PE20100716A1 - Proceso para la sintesis de 1-bromo-3-nitro-5-trifluorometil-benceno - Google Patents

Proceso para la sintesis de 1-bromo-3-nitro-5-trifluorometil-benceno

Info

Publication number: PE20100716A1
Authority: PE; Peru
Prior art keywords: nitro; bromo; trifluorometil; benzeno; synthesis
Prior art date: 2005-06-09

Application number

PE2010000468A

Other languages

English (en)

Spanish (es)

Inventor

Stephan Abel

Murat Acemoglu

Bernhard Erb

Christoph Krell

Joseph Sclafani

Mark Meisenbach

Mahavir Prashad

Wen-Chung Shieh

Song Xue

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-09

Filing date

2006-06-07

Publication date

2010-10-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37149980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20100716(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-06-07 Application filed by Novartis Ag filed Critical Novartis Ag

2010-10-25 Publication of PE20100716A1 publication Critical patent/PE20100716A1/es

Links

238000000034 method Methods 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
-1 1-BROMO-3-NITRO-5-TRIFLUORO-METHYL-BENZENE COMPOUND Chemical class 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
VRLDVERQJMEPIF-UHFFFAOYSA-N dbdmh Chemical compound CC1(C)N(Br)C(=O)N(Br)C1=O VRLDVERQJMEPIF-UHFFFAOYSA-N 0.000 abstract 1
239000012442 inert solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
- C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PE2010000468A 2005-06-09 2006-06-07 Proceso para la sintesis de 1-bromo-3-nitro-5-trifluorometil-benceno PE20100716A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US68897605P	2005-06-09	2005-06-09

Publications (1)

Publication Number	Publication Date
PE20100716A1 true PE20100716A1 (es)	2010-10-25

Family

ID=37149980

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PE2010000468A PE20100716A1 (es)	2005-06-09	2006-06-07	Proceso para la sintesis de 1-bromo-3-nitro-5-trifluorometil-benceno
PE2010000467A PE20100715A1 (es)	2005-06-09	2006-06-07	Proceso para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina
PE2006000628A PE20070109A1 (es)	2005-06-09	2006-06-07	Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
PE2010000467A PE20100715A1 (es)	2005-06-09	2006-06-07	Proceso para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina
PE2006000628A PE20070109A1 (es)	2005-06-09	2006-06-07	Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina

Country Status (25)

Country	Link
US (2)	US7781597B2 (2)
EP (3)	EP1896426B1 (2)
JP (2)	JP5225078B2 (2)
KR (2)	KR101283109B1 (2)
CN (6)	CN102180836B (2)
AR (1)	AR057056A1 (2)
AT (1)	ATE540931T1 (2)
AU (3)	AU2006258050B2 (2)
BR (1)	BRPI0611683A2 (2)
CA (4)	CA2611280C (2)
DK (2)	DK2266961T3 (2)
ES (3)	ES2380489T3 (2)
GT (1)	GT200600202AA (2)
HU (1)	HUE028024T2 (2)
IN (2)	IN2014DN08578A (2)
JO (1)	JO2758B1 (2)
MX (1)	MX2007015609A (2)
MY (1)	MY146795A (2)
PE (3)	PE20100716A1 (2)
PL (3)	PL2292607T3 (2)
PT (3)	PT1896426E (2)
RU (1)	RU2446162C2 (2)
SI (2)	SI2266961T1 (2)
TW (1)	TWI380981B (2)
WO (1)	WO2006135640A2 (2)

