PE20121480A1 - Aminopirimidinas como inhibidores de syk - Google Patents

Aminopirimidinas como inhibidores de syk

Info

Publication number
PE20121480A1
PE20121480A1 PE2012000838A PE2012000838A PE20121480A1 PE 20121480 A1 PE20121480 A1 PE 20121480A1 PE 2012000838 A PE2012000838 A PE 2012000838A PE 2012000838 A PE2012000838 A PE 2012000838A PE 20121480 A1 PE20121480 A1 PE 20121480A1
Authority
PE
Peru
Prior art keywords
pyrimidin
cycloalkyl
hydroxy
phenyl
alkyl
Prior art date
Application number
PE2012000838A
Other languages
English (en)
Spanish (es)
Inventor
Michael D Altman
Brian M Andresen
Kenneth L Arrington
Konrad Childers Kaleen
Francesco Maria Emilia Di
Anthony Donofrio
John Michael Ellis
Christian Fischer
David Joseph Guerin
Andrew M Haidle
Solomon Kattar
Sandra Lee Knowles
Chaomin Li
Jongwon Lim
Michelle R Machacek
Brendan M O'boyle
Ryan D Otte
Alessia Petrocchi
Michael H Reutershan
Eric Romeo
Tony Siu
Brandon M Taoka
B Wesley Trotter
Hua Zhou
Janson Burch
Bernard Cote
Kristina Dupont-Gaudet
Jean-Francois Fournier
Jacques Ives Gauthier
Daniel Guay
Joel S Robichaud
Original Assignee
Merck Sharp & Dohme
Merck Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43502894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20121480(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme, Merck Canada Inc filed Critical Merck Sharp & Dohme
Publication of PE20121480A1 publication Critical patent/PE20121480A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
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  • Biochemistry (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
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  • Psychiatry (AREA)
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PE2012000838A 2009-12-17 2010-12-15 Aminopirimidinas como inhibidores de syk PE20121480A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28726709P 2009-12-17 2009-12-17

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PE20121480A1 true PE20121480A1 (es) 2012-11-10

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US (3) US8551984B2 (ar)
EP (1) EP2513098B1 (ar)
JP (2) JP5242857B2 (ar)
KR (1) KR101445012B1 (ar)
CN (1) CN102858767B (ar)
AR (1) AR080672A1 (ar)
AU (1) AU2010331927B2 (ar)
BR (1) BR112012014703B1 (ar)
CA (1) CA2782889C (ar)
CL (1) CL2012001627A1 (ar)
CO (1) CO6551728A2 (ar)
CR (1) CR20120331A (ar)
DO (1) DOP2012000166A (ar)
EA (1) EA022790B1 (ar)
EC (1) ECSP12011982A (ar)
ES (1) ES2609040T3 (ar)
GE (1) GEP20146125B (ar)
GT (1) GT201200202A (ar)
MA (1) MA33926B1 (ar)
MX (1) MX2012007154A (ar)
NI (1) NI201200108A (ar)
NZ (1) NZ600673A (ar)
PE (1) PE20121480A1 (ar)
PH (1) PH12012501225A1 (ar)
SG (1) SG181803A1 (ar)
TN (1) TN2012000288A1 (ar)
TW (1) TW201132637A (ar)
WO (2) WO2011075517A1 (ar)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101445012B1 (ko) 2009-12-17 2014-09-26 머크 샤프 앤드 돔 코포레이션 Ｓｙｋ 억제제로서의 아미노피리미딘
EP2512246B1 (en) 2009-12-17 2015-09-30 Merck Sharp & Dohme Corp. Aminopyrimidines as syk inhibitors
NZ601267A (en) 2009-12-23 2014-03-28 Takeda Pharmaceutical Fused heteroaromatic pyrrolidinones as syk inhibitors
ES2539170T3 (es) 2010-01-12 2015-06-26 Ab Science Inhibidores de quinasas de oxazol
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
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