PL330361A1 - Leptin fragments (ob proteins) - Google Patents

Leptin fragments (ob proteins)

Info

Publication number: PL330361A1
Authority: PL; Poland
Prior art keywords: proteins; leptin fragments; leptin; fragments
Prior art date: 1996-06-06

Application number

PL97330361A

Other languages

English (en)

Inventor

Kamal A Al-Barazanji

Jonathan Robert Sanders Arch

Patrick Camilleri

William Arthur Neville

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-06

Filing date

1997-06-04

Publication date

1999-05-10

1996-06-06 Priority claimed from GBGB9611775.9A external-priority patent/GB9611775D0/en

1996-09-05 Priority claimed from GBGB9618540.0A external-priority patent/GB9618540D0/en

1997-02-20 Priority claimed from GBGB9703493.8A external-priority patent/GB9703493D0/en

1997-06-04 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1999-05-10 Publication of PL330361A1 publication Critical patent/PL330361A1/xx

Links

102000016267 Leptin Human genes 0.000 title 1
108010092277 Leptin Proteins 0.000 title 1
NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical group O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Child & Adolescent Psychology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

PL97330361A 1996-06-06 1997-06-04 Leptin fragments (ob proteins) PL330361A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9611775.9A GB9611775D0 (en)	1996-06-06	1996-06-06	Novel compounds
GBGB9618540.0A GB9618540D0 (en)	1996-09-05	1996-09-05	Novel compounds
GBGB9703493.8A GB9703493D0 (en)	1997-02-20	1997-02-20	Novel compounds

Publications (1)

Publication Number	Publication Date
PL330361A1 true PL330361A1 (en)	1999-05-10

Family

ID=27268305

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL97330361A PL330361A1 (en)	1996-06-06	1997-06-04	Leptin fragments (ob proteins)

Country Status (15)

Country	Link
EP (1)	EP0912609A2 (de)
JP (1)	JP2000512137A (de)
KR (1)	KR20000016402A (de)
CN (1)	CN1221426A (de)
AR (1)	AR008765A1 (de)
AU (1)	AU3337297A (de)
BR (1)	BR9709529A (de)
CA (1)	CA2257240A1 (de)
CZ (1)	CZ397898A3 (de)
IL (1)	IL127153A0 (de)
NO (1)	NO985683D0 (de)
NZ (1)	NZ332879A (de)
PL (1)	PL330361A1 (de)
TR (1)	TR199802534T2 (de)
WO (1)	WO1997046585A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6001968A (en)	1994-08-17	1999-12-14	The Rockefeller University	OB polypeptides, modified forms and compositions
CA2335107C (en)	1998-07-28	2010-01-19	Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw	Leptin-mediated gene-induction
US7208572B2 (en) *	1998-08-21	2007-04-24	Albany Medical College	Leptin-related peptides
US6777388B1 (en)	1998-08-21	2004-08-17	Clf Medical Technology Acceleration Program, Inc.	Leptin-related peptides
US6420339B1 (en)	1998-10-14	2002-07-16	Amgen Inc.	Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
AU782230B2 (en)	1999-09-22	2005-07-14	Serono Genetics Institute S.A.	Methods of screening for compounds that modulate the LSR-leptin interaction and their use in the prevention and treatment of obesity-related diseases
ATE300611T1 (de)	2000-05-22	2005-08-15	Vlaams Interuniv Inst Biotech	Auf rezeptorgrundlage arbeitende screening- verfahren für protein wechselwirkungen
EP1444516B1 (de)	2001-10-22	2010-07-21	Amgen, Inc.	Verwendung von leptin zur behandlung von lipoatrophie im menschen und verfahren zur bestimmmung einer prädisposition gegenüber der behandlung
DE602004012759T2 (de)	2003-09-08	2008-07-17	Laboratoires Serono S.A., Coinsins	Behandlung von fibrosen
CN1961000B (zh)	2004-02-11	2011-05-04	安米林药品公司	具有可选择特性的杂合多肽
EP1812038A1 (de)	2004-11-18	2007-08-01	VIB vzw	Fibronectin iii domäne als leptin-rezeptor-antagonisten
SG159551A1 (en)	2005-02-11	2010-03-30	Amylin Pharmaceuticals Inc	Gip analog and hybrid polypeptides with selectable properties
US7629315B2 (en)	2005-03-09	2009-12-08	University Of Pittsburgh Of The Commonwealth System Of Higher Education	Compositions for blocking the inhibitory effect of human CRP on human leptin
EP2330125A3 (de)	2005-08-11	2012-12-12	Amylin Pharmaceuticals, Inc.	Hybridpolypeptide mit auswählbaren Eigenschaften
CA2617649A1 (en)	2005-08-11	2007-02-22	Amylin Pharmaceuticals, Inc.	Hybrid polypeptides with selectable properties
ES2319048B1 (es) *	2007-06-20	2010-02-10	Universitat De Les Illes Balears	Uso de leptina en el tratamiento de alteraciones en los habitos alimentarios.
US8889622B2 (en)	2007-07-25	2014-11-18	Washington University	Methods of inhibiting seizure in a subject
GB2451858A (en) *	2007-08-15	2009-02-18	Sergiy Konovchuk	Methods of reducing body fat and treating obesity
US20110059969A1 (en)	2007-12-05	2011-03-10	Astrazeneca Ab	Piperazines as anti-obesity agents
EP2234992B1 (de)	2007-12-05	2012-02-22	AstraZeneca AB	Piperazinderivate und ihre verwendung als modulatoren des leptinrezeptors
KR20110015446A (ko) *	2008-06-04	2011-02-15	아스트라제네카 아베	렙틴 수용체 조절제 유사체로서의 신규한 피리딘 유도체
US20110275637A1 (en) *	2008-06-04	2011-11-10	Emma Chapman	Piperazine derivatives and their use as leptin receptor modulators
US20120071401A1 (en)	2009-04-10	2012-03-22	Amylin Pharamaceuticals, Inc.	Amylin agonist compounds for estrogen-deficient mammals
EP2569326B1 (de) *	2010-05-11	2016-08-10	The U.S.A. as represented by the Secretary, Department of Health and Human Services	Peptidbasierter inhibitor des interleukin-10- oder der stat-3 aktivierung
WO2012050930A2 (en)	2010-09-28	2012-04-19	Amylin Pharmaceuticals, Inc	Engineered polypeptides having enhanced duration of action
CN104829707B (zh) *	2015-05-06	2017-12-19	广东省生物资源应用研究所	一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用
CN110183530A (zh)	2019-06-21	2019-08-30	深圳市亚辉龙生物科技股份有限公司	瘦素免疫原、杂交瘤细胞、单克隆抗体、多克隆抗体及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6309853B1 (en) *	1994-08-17	2001-10-30	The Rockfeller University	Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
CA2211656A1 (en) *	1995-01-31	1996-08-08	Margret B. Basinski	Anti-obesity proteins
US5552523A (en) *	1995-01-31	1996-09-03	Eli Lilly And Company	Anti-obesity proteins
AU4766596A (en) *	1995-01-31	1996-08-21	Eli Lilly And Company	Ob gene product antibodies
AU5539596A (en) *	1995-04-06	1996-10-23	Amylin Pharmaceuticals, Inc.	Anti-obesity agents
GB9509164D0 (en) *	1995-05-05	1995-06-28	Smithkline Beecham Plc	Novel compounds

