PL1603566T3 - Zastosowanie pochodnych izochinoliny do leczenia raka i chorób związanych z kinezą MAP - Google Patents

Zastosowanie pochodnych izochinoliny do leczenia raka i chorób związanych z kinezą MAP

Info

Publication number: PL1603566T3
Authority: PL; Poland
Prior art keywords: map kinase; treating cancer; related diseases; isoquinoline derivatives; kinase related
Prior art date: 2003-03-11

Application number

PL04718960T

Other languages

English (en)

Inventor

David Bryant Batt

Guido Bold

Sunkyu Kim

Timothy Michael Ramsey

Michael Lloyd Sabio

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-11

Filing date

2004-03-10

Publication date

2009-07-31

2004-03-10 Application filed by Novartis Ag filed Critical Novartis Ag

2009-07-31 Publication of PL1603566T3 publication Critical patent/PL1603566T3/pl

Links

206010028980 Neoplasm Diseases 0.000 title abstract 2
201000010099 disease Diseases 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
108091000080 Phosphotransferase Proteins 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title 1
102000020233 phosphotransferase Human genes 0.000 title 1
102000043136 MAP kinase family Human genes 0.000 abstract 1
108091054455 MAP kinase family Proteins 0.000 abstract 1
230000001594 aberrant effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000001441 melanoma Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
102000009929 raf Kinases Human genes 0.000 abstract 1
108010077182 raf Kinases Proteins 0.000 abstract 1
230000019491 signal transduction Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Quinoline Compounds (AREA)

PL04718960T 2003-03-11 2004-03-10 Zastosowanie pochodnych izochinoliny do leczenia raka i chorób związanych z kinezą MAP PL1603566T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US45362403P	2003-03-11	2003-03-11
EP04718960A EP1603566B1 (en)	2003-03-11	2004-03-10	Use of isoquinoline derivatives for treating cancer and map kinase related diseases
PCT/EP2004/002460 WO2004080464A1 (en)	2003-03-11	2004-03-10	Use of isoquinoline derivatives for treating cancer and map kinase related diseases

Publications (1)

Publication Number	Publication Date
PL1603566T3 true PL1603566T3 (pl)	2009-07-31

Family

ID=32990797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04718960T PL1603566T3 (pl)	2003-03-11	2004-03-10	Zastosowanie pochodnych izochinoliny do leczenia raka i chorób związanych z kinezą MAP

Country Status (22)

