PL1888556T3 - Metody syntetyzowania związków heterocyklicznych - Google Patents
Metody syntetyzowania związków heterocyklicznychInfo
- Publication number
- PL1888556T3 PL1888556T3 PL06760144T PL06760144T PL1888556T3 PL 1888556 T3 PL1888556 T3 PL 1888556T3 PL 06760144 T PL06760144 T PL 06760144T PL 06760144 T PL06760144 T PL 06760144T PL 1888556 T3 PL1888556 T3 PL 1888556T3
- Authority
- PL
- Poland
- Prior art keywords
- solvent
- methods
- heterocyclic compounds
- synthesizing
- nitroaniline
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002194 synthesizing effect Effects 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 3
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 abstract 2
- ZCWXYZBQDNFULS-UHFFFAOYSA-N 5-chloro-2-nitroaniline Chemical compound NC1=CC(Cl)=CC=C1[N+]([O-])=O ZCWXYZBQDNFULS-UHFFFAOYSA-N 0.000 abstract 2
- 238000009835 boiling Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68189305P | 2005-05-17 | 2005-05-17 | |
| PCT/US2006/019349 WO2006125130A1 (en) | 2005-05-17 | 2006-05-17 | Methods for synthesizing heterocyclic compounds |
| EP06760144A EP1888556B1 (en) | 2005-05-17 | 2006-05-17 | Methods for synthesizing heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1888556T3 true PL1888556T3 (pl) | 2012-03-30 |
Family
ID=37431595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06760144T PL1888556T3 (pl) | 2005-05-17 | 2006-05-17 | Metody syntetyzowania związków heterocyklicznych |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8222413B2 (pl) |
| EP (2) | EP1888556B1 (pl) |
| JP (2) | JP5545925B2 (pl) |
| KR (1) | KR101324863B1 (pl) |
| CN (1) | CN101223157B (pl) |
| AT (1) | ATE530533T1 (pl) |
| AU (1) | AU2006247062A1 (pl) |
| BR (1) | BRPI0610355A2 (pl) |
| CA (1) | CA2608087C (pl) |
| ES (1) | ES2376347T3 (pl) |
| MX (1) | MX2007014381A (pl) |
| PL (1) | PL1888556T3 (pl) |
| PT (1) | PT1888556E (pl) |
| RU (1) | RU2437878C2 (pl) |
| WO (1) | WO2006125130A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1888556T3 (pl) * | 2005-05-17 | 2012-03-30 | Novartis Ag | Metody syntetyzowania związków heterocyklicznych |
| JP5541454B2 (ja) * | 2009-09-16 | 2014-07-09 | Ｊｓｒ株式会社 | 液晶配向剤および液晶表示素子 |
| KR102087662B1 (ko) | 2018-06-20 | 2020-03-11 | 강원대학교산학협력단 | 4-[[4-[3-(사이클로프로필메톡시)-4-(디플루오로메톡시)페닐]-2-티아졸릴]아미노]페놀 화합물을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물 |
| KR102087661B1 (ko) | 2018-07-27 | 2020-03-11 | 강원대학교산학협력단 | Ｇｅｂｒ―７ｂ 화합물을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물 |
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| DE2363459A1 (de) | 1973-12-20 | 1975-06-26 | Basf Ag | Neue fluoreszierende chinolinverbindungen |
| DE3248043A1 (de) | 1982-12-24 | 1984-06-28 | Bayer Ag, 5090 Leverkusen | Fluorogene phosphorsaeureester, verfahren zu deren herstellung sowie verfahren und mittel zum nachweis und zur fluorometrischen bestimmung von phosphaten |
| US4659657A (en) * | 1982-12-24 | 1987-04-21 | Bayer Aktiengesellschaft | Chromogenic and fluorogenic esters for photometric or fluorimetric determination of phosphatases or sulphatases |
| DE3634066A1 (de) | 1986-10-07 | 1988-04-21 | Boehringer Mannheim Gmbh | Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel |
| JPH07121937B2 (ja) | 1987-03-18 | 1995-12-25 | 大塚製薬株式会社 | カルボスチリル誘導体 |
| JPH0699497B2 (ja) | 1987-04-16 | 1994-12-07 | 富士写真フイルム株式会社 | 光重合性組成物 |
| GB8709448D0 (en) | 1987-04-21 | 1987-05-28 | Pfizer Ltd | Heterobicyclic quinoline derivatives |
| DE3932953A1 (de) * | 1989-10-03 | 1991-04-11 | Boehringer Mannheim Gmbh | Neue 2-bicyclo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| GB9107742D0 (en) | 1991-04-11 | 1991-05-29 | Rhone Poulenc Agriculture | New compositions of matter |
| GB9108369D0 (en) | 1991-04-18 | 1991-06-05 | Rhone Poulenc Agriculture | Compositions of matter |
| GB9108547D0 (en) | 1991-04-22 | 1991-06-05 | Fujisawa Pharmaceutical Co | Quinoline derivatives |
| USRE37650E1 (en) * | 1991-05-10 | 2002-04-09 | Aventis Pharmacetical Products, Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
