ATE482219T1 - 8-methoxy-9h-isothiazoloä5,4-büchinolin-3,4-dio e und verwandte verbindungen als antiinfektive mittel - Google Patents
8-methoxy-9h-isothiazoloä5,4-büchinolin-3,4-dio e und verwandte verbindungen als antiinfektive mittelInfo
- Publication number
- ATE482219T1 ATE482219T1 AT06800428T AT06800428T ATE482219T1 AT E482219 T1 ATE482219 T1 AT E482219T1 AT 06800428 T AT06800428 T AT 06800428T AT 06800428 T AT06800428 T AT 06800428T AT E482219 T1 ATE482219 T1 AT E482219T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- compounds
- compound
- buquinoline
- dio
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- 229960005475 antiinfective agent Drugs 0.000 title 1
- 239000004599 antimicrobial Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- 230000000845 anti-microbial effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 108020000946 Bacterial DNA Proteins 0.000 abstract 1
- 230000006820 DNA synthesis Effects 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70281105P | 2005-07-27 | 2005-07-27 | |
| PCT/US2006/029302 WO2007014308A1 (en) | 2005-07-27 | 2006-07-27 | 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE482219T1 true ATE482219T1 (de) | 2010-10-15 |
Family
ID=37106335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06800428T ATE482219T1 (de) | 2005-07-27 | 2006-07-27 | 8-methoxy-9h-isothiazoloä5,4-büchinolin-3,4-dio e und verwandte verbindungen als antiinfektive mittel |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8044204B2 (de) |
| EP (1) | EP1913004B1 (de) |
| JP (1) | JP5143000B2 (de) |
| KR (1) | KR101272263B1 (de) |
| CN (1) | CN101263146B (de) |
| AT (1) | ATE482219T1 (de) |
| AU (1) | AU2006272571B2 (de) |
| BR (1) | BRPI0614456B8 (de) |
| CA (1) | CA2616768C (de) |
| DE (1) | DE602006017082D1 (de) |
| DK (1) | DK1913004T3 (de) |
| EA (1) | EA013244B1 (de) |
| ES (1) | ES2352799T3 (de) |
| IL (1) | IL189017A (de) |
| NO (1) | NO343376B1 (de) |
| NZ (1) | NZ566209A (de) |
| PL (1) | PL1913004T3 (de) |
| PT (1) | PT1913004E (de) |
| WO (1) | WO2007014308A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008021491A2 (en) * | 2006-08-16 | 2008-02-21 | Achillion Pharmaceuticals, Inc. | Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones |
| WO2010115184A2 (en) * | 2009-04-03 | 2010-10-07 | Achillion Pharmaceuticals, Inc. | Hydroxythienoquinolones and related compounds as anti-infective agents |
| WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
| BR112012008759A2 (pt) | 2009-10-16 | 2020-08-25 | Rib-X Pharmaceuticals, Inc. | compostos antimicrobianos e métodos de fabricação e uso dos mesmos |
| WO2011047323A2 (en) | 2009-10-16 | 2011-04-21 | Rib-X Pharmaceuticals, Inc. | Antimicrobial compounds and methods of making and using the same |
| CN105646370A (zh) * | 2009-10-16 | 2016-06-08 | 梅琳塔治疗公司 | 抗微生物化合物和其制备和使用方法 |
| TN2010000566A1 (en) * | 2010-12-03 | 2012-05-24 | Rekik Raouf | Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs |
| CN103819401B (zh) * | 2012-11-19 | 2016-04-13 | 浙江中欣氟材股份有限公司 | 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法 |
| EP3039025A4 (de) | 2013-09-09 | 2017-05-31 | Melinta Therapeutics, Inc. | Antimikrobielle verbindungen und verfahren zur herstellung und verwendung davon |
