PH25493A - 2,3,4,5-tetrahydro-2-£(imidazol-(or-5)-yl)methyl-ih-pyrido£4,3-b|indol-1-ones , derivatives having 5-ht antagonist activity 3 - Google Patents

2,3,4,5-tetrahydro-2-£(imidazol-(or-5)-yl)methyl-ih-pyrido£4,3-b|indol-1-ones , derivatives having 5-ht antagonist activity 3

Info

Publication number
PH25493A
PH25493A PH37492A PH37492A PH25493A PH 25493 A PH25493 A PH 25493A PH 37492 A PH37492 A PH 37492A PH 37492 A PH37492 A PH 37492A PH 25493 A PH25493 A PH 25493A
Authority
PH
Philippines
Prior art keywords
group
hydrogen atom
6alkyl
phenyl
phenylc1
Prior art date
Application number
PH37492A
Other languages
English (en)
Inventor
Ian Harold Coates
Peter Charles North
Alexander William Oxford
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878720695A external-priority patent/GB8720695D0/en
Priority claimed from GB888819382A external-priority patent/GB8819382D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PH25493A publication Critical patent/PH25493A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PH37492A 1987-09-03 1988-09-02 2,3,4,5-tetrahydro-2-£(imidazol-(or-5)-yl)methyl-ih-pyrido£4,3-b|indol-1-ones , derivatives having 5-ht antagonist activity 3 PH25493A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878720695A GB8720695D0 (en) 1987-09-03 1987-09-03 Chemical compounds
GB888819382A GB8819382D0 (en) 1988-08-15 1988-08-15 Lactame derivatives

Publications (1)

Publication Number Publication Date
PH25493A true PH25493A (en) 1991-07-24

Family

ID=26292675

Family Applications (1)

Application Number Title Priority Date Filing Date
PH37492A PH25493A (en) 1987-09-03 1988-09-02 2,3,4,5-tetrahydro-2-£(imidazol-(or-5)-yl)methyl-ih-pyrido£4,3-b|indol-1-ones , derivatives having 5-ht antagonist activity 3

Country Status (15)