| US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| DK0584222T3 (da) | 1991-05-10 | 1998-02-23 | Rhone Poulenc Rorer Int | Bis-mono- og bicycliske aryl- og heteroarylforbindelser, som inhiberer EGF- og/eller PDGF-receptor-tyrosinkinase |
| US5710158A (en) * | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| US5856115A (en) * | 1991-05-24 | 1999-01-05 | Fred Hutchinson Cancer Research Center | Assay for identification therapeutic agents |
| JP3142378B2 (ja) | 1992-06-22 | 2001-03-07 | ティーディーケイ株式会社 | 有機ｅｌ素子 |
| US5330992A (en) * | 1992-10-23 | 1994-07-19 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolinones |
| US5981569A (en) * | 1992-11-13 | 1999-11-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease |
| US5763441A (en) | 1992-11-13 | 1998-06-09 | Sugen, Inc. | Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis |
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| JPH0743896A (ja) | 1993-07-28 | 1995-02-14 | Toyobo Co Ltd | 光重合性組成物 |
| WO1995018801A1 (en) | 1994-01-08 | 1995-07-13 | Rhone-Poulenc Agriculture Ltd. | Benzimidazolyl quinoline-3-carboxylate derivatives, intermediates thereto, and their use as herbicides |
| JPH0829973A (ja) | 1994-07-11 | 1996-02-02 | Toyobo Co Ltd | 光重合性組成物 |
| JP3441246B2 (ja) | 1995-06-07 | 2003-08-25 | 富士写真フイルム株式会社 | 光重合性組成物 |
| GB9514265D0 (en) | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| US6514971B1 (en) | 1996-03-15 | 2003-02-04 | Zeneca Limited | Cinnoline derivatives and use as medicine |
| DE19610723A1 (de) | 1996-03-19 | 1997-09-25 | Bayer Ag | Elektrolumineszierende Anordnungen unter Verwendung von Blendsystemen |
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| BR9711805A (pt) | 1996-06-20 | 2002-01-15 | Regents The Univesity Of Texas | Compostos e métodos para providenciar preparações farmacologicamente ativas e uso dos mesmos |
| ATE300521T1 (de) | 1996-09-25 | 2005-08-15 | Astrazeneca Ab | Chinolin-derivate die den effekt von wachstumsfaktoren wie vegf vezögern |
| US6245760B1 (en) | 1997-05-28 | 2001-06-12 | Aventis Pharmaceuticals Products, Inc | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
| ATE368665T1 (de) | 1997-08-22 | 2007-08-15 | Astrazeneca Ab | Oxindolylchinazolinderivate als angiogenesehemmer |
| DE19756235A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide |
| CA2312953A1 (en) | 1998-03-31 | 1999-10-07 | Warner-Lambert Company | Quinolones as serine protease inhibitors |
| CA2328893A1 (en) | 1998-05-20 | 1999-11-25 | Kyowa Hakko Kogyo Co., Ltd. | Vegf activity inhibitors |
| ATE274510T1 (de) | 1998-06-19 | 2004-09-15 | Chiron Corp | Glycogen synthase kinase 3 inhibitoren |
| AU4584199A (en) | 1998-06-29 | 2000-01-17 | Du Pont Pharmaceuticals Company | Cyclic carbamates and isoxazolidines as iib/iiia antagonists |
| FR2781218B1 (fr) | 1998-07-15 | 2001-09-07 | Lafon Labor | Compositions pharmaceutiques comprenant des 2-quinolones |
| US6174912B1 (en) * | 1998-08-21 | 2001-01-16 | Dupont Pharmaceuticals Company | Nitrogen substituted imidazo[4,5-C]pyrazoles as corticotropin releasing hormone antagonists |
| DE19841985A1 (de) | 1998-09-03 | 2000-03-09 | Schering Ag | Dialkylsulfonsäure- und Dialkylcarbonsäure-Derivate |
| WO2000020400A1 (en) | 1998-10-05 | 2000-04-13 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions for treating hepatitis c infections |
| IL126953A0 (en) | 1998-11-08 | 1999-09-22 | Yeda Res & Dev | Pharmaceutical compositions comprising porphyrins and some novel porphyrin derivatives |
| KR100373203B1 (ko) | 1999-03-31 | 2003-02-25 | 주식회사 엘지화학 | 새로운 큐마린계 착물 및 이를 이용한 유기 발광 소자 |
| DK1183033T3 (da) | 1999-05-21 | 2006-06-06 | Bristol Myers Squibb Co | Pyrrolotriazininhibitorer af kinaser |
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| WO2001028993A2 (en) | 1999-10-19 | 2001-04-26 | Merck & Co. Inc. | Tyrosine kinase inhibitors |
| US7045133B2 (en) | 2000-01-18 | 2006-05-16 | Ludwig Institute For Cancer Research | VEGF-D/VEGF-C/VEGF peptidomimetic inhibitor |