| MX2016003046A (es) | 2013-09-09 | 2016-09-08 | Melinta Therapeutics Inc | Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos. |
| WO2015114317A1 (en) * | 2014-01-28 | 2015-08-06 | Redx Pharma Plc | 5h-isothiazolo[4,5-c]pyridine-3,4-dione or 5h-pyrazolo[4,3-c]pyridin-3,4-dione as antibacterial compounds |
| CN107922418A (zh) | 2015-03-11 | 2018-04-17 | 梅琳塔治疗公司 | 抗微生物化合物及制备和使用所述化合物的方法 |
| JP2019515041A (ja) | 2016-05-06 | 2019-06-06 | メリンタ セラピューティクス、 インコーポレイテッドＭｅｌｉｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 抗菌剤ならびにそれを作製および使用する方法 |
| EP4483875A3 (de) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Spirocyclische degronimere für zielproteinabbau |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| EP3455219A4 (de) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | Amingebundene c3-glutarimiddegronimere für zielproteinabbau |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| EP3641762B1 (de) | 2017-06-20 | 2026-02-18 | C4 Therapeutics, Inc. | N/o-gebundene degrone und degronimere zum proteinabbau |
| KR102534570B1 (ko) * | 2019-02-01 | 2023-05-18 | 에어리 파마슈티컬즈, 인코포레이티드 | 근시의 치료를 위한 화합물, 조성물 및 방법 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767762A (en) | 1985-12-23 | 1988-08-30 | Abbott Laboratories | Tricyclic quinoline and naphthyride antibacterials |
| JPH01160985A (ja) | 1987-12-17 | 1989-06-23 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
| JPH01193275A (ja) | 1988-01-28 | 1989-08-03 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
| JP2681190B2 (ja) | 1988-04-13 | 1997-11-26 | 塩野義製薬株式会社 | ピリドン系抗菌剤 |
| CA2001203C (en) | 1988-10-24 | 2001-02-13 | Thomas P. Demuth, Jr. | Novel antimicrobial dithiocarbamoyl quinolones |
| US5328908A (en) | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
| JPH02174784A (ja) | 1988-12-27 | 1990-07-06 | Hokuriku Seiyaku Co Ltd | イソチアゾロキノリン誘導体 |
| JPH02243692A (ja) | 1989-03-16 | 1990-09-27 | Dainippon Pharmaceut Co Ltd | 三環式化合物 |
| JPH02255687A (ja) | 1989-03-27 | 1990-10-16 | Dainippon Pharmaceut Co Ltd | 三環式化合物 |
| FR2645862B1 (fr) | 1989-04-18 | 1991-07-12 | Esteve Labor Dr | Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments |
| JP2787713B2 (ja) | 1989-07-28 | 1998-08-20 | 富山化学工業株式会社 | 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩 |
| US5071848A (en) | 1989-10-23 | 1991-12-10 | Abbott Laboratories | Tricyclic quinoline antineoplastic agents |
| JP2939280B2 (ja) | 1990-01-10 | 1999-08-25 | 三共株式会社 | フッ素置換メトキシキノロンカルボン酸誘導体 |
| US5580872A (en) | 1990-05-02 | 1996-12-03 | Abbott Laboratories | Quinolizinone type compounds |
| NO304832B1 (no) | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
| US5646163A (en) | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
| HUP9901642A3 (en) | 1996-01-31 | 2000-07-28 | Ube Ind Ltd Ube Shi | Remedies or preventives for aids |
| JP3616454B2 (ja) | 1996-04-19 | 2005-02-02 | 栄研化学株式会社 | 生体成分測定用試薬 |
| JPH10130149A (ja) | 1996-07-12 | 1998-05-19 | Sankyo Co Ltd | Ｔｎｆ産生抑制剤 |
| DE19652219A1 (de) | 1996-12-16 | 1998-06-18 | Bayer Ag | Verwendung von 7-(1-Aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-chinolon- und naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen |
| NZ525571A (en) * | 2000-12-14 | 2004-09-24 | Procter & Gamble | Antimicrobial quinolones |