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MY146795A (en) *	2005-06-09	2012-09-28	Novartis Ag	Process for the synthesis of organic compounds
TW200803740A (en)	2005-12-16	2008-01-16	Du Pont	5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh)	2005-12-30	2013-10-21	Du Pont	控制無脊椎害蟲之異唑啉
AU2008261793A1 (en)	2007-06-13	2008-12-18	E. I. Du Pont De Nemours And Company	Isoxazoline insecticides
TWI430995B (zh)	2007-06-26	2014-03-21	Du Pont	萘異唑啉無脊椎有害動物控制劑
ES2549731T3 (es)	2007-06-27	2015-11-02	E. I. Du Pont De Nemours And Company	Método para el control de plagas en animales
TWI649303B (zh)	2007-08-17	2019-02-01	杜邦股份有限公司	製備４-乙醯基-ｎ-〔２-側氧基-２-〔（２，２，２-三氟乙基）胺基〕乙基〕-１-萘甲醯胺之化合物及方法
US8367584B2 (en)	2007-10-03	2013-02-05	E.I. Du Pont De Nemours And Company	Naphthalene isoxazoline compounds for control of invertebrate pests
TWI518076B (zh)	2008-04-09	2016-01-21	杜邦股份有限公司	製備雜環化合物之方法
EP2305667A3 (en)	2008-07-17	2011-05-11	Teva Pharmaceutical Industries Ltd.	Nilotinib intermediates and preparation thereof
WO2010054056A2 (en)	2008-11-05	2010-05-14	Teva Pharmaceutical Industries Ltd.	Nilotinib hci crystalline forms
WO2010060074A1 (en) *	2008-11-24	2010-05-27	Teva Pharmaceutical Industries Ltd.	Preparation of nilotinib and intermediates thereof
US20110053968A1 (en) *	2009-06-09	2011-03-03	Auspex Pharmaceuticals, Inc.	Aminopyrimidine inhibitors of tyrosine kinase
RS54677B1 (sr)	2010-05-27	2016-08-31	E. I. Du Pont De Nemours And Company	Kristalni oblici 4-[5-[3-hloro-5-(trifluorometil)fenil]-4,5 -dihidro-5-(trifluorometil)-3-izoksazolil]-n-[2-okso-2-[(2,2,2-trifluoroetil)amino]etil]-1-naftalenkarboksamida
BR112014015720B1 (pt)	2011-12-30	2020-03-17	Hanmi Pharm. Co., Ltd.	Derivados de tieno[3,2-d]pirimidina, composição farmacêutica e uso dos mesmos para a prevenção ou tratamento de uma doença causada por ativação anormal de uma proteína quinase
CN102592837B (zh) *	2012-03-12	2014-01-15	河北师范大学	制备超级电容器用四氯合金属季铵盐掺杂聚苯胺电极的方法
CN103694176B (zh) *	2014-01-07	2015-02-18	苏州立新制药有限公司	尼洛替尼中间体的制备方法
CN104592122B (zh) *	2014-12-09	2018-01-23	凯莱英医药集团（天津）股份有限公司	3‑(4‑甲基‑1h‑咪唑‑1‑基)‑5‑(三氟甲基)苯胺的制备方法
CN105985293B (zh) *	2015-03-04	2018-04-03	埃斯特维华义制药有限公司	尼洛替尼中间体的制备方法
EP3095782A1 (en)	2015-05-18	2016-11-23	Esteve Química, S.A.	New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
CN107201532B (zh) *	2017-05-09	2019-08-27	吉林凯莱英医药化学有限公司	芳香化合物的硝化方法
US11053220B2 (en)	2018-01-01	2021-07-06	Laurus Labs Ltd	Process for 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl) aniline
CN108530364B (zh)	2018-04-10	2020-01-21	江苏创诺制药有限公司	一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用
TWI831259B (zh)	2018-06-15	2024-02-01	漢達生技醫藥股份有限公司	包含達沙替尼十二烷基硫酸鹽組合物的膠囊
EP3953336A4 (en) *	2019-04-06	2023-05-03	Trinapco, Inc	SULFONYLDIAZOLES AND N-(FLUOROSULFONYL)AZOLES, AND METHODS FOR THE PREPARATION THEREOF
EP3904342A1 (en)	2020-04-28	2021-11-03	Grindeks, A Joint Stock Company	Process for the preparation of 3-(trifluoromethyl)-5-(4-methyl-1h-imidazole-1-yl)-benzeneamine hydrochloride
CN114751836B (zh) *	2021-02-23	2024-05-31	四川青木制药有限公司	3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺合成方法及其中间体
CN114853734A (zh) *	2022-06-14	2022-08-05	海南鑫开源医药科技有限公司	一种尼洛替尼游离碱的制备方法
CN116478319B (zh) *	2022-11-07	2025-07-01	华北电力大学	一种离子共价有机聚合物的制备方法及其在碱性环境吸附ReO4-的应用
CN115626880B (zh) *	2022-11-15	2023-11-14	常州大学	3-硝基-5-氰基三氟甲苯的合成方法
CN118108670B (zh) *	2023-12-28	2025-07-01	江苏希迪制药有限公司	尼罗替尼中间体3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺的精制纯化方法
CN121517361A (zh) *	2026-01-15	2026-02-13	湖南阿斯迪康药业有限公司	一种基于溴苯类化合物合成1-芳基咪唑类化合物的方法

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PE20040522A1 (es) *	2002-05-29	2004-09-28	Novartis Ag	Derivados de diarilurea dependientes de la cinasa de proteina
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MY146795A (en) *	2005-06-09	2012-09-28	Novartis Ag	Process for the synthesis of organic compounds