Country Link
EP (1) EP0306323B1 (de)
AT (1) ATE111910T1 (de)
AU (1) AU613662B2 (de)
CY (1) CY1789A (de)
CZ (1) CZ404491A3 (de)
DE (1) DE3851597T2 (de)
ES (1) ES2060655T3 (de)
GB (1) GB2209335B (de)
HK (1) HK75591A (de)
HU (1) HU211843A9 (de)
IE (1) IE61669B1 (de)
IL (1) IL87658A (de)
NZ (1) NZ226032A (de)
PH (1) PH25493A (de)
SK (1) SK404491A3 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636563A (en) * 1985-09-16 1987-01-13 American Home Products Corporation Antipsychotic γ-carbolines
US4672117A (en) * 1985-09-16 1987-06-09 American Home Products Corporation Antipsychotic gamma-carbolines
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
HU207078B (en) * 1988-08-02 1993-03-01 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising such compounds
DE68926553T2 (de) * 1988-08-02 1996-10-17 Glaxo Group Ltd., London Lactamderivate
JPH02167280A (ja) * 1988-08-15 1990-06-27 Glaxo Group Ltd ラクタム誘導体
GB8820651D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
GB8820653D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
GB8820650D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
JPH02180885A (ja) * 1988-09-01 1990-07-13 Glaxo Group Ltd ラクタム誘導体
EP0377238A1 (de) * 1988-12-22 1990-07-11 Duphar International Research B.V Annelierte Indolo(3,2-c)-lactame
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
HU204049B (en) * 1989-02-28 1991-11-28 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising same
GB8904552D0 (en) * 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical process
GB8904551D0 (en) * 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical compounds
EP0392663A1 (de) * 1989-03-13 1990-10-17 Ono Pharmaceutical Co., Ltd. Ein Carbolin-Derivat als 5-HT3-Rezeptor-Antagonist
ZA902794B (en) * 1989-04-18 1991-04-24 Duphar Int Res New 3-n substituted carbamoyl-indole derivatives
US5530008A (en) * 1989-04-21 1996-06-25 Sandoz Ltd. Use of 5-HT3 receptor antagonists in treating panic disorders or obsessive compulsive disorders
JPH0669963B2 (ja) 1989-04-21 1994-09-07 サンド・アクチエンゲゼルシャフト ５ｈｔ▲下３▼受容体拮抗薬の治療的用途
GB8913646D0 (en) * 1989-06-14 1989-08-02 Glaxo Group Ltd Chemical compounds
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5180728A (en) * 1989-09-25 1993-01-19 Fujisawa Pharmaceutical Company, Ltd. Pyrimidoindole derivatives and processes for preparation thereof
GB8928208D0 (en) * 1989-12-13 1990-02-14 Glaxo Group Ltd Medicaments
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
GB9011469D0 (en) * 1990-05-23 1990-07-11 Glaxo Group Ltd Chemical process
US5229517A (en) * 1990-09-27 1993-07-20 Hoechst-Roussel Pharmaceuticals Incorporated 2-(4-Piperindinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds
US5102889B1 (en) * 1990-09-27 1993-05-11 2-(4-piperidinyl)-1h-pyrido(4,3-b)indol-1-ones and related compounds
US5189041A (en) * 1990-11-16 1993-02-23 Syntex (U.S.A.) Inc. Tricyclic 5-ht3 receptor antagonists
GB9721139D0 (en) 1997-10-07 1997-12-03 Glaxo Group Ltd Medicaments
WO2001058869A2 (en) * 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
DE60312474T2 (de) 2002-01-18 2007-12-06 Aryx Therapeutics, Fremont 5-ht3-rezeptorantagonisten und verwendungsverfahren
RU2544856C2 (ru) 2008-01-25 2015-03-20 Сергей Олегович Бачурин НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
ES2432618T3 (es) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
DK2432467T3 (en) 2009-05-20 2018-04-16 Inst Nat Sante Rech Med SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS FOR USE IN TREATMENT OF VESTIBULAR DAMAGE LESSONS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0191562B1 (de) * 1985-01-23 1991-07-10 Glaxo Group Limited Tetrahydrocarbazolonderivate
DE68926553T2 (de) * 1988-08-02 1996-10-17 Glaxo Group Ltd., London Lactamderivate
HU204049B (en) * 1989-02-28 1991-11-28 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising same

Also Published As

Publication number Publication date
CZ404491A3 (en) 1993-04-14
ES2060655T3 (es) 1994-12-01
IE61669B1 (en) 1994-11-16
ATE111910T1 (de) 1994-10-15
EP0306323A3 (en) 1990-07-18
GB2209335A (en) 1989-05-10
IE882669L (en) 1989-03-03
AU2174288A (en) 1989-03-09
AU613662B2 (en) 1991-08-08
EP0306323A2 (de) 1989-03-08
DE3851597D1 (de) 1994-10-27
EP0306323B1 (de) 1994-09-21
GB2209335B (en) 1991-05-29
NZ226032A (en) 1991-12-23
IL87658A0 (en) 1989-02-28
SK404491A3 (en) 2000-12-11
CY1789A (en) 1995-10-20
HK75591A (en) 1991-10-04
IL87658A (en) 1994-06-24
DE3851597T2 (de) 1995-01-26
HU211843A9 (en) 1995-12-28
GB8820736D0 (en) 1988-10-05

Similar Documents

Publication Publication Date Title
PH25493A (en) 2,3,4,5-tetrahydro-2-£(imidazol-(or-5)-yl)methyl-ih-pyrido£4,3-b|indol-1-ones , derivatives having 5-ht antagonist activity 3
AU631131B2 (en) Lactam derivatives
GB8904551D0 (en) Chemical compounds
MA22554A1 (fr) Derives d'imidazo (1,2-a) (pyrrolo, thieno ou furano) (3,2-d) azepines, compositions les renfermant et methodes pour leur utilisation
ES2115608T3 (es) Procedimiento para preparar derivados lactamicos.
EP0276163A3 (en) Indole derivatives
EP0356098A3 (de) Lactamderivate
FI884049A7 (fi) Laktamderivat.
ZA893767B (en) Tricyclic ketones
MY102646A (en) Tricyclic ketones
MY103831A (en) Lactam derivatives.