PL318766A1 - Derivatives of benzoxazoles and pyridines useful in treating diabetes of type ii - Google Patents

Derivatives of benzoxazoles and pyridines useful in treating diabetes of type ii

Info

Publication number
PL318766A1
PL318766A1 PL95318766A PL31876695A PL318766A1 PL 318766 A1 PL318766 A1 PL 318766A1 PL 95318766 A PL95318766 A PL 95318766A PL 31876695 A PL31876695 A PL 31876695A PL 318766 A1 PL318766 A1 PL 318766A1
Authority
PL
Poland
Prior art keywords
benzoxazoles
derivatives
type
treating diabetes
pyridines useful
Prior art date
Application number
PL95318766A
Other languages
English (en)
Inventor
David Haigh
Harshad Kantilal Rami
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9415330A external-priority patent/GB9415330D0/en
Priority claimed from GBGB9425599.9A external-priority patent/GB9425599D0/en
Priority claimed from GBGB9509923.0A external-priority patent/GB9509923D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of PL318766A1 publication Critical patent/PL318766A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PL95318766A 1994-07-29 1995-07-28 Derivatives of benzoxazoles and pyridines useful in treating diabetes of type ii PL318766A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9415330A GB9415330D0 (en) 1994-07-29 1994-07-29 Novel compounds
GBGB9425599.9A GB9425599D0 (en) 1994-12-19 1994-12-19 Novel compounds
GBGB9509923.0A GB9509923D0 (en) 1995-05-17 1995-05-17 Novel compounds
PCT/GB1995/001323 WO1996004261A1 (fr) 1994-07-29 1995-06-07 Benzoxoazoles et derives de pryridine destines a etre utilises pour le traitement du diabete tardif

Publications (1)

Publication Number Publication Date
PL318766A1 true PL318766A1 (en) 1997-07-07

Family

ID=27267309

Family Applications (1)

Application Number Title Priority Date Filing Date
PL95318766A PL318766A1 (en) 1994-07-29 1995-07-28 Derivatives of benzoxazoles and pyridines useful in treating diabetes of type ii

Country Status (16)

