PL1894564T3 - Zastosowanie inhibitora IBAT do leczenia lub profilaktyki zaparcia - Google Patents
Zastosowanie inhibitora IBAT do leczenia lub profilaktyki zaparciaInfo
- Publication number
- PL1894564T3 PL1894564T3 PL07023058T PL07023058T PL1894564T3 PL 1894564 T3 PL1894564 T3 PL 1894564T3 PL 07023058 T PL07023058 T PL 07023058T PL 07023058 T PL07023058 T PL 07023058T PL 1894564 T3 PL1894564 T3 PL 1894564T3
- Authority
- PL
- Poland
- Prior art keywords
- constipation
- prophylaxis
- treatment
- ibat inhibitor
- ibat
- Prior art date
Links
- 206010010774 Constipation Diseases 0.000 title 1
- 229940125922 IBAT inhibitor Drugs 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0307918.3A GB0307918D0 (en) | 2003-04-05 | 2003-04-05 | Therapeutic use |
| EP04725081A EP1610770B1 (en) | 2003-04-05 | 2004-04-01 | Use of an ibat inhibitor for the treatment or prophylaxis of constipation |
| EP07023058A EP1894564B1 (en) | 2003-04-05 | 2004-04-01 | Use of an IBAT inhibitor for the treatment or prophylaxis of constipation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1894564T3 true PL1894564T3 (pl) | 2011-11-30 |
Family
ID=9956272
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07023058T PL1894564T3 (pl) | 2003-04-05 | 2004-04-01 | Zastosowanie inhibitora IBAT do leczenia lub profilaktyki zaparcia |
| PL04725081T PL1610770T3 (pl) | 2003-04-05 | 2004-04-01 | Zastosowanie inhibitora IBAT do leczenia lub profilaktyki zaparcia |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04725081T PL1610770T3 (pl) | 2003-04-05 | 2004-04-01 | Zastosowanie inhibitora IBAT do leczenia lub profilaktyki zaparcia |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7514421B2 (pl) |
| EP (2) | EP1610770B1 (pl) |
| JP (2) | JP4870552B2 (pl) |
| KR (1) | KR101321577B1 (pl) |
| CN (1) | CN100366241C (pl) |
| AR (1) | AR043985A1 (pl) |
| AT (2) | ATE387194T1 (pl) |
| AU (1) | AU2004228731B2 (pl) |
| BR (1) | BRPI0408858A (pl) |
| CA (1) | CA2520109C (pl) |
| CO (1) | CO5640076A2 (pl) |
| CY (2) | CY1107424T1 (pl) |
| DE (1) | DE602004012079T2 (pl) |
| DK (2) | DK1894564T3 (pl) |
| ES (2) | ES2368350T3 (pl) |
| GB (1) | GB0307918D0 (pl) |
| IL (1) | IL170913A (pl) |
| IS (1) | IS8113A (pl) |
| MX (1) | MXPA05010706A (pl) |
| MY (1) | MY137757A (pl) |
| NO (1) | NO335140B1 (pl) |
| NZ (1) | NZ542835A (pl) |
| PL (2) | PL1894564T3 (pl) |
| PT (2) | PT1610770E (pl) |
| RU (2) | RU2342928C2 (pl) |
| SA (1) | SA04250066B1 (pl) |
| SI (2) | SI1610770T1 (pl) |
| TW (1) | TWI338577B (pl) |
| UA (1) | UA84141C2 (pl) |
| UY (1) | UY28258A1 (pl) |
| WO (1) | WO2004089350A1 (pl) |
| ZA (1) | ZA200507996B (pl) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| MY131995A (en) | 2001-09-08 | 2007-09-28 | Astrazeneca Ab | Benzothiazepine and benzothiadiazepine derivatives with illeal bile acid transport (ibat) inhibitory activity for the treatment hyperlipidaemia |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) * | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| AR057828A1 (es) * | 2005-09-29 | 2007-12-19 | Astrazeneca Ab | Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica |
| AU2008221673B2 (en) * | 2007-03-08 | 2013-03-28 | Albireo Ab | 2 -substituted- 3 -phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease |
| EP2367554A4 (en) | 2008-11-26 | 2020-03-25 | Satiogen Pharmaceuticals, Inc. | Bile acid reflux inhibitor for the treatment of obesity and diabetes |
| EP4137137A1 (en) | 2010-05-26 | 2023-02-22 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| MX366925B (es) * | 2010-11-04 | 2019-07-31 | Albireo Ab | Inhibidores de ibat para el tratamiento de enfermedades hepaticas. |
| EA038594B1 (ru) | 2011-10-28 | 2021-09-21 | Шайр Хьюман Дженетик Терапис, Инк. | Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени |
| JP6217938B2 (ja) | 2011-10-28 | 2017-10-25 | ルメナ ファーマシューティカルズ エルエルシー | 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 |
| KR20160002773A (ko) | 2013-03-15 | 2016-01-08 | 루메나 파마수티컬즈, 인코포레이티드 | 원발성 담관염 및 염증성 장 질환 치료용 담즙산 재순환 억제제 |
| AU2014229050A1 (en) | 2013-03-15 | 2015-10-22 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| KR101420315B1 (ko) * | 2014-03-19 | 2014-07-17 | 남봉길 | 약학적 액제 조성물 |
| CN106573033A (zh) * | 2014-06-25 | 2017-04-19 | Ea制药株式会社 | 固体制剂及其稳定化方法 |
| CA2952406A1 (en) | 2014-06-25 | 2015-12-30 | Ea Pharma Co., Ltd. | Solid formulation and method for preventing or reducing coloration thereof |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| CA2995798A1 (en) | 2015-08-17 | 2017-02-23 | Nipul Ghanshyambhai PATEL | Liquid formulations containing picosulfate and magnesium citrate |
| JP6954927B2 (ja) | 2016-02-09 | 2021-10-27 | アルビレオ・アクチボラグ | 経口コレスチラミン製剤及びその使用 |
| CA3011595C (en) | 2016-02-09 | 2024-01-02 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| CN108601744B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 口服考来烯胺制剂及其用途 |
| AR108992A1 (es) | 2016-07-08 | 2018-10-17 | Ferring Bv | Formulaciones líquidas estabilizadas que contienen picosulfato |
| US11236099B2 (en) | 2017-06-20 | 2022-02-01 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| WO2019172834A1 (en) | 2018-03-09 | 2019-09-12 | Elobix Ab | Process for the preparation of elobixibat |
| JP7391048B2 (ja) | 2018-06-05 | 2023-12-04 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| KR20210024033A (ko) | 2018-06-20 | 2021-03-04 | 알비레오 에이비 | 오데빅시바트의 약학 제제 |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| CN113453753B (zh) | 2019-02-06 | 2024-07-23 | 阿尔比里奥公司 | 苯并硫氮杂环庚三烯化合物及其用作胆汁酸调节剂的用途 |
| SG11202108566VA (en) | 2019-02-06 | 2021-09-29 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| EP4424363B1 (en) | 2019-02-12 | 2026-04-29 | Mirum Pharmaceuticals, Inc. | Methods for increasing growth in pediatric subjects having cholestatic liver disease |
| WO2021049311A1 (ja) | 2019-09-09 | 2021-03-18 | エロビクス・アーベー | １，５－ベンゾチアゼピン化合物を製造するための方法 |
| CA3158195A1 (en) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CN114786772B (zh) | 2019-12-04 | 2024-04-09 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| JP7665621B2 (ja) | 2019-12-04 | 2025-04-21 | アルビレオ・アクチボラグ | ベンゾチアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| CA3158181A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2021110885A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| ES3002777T3 (en) | 2020-08-03 | 2025-03-07 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| AU2021379076A1 (en) | 2020-11-12 | 2023-06-08 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| BR112023010799A2 (pt) | 2020-12-04 | 2023-10-03 | Albireo Ab | Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares |
