PL1983000T3 - Sposób leczenia stwardnienia rozsianego przez hamowanie aktywności IL-17 - Google Patents
Sposób leczenia stwardnienia rozsianego przez hamowanie aktywności IL-17Info
- Publication number
- PL1983000T3 PL1983000T3 PL08008814T PL08008814T PL1983000T3 PL 1983000 T3 PL1983000 T3 PL 1983000T3 PL 08008814 T PL08008814 T PL 08008814T PL 08008814 T PL08008814 T PL 08008814T PL 1983000 T3 PL1983000 T3 PL 1983000T3
- Authority
- PL
- Poland
- Prior art keywords
- activity
- treatment
- multiple sclerosis
- inhibiting
- prophylaxis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0327181A GB0327181D0 (en) | 2003-11-21 | 2003-11-21 | Biological products |
| GB0417115A GB0417115D0 (en) | 2004-07-30 | 2004-07-30 | Biological products |
| EP04798568A EP1687026B1 (en) | 2003-11-21 | 2004-11-16 | Method for the treatment of multiple sclerosis by inhibiting il-17 activity |
| EP08008814.9A EP1983000B1 (en) | 2003-11-21 | 2004-11-16 | Method for the treatment of multiple sclerosis by inhibiting IL-17 activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1983000T3 true PL1983000T3 (pl) | 2016-02-29 |
Family
ID=34635441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08008814T PL1983000T3 (pl) | 2003-11-21 | 2004-11-16 | Sposób leczenia stwardnienia rozsianego przez hamowanie aktywności IL-17 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20070269428A1 (pl) |
| EP (3) | EP2974742A1 (pl) |
| JP (1) | JP4833850B2 (pl) |
| AT (1) | ATE395083T1 (pl) |
| AU (1) | AU2004292393C1 (pl) |
| CA (1) | CA2544920C (pl) |
| CY (1) | CY1116992T1 (pl) |
| DE (1) | DE602004013825D1 (pl) |
| DK (1) | DK1983000T3 (pl) |
| ES (2) | ES2554645T3 (pl) |
| HR (1) | HRP20151210T1 (pl) |
| HU (1) | HUE026260T2 (pl) |
| PL (1) | PL1983000T3 (pl) |
| PT (1) | PT1983000E (pl) |
| SI (1) | SI1983000T1 (pl) |
| WO (1) | WO2005051422A1 (pl) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1013141A (en) * | 1960-12-30 | 1965-12-15 | Secr Aviation | Improvements in or relating to the stabilisation of electronic oscillators |
| US20070160576A1 (en) * | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
| US20040219150A1 (en) * | 2003-02-06 | 2004-11-04 | Cua Daniel J. | Uses of mammalian cytokine; related reagents |
| ES2424353T3 (es) | 2003-07-08 | 2013-10-01 | Genentech, Inc. | Polipéptidos heterólogos IL-17 A/F y usos terapéuticos de los mismos |
| GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
| GB0425569D0 (en) | 2004-11-19 | 2004-12-22 | Celltech R&D Ltd | Biological products |
| LT2481753T (lt) | 2005-12-13 | 2018-05-25 | Eli Lilly And Company | Anti-il-17 antikūnai |
| WO2007071439A1 (en) * | 2005-12-22 | 2007-06-28 | Laboratoires Serono S.A. | Soluble il-17rc variant and uses thereof |
| US7910703B2 (en) | 2006-03-10 | 2011-03-22 | Zymogenetics, Inc. | Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use |
| CA2646478A1 (en) | 2006-03-10 | 2007-09-20 | Zymogenetics, Inc. | Antibodies that bind both il-17a and il-17f and methods of using the same |
| US7790163B2 (en) | 2006-03-10 | 2010-09-07 | Zymogenetics, Inc. | Antibodies that bind both IL-17A and IL-17F and methods of using the same |
| GB0612928D0 (en) * | 2006-06-29 | 2006-08-09 | Ucb Sa | Biological products |
| CA2660463C (en) | 2006-08-11 | 2013-07-16 | Schering Corporation | Antibodies to il-17a |