Country Link
EP (1) EP0772605A1 (fr)
AP (1) AP776A (fr)
BR (1) BR9508468A (fr)
CA (1) CA2196079A1 (fr)
CZ (1) CZ25497A3 (fr)
DZ (1) DZ1916A1 (fr)
FI (1) FI970357A7 (fr)
HU (1) HUT76637A (fr)
IL (3) IL114759A (fr)
MA (1) MA23632A1 (fr)
MX (1) MX9700763A (fr)
NO (1) NO307827B1 (fr)
OA (1) OA10470A (fr)
PL (1) PL318766A1 (fr)
SK (1) SK12297A3 (fr)
WO (2) WO1996004261A1 (fr)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
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GB9600464D0 (en) * 1996-01-09 1996-03-13 Smithkline Beecham Plc Novel method
DK0916651T3 (da) * 1996-04-04 2003-12-01 Sankyo Co Phenylalkylcarboxylsyrederivater
US6160000A (en) * 1996-12-23 2000-12-12 Merck & Co., Inc. Antidiabetic agents based on aryl and heteroarylacetic acids
US6090839A (en) * 1996-12-23 2000-07-18 Merck & Co., Inc. Antidiabetic agents
WO1999018066A1 (fr) 1997-10-02 1999-04-15 Sankyo Company, Limited Derives d'acide amidocarboxylique
US6369067B1 (en) 1997-10-27 2002-04-09 Dr. Reddy's Research Foundation Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
BR9812770A (pt) 1997-10-27 2000-12-12 Reddy Research Foundation Compostos bicìclicos, processo para seu preparo e composições farmacêuticas contendo os mesmos
CN1280574A (zh) 1997-10-27 2001-01-17 雷迪研究基金会 新的杂环化合物及其在医药中的应用、它们的制备方法和含有它们的药物组合物
WO1999019313A1 (fr) * 1997-10-27 1999-04-22 Dr. Reddy's Research Foundation Nouveaux composes tricycliques et leur utilisation en medecine, procede de preparation de ces derniers et compositions pharmaceutiques les contenant
US6265401B1 (en) * 1997-10-27 2001-07-24 Reddy-Cheminor, Inc. Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
PL193086B1 (pl) * 1997-10-27 2007-01-31 Reddys Lab Ltd Dr Nowe związki tricykliczne i związki pośrednie, sposób ich wytwarzania, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie
US6444816B1 (en) 1997-10-27 2002-09-03 Dr. Reddy's Research Foundation Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof
US6440961B1 (en) 1997-10-27 2002-08-27 Dr. Reddy's Research Foundation Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
NZ504106A (en) * 1998-05-27 2003-02-28 Dr Fused Oxazine, Thiazine and pipyridine compounds, process for their preparation and pharmaceutical compositions containing them
CZ2001965A3 (cs) 1998-09-17 2002-02-13 Bristol-Myers Squibb Company Lék pro oąetřování atherosklerózy nebo diabetes typu II, farmaceutická kombinace a její pouľití
JP2002527502A (ja) * 1998-10-21 2002-08-27 ノボ ノルディスク アクティーゼルスカブ 新規化合物、それらの調製及び使用
US6214820B1 (en) 1998-10-21 2001-04-10 Novo Nordisk A/S Compounds, their preparation and use
WO2000023451A1 (fr) * 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
US6248781B1 (en) 1998-10-21 2001-06-19 Novo Nordisk A/S Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR)
US6468996B1 (en) 1998-10-21 2002-10-22 Novo Nordisk A/S Substituted hetero-polycyclic compounds as PPARα and PPARγ activators
AU6190299A (en) * 1998-10-21 2000-05-08 Dr. Reddy's Research Foundation New compounds, their preparation and use
WO2000023415A1 (fr) * 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, preparation et utilisation correspondantes
AU6325599A (en) * 1998-10-21 2000-05-08 Dr. Reddy's Research Foundation New compounds, their preparation and use
US6365586B1 (en) 1998-10-21 2002-04-02 Novo Nordisk A/S Compounds, their preparation and use
US6300339B1 (en) 1998-10-21 2001-10-09 Novo Nordisk A/S Compounds, their preparation and use
EP1123269A1 (fr) * 1998-10-21 2001-08-16 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
US6531596B1 (en) 1998-10-29 2003-03-11 Dr. Reddy's Laboratories Ltd. Process for the preparation of new antidiabetic agents
CN1323300A (zh) * 1998-10-29 2001-11-21 雷迪研究基金会 制备新的抗糖尿病剂的改进方法
WO2000063189A1 (fr) * 1999-04-16 2000-10-26 Novo Nordisk A/S Formes cristallines de r-guanidines, d'arginine ou de (l)-arginine (2s-2-ethoxy-3-{4-[2-(10h-phenoxazin-10-yl)ethoxy]phenyl}propanoate
US6369055B1 (en) 1999-04-20 2002-04-09 Novo Nordisk A/S Compounds, their preparation and use
US6972294B1 (en) 1999-04-20 2005-12-06 Novo Nordisk, A/S Compounds, their preparation and use
CN1348439A (zh) * 1999-04-20 2002-05-08 诺沃挪第克公司 新化合物及其制备和用途
US7414128B2 (en) 1999-04-20 2008-08-19 Dr. Reddy's Laboratories, Limited Crystalline R-guanidines, Arginine or (L)-Arginine (2S)-2-Ethoxy-3-{4-[2-(10H -phenoxazin-10-yl)ethoxy]phenyl}propanoate
EP1171438A1 (fr) 1999-04-20 2002-01-16 Novo Nordisk A/S Composes, preparation et utilisation associees