| CN117412955A (zh) | 2021-06-03 | 2024-01-16 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| WO2022166680A1 (zh) * | 2021-06-25 | 2022-08-11 | 苏州科睿思制药有限公司 | 奥德昔巴特的晶型及其制备方法和用途 |
| CN119053330A (zh) | 2022-04-22 | 2024-11-29 | 阿尔比里奥公司 | 皮下给药asbt抑制剂 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4771072A (en) | 1985-01-10 | 1988-09-13 | Tanabe Seiyaku Co., Ltd. | Alkoxynaphthalene derivatives |
| JPS6310746A (ja) | 1986-07-01 | 1988-01-18 | Tanabe Seiyaku Co Ltd | ナフタレン誘導体 |
| US4900757A (en) | 1988-12-08 | 1990-02-13 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane |
| DE3930696A1 (de) | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
| US5250524A (en) | 1990-12-06 | 1993-10-05 | Hoechst Aktiengesellschaft | Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals |
| ATE139990T1 (de) | 1991-10-17 | 1996-07-15 | Shionogi & Co | Lignan-analoge, ihre herstellung und hypolipidemische arzneimittel |
| FI108451B (fi) | 1991-12-20 | 2002-01-31 | Hoechst Ag | Menetelmõ polymeeristen ja oligomeeristen sappihappojohdannaisten valmistamiseksi |
| JPH05186357A (ja) | 1991-12-31 | 1993-07-27 | Shigeo Ochi | 飲食物消化分解産物吸収抑制手段 |
| GB9201180D0 (en) * | 1992-01-21 | 1992-03-11 | Glaxo Group Ltd | Chemical compounds |
| GB9203347D0 (en) * | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| DK0573848T3 (da) | 1992-06-12 | 1998-08-10 | Hoechst Ag | Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemidler |
| IL108633A (en) | 1993-02-15 | 1998-07-15 | Wellcome Found | History of Benzothiazepine Hypolipidemic Preparation and Pharmaceutical Preparations Containing Them |
| IL108634A0 (en) | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
| EP0646570B1 (en) | 1993-04-16 | 1998-06-24 | Shionogi & Co., Ltd. | Process for producing lignan compound |
| TW289021B (pl) | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
| EP0624593A3 (de) | 1993-05-08 | 1995-06-07 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel. |
| TW289020B (pl) | 1993-05-08 | 1996-10-21 | Hoechst Sktiengesellschaft | |
| ZA956647B (en) | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
| ES2155136T3 (es) | 1994-09-13 | 2001-05-01 | Monsanto Co | Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato. |
| US5994391A (en) | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| GB9423172D0 (en) | 1994-11-17 | 1995-01-04 | Wellcom Foundation The Limited | Hypolipidemic benzothiazepines |
| DE04010088T1 (de) | 1996-03-11 | 2005-07-14 | G.D. Searle Llc | Neue Benzothiepine mit pharmazeutischer Wirkung. |
| WO1998007749A1 (en) | 1996-08-23 | 1998-02-26 | Human Genome Sciences, Inc. | Novel human growth factors |
| JPH1072371A (ja) | 1996-08-28 | 1998-03-17 | Sankyo Co Ltd | 回腸型胆汁酸トランスポーター阻害剤 |
| GB9704208D0 (en) | 1997-02-28 | 1997-04-16 | Glaxo Group Ltd | Chemical compounds |
| NZ337830A (en) | 1997-03-11 | 2001-07-27 | G | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| ATE242258T1 (de) | 1997-03-14 | 2003-06-15 | Aventis Pharma Gmbh | Hypolipidemische 1,4-benzothiazepin-1,1-dioxide |
