PE20041040A1 - Compuestos derivados de amidas como inhibidores de 11-beta-hidroxiesteroide-deshidroxigenasa de tipo 1 - Google Patents

Compuestos derivados de amidas como inhibidores de 11-beta-hidroxiesteroide-deshidroxigenasa de tipo 1

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Publication number
PE20041040A1
PE20041040A1 PE2004000085A PE2004000085A PE20041040A1 PE 20041040 A1 PE20041040 A1 PE 20041040A1 PE 2004000085 A PE2004000085 A PE 2004000085A PE 2004000085 A PE2004000085 A PE 2004000085A PE 20041040 A1 PE20041040 A1 PE 20041040A1
Authority
PE
Peru
Prior art keywords
optionally substituted
ring
type
nr5c
hydroxiesteroid
Prior art date
Application number
PE2004000085A
Other languages
English (en)
Inventor
Gary Mark Coppola
Robert Edson Damon
Paivi Jaana Kukkola
James Lawrence Staton
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20041040A1 publication Critical patent/PE20041040A1/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
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  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE AMINA DE FORMULA I, DONDE R1 Y R2 SON H, CIANO, HALOGENO, NITRO, TRIFLUOROMETILO, ENTRE OTROS; O JUNTOS FORMAN UN ANILLO AROMATICO O HETEROAROMATICO DE 5 A 7 MIEMBROS OPCIONALMENTE SUSTITUIDO; R3 ES ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO; O BIEN R3 Y R2 JUNTOS CON EL GRUPO AMIDA AL CUAL R3 ESTA UNIDO Y LOS ATOMOS DE C AL CUAL R2 Y LA AMIDA ESTAN UNIDOS FORMAN UN ANILLO CARBOCICLICO O HETEROCICLICO DE 5 A 7 MIEMBROS OPCIONALMENTE SUSTITUIDO; R4 ES ALQUILO OPCIONALMENTE SUSTITUIDO, CICLOALQUILO, HETEROCICLILO, ENTRE OTROS; O R4 Y R3 JUNTOS FORMAN UN ANILLO DE 5-8 MIEMBROS OPCIONALMENTE SUSTITUIDO O PUEDEN FORMAR UN ANILLO BICICLICO FUSIONADO DE 8-12 MIEMBROS OPCIONALMENTE SUSTITUIDO O PUEDE CONTENER OTRO ATOMO HETEROGENEO DE O, N, o S; W ES NR5C(O)R6, NR5C(O)OR6, NR5C(O)NR6R7, ENTRE OTROS; X E Y SON CH O N, o -X=Y ES -CH2-, O, S O -NR10-. SON COMPUESTOS PREFERIDOS: N-CICLOHEXILMETIL-4-FLUOROBENZOILAMINO-N-METILBENZAMIDA, 4-(4-CLOROBENZILAMINO)-N-CICLOHEXILMETIL-N-METILBENZAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE LOS CONTIENE. ESTOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE REDUCTASA DE 11-BETA-HIDROXIESTEROIDE-DESHIDROXIGENASA DE TIPO 1 (11B-HSD1) Y SON UTILES PARA TRATAR O PREVENIR TRASTORNOS RELACIONADOS CON UNA ELEVACION DE LAS CONCENTRACIONES INTRACELULARES DE GLUCOCORTICOIDE Y COMO AGENTES HIPOGLICEMIANTES PARA EL TRATAMIENTO DE DIABETES TIPO 2
PE2004000085A 2003-01-24 2004-01-21 Compuestos derivados de amidas como inhibidores de 11-beta-hidroxiesteroide-deshidroxigenasa de tipo 1 PE20041040A1 (es)

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