JP2000512137A - レプチン（ｏｂタンパク質）のフラグメント - Google Patents

レプチン（ｏｂタンパク質）のフラグメント

Info

Publication number
JP2000512137A
JP2000512137A JP10500240A JP50024098A JP2000512137A JP 2000512137 A JP2000512137 A JP 2000512137A JP 10500240 A JP10500240 A JP 10500240A JP 50024098 A JP50024098 A JP 50024098A JP 2000512137 A JP2000512137 A JP 2000512137A
Authority
JP
Japan
Prior art keywords
peptide
dna
peptides
compound
functional derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10500240A
Other languages
English (en)
Japanese (ja)
Inventor
アル―バラザンジ，カマル・エイ
アーチ，ジョナサン・ロバート・サンダース
カミレリ，パトリック
ネビル，ウィリアム・アーサー
Original Assignee
スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9611775.9A external-priority patent/GB9611775D0/en
Priority claimed from GBGB9618540.0A external-priority patent/GB9618540D0/en
Priority claimed from GBGB9703493.8A external-priority patent/GB9703493D0/en
Application filed by スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー filed Critical スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー
Publication of JP2000512137A publication Critical patent/JP2000512137A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP10500240A 1996-06-06 1997-06-04 レプチン（ｏｂタンパク質）のフラグメント Pending JP2000512137A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB9611775.9A GB9611775D0 (en) 1996-06-06 1996-06-06 Novel compounds
GB9611775.9 1996-06-06
GBGB9618540.0A GB9618540D0 (en) 1996-09-05 1996-09-05 Novel compounds
GB9618540.0 1996-09-05
GBGB9703493.8A GB9703493D0 (en) 1997-02-20 1997-02-20 Novel compounds
GB9703493.8 1997-02-20
PCT/EP1997/002968 WO1997046585A2 (en) 1996-06-06 1997-06-04 Fragments of leptin (ob protein)

Publications (1)

Publication Number Publication Date
JP2000512137A true JP2000512137A (ja) 2000-09-19

Family

ID=27268305

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10500240A Pending JP2000512137A (ja) 1996-06-06 1997-06-04 レプチン（ｏｂタンパク質）のフラグメント

Country Status (15)

Country Link
EP (1) EP0912609A2 (de)
JP (1) JP2000512137A (de)
KR (1) KR20000016402A (de)
CN (1) CN1221426A (de)
AR (1) AR008765A1 (de)
AU (1) AU3337297A (de)
BR (1) BR9709529A (de)
CA (1) CA2257240A1 (de)
CZ (1) CZ397898A3 (de)
IL (1) IL127153A0 (de)
NO (1) NO985683D0 (de)
NZ (1) NZ332879A (de)
PL (1) PL330361A1 (de)
TR (1) TR199802534T2 (de)
WO (1) WO1997046585A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018504913A (ja) * 2015-05-06 2018-02-22 広東省生物資源応用研究所Ｇｕａｎｇｄｏｎｇ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ａｐｐｌｉｅｄ Ｂｉｏｌｏｇｉｃａｌ Ｒｅｓｏｕｒｃｅｓ Ｃｄループとｅへリックス領域とでの突然変異を有するレプチン活性ペプチド、そのコード遺伝子およびその応用