| DE19845402B4 (de) | 1998-10-02 | 2005-04-07 | Aventis Pharma Deutschland Gmbh | Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| ATE268758T1 (de) | 1997-04-04 | 2004-06-15 | Aventis Pharma Gmbh | Hypolipidämische propanolaminderivate |
| AU7552198A (en) | 1997-06-11 | 1998-12-30 | Sankyo Company Limited | Benzylamine derivatives |
| AUPO763197A0 (en) | 1997-06-30 | 1997-07-24 | Sigma Pharmaceuticals Pty Ltd | Health supplement |
| BR9814300A (pt) | 1997-12-19 | 2002-02-05 | Searle & Co | Método de preparação de óxidos de tetraidrobenzotiepina enanciomericamente enriquecidos |
| GB9800428D0 (en) | 1998-01-10 | 1998-03-04 | Glaxo Group Ltd | Chemical compounds |
| DE19825804C2 (de) | 1998-06-10 | 2000-08-24 | Aventis Pharma Gmbh | 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE19845405C2 (de) | 1998-10-02 | 2000-07-13 | Aventis Pharma Gmbh | Arylsubstituierte Propanolaminderivate und deren Verwendung |
| DE19845403B4 (de) | 1998-10-02 | 2005-02-10 | Aventis Pharma Deutschland Gmbh | Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE19845406C2 (de) | 1998-10-02 | 2001-10-18 | Aventis Pharma Gmbh | Substituierte 1,3-Diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)- propanolderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| WO2000035889A1 (en) | 1998-12-11 | 2000-06-22 | Sankyo Company, Limited | Substituted benzylamines |
| DK1140189T3 (da) | 1998-12-23 | 2003-09-15 | Searle Llc | Kombinationer af ileal galdesyre-transportinhibitorer og fibrinsyrederivater til cardiovaskulære indikationer |
| JP2002533415A (ja) | 1998-12-23 | 2002-10-08 | ジー．ディー．サール エルエルシー | 心臓血管に適用するための回腸胆汁酸輸送阻害剤およびニコチン酸誘導体の組み合わせ |
| EA004877B1 (ru) | 1998-12-23 | 2004-08-26 | Джи.Ди.Сирл Ллс | Сочетания ингибиторов транспорта желчных кислот в подвздошной кишке и агентов, секвестрирующих желчные кислоты, для сердечно-сосудистых показаний |
| DE69911058T2 (de) | 1998-12-23 | 2004-06-03 | G.D. Searle Llc, Chicago | Kombinationen einem ibat inhibitor und einem mtp inhibitor für kardiovaskuläre indikationen |
| BR9916486A (pt) | 1998-12-23 | 2002-02-05 | Searle Llc | Combinações de inibidores do transporte de ácidos biliares no ìleo e inibidores da proteìna de transferência do ester colesteril para indicações cardiovasculares |
| CN1195748C (zh) | 1999-02-12 | 2005-04-06 | G.D.瑟尔有限公司 | 具有作为回肠胆汁酸转运和牛磺胆酸摄取抑制剂活性的新的1,2－苯并硫氮杂 |
| DE19916108C1 (de) | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| SE9901387D0 (sv) | 1999-04-19 | 1999-04-19 | Astra Ab | New pharmaceutical foromaulations |
| US6287609B1 (en) | 1999-06-09 | 2001-09-11 | Wisconsin Alumni Research Foundation | Unfermented gel fraction from psyllium seed husks |
| TR200002099A2 (tr) | 1999-07-22 | 2001-06-21 | Sankyo Company Limited | Siklobüten türevleri, bunların hazırlanması ve terapötik kullanımları |
| WO2001034570A1 (en) | 1999-11-08 | 2001-05-17 | Sankyo Company, Limited | Nitrogenous heterocycle derivatives |
| JP2003523336A (ja) | 2000-02-18 | 2003-08-05 | メルク エンド カムパニー インコーポレーテッド | 糖尿病及び脂質障害のためのアリールオキシ酢酸 |
| SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| WO2001068096A2 (en) | 2000-03-10 | 2001-09-20 | Pharmacia Corporation | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| EP1286984A2 (en) | 2000-03-10 | 2003-03-05 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
