PE20131412A1 - Inmunoglobulinas con dominio variable dual y usos de las mismas - Google Patents

Inmunoglobulinas con dominio variable dual y usos de las mismas

Info

Publication number
PE20131412A1
PE20131412A1 PE2013000182A PE2013000182A PE20131412A1 PE 20131412 A1 PE20131412 A1 PE 20131412A1 PE 2013000182 A PE2013000182 A PE 2013000182A PE 2013000182 A PE2013000182 A PE 2013000182A PE 20131412 A1 PE20131412 A1 PE 20131412A1
Authority
PE
Peru
Prior art keywords
variable domain
immunoglobulins
dual variable
same
seq
Prior art date
Application number
PE2013000182A
Other languages
English (en)
Inventor
Tariq Ghayur
Junjian Liu
Peter C Isakson
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PE20131412A1 publication Critical patent/PE20131412A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

REFERIDA A INMUNOGLOBULINAS CON DOMINIO VARIABLE DUAL QUE COMPRENDE UNA PRIMERA Y UNA SEGUNDA CADENA DE POLIPEPTIDOS, CADA UNA DE LAS CUALES COMPRENDE DE MANERA INDEPENDIENTE VD1-(X1)n-VD2-C-(X2)n, EN DONDE: VD1 ES UN PRIMER DOMINIO VARIABLE QUE FORMA EN AMBAS CADENAS UN PRIMER SITIO DE UNION BLANCO FUNCIONAL; VD2 ES UN SEGUNDO DOMINIO VARIABLE QUE FORMA EN AMBAS CADENAS UN SEGUNDO SITIO DE UNION BLANCO FUNCIONAL; C ES UN DOMINIO CONSTANTE; X1 ES UN CONECTOR CON LA CONDICION QUE NO SEA CH1; X2 ES UNA REGION Fc; n ES 0 -1. ADEMAS DICHA PROTEINA TIENE CAPACIDAD DE UNIR IL-1BETA QUE COMPRENDE UNA SECUENCIA SELECCIONADA ENTRE LAS SEQ ID N� 30-39 Y IL-17 QUE COMPRENDE UNA SECUENCIA SELECCIONADA ENTRE LAS SEQ ID N� 40-45. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHA PROTEINA ES UTIL EN EL TRATAMIENTO DE ARTRITIS REUMATOIDEA, DERMATITIS ENTRE OTRAS
PE2013000182A 2010-08-03 2011-08-02 Inmunoglobulinas con dominio variable dual y usos de las mismas PE20131412A1 (es)

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