-02
JP2005526057A (ja) 2005-09-02
US7091347B2 (en) 2006-08-15
US20030207900A1 (en) 2003-11-06
ES2314224T3 (es) 2009-03-16
CN1639168A (zh) 2005-07-13
KR100714519B1 (ko) 2007-05-07
PL372886A1 (en) 2005-08-08
RU2004129768A (ru) 2005-08-27
RU2301233C2 (ru) 2007-06-20
DE60323946D1 (de) 2008-11-20
CN100386328C (zh) 2008-05-07
EP1485390B1 (en) 2008-10-08
ATE410429T1 (de) 2008-10-15
MXPA04008592A (es) 2004-12-06
PA8568401A1 (es) 2003-12-10
AU2003210388B2 (en) 2007-05-17
US20060084803A1 (en) 2006-04-20
CA2477721A1 (en) 2003-09-12
AU2003210388A1 (en) 2003-09-16
EP1485390A1 (en) 2004-12-15
JP4187657B2 (ja) 2008-11-26
BR0308232A (pt) 2004-12-28

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