| US20020183307A1 (en) | 2000-07-26 | 2002-12-05 | Tremont Samuel J. | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake |
| SE0003766D0 (sv) | 2000-10-18 | 2000-10-18 | Astrazeneca Ab | Novel formulation |
| EG26979A (en) * | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| WO2002053548A1 (fr) | 2000-12-27 | 2002-07-11 | Banyu Pharmaceutical Co.,Ltd. | Derives de la benzothiazepine |
| US6506921B1 (en) * | 2001-06-29 | 2003-01-14 | Virginia Tech Intellectual Properties, Inc. | Amine compounds and curable compositions derived therefrom |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| AR036873A1 (es) * | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento |
| MY131995A (en) * | 2001-09-08 | 2007-09-28 | Astrazeneca Ab | Benzothiazepine and benzothiadiazepine derivatives with illeal bile acid transport (ibat) inhibitory activity for the treatment hyperlipidaemia |
| GB0201850D0 (en) | 2002-01-26 | 2002-03-13 | Astrazeneca Ab | Therapeutic treatment |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0216321D0 (en) | 2002-07-13 | 2002-08-21 | Astrazeneca Ab | Therapeutic treatment |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) * | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
-
2003
- 2003-04-05 GB GBGB0307918.3A patent/GB0307918D0/en not_active Ceased
-
2004
- 2004-04-01 UA UAA200508758A patent/UA84141C2/ru unknown
- 2004-04-01 AT AT04725081T patent/ATE387194T1/de active
- 2004-04-01 KR KR1020057018959A patent/KR101321577B1/ko not_active Expired - Lifetime
- 2004-04-01 PL PL07023058T patent/PL1894564T3/pl unknown
- 2004-04-01 PL PL04725081T patent/PL1610770T3/pl unknown
- 2004-04-01 CA CA2520109A patent/CA2520109C/en not_active Expired - Lifetime
- 2004-04-01 PT PT04725081T patent/PT1610770E/pt unknown
- 2004-04-01 ES ES07023058T patent/ES2368350T3/es not_active Expired - Lifetime
- 2004-04-01 DK DK07023058.6T patent/DK1894564T3/da active
- 2004-04-01 DK DK04725081T patent/DK1610770T3/da active
- 2004-04-01 JP JP2006506065A patent/JP4870552B2/ja not_active Expired - Lifetime
- 2004-04-01 DE DE602004012079T patent/DE602004012079T2/de not_active Expired - Lifetime
- 2004-04-01 AU AU2004228731A patent/AU2004228731B2/en not_active Ceased
- 2004-04-01 CN CNB200480009415XA patent/CN100366241C/zh not_active Expired - Lifetime
- 2004-04-01 US US10/551,999 patent/US7514421B2/en not_active Expired - Lifetime
- 2004-04-01 ES ES04725081T patent/ES2299832T3/es not_active Expired - Lifetime
- 2004-04-01 PT PT07023058T patent/PT1894564E/pt unknown
- 2004-04-01 SI SI200430662T patent/SI1610770T1/sl unknown
- 2004-04-01 MX MXPA05010706A patent/MXPA05010706A/es active IP Right Grant
- 2004-04-01 NZ NZ542835A patent/NZ542835A/en not_active IP Right Cessation
- 2004-04-01 BR BRPI0408858-1A patent/BRPI0408858A/pt not_active Application Discontinuation
- 2004-04-01 AT AT07023058T patent/ATE513550T1/de active
- 2004-04-01 SI SI200431710T patent/SI1894564T1/sl unknown
- 2004-04-01 WO PCT/GB2004/001396 patent/WO2004089350A1/en not_active Ceased
- 2004-04-01 EP EP04725081A patent/EP1610770B1/en not_active Expired - Lifetime
- 2004-04-01 EP EP07023058A patent/EP1894564B1/en not_active Expired - Lifetime