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
CA2335107C (en) 1998-07-28 2010-01-19 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Leptin-mediated gene-induction
US7208572B2 (en) * 1998-08-21 2007-04-24 Albany Medical College Leptin-related peptides
US6777388B1 (en) 1998-08-21 2004-08-17 Clf Medical Technology Acceleration Program, Inc. Leptin-related peptides
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
AU782230B2 (en) 1999-09-22 2005-07-14 Serono Genetics Institute S.A. Methods of screening for compounds that modulate the LSR-leptin interaction and their use in the prevention and treatment of obesity-related diseases
ATE300611T1 (de) 2000-05-22 2005-08-15 Vlaams Interuniv Inst Biotech Auf rezeptorgrundlage arbeitende screening- verfahren für protein wechselwirkungen
EP1444516B1 (de) 2001-10-22 2010-07-21 Amgen, Inc. Verwendung von leptin zur behandlung von lipoatrophie im menschen und verfahren zur bestimmmung einer prädisposition gegenüber der behandlung
DE602004012759T2 (de) 2003-09-08 2008-07-17 Laboratoires Serono S.A., Coinsins Behandlung von fibrosen
CN1961000B (zh) 2004-02-11 2011-05-04 安米林药品公司 具有可选择特性的杂合多肽
EP1812038A1 (de) 2004-11-18 2007-08-01 VIB vzw Fibronectin iii domäne als leptin-rezeptor-antagonisten
SG159551A1 (en) 2005-02-11 2010-03-30 Amylin Pharmaceuticals Inc Gip analog and hybrid polypeptides with selectable properties
US7629315B2 (en) 2005-03-09 2009-12-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Compositions for blocking the inhibitory effect of human CRP on human leptin
EP2330125A3 (de) 2005-08-11 2012-12-12 Amylin Pharmaceuticals, Inc. Hybridpolypeptide mit auswählbaren Eigenschaften
CA2617649A1 (en) 2005-08-11 2007-02-22 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
ES2319048B1 (es) * 2007-06-20 2010-02-10 Universitat De Les Illes Balears Uso de leptina en el tratamiento de alteraciones en los habitos alimentarios.
US8889622B2 (en) 2007-07-25 2014-11-18 Washington University Methods of inhibiting seizure in a subject
GB2451858A (en) * 2007-08-15 2009-02-18 Sergiy Konovchuk Methods of reducing body fat and treating obesity
US20110059969A1 (en) 2007-12-05 2011-03-10 Astrazeneca Ab Piperazines as anti-obesity agents
EP2234992B1 (de) 2007-12-05 2012-02-22 AstraZeneca AB Piperazinderivate und ihre verwendung als modulatoren des leptinrezeptors
KR20110015446A (ko) * 2008-06-04 2011-02-15 아스트라제네카 아베 렙틴 수용체 조절제 유사체로서의 신규한 피리딘 유도체
US20110275637A1 (en) * 2008-06-04 2011-11-10 Emma Chapman Piperazine derivatives and their use as leptin receptor modulators
US20120071401A1 (en) 2009-04-10 2012-03-22 Amylin Pharamaceuticals, Inc. Amylin agonist compounds for estrogen-deficient mammals
EP2569326B1 (de) * 2010-05-11 2016-08-10 The U.S.A. as represented by the Secretary, Department of Health and Human Services Peptidbasierter inhibitor des interleukin-10- oder der stat-3 aktivierung
WO2012050930A2 (en) 2010-09-28 2012-04-19 Amylin Pharmaceuticals, Inc Engineered polypeptides having enhanced duration of action
CN110183530A (zh) 2019-06-21 2019-08-30 深圳市亚辉龙生物科技股份有限公司 瘦素免疫原、杂交瘤细胞、单克隆抗体、多克隆抗体及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309853B1 (en) * 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
CA2211656A1 (en) * 1995-01-31 1996-08-08 Margret B. Basinski Anti-obesity proteins
US5552523A (en) * 1995-01-31 1996-09-03 Eli Lilly And Company Anti-obesity proteins
AU4766596A (en) * 1995-01-31 1996-08-21 Eli Lilly And Company Ob gene product antibodies
AU5539596A (en) * 1995-04-06 1996-10-23 Amylin Pharmaceuticals, Inc. Anti-obesity agents
GB9509164D0 (en) * 1995-05-05 1995-06-28 Smithkline Beecham Plc Novel compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018504913A (ja) * 2015-05-06 2018-02-22 広東省生物資源応用研究所Ｇｕａｎｇｄｏｎｇ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ａｐｐｌｉｅｄ Ｂｉｏｌｏｇｉｃａｌ Ｒｅｓｏｕｒｃｅｓ Ｃｄループとｅへリックス領域とでの突然変異を有するレプチン活性ペプチド、そのコード遺伝子およびその応用

Also Published As

Publication number Publication date
TR199802534T2 (xx) 1999-03-22
CA2257240A1 (en) 1997-12-11
NO985683L (no) 1998-12-04
NZ332879A (en) 2000-09-29
AR008765A1 (es) 2000-02-23
PL330361A1 (en) 1999-05-10
CN1221426A (zh) 1999-06-30
WO1997046585A3 (en) 1998-04-23
CZ397898A3 (cs) 1999-04-14
IL127153A0 (en) 1999-09-22
NO985683D0 (no) 1998-12-04
WO1997046585A2 (en) 1997-12-11
BR9709529A (pt) 1999-08-10
AU3337297A (en) 1998-01-05
KR20000016402A (ko) 2000-03-25
EP0912609A2 (de) 1999-05-06

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