2006
- 2006-05-31 MY MYPI20062506A patent/MY146795A/en unknown
- 2006-06-06 JO JO2006161A patent/JO2758B1/en active
- 2006-06-07 DK DK10171941.7T patent/DK2266961T3/en active
- 2006-06-07 EP EP06772447A patent/EP1896426B1/en active Active
- 2006-06-07 HU HUE10171941A patent/HUE028024T2/en unknown
- 2006-06-07 SI SI200632010T patent/SI2266961T1/sl unknown
- 2006-06-07 WO PCT/US2006/022154 patent/WO2006135640A2/en not_active Ceased
- 2006-06-07 RU RU2007148238/04A patent/RU2446162C2/ru active
- 2006-06-07 MX MX2007015609A patent/MX2007015609A/es active IP Right Grant
- 2006-06-07 KR KR1020127011979A patent/KR101283109B1/ko not_active Expired - Fee Related
- 2006-06-07 PT PT06772447T patent/PT1896426E/pt unknown
- 2006-06-07 CN CN2011100574125A patent/CN102180836B/zh not_active Expired - Fee Related
- 2006-06-07 ES ES06772447T patent/ES2380489T3/es active Active
- 2006-06-07 CN CN200680019924XA patent/CN101189212B/zh not_active Expired - Fee Related
- 2006-06-07 AU AU2006258050A patent/AU2006258050B2/en not_active Ceased
- 2006-06-07 CA CA2611280A patent/CA2611280C/en active Active
- 2006-06-07 CN CN2011100581769A patent/CN102180796A/zh active Pending
- 2006-06-07 DK DK10171942.5T patent/DK2292607T3/da active
- 2006-06-07 CA CA2942046A patent/CA2942046A1/en not_active Abandoned
- 2006-06-07 CN CN2011100581773A patent/CN102174020B/zh not_active Expired - Fee Related
- 2006-06-07 PE PE2010000468A patent/PE20100716A1/es not_active Application Discontinuation
- 2006-06-07 AR ARP060102367A patent/AR057056A1/es unknown
- 2006-06-07 ES ES10171942.5T patent/ES2465522T3/es active Active
- 2006-06-07 CN CN2011100572469A patent/CN102174019B/zh not_active Expired - Fee Related
- 2006-06-07 US US11/915,691 patent/US7781597B2/en active Active
- 2006-06-07 KR KR1020077028642A patent/KR101249199B1/ko not_active Expired - Fee Related
- 2006-06-07 PE PE2010000467A patent/PE20100715A1/es not_active Application Discontinuation
- 2006-06-07 PL PL10171942T patent/PL2292607T3/pl unknown
- 2006-06-07 BR BRPI0611683-3A patent/BRPI0611683A2/pt active Search and Examination
- 2006-06-07 CN CN2011100581788A patent/CN102174021B/zh not_active Expired - Fee Related
- 2006-06-07 JP JP2008515880A patent/JP5225078B2/ja not_active Expired - Fee Related
- 2006-06-07 PL PL10171941T patent/PL2266961T3/pl unknown
- 2006-06-07 SI SI200631789T patent/SI2292607T1/sl unknown
- 2006-06-07 PE PE2006000628A patent/PE20070109A1/es not_active Application Discontinuation
- 2006-06-07 PT PT101719417T patent/PT2266961E/pt unknown
- 2006-06-07 IN IN8578DEN2014 patent/IN2014DN08578A/en unknown
- 2006-06-07 PL PL06772447T patent/PL1896426T3/pl unknown
- 2006-06-07 CA CA2833394A patent/CA2833394C/en active Active
- 2006-06-07 IN IN8588DEN2014 patent/IN2014DN08588A/en unknown
- 2006-06-07 AT AT06772447T patent/ATE540931T1/de active
- 2006-06-07 EP EP10171942.5A patent/EP2292607B1/en active Active
- 2006-06-07 ES ES10171941.7T patent/ES2558696T3/es active Active
- 2006-06-07 CA CA2886482A patent/CA2886482C/en active Active
- 2006-06-07 EP EP10171941.7A patent/EP2266961B1/en active Active
- 2006-06-07 PT PT101719425T patent/PT2292607E/pt unknown
- 2006-06-08 TW TW095120304A patent/TWI380981B/zh not_active IP Right Cessation
2010
- 2010-07-12 US US12/834,295 patent/US8008504B2/en not_active Expired - Fee Related
- 2010-11-11 AU AU2010241374A patent/AU2010241374B2/en not_active Ceased
2011
- 2011-03-09 AU AU2011201044A patent/AU2011201044A1/en not_active Abandoned
2012
- 2012-05-17 GT GT200600202AK patent/GT200600202AA/es unknown
- 2012-09-21 JP JP2012208775A patent/JP2013035855A/ja active Pending

