PE20090318A1 - Macrociclos y sus usos - Google Patents

Macrociclos y sus usos

Info

Publication number
PE20090318A1
PE20090318A1 PE2008000935A PE2008000935A PE20090318A1 PE 20090318 A1 PE20090318 A1 PE 20090318A1 PE 2008000935 A PE2008000935 A PE 2008000935A PE 2008000935 A PE2008000935 A PE 2008000935A PE 20090318 A1 PE20090318 A1 PE 20090318A1
Authority
PE
Peru
Prior art keywords
alkyl
compounds
alcoxyl
oxo
alkenyl
Prior art date
Application number
PE2008000935A
Other languages
English (en)
Inventor
Roger Aki Fujimoto
Matthew J Lamarche
Philipp Krastel
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20090318A1 publication Critical patent/PE20090318A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPUESTOS MACROCICLOS DE FORMULA (I) DONDE q ES DE 0 A 3; E ESTA AUSENTE O ES C(O), C(O)O, ENTRE OTROS; R1 ES H, ALQUILO(C1-C8), ALQUENILO(C2-C8), ALCOXILO(C1-C8), ENTRE OTROS; R2, R3 Y R6 SON CADA UNO H, HALOGENO, OH, OXO, ALCOXILO(C1-C8), ENTRE OTROS; R5 ES H, ALQUILO(C1-C8), ENTRE OTROS; R4 ES H, OXO, NH, COOH, CONH2, ENTRE OTROS; R7 ES H, OH, NH2, ALQUILO(C1-C8), ENTRE OTROS; R7a ES OR7b O N(R7b)2, EN DONDE R7b ES H, ALQUILO(C1-C8), ALQUENILO(C2-C8), ALQUINILO(C2-C8), ENTRE OTROS. SON COMPUESTOS PREFERIDOS LOS COMPUESTOS DE FORMULA (i), (ii), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTIBACTERIANOS SIENDO UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS PRODUCIDAS POR STAPHYLOCCOCUS AUREUS, STREPTOCOCCUS NEUMONIAE, MYCOBACTERIUM TUBERCULOSIS, CLOSTRIDIUM DIFFICILE
PE2008000935A 2007-06-04 2008-06-03 Macrociclos y sus usos PE20090318A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94177707P 2007-06-04 2007-06-04

Publications (1)

Publication Number Publication Date
PE20090318A1 true PE20090318A1 (es) 2009-04-17

Family

ID=40094226

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000935A PE20090318A1 (es) 2007-06-04 2008-06-03 Macrociclos y sus usos

Country Status (24)

Country Link
US (2) US8476224B2 (es)
EP (1) EP2170907A2 (es)
JP (1) JP2010529076A (es)
KR (1) KR101202483B1 (es)
CN (1) CN101772506B (es)
AR (1) AR066865A1 (es)
AU (1) AU2008258639B2 (es)
BR (1) BRPI0812340A2 (es)
CA (1) CA2688621A1 (es)
CL (1) CL2008001613A1 (es)
CO (1) CO6270222A2 (es)
CR (1) CR11158A (es)
EA (1) EA200901613A1 (es)
EC (1) ECSP099836A (es)
GT (1) GT200900310A (es)
IL (1) IL202285A0 (es)
MA (1) MA31562B1 (es)
MX (1) MX2009013214A (es)
NZ (1) NZ581917A (es)
PE (1) PE20090318A1 (es)
TN (1) TN2009000495A1 (es)
TW (1) TW200902540A (es)
WO (1) WO2008148754A2 (es)
ZA (1) ZA200908262B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ585788A (en) 2007-12-12 2011-07-29 Novartis Ag Aminothiazoles and their uses
US10933019B2 (en) * 2016-10-21 2021-03-02 Xellia Pharmaceuticals Aps Liquid formulations of daptomycin
CN109485617B (zh) * 2018-12-11 2023-01-31 贵州永诺菲特生物制药有限公司 一种n-甲基-2-异丙基-4-噻唑甲胺的制备方法
WO2024044751A2 (en) * 2022-08-26 2024-02-29 Wake Forest University Health Sciences Peroxiredoxin 3 inhibitors and methods of use for treating cancer
CN121843700A (zh) * 2023-08-14 2026-04-10 Rs肿瘤学有限责任公司 用于治疗癌症的改性硫链丝菌素激发化合物以及其制备
WO2025265000A1 (en) * 2024-06-21 2025-12-26 Rs Oncology, Llc Modified thiostrepton-inspired compounds for treatment of cancer and preparation thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2071143T3 (es) * 1990-03-08 1995-06-16 Lepetit Spa Factores b1, b2, c1, c2, d1, d2, e y t del antibiotico ge 2270.
DE4011378A1 (de) 1990-04-07 1991-10-10 Hausen Auto Kabel Gmbh & Co Kg Anschlussklemme fuer akkumulator oder dergleichen
IL100572A (en) 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
EP0529410B1 (en) * 1991-08-30 1998-02-25 Biosearch Italia S.p.A. Antibiotic GE 2270 factor C2a
DE69718442T2 (de) * 1996-02-14 2003-04-30 Biosearch Italia S.P.A., Gerenzano Derivate des antibiotisch wirkenden faktors ge2270
JPH1059997A (ja) * 1996-08-22 1998-03-03 Microbial Chem Res Found アミチアマイシンアミド誘導体
KR20050026401A (ko) 2002-06-17 2005-03-15 비큐론 파마세티컬스 인코포레이티드 여드름 치료를 위한 ｇｅ 2270 인자 ａ3의 아미드유도체의 용도
US20050106159A1 (en) * 2003-08-12 2005-05-19 Thompson Stuart A. Campylobacter jejuni outer membrane protein immunogenic composition
AR060977A1 (es) * 2006-05-31 2008-07-23 Novartis Ag Aminotiazoles y sus usos
EA200900816A1 (ru) * 2006-12-20 2009-12-30 Новартис Аг Антибактериальные соединения и способы их получения

