PH21951A - Octahydrothiazolo(4,5-g)quinolines and use as prolactin secretion inhibitors - Google Patents

Octahydrothiazolo(4,5-g)quinolines and use as prolactin secretion inhibitors

Info

Publication number: PH21951A
Authority: PH; Philippines
Prior art keywords: sub; octahydrothiazolo; quinolines; alkyl; secretion inhibitors
Prior art date: 1984-04-27

Application number

PH32196A

Other languages

English (en)

Inventor

Robert Daniel Titus

Edmund Carl Kornfield

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-27

Filing date

1985-04-25

Publication date

1988-04-15

1985-04-25 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1988-04-15 Publication of PH21951A publication Critical patent/PH21951A/en

Links

102000003946 Prolactin Human genes 0.000 title 1
108010057464 Prolactin Proteins 0.000 title 1
229940111121 antirheumatic drug quinolines Drugs 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
229940097325 prolactin Drugs 0.000 title 1
150000003248 quinolines Chemical class 0.000 title 1
230000028327 secretion Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
150000003839 salts Chemical group 0.000 abstract 2
125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
229940052760 dopamine agonists Drugs 0.000 abstract 1
239000003136 dopamine receptor stimulating agent Substances 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
-1 substituted-octahydrothiazolo [4,5-g]quinolines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/30—Metal salts; Chelates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

PH32196A 1984-04-27 1985-04-25 Octahydrothiazolo(4,5-g)quinolines and use as prolactin secretion inhibitors PH21951A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/604,687 US4537893A (en)	1984-04-27	1984-04-27	Octahydrothiazolo[4,5-g]quinolines and use as prolactin secretion inhibitors

Publications (1)

Publication Number	Publication Date
PH21951A true PH21951A (en)	1988-04-15

Family

ID=24420601

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH32196A PH21951A (en)	1984-04-27	1985-04-25	Octahydrothiazolo(4,5-g)quinolines and use as prolactin secretion inhibitors

Country Status (19)

Country	Link
US (1)	US4537893A (fr)
EP (1)	EP0160502B1 (fr)
JP (1)	JPH0631262B2 (fr)
KR (1)	KR870001072B1 (fr)
CN (1)	CN85101547A (fr)
AT (1)	ATE67767T1 (fr)
AU (1)	AU564946B2 (fr)
CA (1)	CA1287356C (fr)
DE (1)	DE3584183D1 (fr)
DK (1)	DK185485A (fr)
ES (1)	ES8704177A1 (fr)
GR (1)	GR850989B (fr)
HU (1)	HU193113B (fr)
IL (1)	IL74988A0 (fr)
NZ (1)	NZ211863A (fr)
PH (1)	PH21951A (fr)
PT (1)	PT80339B (fr)
SU (1)	SU1414318A3 (fr)
ZA (1)	ZA852999B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4778894A (en) *	1983-09-26	1988-10-18	Eli Lilly And Company	6 oxo-decahydroquinolines
US4977160A (en) *	1986-06-16	1990-12-11	Eli Lilly And Company	BCD tricyclic ergoline part-structure analogues
US5134143A (en) *	1986-06-16	1992-07-28	Eli Lilly And Company	BCD tricyclic ergoline part-structure analogues
US4826986A (en) *	1986-06-16	1989-05-02	Eli Lilly And Company	6-Oxo-trans-octa- and decahydroquinolines
DE3624607A1 (de) *	1986-07-21	1988-01-28	Boehringer Ingelheim Kg	Neue tetrahydrobenzothiazolo-chinoline ihre herstellung und verwendung
US4762843A (en) *	1986-09-15	1988-08-09	Warner-Lambert Company	Hetero [f] fused carbocyclic pyridines as dopaminergic agents
US4939259A (en) *	1989-07-24	1990-07-03	Eli Lilly And Company	2-oxo-pyrido[2,3-g]quinoline derivatives
US5006525A (en) *	1989-07-24	1991-04-09	Eli Lilly And Company	Dopamine agonists method
US4977149A (en) *	1989-07-24	1990-12-11	Eli Lilly And Company	Pyridoquinoline dopamine agonists, compositions and use
US5057515A (en) *	1989-07-24	1991-10-15	Eli Lilly And Company	Method for agonizing a dopamine receptor
US5416090A (en) *	1991-01-31	1995-05-16	Eli Lilly And Company	Method of treating inflammation
CA2144669A1 (fr) *	1994-03-29	1995-09-30	Kozo Akasaka	Derives du biphenyle
EP0816406B1 (fr) *	1996-06-26	2000-09-06	Bayer Ag	Procedure pour la préparation de produits de condensation pauvres en sel
WO2009139855A2 (fr) *	2008-05-14	2009-11-19	Ipsen Pharma S.A.S.	Compositions pharmaceutiques de conjugués somatostatine-dopamine
TWI537274B (zh) *	2011-03-14	2016-06-11	橘生藥品工業股份有限公司	新穎之八氫噻吩并喹啉衍生物、含有其之醫藥組成物及該等之用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2056224A1 (de) *	1969-11-17	1971-06-03	Danchi Seiyaku Co , Ltd , Tokio	Neue Thiazolochinohnderivate und Ver fahren zu ihrer Herstellung
US4198415A (en) *	1979-01-22	1980-04-15	Eli Lilly And Company	Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines
US4258049A (en) *	1979-07-02	1981-03-24	Smithkline Corporation	Inhibiting phenylethanolamine N-methyltransferase with thiadiazolo and oxadiazolotetrahydroisoquinolines
US4367231A (en) *	1979-09-14	1983-01-04	Eli Lilly And Company	Method of using octahydro pyrazolo[3,4-g]quinolines