| AU2004267052B2 (en) * | 2003-08-12 | 2009-02-05 | Achillion Pharmaceuticals, Inc. | Isothiazoloquinolones and related compounds as anti-infective agents |
| ATE445623T1 (de) * | 2004-11-11 | 2009-10-15 | Achillion Pharmaceuticals Inc | 8a, 9-dihydro-4a-h-isothiazoloä5,4-bü chinolin-3, 4-dione und verwandte verbindungen als infektionsschutzmittel |
| EP1848723B1 (de) * | 2005-02-16 | 2010-12-15 | Achillion Pharmaceuticals, Inc. | Neue isothiazolochinolone und verwandte verbindungen als infektionsschutzmittel |
| WO2010115184A2 (en) | 2009-04-03 | 2010-10-07 | Achillion Pharmaceuticals, Inc. | Hydroxythienoquinolones and related compounds as anti-infective agents |
-
2006
- 2006-07-27 CN CN200680033548XA patent/CN101263146B/zh active Active
- 2006-07-27 ES ES06800428T patent/ES2352799T3/es active Active
- 2006-07-27 JP JP2008524168A patent/JP5143000B2/ja not_active Expired - Fee Related
- 2006-07-27 EP EP06800428A patent/EP1913004B1/de active Active
- 2006-07-27 BR BRPI0614456A patent/BRPI0614456B8/pt active IP Right Grant
- 2006-07-27 DE DE602006017082T patent/DE602006017082D1/de active Active
- 2006-07-27 AT AT06800428T patent/ATE482219T1/de active
- 2006-07-27 DK DK06800428.2T patent/DK1913004T3/da active
- 2006-07-27 KR KR1020087004769A patent/KR101272263B1/ko active Active
- 2006-07-27 CA CA2616768A patent/CA2616768C/en not_active Expired - Fee Related
- 2006-07-27 EA EA200800444A patent/EA013244B1/ru unknown
- 2006-07-27 US US11/494,205 patent/US8044204B2/en active Active
- 2006-07-27 PT PT06800428T patent/PT1913004E/pt unknown
- 2006-07-27 AU AU2006272571A patent/AU2006272571B2/en not_active Ceased
- 2006-07-27 PL PL06800428T patent/PL1913004T3/pl unknown
- 2006-07-27 NZ NZ566209A patent/NZ566209A/en unknown
- 2006-07-27 WO PCT/US2006/029302 patent/WO2007014308A1/en not_active Ceased
-
2008
- 2008-01-24 IL IL189017A patent/IL189017A/en active IP Right Grant
- 2008-02-27 NO NO20081005A patent/NO343376B1/no unknown
-
2011
- 2011-10-24 US US13/279,852 patent/US8946422B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PT1913004E (pt) | 2010-12-09 |
| EA200800444A1 (ru) | 2008-06-30 |
| AU2006272571B2 (en) | 2012-03-08 |
| BRPI0614456B8 (pt) | 2021-05-25 |
| PL1913004T3 (pl) | 2011-03-31 |
| WO2007014308A1 (en) | 2007-02-01 |
| US20120040959A1 (en) | 2012-02-16 |
| NO343376B1 (no) | 2019-02-11 |
| US20070049586A1 (en) | 2007-03-01 |
| AU2006272571A1 (en) | 2007-02-01 |
| CA2616768C (en) | 2014-05-06 |
| EA013244B1 (ru) | 2010-04-30 |
| IL189017A (en) | 2014-01-30 |
| DE602006017082D1 (de) | 2010-11-04 |
| HK1122024A1 (en) | 2009-05-08 |
| CA2616768A1 (en) | 2007-02-01 |
| JP5143000B2 (ja) | 2013-02-13 |
| BRPI0614456B1 (pt) | 2019-08-27 |
| NZ566209A (en) | 2011-03-31 |
| EP1913004A1 (de) | 2008-04-23 |
| KR101272263B1 (ko) | 2013-06-13 |
| KR20080035661A (ko) | 2008-04-23 |
| IL189017A0 (en) | 2008-08-07 |
| BRPI0614456A2 (pt) | 2011-03-29 |
| JP2009502953A (ja) | 2009-01-29 |
| DK1913004T3 (da) | 2011-01-10 |
| US8044204B2 (en) | 2011-10-25 |
| CN101263146A (zh) | 2008-09-10 |
| EP1913004B1 (de) | 2010-09-22 |
| US8946422B2 (en) | 2015-02-03 |
| CN101263146B (zh) | 2012-12-05 |
| NO20081005L (no) | 2008-04-09 |
| ES2352799T3 (es) | 2011-02-23 |
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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