1997
- 1997-06-04 EP EP97929156A patent/EP0912609A2/de not_active Withdrawn
- 1997-06-04 JP JP10500240A patent/JP2000512137A/ja active Pending
- 1997-06-04 AU AU33372/97A patent/AU3337297A/en not_active Abandoned
- 1997-06-04 BR BR9709529A patent/BR9709529A/pt not_active Application Discontinuation
- 1997-06-04 WO PCT/EP1997/002968 patent/WO1997046585A2/en not_active Ceased
- 1997-06-04 AR ARP970102432A patent/AR008765A1/es unknown
- 1997-06-04 CN CN97195311A patent/CN1221426A/zh active Pending
- 1997-06-04 IL IL12715397A patent/IL127153A0/xx unknown
- 1997-06-04 TR TR1998/02534T patent/TR199802534T2/xx unknown
- 1997-06-04 CZ CZ983978A patent/CZ397898A3/cs unknown
- 1997-06-04 NZ NZ332879A patent/NZ332879A/xx not_active IP Right Cessation
- 1997-06-04 PL PL97330361A patent/PL330361A1/xx unknown
- 1997-06-04 CA CA002257240A patent/CA2257240A1/en not_active Abandoned
- 1997-06-04 KR KR1019980709976A patent/KR20000016402A/ko not_active Ceased
1998
- 1998-12-04 NO NO985683A patent/NO985683D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
TR199802534T2 (xx)	1999-03-22
CA2257240A1 (en)	1997-12-11
JP2000512137A (ja)	2000-09-19
NO985683L (no)	1998-12-04
NZ332879A (en)	2000-09-29
AR008765A1 (es)	2000-02-23
CN1221426A (zh)	1999-06-30
WO1997046585A3 (en)	1998-04-23
CZ397898A3 (cs)	1999-04-14
IL127153A0 (en)	1999-09-22
NO985683D0 (no)	1998-12-04
WO1997046585A2 (en)	1997-12-11
BR9709529A (pt)	1999-08-10
AU3337297A (en)	1998-01-05
KR20000016402A (ko)	2000-03-25
EP0912609A2 (de)	1999-05-06

Publication	Publication Date	Title
PL330361A1 (en)	1999-05-10	Leptin fragments (ob proteins)
AU4922497A (en)	1998-07-02	Interleukin-18-receptor proteins
AU4467497A (en)	1998-04-17	Chaperone fragments
AU6721696A (en)	1998-03-06	Cd44-like protein
ZA9710338B (en)	1999-05-17	Proteins
GB9614033D0 (en)	1996-09-04	Modified protein G and fragments thereof
AU1538497A (en)	1997-08-28	Anti-gp46 antibodies and fragments thereof and their use
AU3640397A (en)	1998-01-05	Ob protein binding protein
SG65040A1 (en)	1999-05-25	Anti-obesity proteins
AU4586497A (en)	1998-04-24	Calcium-integrin binding protein
AU4582597A (en)	1998-05-11	Therapeutic proteins
AU4505497A (en)	1998-04-17	Snrnp sm proteins
AU1036397A (en)	1998-06-29	Chaperone fragments
EP1007648A4 (de)	2003-01-15	Proteine gegen fettleibigkeit
ZA971900B (en)	1998-09-07	Modified proteins
AU2003204475A1 (en)	2003-06-26	Fragments of leptin (ob protein)
HK1019756A (en)	2000-06-02	Fragments of leptin (ob protein)
AU5137598A (en)	1998-06-29	Novel protein
AU5211899A (en)	2000-02-07	Chromatin associated proteins
GB9828306D0 (en)	1999-02-17	Modified protein G and fragments thereof
GB9707599D0 (en)	1997-06-04	Proteins
GB9607689D0 (en)	1996-06-12	Proteins
GB9624028D0 (en)	1997-01-08	Modified proteins
GB9614293D0 (en)	1996-09-04	Modified proteins
GB9611896D0 (en)	1996-08-07	Modified proteins