Country	Link
EP (1)	EP1603566B1 (pl)
JP (1)	JP2006519807A (pl)
KR (1)	KR20050108383A (pl)
CN (1)	CN1758910A (pl)
AT (1)	ATE421324T1 (pl)
AU (1)	AU2004218914A1 (pl)
BR (1)	BRPI0408257A (pl)
CA (1)	CA2518530A1 (pl)
DE (1)	DE602004019193D1 (pl)
ES (1)	ES2318276T3 (pl)
HR (1)	HRP20050788A2 (pl)
IS (1)	IS8064A (pl)
MA (1)	MA27724A1 (pl)
MX (1)	MXPA05009687A (pl)
NO (1)	NO20054647L (pl)
PL (1)	PL1603566T3 (pl)
PT (1)	PT1603566E (pl)
RU (1)	RU2325159C2 (pl)
TN (1)	TNSN05223A1 (pl)
TW (1)	TW200501955A (pl)
WO (1)	WO2004080464A1 (pl)
ZA (1)	ZA200506571B (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7902192B2 (en)	2003-05-15	2011-03-08	Arqule, Inc.	Inhibitors of P38 and methods of using the same
AR045944A1 (es) *	2003-09-24	2005-11-16	Novartis Ag	Derivados de isoquinolina 1.4-disustituidas
WO2006010082A1 (en)	2004-07-08	2006-01-26	Arqule, Inc.	1,4-disubstituted naphtalenes as inhibitors of p38 map kinase
EP2258704A1 (en)	2004-10-19	2010-12-08	ArQule, Inc.	Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
MX2007011866A (es) *	2005-02-25	2007-10-10	Novartis Ag	Combinacion farmaceutica de inhibidores de bcr-abl y raf.
SI1912949T1 (sl) *	2005-07-26	2011-12-30	Sanofi Sa	Cikloheksilamin izokinolonski derivati kot inhibitorji Rho-kinaze
WO2008005910A2 (en)	2006-07-06	2008-01-10	Bristol-Myers Squibb Company	Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
CA2639416C (en) *	2007-09-11	2019-12-31	F. Hoffmann-La Roche Ag	Diagnostic test for susceptibility to b-raf kinase inhibitors
EP2724739B1 (en)	2009-07-30	2015-07-01	Tandem Diabetes Care, Inc.	Portable infusion pump system
EP2545187B1 (en)	2010-03-09	2018-09-05	Dana-Farber Cancer Institute, Inc.	Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy
CA2816088A1 (en) *	2010-10-28	2012-05-03	Viamet Pharmaceuticals, Inc.	Metalloenzyme inhibitor compounds
CN103435430B (zh) *	2013-08-08	2015-02-18	四川大学	一种还原酰胺类化合物的方法
KR102119943B1 (ko)	2018-05-23	2020-06-05	주식회사 포스코	시편배치유닛 및 이를 포함하는 도장밀착성 실험장치
CN112384503A (zh) *	2018-07-02	2021-02-19	洛桑联邦理工学院(Epfl)	乳酸增强化合物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW544448B (en) *	1997-07-11	2003-08-01	Novartis Ag	Pyridine derivatives
EP1107964B8 (en) *	1998-08-11	2010-04-07	Novartis AG	Isoquinoline derivatives with angiogenesis inhibiting activity
CO5200835A1 (es) *	1999-09-28	2002-09-27	Bayer Corp	Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis
PT1254138E (pt) *	2000-02-09	2005-09-30	Novartis Ag	Derivados de piridina que inibem a angiogenese e/ou o receptor de tirosina cinase do vegf
WO2002060392A2 (en) *	2001-01-31	2002-08-08	Synaptic Pharmaceutical Corporation	Use of gal3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
US20030165873A1 (en) *	2001-03-02	2003-09-04	Come Jon H.	Three hybrid assay system
US20050019424A1 (en) *	2001-12-21	2005-01-27	Adams Paul E.	Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives
US7220775B2 (en) *	2002-08-07	2007-05-22	H. Lundbeck A/S	Compound useful for the treatment of neuropathic pain

2004
- 2004-03-10 EP EP04718960A patent/EP1603566B1/en not_active Expired - Lifetime
- 2004-03-10 RU RU2005131168/04A patent/RU2325159C2/ru not_active IP Right Cessation
- 2004-03-10 DE DE602004019193T patent/DE602004019193D1/de not_active Expired - Lifetime
- 2004-03-10 ES ES04718960T patent/ES2318276T3/es not_active Expired - Lifetime
- 2004-03-10 BR BRPI0408257-5A patent/BRPI0408257A/pt not_active IP Right Cessation
- 2004-03-10 PT PT04718960T patent/PT1603566E/pt unknown
- 2004-03-10 KR KR1020057016936A patent/KR20050108383A/ko not_active Ceased
- 2004-03-10 AU AU2004218914A patent/AU2004218914A1/en not_active Abandoned
- 2004-03-10 WO PCT/EP2004/002460 patent/WO2004080464A1/en not_active Ceased
- 2004-03-10 HR HR20050788A patent/HRP20050788A2/xx not_active Application Discontinuation
- 2004-03-10 MX MXPA05009687A patent/MXPA05009687A/es active IP Right Grant
- 2004-03-10 JP JP2006504625A patent/JP2006519807A/ja active Pending
- 2004-03-10 TW TW093106341A patent/TW200501955A/zh unknown
- 2004-03-10 AT AT04718960T patent/ATE421324T1/de active
- 2004-03-10 CA CA002518530A patent/CA2518530A1/en not_active Abandoned
- 2004-03-10 CN CNA2004800065706A patent/CN1758910A/zh active Pending
- 2004-03-10 PL PL04718960T patent/PL1603566T3/pl unknown
2005
- 2005-08-17 ZA ZA200506571A patent/ZA200506571B/en unknown
- 2005-09-09 TN TNP2005000223A patent/TNSN05223A1/en unknown
- 2005-09-23 MA MA28511A patent/MA27724A1/fr unknown
- 2005-10-10 IS IS8064A patent/IS8064A/is unknown
- 2005-10-10 NO NO20054647A patent/NO20054647L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
TNSN05223A1 (en)	2007-06-11
ES2318276T3 (es)	2009-05-01
JP2006519807A (ja)	2006-08-31
DE602004019193D1 (de)	2009-03-12
BRPI0408257A (pt)	2006-03-07
HRP20050788A2 (en)	2006-12-31
KR20050108383A (ko)	2005-11-16
IS8064A (is)	2005-10-10
WO2004080464A1 (en)	2004-09-23
RU2005131168A (ru)	2006-05-27
ZA200506571B (en)	2006-07-26
CA2518530A1 (en)	2004-09-23
RU2325159C2 (ru)	2008-05-27
NO20054647D0 (no)	2005-10-10
ATE421324T1 (de)	2009-02-15
NO20054647L (no)	2005-12-09
PT1603566E (pt)	2009-04-27
AU2004218914A1 (en)	2004-09-23
EP1603566A1 (en)	2005-12-14
MA27724A1 (fr)	2006-01-02
TW200501955A (en)	2005-01-16
CN1758910A (zh)	2006-04-12
EP1603566B1 (en)	2009-01-21
MXPA05009687A (es)	2005-10-20

