PL2027280T3 - Sposób wytwarzania polimyksyny B wykorzystujący (paeni) bacillus polymyxa - Google Patents

Sposób wytwarzania polimyksyny B wykorzystujący (paeni) bacillus polymyxa

Info

Publication number: PL2027280T3
Authority: PL; Poland
Prior art keywords: polymyxin; bacillus polymyxa; paeni; employing; preparation
Prior art date: 2006-06-15

Application number

PL07748763T

Other languages

English (en)

Inventor

Ivan Varga

Katarína Vrúblová

Ludmila Kovácová

Jana Kluková

Original Assignee

Biotika As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-15

Filing date

2007-05-21

Publication date

2010-12-31

2007-05-21 Application filed by Biotika As filed Critical Biotika As

2010-12-31 Publication of PL2027280T3 publication Critical patent/PL2027280T3/pl

Links

241000194105 Paenibacillus polymyxa Species 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
229960005266 polymyxin b Drugs 0.000 title abstract 2
ZBJNZFQKYZCUJU-PAHFEQBRSA-N N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methylheptanamide (6S)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide Polymers CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O.CC[C@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O ZBJNZFQKYZCUJU-PAHFEQBRSA-N 0.000 title 1
238000000855 fermentation Methods 0.000 abstract 2
230000004151 fermentation Effects 0.000 abstract 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
108010093965 Polymyxin B Proteins 0.000 abstract 1
238000005273 aeration Methods 0.000 abstract 1
-1 ammonium ions Chemical class 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
239000000706 filtrate Substances 0.000 abstract 1
239000008103 glucose Substances 0.000 abstract 1
238000009776 industrial production Methods 0.000 abstract 1
238000012423 maintenance Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229920000024 polymyxin B Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL07748763T 2006-06-15 2007-05-21 Sposób wytwarzania polimyksyny B wykorzystujący (paeni) bacillus polymyxa PL2027280T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
SK90-2006A SK287293B6 (sk)	2006-06-15	2006-06-15	Spôsob fermentácie polymyxínu B pomocou produkčného mikroorganizmu Bacillus polymyxa
PCT/SK2007/050011 WO2007145602A1 (en)	2006-06-15	2007-05-21	Process for the preparation of polymyxin b employing ( paeni ) bacillus polymyxa
EP07748763A EP2027280B1 (en)	2006-06-15	2007-05-21	Process for the preparation of polymyxin b employing (paeni)bacillus polymyxa

Publications (1)

Publication Number	Publication Date
PL2027280T3 true PL2027280T3 (pl)	2010-12-31

Family

ID=38328655

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL07748763T PL2027280T3 (pl)	2006-06-15	2007-05-21	Sposób wytwarzania polimyksyny B wykorzystujący (paeni) bacillus polymyxa

Country Status (8)

Country	Link
US (1)	US8119371B2 (pl)
EP (1)	EP2027280B1 (pl)
AT (1)	ATE474060T1 (pl)
ES (1)	ES2349188T3 (pl)
PL (1)	PL2027280T3 (pl)
SI (1)	SI2027280T1 (pl)
SK (1)	SK287293B6 (pl)
WO (1)	WO2007145602A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101171862B1 (ko)	2009-09-18	2012-08-31	한국생명공학연구원	재조합 바실러스 균을 이용한 폴리믹신 생산방법
WO2010058427A2 (en)	2008-11-24	2010-05-27	Reliance Life Sciences Pvt. Ltd.	Process for production and purification of polymyxin b sulfate
CN103509839B (zh) *	2013-10-12	2015-02-25	河北圣雪大成制药有限责任公司	一种降低多粘菌素e发酵液中氨氮含量的方法
CN103540633B (zh) *	2013-10-24	2016-01-20	河北圣雪大成制药有限责任公司	一种发酵法生产多粘菌素b的方法
CN104774892B (zh) *	2014-01-13	2018-11-30	上海医药工业研究院	一种用于生产多黏菌素b的发酵培养基及其制备方法和用途
CN110551786B (zh) *	2019-09-12	2021-12-07	浙江海正药业股份有限公司	一种提高a40926 b0产量的发酵培养基及其方法
CN113755548A (zh) *	2021-09-02	2021-12-07	河北圣雪大成制药有限责任公司	一种提高多粘菌素b发酵水平的方法
CN115181774B (zh) *	2022-08-04	2025-11-18	河北圣雪大成制药有限责任公司	一种提高多粘菌素b有效组分含量的发酵液制备方法