- 2004-04-01 RU RU2005128792/15A patent/RU2342928C2/ru active
- 2004-04-02 MY MYPI20041236A patent/MY137757A/en unknown
- 2004-04-05 UY UY28258A patent/UY28258A1/es not_active Application Discontinuation
- 2004-04-05 SA SA04250066A patent/SA04250066B1/ar unknown
- 2004-04-05 TW TW093109383A patent/TWI338577B/zh not_active IP Right Cessation
- 2004-04-06 AR ARP040101159A patent/AR043985A1/es not_active Application Discontinuation
-
2005
- 2005-09-15 IL IL170913A patent/IL170913A/en unknown
- 2005-09-21 NO NO20054369A patent/NO335140B1/no unknown
- 2005-10-03 ZA ZA200507996A patent/ZA200507996B/xx unknown
- 2005-10-25 CO CO05108676A patent/CO5640076A2/es not_active Application Discontinuation
- 2005-11-01 IS IS8113A patent/IS8113A/is unknown
-
2008
- 2008-04-24 CY CY20081100461T patent/CY1107424T1/el unknown
- 2008-07-17 RU RU2008129204/15A patent/RU2482850C2/ru active
-
2011
- 2011-06-07 JP JP2011127175A patent/JP5421326B2/ja not_active Expired - Lifetime
- 2011-09-07 CY CY20111100862T patent/CY1111995T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA200507996B (en) | Use of an IBAT inhibitor for the treatment or prophylaxis of constipation | |
| ZA200501913B (en) | New compounds for the inhibition of rotamases and use thereof | |
| EP1628530B8 (en) | Methods and compositions for the prevention and treatment of sepsis | |
| PL375532A1 (pl) | Związki benzimidazol-1-ilotiofenowe do leczenia nowotworów | |
| HUS2200036I1 (hu) | Dihidroimidazolonok alkalmazása kutyák kezelésére | |
| GB2418025B (en) | Device for the prevention or treatment of ulcers | |
| GB0329874D0 (en) | Compounds useful for the treatment of diseases | |
| AU2003258145A8 (en) | Substituted phenylindoles for the treatment of hiv | |
| IL164899A0 (en) | Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors | |
| AU2001228703A1 (en) | Use of cox-2 inhibitors for the treatment of constipation | |
| IL165839A0 (en) | Compounds useful for the treatment of cancer compositions thereof and methods therewith | |
| IL162818A0 (en) | Combination therapy for the treatment of bacterialinfections | |
| PL375564A1 (pl) | Podstawione 5-chroman-5-ylo-etyloaminy i ich zastosowanie do leczenia jaskry | |
| LT1496918T (lt) | Natrio meta-arsenito naudojimas navikams gydyti | |
| AU2003270683A8 (en) | Compounds for the treatment of premature ejaculation | |
| AU2003291368A8 (en) | Compounds for the treatment of tobacco dependence and withdrawal | |
| AU2003205452A8 (en) | Bmp inhibitors for the treatment of spondyloarthropathies | |
| GB2410744B (en) | Kinase inhibitors for the treatment of disease | |
| AU2003240174A8 (en) | Compositions for the treatment of edematous-firbrosclerotic panniculopathy | |
| IL162492A0 (en) | Use of alkylphosphocholines for the preventative treatment of protozoandiseases | |
| AU2000272704A1 (en) | Use of compounds for the treatment of obesity | |
| IL170706A0 (en) | Use of atii antagonist for the treatment or prevention of metabolic syndrome | |
| AU2002343085A1 (en) | Tnf-alpha inhibitors for the treatment of hepatic diseases | |
| IL165870A0 (en) | Use of chymase inhibitors for the prevention and/or | |
| GB2398069B (en) | Treatment of ferrous waste |