Also Published As

Publication number	Publication date
AU2006258050A1 (en)	2006-12-21
EP2266961B1 (en)	2015-10-21
CA2833394C (en)	2016-03-29
AU2006258050B2 (en)	2010-12-09
JP5225078B2 (ja)	2013-07-03
EP1896426A2 (en)	2008-03-12
KR101249199B1 (ko)	2013-04-03
CN102174019B (zh)	2013-02-13
PT2292607E (pt)	2014-06-24
US7781597B2 (en)	2010-08-24
CN101189212A (zh)	2008-05-28
PL2266961T3 (pl)	2016-04-29
PT2266961E (pt)	2016-02-05
ATE540931T1 (de)	2012-01-15
WO2006135640A2 (en)	2006-12-21
KR20120099028A (ko)	2012-09-06
CN102174020A (zh)	2011-09-07
CA2886482C (en)	2017-09-05
JP2008546645A (ja)	2008-12-25
CN102174019A (zh)	2011-09-07
CN102174020B (zh)	2012-11-07
MY146795A (en)	2012-09-28
CA2833394A1 (en)	2006-12-21
SI2292607T1 (sl)	2014-09-30
EP2292607A3 (en)	2011-04-27
ES2558696T3 (es)	2016-02-08
KR101283109B1 (ko)	2013-07-05
CN102180836B (zh)	2012-11-21
EP2292607B1 (en)	2014-04-09
PL1896426T3 (pl)	2012-06-29
US8008504B2 (en)	2011-08-30
WO2006135640A3 (en)	2007-08-02
PE20100715A1 (es)	2010-10-25
US20080200692A1 (en)	2008-08-21
CA2611280A1 (en)	2006-12-21
TWI380981B (zh)	2013-01-01
CA2611280C (en)	2014-01-28
RU2446162C2 (ru)	2012-03-27
JP2013035855A (ja)	2013-02-21
JO2758B1 (en)	2014-03-15
EP1896426B1 (en)	2012-01-11
IN2014DN08588A (2)	2015-07-10
HUE028024T2 (en)	2016-11-28
TW200716563A (en)	2007-05-01
RU2007148238A (ru)	2009-07-20
KR20080014010A (ko)	2008-02-13
MX2007015609A (es)	2008-02-25
CA2942046A1 (en)	2006-12-21
AU2010241374A1 (en)	2010-12-02
AU2011201044A1 (en)	2011-03-31
ES2465522T3 (es)	2014-06-06
GT200600202AA (es)	2014-06-09
PE20070109A1 (es)	2007-04-02
SI2266961T1 (sl)	2016-02-29
EP2292607A2 (en)	2011-03-09
DK2292607T3 (da)	2014-06-30
CN102180836A (zh)	2011-09-14
US20100280257A1 (en)	2010-11-04
EP2266961A2 (en)	2010-12-29
PL2292607T3 (pl)	2014-09-30
EP2266961A3 (en)	2011-07-27
DK2266961T3 (en)	2016-01-25
CN102174021B (zh)	2013-02-27
ES2380489T3 (es)	2012-05-14
AR057056A1 (es)	2007-11-14
AU2010241374B2 (en)	2011-11-03
CA2886482A1 (en)	2006-12-21
CN102180796A (zh)	2011-09-14
IN2014DN08578A (2)	2015-07-10
PT1896426E (pt)	2012-04-12
CN101189212B (zh)	2011-05-18
BRPI0611683A2 (pt)	2010-09-28
CN102174021A (zh)	2011-09-07
ES2380489T8 (es)	2012-06-22

Legal Events

Date	Code	Title	Description
2014-08-22	FG	Grant, registration
2019-01-30	FD	Application declared void or lapsed

Publication	Publication Date	Title
PE20100716A1 (es)	2010-10-25	Proceso para la sintesis de 1-bromo-3-nitro-5-trifluorometil-benceno
UY28968A1 (es)	2006-01-31	(orto-fenil)-anilidas de ácido 1-metil-3-trifluorometil-pirazol-4-carboxílico y su uso como fungicida
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BRPI0615705A2 (pt)	2016-08-23	processo para preparar um composto, e, composto
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