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| WO2001062252A1 (en) | 2000-02-25 | 2001-08-30 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
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| US6693125B2 (en) | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
| US7081454B2 (en) | 2001-03-28 | 2006-07-25 | Bristol-Myers Squibb Co. | Tyrosine kinase inhibitors |
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| EP1447405A4 (en) | 2001-10-17 | 2005-01-12 | Kirin Brewery | CHINOLIN OR CHINAZOLINE DERIVATIVES THAT PREVENT THE AUTOPHOSPHORYLATION OF RECEPTORS FOR THE FIBROBLAST GROWTH FACTOR |
| BR0313743A (pt) * | 2002-08-23 | 2005-07-05 | Chiron Corp | Benzimidazol quinolinonas e usos destas |
| US7825132B2 (en) * | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
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| BR0316229A (pt) * | 2002-11-13 | 2005-10-04 | Chiron Corp | Métodos de tratamento de câncer e métodos relacionados |
| EP1581539A4 (en) | 2003-01-03 | 2007-09-19 | Bristol Myers Squibb Co | NEW TYROSINE KINASE HEMMER |
| EP1590332B1 (en) * | 2003-01-09 | 2011-04-27 | University of Delhi | A process for the synthesis of bisbenzimidazoles and their derivatives. |
| CA2520124A1 (en) | 2003-03-28 | 2004-10-14 | Chiron Corporation | Use of benzazole compounds for immunopotentiation |
| AU2004288709B2 (en) | 2003-11-07 | 2011-01-06 | Novartis Vaccines And Diagnostics, Inc. | Methods for synthesizing quinolinone compounds |
| BRPI0507891A (pt) * | 2004-02-20 | 2007-07-24 | Chiron Corp | modulação dos processos inflamatório e metastático |
| PL1888556T3 (pl) * | 2005-05-17 | 2012-03-30 | Novartis Ag | Metody syntetyzowania związków heterocyklicznych |
-
2006
- 2006-05-17 PL PL06760144T patent/PL1888556T3/pl unknown
- 2006-05-17 EP EP06760144A patent/EP1888556B1/en active Active
- 2006-05-17 JP JP2008512523A patent/JP5545925B2/ja not_active Expired - Fee Related
- 2006-05-17 BR BRPI0610355-3A patent/BRPI0610355A2/pt not_active IP Right Cessation
- 2006-05-17 US US11/920,078 patent/US8222413B2/en not_active Expired - Fee Related
- 2006-05-17 ES ES06760144T patent/ES2376347T3/es active Active
- 2006-05-17 PT PT06760144T patent/PT1888556E/pt unknown
- 2006-05-17 EP EP11186414.6A patent/EP2465857B1/en active Active
- 2006-05-17 AT AT06760144T patent/ATE530533T1/de active
- 2006-05-17 CA CA2608087A patent/CA2608087C/en not_active Expired - Fee Related
- 2006-05-17 WO PCT/US2006/019349 patent/WO2006125130A1/en not_active Ceased
- 2006-05-17 KR KR1020077029274A patent/KR101324863B1/ko not_active Expired - Fee Related
- 2006-05-17 CN CN2006800259861A patent/CN101223157B/zh not_active Expired - Fee Related
- 2006-05-17 RU RU2007146394/04A patent/RU2437878C2/ru not_active IP Right Cessation
- 2006-05-17 MX MX2007014381A patent/MX2007014381A/es active IP Right Grant
- 2006-05-17 AU AU2006247062A patent/AU2006247062A1/en not_active Abandoned
-
2013
- 2013-08-08 JP JP2013164660A patent/JP2014012682A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATE530533T1 (de) | 2011-11-15 |
| RU2437878C2 (ru) | 2011-12-27 |
| JP2008540675A (ja) | 2008-11-20 |
| EP1888556A1 (en) | 2008-02-20 |
| EP1888556B1 (en) | 2011-10-26 |
| PT1888556E (pt) | 2012-02-03 |
| EP1888556A4 (en) | 2009-12-02 |
| JP5545925B2 (ja) | 2014-07-09 |
| RU2007146394A (ru) | 2009-06-27 |
| KR20080026106A (ko) | 2008-03-24 |
| ES2376347T3 (es) | 2012-03-13 |
| AU2006247062A1 (en) | 2006-11-23 |
| EP2465857B1 (en) | 2014-06-04 |
| CA2608087A1 (en) | 2006-11-23 |
| CA2608087C (en) | 2013-12-10 |
| CN101223157B (zh) | 2013-03-06 |
| BRPI0610355A2 (pt) | 2010-06-15 |
| US20110046376A1 (en) | 2011-02-24 |
| JP2014012682A (ja) | 2014-01-23 |
| EP2465857A1 (en) | 2012-06-20 |
| KR101324863B1 (ko) | 2013-11-01 |
| US8222413B2 (en) | 2012-07-17 |
| WO2006125130A1 (en) | 2006-11-23 |
| CN101223157A (zh) | 2008-07-16 |
| MX2007014381A (es) | 2008-02-06 |
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