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2565057A (en)	1946-12-21	1951-08-21	Burroughs Wellcome Co	Polymyxin antibiotic
US2602041A (en) *	1947-04-21	1952-07-01	Burroughs Wellcome Co	Method for the manufacture of polymyxin
US2571104A (en) *	1948-05-07	1951-10-16	Robert G Benedict	Polymyxin production
US2595605A (en) *	1948-08-07	1952-05-06	American Cyanamid Co	Method of producing polymyxin
GB742589A (en)	1953-01-03	1955-12-30	Distillers Co Yeast Ltd	Recovery of polymyxin
GB757246A (en)	1953-02-13	1956-09-19	Schaefer Brewing Co	Improvements relating to the treatment of fermentations employing yeasts
FR1096978A (fr)	1953-02-13	1955-06-28	Schaefer Brewing Co	Perfectionnements apportés aux traitements de fermentations pour lesquels on utilise des levures
GB755370A (en)	1953-07-23	1956-08-22	Schaefer Brewing Co	Improvements relating to the control of micro-biological growth in beer
US2964406A (en)	1953-12-08	1960-12-13	Schaefer Brewing Co	Inhibiting microbiological growth in fermentations employing yeast
GB782926A (en)	1955-01-06	1957-09-18	Distillers Co Yeast Ltd	Purification of polymyxin
GB874188A (en)	1957-11-27	1961-08-02	Pfizer & Co C	Preparation of steroids
US3094460A (en)	1959-01-20	1963-06-18	Upjohn Co	Decoyinine
CH392779A (fr)	1960-03-29	1965-05-31	Chinoin Gyogyszer Es Vegyeszet	Verfahren zur Herstellung eines Heilmittels gegen Polycythaemie
GB991602A (en)	1961-03-10	1965-05-12	Wellcome Found	Antibiotics and their purification
US3132994A (en)	1961-03-10	1964-05-12	Burroughs Wellcome Co	Polymyxin purification
US3281331A (en)	1961-11-08	1966-10-25	Astra Ab	Process of isolating and separating proteolytic enzymes
FR1357969A (fr)	1962-05-19	1964-04-10	Hoechst Ag	Procédé pour augmenter la croissance de bactéries et de streptomycètes et la production de métabolites par ces organismes
GB979887A (en)	1962-06-12	1965-01-06	Gert Svanholm	Improvements in or relating to the recovery and purification of amphoteric and basic antibiotics
GB1064300A (en)	1962-12-17	1967-04-05	Bristol Banyu Res Inst Ltd	A new antibiotic coumermycin
GB1089765A (en)	1963-08-30	1967-11-08	Wellcome Found	Purification of polymyxin
US3318867A (en)	1964-08-20	1967-05-09	Upjohn Co	Process for separating nitrogen-basic materials from aqueous solution
GB1119668A (en)	1965-08-26	1968-07-10	Walter Koch	Method of testing microbial sensitivity to drugs
FR1473145A (fr)	1966-01-17	1967-03-17	Rhone Poulenc Sa	Procédé de fabrication de l'acide d. lactique et de ses sels
US3679742A (en)	1969-05-08	1972-07-25	Zaidan Hojin Biseibutsu	Negamycin
JPS5544597B1 (pl)	1969-06-09	1980-11-13
US3929571A (en)	1973-05-24	1975-12-30	Ajinomoto Kk	Process for preparing L-lysine
JPS5831918B2 (ja)	1976-10-27	1983-07-09	塩野義製薬株式会社	新規抗生物質ポリミキシンｓ↓１
JPS5946502B2 (ja)	1977-02-02	1984-11-13	塩野義製薬株式会社	新規抗生物質ポリミキシンｔ↓１
DE2733091C2 (de) *	1977-07-22	1982-08-12	Friedhelm 4600 Dortmund Heymann	Vorrichtung zur Bearbeitung der Oberfläche von unregelmäßige Konturen aufweisenden Körpern
JPS54128501A (en)	1978-03-22	1979-10-05	Squibb & Sons Inc	Polymyxin f and its manufacture
USRE32455E (en)	1978-10-16	1987-07-07	Eli Lilly And Company	A-21978 antibiotics and process for their production
JPS5581584A (en)	1978-12-14	1980-06-19	Eiken Kagaku Kk	Culture for isolating serratia
JPS5648897A (en)	1979-09-25	1981-05-02	Nitsusui Seiyaku Kk	Selective isolation medium for cholera bacillus
US4444883A (en)	1982-08-09	1984-04-24	E. R. Squibb & Sons, Inc.	Method for the isolation and presumptive diagnosis of Bacillus cereus and tellurite medium therefor
CA1205029A (en)	1984-02-21	1986-05-27	George L. Evans	Selective agent for group a streptococci
JPS60184100A (ja)	1984-03-02	1985-09-19	Toray Ind Inc	ポリミキシンの固定化方法