Publication	Publication Date	Title
SG132672A1 (en)	2007-06-28	1,4-disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases
TNSN05223A1 (en)	2007-06-11	Use of isoquinoline derivatives for treating cancer and map kinase related diseases
ES2176251T3 (es)	2002-12-01	Compuestos utilizados como inhibidores de pde iv y del factor de necrosis tumoral(tnf).
GB0112348D0 (en)	2001-07-11	Compounds
JO2764B1 (en)	2014-03-15	Indole derivatives or benzimidazole derivatives to modify the enzyme AKP kinase
BRPI0411365A (pt)	2006-07-25	derivados de aminopiridina
MXPA05009595A (es)	2005-11-04	Compuestos 7-amino-isoindolilo y sus usos farmaceuticos.
TNSN05044A1 (en)	2007-05-14	Use of ikappab kinase inhibitors for the treatment of pain
PH12013500123A1 (en)	2015-10-26	Hemiasterlin derivatives and uses thereof
EA200500377A1 (ru)	2005-08-25	Пиразольные производные как ингибиторы трансформирующего фактора роста (tgf)
MX2009009574A (es)	2009-09-16	Tratamiento de melanoma.
EA200800516A1 (ru)	2008-08-29	Производные n-фенил-2-пиримидинамина и процесс их получения
TNSN07294A1 (en)	2008-12-31	Treatment of metastasized tumors
PT1390371E (pt)	2006-07-31	Oxazolo- e furopirimidinas e sua utilizacao em medicamentos contra tumores
ATE311389T1 (de)	2005-12-15	Wirkstoffvorläufer von imidazopyridin-derivaten
EA200501310A1 (ru)	2006-06-30	Производные бензолсульфонамидов, способ их получения и их применение для лечения боли
CY1109569T1 (el)	2014-08-13	Υποκατεστημενα παραγωγα κυκλοεξανο-1,4-διαμινης
NO20050640L (no)	2005-03-22	Rutenium anticancer komplekser
TW200504051A (en)	2005-02-01	Novel acridine derivatives and their use as medicaments
DE50211672D1 (de)	2008-03-27	Urokinase-inhibitoren
DE502004007950D1 (en)	2008-10-09	Antitumor wirksame 2-substituierte d-homoestra-1,3,5(10)-trien-3-yl sulfamate
NO20055650L (no)	2006-01-19	Ruteinum (II)-komplekser for behandling av tumorer
ATE423780T1 (de)	2009-03-15	Makrozyclen zur behandlung von krebserkrankungen
ATE328883T1 (de)	2006-06-15	Imidazopyridin-8-one
UY27768A1 (es)	2003-11-28	2-(2,6- diclorofenil)-diarilimidazoles