US6274608B1 (en) 1999-04-20 2001-08-14 Novo Nordisk A/S Compounds, their preparation and use
EP1171431A1 (fr) * 1999-04-20 2002-01-16 Novo Nordisk A/S Composes, leur preparation et utilisation
EP1175412A1 (fr) 1999-04-28 2002-01-30 Dr. Reddy's Research Foundation Heterocycles bicycliques substitues, procede pour leur preparation et leur utilisation comme agents contre l'obesite et comme agents hypocholesterolemiques
AU7073400A (en) 1999-08-27 2001-03-26 Eli Lilly And Company Biaryl-oxa(thia)zole derivatives and their use as ppars modulators
CN1266129C (zh) * 2000-01-19 2006-07-26 卡地拉健康护理有限公司 具有降血脂和降低血中胆固醇活性的新化合物、其制备方法和含有它们的药物组合物
CA2396372A1 (fr) * 2000-01-28 2001-08-02 Novo Nordisk A/S Derives d'acide propionique a substitution alkynyle et leur utilisation pour lutter contre le diabete et l'obesite
US6569901B2 (en) 2000-01-28 2003-05-27 Novo Nordisk A/S Alkynyl-substituted propionic acid derivatives, their preparation and use
US6555577B1 (en) 2000-01-28 2003-04-29 Novo Nordisk A/S Compounds, their preparation and use
US6509374B2 (en) 2000-04-17 2003-01-21 Novo Nordisk A/S Compounds, their preparation and use
WO2001087860A2 (fr) * 2000-05-12 2001-11-22 Ortho-Mcneil Pharmaceutical, Inc. Nouveaux benzoxazinones utilises comme modulateurs du recepteur gamma active de la proliferation des peroxysomes, et methode de traitement associee
US6908908B2 (en) 2000-05-12 2005-06-21 Ortho-Mcneil Pharmaceutical, Inc. Biologically active 4H-benzo [1,4] oxazin-3-ones
ES2288957T3 (es) * 2000-05-12 2008-02-01 Ortho-Mcneil Pharmaceutical, Inc. 4h-benzo(1.4)oxazin-3-ina biologicamente activas.
AU2001261503A1 (en) * 2000-05-12 2001-11-26 Ortho-Mcneil Pharmaceutical, Inc. Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators
US6987123B2 (en) 2001-07-26 2006-01-17 Cadila Healthcare Limited Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
US6869967B2 (en) 2001-07-30 2005-03-22 Novo Nordisk A/S Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
US7067530B2 (en) 2001-07-30 2006-06-27 Novo Nordisk A/S Compounds, their preparation and use
US7220877B2 (en) 2001-10-17 2007-05-22 Novo Nordisk A/S Compounds, their preparation and use
JP2005518408A (ja) 2001-12-29 2005-06-23 ノボ　ノルディスク　アクティーゼルスカブ 異常脂肪血症を治療するための、ｇｌｐ−１化合物と他の薬物との組み合わせ使用
US7015345B2 (en) 2002-02-21 2006-03-21 Asahi Kasei Pharma Corporation Propionic acid derivatives
US7816385B2 (en) 2002-12-20 2010-10-19 High Point Pharmaceuticals, Llc Dimeric dicarboxylic acid derivatives, their preparation and use
US6653334B1 (en) 2002-12-27 2003-11-25 Kowa Co., Ltd. Benzoxazole compound and pharmaceutical composition containing the same
WO2008139879A1 (fr) * 2007-04-26 2008-11-20 Pharmafrontier, Co., Ltd. Inhibiteur du récepteur couplé à protéine g et produit pharmaceutique
CN103354757A (zh) 2011-01-31 2013-10-16 卡迪拉保健有限公司 脂肪代谢障碍的治疗
EP2988736A1 (fr) 2013-04-22 2016-03-02 Cadila Healthcare Limited Nouvelle composition pour la stéatose hépatique non alcoolique (nafld)
US20160107989A1 (en) 2013-05-30 2016-04-21 Cadila Healthcare Limited A process for preparation of pyrroles having hypolipidemic hypocholesteremic activities
TW201636015A (zh) 2013-07-05 2016-10-16 卡地拉保健有限公司 協同性組成物
IN2013MU02470A (fr) 2013-07-25 2015-06-26 Cadila Healthcare Ltd
IN2013MU02905A (fr) 2013-09-06 2015-07-03 Cadila Healthcare Ltd
US10385017B2 (en) 2015-10-14 2019-08-20 Cadila Healthcare Limited Pyrrole compound, compositions and process for preparation thereof
WO2018104916A1 (fr) 2016-12-09 2018-06-14 Cadila Healthcare Limited Traitement de la cholangite biliaire primitive

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
PL174610B1 (pl) * 1992-07-03 1998-08-31 Smithkline Beecham Plc Nowe związki heterocykliczne

Also Published As

Publication number Publication date
IL125525A (en) 2000-02-29
EP0772605A1 (fr) 1997-05-14
NO970373L (no) 1997-03-18
BR9508468A (pt) 1997-11-25
AP776A (en) 1999-10-28
IL114759A0 (en) 1995-12-31
MA23632A1 (fr) 1996-04-01
FI970357L (fi) 1997-03-26
SK12297A3 (en) 1997-08-06
WO1996004260A1 (fr) 1996-02-15
AP9700918A0 (en) 1997-01-31
NO970373D0 (no) 1997-01-28
DZ1916A1 (fr) 2002-02-17
IL114759A (en) 1999-10-28
WO1996004261A1 (fr) 1996-02-15
IL125525A0 (en) 1999-03-12
CA2196079A1 (fr) 1996-02-15
FI970357A0 (fi) 1997-01-28
CZ25497A3 (en) 1997-09-17
MX9700763A (es) 1997-05-31
HUT76637A (en) 1997-10-28
NO307827B1 (no) 2000-06-05
FI970357A7 (fi) 1997-03-26
OA10470A (en) 2002-04-08

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