JPH062049B2 (ja)	1984-03-24	1994-01-12	栄研化学株式会社	レジオネラ菌選択分離用培地
EP0173937A2 (en)	1984-09-07	1986-03-12	Miles Laboratories, Inc.	Method of increasing the permeability of yeast cells
CA1267374A (en)	1984-09-07	1990-04-03	George Boguslawski	Enhanced inhibition of yeast cell growth
US4912036A (en)	1986-09-24	1990-03-27	Eastman Kodak Company	Rapid differentiation of bacteria using cyclic polypeptide antibiotics
GB8624253D0 (en)	1986-10-09	1986-11-12	Harvey W	Endotoxin assay
US4870158A (en)	1987-01-05	1989-09-26	University Of Pittsburgh Of The Commonwealth System Of Higher Education	Polymyxin lipopolysaccharide antigen and associated method
JPS63180860A (ja)	1987-01-22	1988-07-25	Kyowa Hakko Kogyo Co Ltd	抗ｇ−ｃｓｆモノクロ−ナル抗体
EP0328256A1 (en)	1988-01-21	1989-08-16	Owens-Corning Fiberglas Corporation	Glass fibers coated with agarose for use as column packing or chromatographic media for bioseparations
JPH0773509B2 (ja)	1988-05-23	1995-08-09	味の素株式会社	ビブリオ属細菌の迅速検出方法
JP3085310B2 (ja)	1990-04-26	2000-09-04	日本バイリーン株式会社	微生物除去材
JPH04270965A (ja)	1990-05-18	1992-09-28	Burton W Blais	オリゴペプタイド吸着担体の調製方法、及びこれを使用したリポ多糖類の検定と除去方法
JPH0471478A (ja)	1990-07-09	1992-03-06	Bio Material Kenkyusho:Kk	細胞培養用容器およびその製造方法
US5080209A (en)	1990-10-15	1992-01-14	General Electric Company	Manual override of an automatic ratio controller in a hydromechanical transmission
JPH04200388A (ja)	1990-11-29	1992-07-21	Chemo Sero Therapeut Res Inst	流行性非ａ非ｂ型肝炎ウイルス抗原ペプチドおよびこれをコードする核酸断片
US5147441A (en)	1991-05-31	1992-09-15	Megeed Mohamed E A	Biological product for soil improvement and method of application to soil
DE4227682C1 (de)	1992-08-21	1993-10-07	Em Te Vertrieb Erika Prochaska	Modifiziertes bakteriologisches Transportmedium
US6579696B1 (en)	1992-12-21	2003-06-17	Promega Corporation	Polymyxin B conjugates
CA2261433A1 (en)	1993-12-09	1995-06-10	Belinda Sanchez Ramirez	Composition comprising autologous epidermal growth factor
RU2115721C1 (ru)	1994-01-05	1998-07-20	Закрытое акционерное общество "Гекта"	Штамм bacillus polymyxa - продуцент антибиотика полимиксина м
US5648343A (en)	1994-02-28	1997-07-15	The University Of Georgia Research Foundation	Method for treating LPS-mediated disorders
JP3652388B2 (ja)	1994-10-03	2005-05-25	日水製薬株式会社	セレウス菌分離用培地
JP3687859B2 (ja)	1994-10-31	2005-08-24	▲いん▼▲てつ▼ 小林	微生物輸送用培地
CA2182805A1 (en)	1994-12-13	1996-06-20	Welfide Corporation	Helicobacter pylori-colonized mongolian gerbil, process for preparation thereof, medium for separating helicobacter pylori, and method of screening anti-helicobacter pylori-activesubstance by using the same
CN1056407C (zh)	1995-06-30	2000-09-13	齐涵	含有枯草芽胞杆菌的活菌制剂及其在烧伤治疗中的应用
JP3215309B2 (ja)	1995-11-07	2001-10-02	渡邊定治	顆粒球マクロファージコロニー刺激因子の製造方法
RU2113472C1 (ru)	1996-06-05	1998-06-20	Башкирский государственный медицинский университет	Штамм бактерий proteus mirabilis - продуцент термолабильного энтеротоксина
RU2113471C1 (ru)	1996-06-05	1998-06-20	Башкирский государственный медицинский университет	Штамм бактерий proteus mirabilis - продуцент термолабильного энтеротоксина
RU2132880C1 (ru)	1997-07-31	1999-07-10	Ставропольский научно-исследовательский противочумный институт	Способ выявления возбудителя бруцеллеза
RU2139348C1 (ru)	1997-10-06	1999-10-10	Институт биохимии и физиологии микроорганизмов им.Г.К.Скрябина РАН	Средство для лизиса клеток грамположительных и грамотрицательных микроорганизмов
US20030008355A1 (en)	1998-08-28	2003-01-09	Peter Harrison	High-affinity antibodies
RU2158758C2 (ru)	1998-11-02	2000-11-10	Научно-производственное объединение "Питательные среды"	Питательная среда для накопления листерий
US6719973B1 (en)	1998-12-24	2004-04-13	National University Of Singapore	Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics
EP1190037A4 (en)	1999-06-03	2002-07-31	Us Agriculture	SELECTIVE MEDIA FOR RECOVERY AND ENUMERATION OF i CAMPYLOBACTERS /i
AU1083501A (en)	1999-10-13	2001-04-23	Kallestad Laboratories, Inc.	Antibiotic-metal complex and methods
RU2223499C2 (ru)	2000-04-12	2004-02-10	Ставропольский научно-исследовательский противочумный институт	Способ индикации возбудителя сибирской язвы в объектах внешней среды
DE10045016B4 (de)	2000-09-12	2004-07-29	Heinrich-Pette-Institut	Retrovirale Vektoren mit Fremdsequenzinsertion zwischen retroviraler Primerbindungsstelle und retroviralem Spleißdonor
RU2203317C2 (ru)	2001-05-04	2003-04-27	Ставропольский научно-исследовательский противочумный институт	Спрособ обнаружения bacillus anthracis в молоке
RU2213779C2 (ru)	2001-08-27	2003-10-10	Научно-производственное объединение "Питательные среды"	Питательная среда для выделения лактобактерий
RU2214453C2 (ru)	2001-08-29	2003-10-20	Научно-производственное объединение "Питательные среды"	Питательная среда для накопления сибиреязвенного микроба
JP4071478B2 (ja)	2001-11-12	2008-04-02	株式会社ユタカ技研	流体伝動装置用羽根車
RU2223313C2 (ru)	2001-12-26	2004-02-10	Государственный научный центр прикладной микробиологии	Дифференциально-диагностическая среда для выделения листерий
RU2260040C2 (ru)	2002-02-11	2005-09-10	Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика"	Способ получения инозина и инозин 5'-монофосфата, штамм бактерии, принадлежащей к роду bacillus - продуцент инозина (варианты)
RU2218395C2 (ru)	2002-02-20	2003-12-10	Московская государственная академия ветеринарной медицины и биотехнологии им. К.И. Скрябина	ШТАММ БАКТЕРИЙ Proteus vulgaris № 25, ИСПОЛЬЗУЕМЫЙ ДЛЯ ИЗГОТОВЛЕНИЯ ИММУННЫХ ПРЕПАРАТОВ
CN1384200A (zh)	2002-03-13	2002-12-11	杜念兴	畜禽去势基因疫苗(dna疫苗)的基因工程体
MD2078G2 (ro)	2002-03-14	2003-08-31	Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова	Mediu nutritiv pentru cultivarea Campylobacter jejuni şi Campylobacter coli
MD2285G2 (ro)	2002-09-27	2004-04-30	Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова	Mediu nutritiv pentru cultivarea Campylobacter jejuni şi Campylobacte coli
RU2225441C1 (ru)	2003-03-05	2004-03-10	Закрытое акционерное общество "Научно-производственное предприятие "Тринита"	Способ получения препарата коллагеназы
CN1292794C (zh)	2003-08-22	2007-01-03	福建省农业科学院畜牧兽医研究所	嗜水气单胞菌中溶血素的免疫刺激复合物的制备工艺
US20070028055A1 (en)	2003-09-19	2007-02-01	Matsushita Electric Industrial Co., Ltd	Cache memory and cache memory control method
BR0305373A (pt)	2003-11-06	2005-06-28	Iseu Da Silva Nunes Nelson Edu	Imunomodulador agregado proteico de anidrido de fosfolinoleato-palmitoleato de amÈnia e magnésio e processo de sua obtenção e formulação
JP4200388B2 (ja)	2006-06-23	2008-12-24	セイコーエプソン株式会社	印刷用紙、印刷制御プログラムを記録した媒体、印刷制御装置および印刷制御方法

2006
- 2006-06-15 SK SK90-2006A patent/SK287293B6/sk not_active IP Right Cessation
2007
- 2007-05-21 AT AT07748763T patent/ATE474060T1/de active
- 2007-05-21 EP EP07748763A patent/EP2027280B1/en not_active Not-in-force
- 2007-05-21 PL PL07748763T patent/PL2027280T3/pl unknown
- 2007-05-21 WO PCT/SK2007/050011 patent/WO2007145602A1/en not_active Ceased
- 2007-05-21 ES ES07748763T patent/ES2349188T3/es active Active
- 2007-05-21 SI SI200730376T patent/SI2027280T1/sl unknown
- 2007-05-21 US US12/304,321 patent/US8119371B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE474060T1 (de)	2010-07-15
US8119371B2 (en)	2012-02-21
US20090197305A1 (en)	2009-08-06
SK287293B6 (sk)	2010-05-07
WO2007145602A1 (en)	2007-12-21
EP2027280B1 (en)	2010-07-14
EP2027280A1 (en)	2009-02-25
SK902006A3 (sk)	2008-02-05
ES2349188T3 (es)	2010-12-28
SI2027280T1 (sl)	2010-12-31

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