| GB0620729D0 (en) | 2006-10-18 | 2006-11-29 | Ucb Sa | Biological products |
| JPWO2009054454A1 (ja) | 2007-10-24 | 2011-03-03 | 国立大学法人 東京医科歯科大学 | カテプシン阻害剤を有効成分として含有するToll様受容体のシグナル伝達の調整剤 |
| WO2009082624A2 (en) * | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| GB0807413D0 (en) * | 2008-04-23 | 2008-05-28 | Ucb Pharma Sa | Biological products |
| KR20150002874A (ko) | 2008-05-05 | 2015-01-07 | 노비뮨 에스 에이 | 항-il-17a/il-17f 교차-반응성 항체 및 그의 사용 방법 |
| KR101318549B1 (ko) | 2008-09-29 | 2013-10-16 | 로슈 글리카트 아게 | 인간 il17 에 대한 항체 및 이의 용도 |
| US8211434B2 (en) * | 2008-11-26 | 2012-07-03 | Allergan, Inc. | KLK-13 antibody inhibitor for treating dry eye |
| WO2010062858A1 (en) * | 2008-11-26 | 2010-06-03 | Allergan, Inc. | Il-17 antibody inhibitor for treating dry eye |
| US8137671B2 (en) | 2009-05-05 | 2012-03-20 | Genentech, Inc. | Anti-IL-17F antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| RU2550272C2 (ru) | 2009-08-27 | 2015-05-10 | Коваген Аг | Новые il-17-связывающие соединения и их медицинское применение |
| US8828668B2 (en) | 2010-02-11 | 2014-09-09 | The Board Of Trustees Of The Leland Stanford Junior University | Markers for determination of patient responsiveness |
| GB201100282D0 (en) | 2011-01-07 | 2011-02-23 | Ucb Pharma Sa | Biological methods |
| US10208349B2 (en) | 2011-01-07 | 2019-02-19 | Ucb Biopharma Sprl | Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy |
| ME02734B (me) | 2011-01-14 | 2017-10-20 | Ucb Biopharma Sprl | Antitelo koje vezuje il-17a i il-17f |
| CA2824824A1 (en) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Monovalent antigen binding proteins |
| JP5764677B2 (ja) | 2011-02-28 | 2015-08-19 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 抗原結合タンパク質 |
| EP2834273B1 (en) | 2012-04-05 | 2018-08-22 | F.Hoffmann-La Roche Ag | Bispecific antibodies against human tweak and human il17 and uses thereof |
| WO2014155278A2 (en) * | 2013-03-26 | 2014-10-02 | Novartis Ag | Methods of treating autoimmune diseases using il-17 antagonists |
| WO2014161570A1 (en) | 2013-04-03 | 2014-10-09 | Roche Glycart Ag | Antibodies against human il17 and uses thereof |
| BR112016006929A2 (pt) | 2013-10-11 | 2017-09-19 | Hoffmann La Roche | Anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, métodos de preparação de anticorpo, de tratamento de pacientes e de geração de um anticorpo, composição farmacêutica e uso do anticorpo |
| UA117289C2 (uk) | 2014-04-02 | 2018-07-10 | Ф. Хоффманн-Ля Рош Аг | Мультиспецифічне антитіло |
| JP6951825B2 (ja) | 2015-09-04 | 2021-10-20 | ザ スクリプス リサーチ インスティテュート | インスリン免疫グロブリン融合タンパク質 |
| EP3150637A1 (en) | 2015-10-02 | 2017-04-05 | F. Hoffmann-La Roche AG | Multispecific antibodies |
| RU2680011C2 (ru) | 2016-04-29 | 2019-02-14 | Закрытое Акционерное Общество "Биокад" | Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| GB2561352B (en) * | 2017-04-10 | 2023-01-18 | Genome Res Ltd | Animal models and therapeutic molecules |
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| US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
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| DE69531148T2 (de) | 1994-01-31 | 2004-04-29 | Trustees Of Boston University, Boston | Bibliotheken aus polyklonalen antikörpern |