Also Published As

Publication number Publication date
ECSP099836A (es) 2010-01-29
CA2688621A1 (en) 2008-12-11
IL202285A0 (en) 2010-06-16
AR066865A1 (es) 2009-09-16
US20130252883A1 (en) 2013-09-26
ZA200908262B (en) 2010-08-25
GT200900310A (es) 2010-05-21
CO6270222A2 (es) 2011-04-20
AU2008258639A1 (en) 2008-12-11
EA200901613A1 (ru) 2010-06-30
CR11158A (es) 2010-01-20
NZ581917A (en) 2011-04-29
CN101772506A (zh) 2010-07-07
EP2170907A2 (en) 2010-04-07
KR20100021496A (ko) 2010-02-24
JP2010529076A (ja) 2010-08-26
US20090186830A1 (en) 2009-07-23
BRPI0812340A2 (pt) 2015-01-27
US8476224B2 (en) 2013-07-02
KR101202483B1 (ko) 2012-11-16
US8691756B2 (en) 2014-04-08
TW200902540A (en) 2009-01-16
WO2008148754A2 (en) 2008-12-11
WO2008148754A3 (en) 2009-03-05
CL2008001613A1 (es) 2009-05-15
CN101772506B (zh) 2014-02-12
TN2009000495A1 (en) 2011-03-31
MA31562B1 (fr) 2010-08-02
MX2009013214A (es) 2010-01-15
AU2008258639B2 (en) 2012-07-05

Similar Documents

Publication Publication Date Title
PE20070946A1 (es) COMPUESTOS DERIVADOS DE IMIDAZO[1,2-a]PIRIDINA COMO MODULADORES DEL RECEPTOR DE QUIMIOQUINA (CXCR4)
BR0112826A (pt) Derivados da oxazolidinona como antimicrobianos
PE20091573A1 (es) Derivados heterociclicos de urea como inhibidores de adn girasa y/o topoisomerasa
BRPI0414694A (pt) pró-fármaco(s) aciloximetilcarbamato de oxazolidinonas
PE20091000A1 (es) Inhibidores de la replicacion del virus de la inmunodeficiencia humana
ES2180456B1 (es) Isoxazoles sustituidos y su utilizacion como antibioticos.
MX2009010642A (es) Antibioticos de oxazolidinona.
PE20120632A1 (es) Inhibidores de bace
PE20110383A1 (es) Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a)
PE20050346A1 (es) Glucopiranosiloxi-pirazoles como inhibidores del co-transportador de glucosa dependiente de sodio (sglt2)
PE20140397A1 (es) Derivados de fluoro-piridinona utiles como agentes antibacterianos
NO20075270L (no) Antibakterielle amid-makrocykler V
PE20130157A1 (es) Inhibidores de la polimerasa virica
PE20081753A1 (es) Compuestos y composiciones como inhibidores de la proteasa activadora de canal
PA8485101A1 (es) Nuevos antibioticos macrolidos.
DE602008004540D1 (de) 2-oxo-2-(2-phenyl-5,6,7,8-tetrahydroindolizin-3-yl)acetamidderivate und verwandte verbindungen als antipilzmittel
PE20080211A1 (es) Compuestos derivados de 6-(bencilo sustituido con heterociclilo)-4-oxoquinolina como inhibidores de integrasa del vih
EA201590828A1 (ru) Насыщенные азотсодержащие и n-ацилированные гетероциклы, усиливающие действие активного антибиотика против микобактерий
PE20091959A1 (es) Derivados de urea heterociclicos como antibacterianos
ATE482219T1 (de) 8-methoxy-9h-isothiazoloä5,4-büchinolin-3,4-dio e und verwandte verbindungen als antiinfektive mittel
BR0215921A (pt) Derivados de oxazolidinona utilizáveis como antimicrobianos e processo de sua preparação
NO20055893L (no) Nye linkomycinderivativer med antimikrobiell aktivitet
GEP20084306B (en) Antibacterial indolone oxazolidinones, intermediates for their preparation and pharmaceutical compositions containing them
AR062131A1 (es) Profarmacos antimicrobianos de oxazolidinona
PE20070016A1 (es) Compuestos heterociclicos n-enlazados como antagonistas del receptor p2y1

Legal Events

Date Code Title Description
FD Application declared void or lapsed