1984
- 1984-04-27 US US06/604,687 patent/US4537893A/en not_active Expired - Fee Related
1985
- 1985-04-01 CN CN198585101547A patent/CN85101547A/zh active Pending
- 1985-04-22 CA CA000479702A patent/CA1287356C/fr not_active Expired - Lifetime
- 1985-04-22 NZ NZ211863A patent/NZ211863A/en unknown
- 1985-04-22 ZA ZA852999A patent/ZA852999B/xx unknown
- 1985-04-22 SU SU853883101A patent/SU1414318A3/ru active
- 1985-04-23 IL IL74988A patent/IL74988A0/xx unknown
- 1985-04-23 GR GR850989A patent/GR850989B/el unknown
- 1985-04-23 PT PT80339A patent/PT80339B/pt not_active IP Right Cessation
- 1985-04-24 EP EP85302852A patent/EP0160502B1/fr not_active Expired - Lifetime
- 1985-04-24 AU AU41666/85A patent/AU564946B2/en not_active Ceased
- 1985-04-24 DE DE8585302852T patent/DE3584183D1/de not_active Expired - Lifetime
- 1985-04-24 AT AT85302852T patent/ATE67767T1/de not_active IP Right Cessation
- 1985-04-25 PH PH32196A patent/PH21951A/en unknown
- 1985-04-25 KR KR1019850002803A patent/KR870001072B1/ko not_active Expired
- 1985-04-25 ES ES542565A patent/ES8704177A1/es not_active Expired
- 1985-04-25 DK DK185485A patent/DK185485A/da not_active Application Discontinuation
- 1985-04-26 HU HU851624A patent/HU193113B/hu unknown
- 1985-04-26 JP JP60092157A patent/JPH0631262B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0160502A2 (fr)	1985-11-06
HU193113B (en)	1987-08-28
DK185485D0 (da)	1985-04-25
CA1287356C (fr)	1991-08-06
JPH0631262B2 (ja)	1994-04-27
PT80339A (en)	1985-05-01
EP0160502B1 (fr)	1991-09-25
ZA852999B (en)	1986-11-26
AU4166685A (en)	1985-10-31
CN85101547A (zh)	1987-01-24
JPS60233091A (ja)	1985-11-19
ES542565A0 (es)	1987-03-16
NZ211863A (en)	1987-10-30
IL74988A0 (en)	1985-08-30
HUT37624A (en)	1986-01-23
GR850989B (fr)	1985-11-25
SU1414318A3 (ru)	1988-07-30
ES8704177A1 (es)	1987-03-16
PT80339B (en)	1987-02-16
DK185485A (da)	1985-10-28
AU564946B2 (en)	1987-09-03
EP0160502A3 (en)	1987-03-11
DE3584183D1 (de)	1991-10-31
KR870001072B1 (ko)	1987-05-27
KR850007261A (ko)	1985-12-02
ATE67767T1 (de)	1991-10-15
US4537893A (en)	1985-08-27

Publication	Publication Date	Title
PH21951A (en)	1988-04-15	Octahydrothiazolo(4,5-g)quinolines and use as prolactin secretion inhibitors
GB1423006A (en)	1976-01-28	Herbicidal compositions containing 4-phenoxy-phenoxy-propionic acid derivatives
KR850001171A (ko)	1985-03-16	퀴놀린 화합물의 제조방법
ES8601201A1 (es)	1985-10-16	Procedimiento para preparar derivados de imidazolina
ES8704491A1 (es)	1987-04-01	Procedimiento para la obtencion de nuevas piridopirimidinas
AU7004687A (en)	1987-09-24	3-benzazepine derivatives
DK67384D0 (da)	1984-02-14	N-iminopyridiniumbetainderivater
DE3461375D1 (en)	1987-01-08	1-acetonyl-2-(phenylimino)-imidazolidines, their addition salts, their pharmaceutical compositions and their preparation
ES8800231A1 (es)	1987-10-16	Un procedimiento para la preparacion de una trans-octahidro-oxazolo 4,5-g quinolina
AU562643B2 (en)	1987-06-18	N-arylpiperazine derivatives
AU6599186A (en)	1987-06-02	N-(6-(4-0-hydrxyphenyl-1,3-dioxan-cis-5-yl)hexenoyl) suphonamide derivatives
EP0216323A3 (fr)	1987-11-11	Dérivés de l'acide quinolonecarboxylique et leur préparation
ES8605145A1 (es)	1986-03-16	Perfeccionamientos en las maquinas pasteurizadoras para tra-tar termicamente mezclas liquidas destinadas a la fabrica- cion de helados
EP0094774A3 (fr)	1984-12-19	Dérivés de carboline
ATE30675T1 (de)	1987-11-15	Benzobicyclononanamin-derivate mit antikonvulsiven eigenschaften.