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| US20070160576A1 (en) | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
| AU2002324625B2 (en) | 2001-08-07 | 2008-05-08 | Immunex Corporation | Interleukin-1 receptors in the treatment of diseases |
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| CA2518371A1 (en) | 2003-03-14 | 2004-09-30 | Wyeth | Antibodies against human il-21 receptor and uses therefor |
| RU2006101702A (ru) | 2003-06-23 | 2006-09-10 | Дженетикс Инститьют, Ллс (Us) | Антитела против интерлейкина-22 и их применения |
| GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| AU2004253738A1 (en) | 2003-07-01 | 2005-01-13 | Ucb Pharma S.A. | Modified antibody Fab fragments |
| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| LT2481753T (lt) | 2005-12-13 | 2018-05-25 | Eli Lilly And Company | Anti-il-17 antikūnai |
-
2004
- 2004-11-16 AU AU2004292393A patent/AU2004292393C1/en not_active Ceased
- 2004-11-16 PT PT80088149T patent/PT1983000E/pt unknown
- 2004-11-16 DE DE602004013825T patent/DE602004013825D1/de not_active Expired - Lifetime
- 2004-11-16 ES ES08008814.9T patent/ES2554645T3/es not_active Expired - Lifetime
- 2004-11-16 EP EP15183030.4A patent/EP2974742A1/en not_active Withdrawn
- 2004-11-16 CA CA2544920A patent/CA2544920C/en not_active Expired - Fee Related
- 2004-11-16 DK DK08008814.9T patent/DK1983000T3/en active
- 2004-11-16 ES ES04798568T patent/ES2305879T3/es not_active Expired - Lifetime
- 2004-11-16 PL PL08008814T patent/PL1983000T3/pl unknown
- 2004-11-16 EP EP04798568A patent/EP1687026B1/en not_active Revoked
- 2004-11-16 US US10/580,164 patent/US20070269428A1/en not_active Abandoned
- 2004-11-16 JP JP2006540587A patent/JP4833850B2/ja not_active Expired - Fee Related
- 2004-11-16 EP EP08008814.9A patent/EP1983000B1/en not_active Expired - Lifetime
- 2004-11-16 WO PCT/GB2004/004850 patent/WO2005051422A1/en not_active Ceased
- 2004-11-16 HU HUE08008814A patent/HUE026260T2/en unknown
- 2004-11-16 SI SI200432278T patent/SI1983000T1/sl unknown
- 2004-11-16 AT AT04798568T patent/ATE395083T1/de not_active IP Right Cessation
-
2008
- 2008-11-24 US US12/277,030 patent/US7931900B2/en not_active Expired - Fee Related
-
2015
- 2015-11-11 HR HRP20151210TT patent/HRP20151210T1/hr unknown
- 2015-11-30 CY CY20151101086T patent/CY1116992T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1983000A2 (en) | 2008-10-22 |
| ES2554645T3 (es) | 2015-12-22 |
| DK1983000T3 (en) | 2015-12-07 |
| HRP20151210T1 (hr) | 2015-12-04 |
| ATE395083T1 (de) | 2008-05-15 |
| US20070269428A1 (en) | 2007-11-22 |
| HUE026260T2 (en) | 2016-06-28 |
| DE602004013825D1 (de) | 2008-06-26 |
| EP1983000A3 (en) | 2011-07-27 |
| JP4833850B2 (ja) | 2011-12-07 |
| PT1983000E (pt) | 2015-12-30 |
| EP1687026B1 (en) | 2008-05-14 |
| CA2544920C (en) | 2012-09-11 |
| CA2544920A1 (en) | 2005-06-09 |
| EP1983000B1 (en) | 2015-09-02 |
| WO2005051422A1 (en) | 2005-06-09 |
| SI1983000T1 (sl) | 2015-12-31 |
| AU2004292393A1 (en) | 2005-06-09 |
| EP1687026A1 (en) | 2006-08-09 |
| US20090191200A1 (en) | 2009-07-30 |
| EP2974742A1 (en) | 2016-01-20 |
| JP2007511593A (ja) | 2007-05-10 |
| AU2004292393C1 (en) | 2011-08-04 |
| ES2305879T3 (es) | 2008-11-01 |
| US7931900B2 (en) | 2011-04-26 |
| CY1116992T1 (el) | 2017-04-05 |
| AU2004292393B2 (en) | 2009-10-08 |
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