PL354033A1 - Sposób wytwarzania kwasu 4-amino-1-hydroksybutylidSposób wytwarzania kwasu 4-amino-1-hydroksybutylideno-1,1-bisfosfoniowego i jego trójwodnej soli moneno-1,1-bisfosfoniowego i jego trójwodnej soli monosodowejosodowej - Google Patents

Sposób wytwarzania kwasu 4-amino-1-hydroksybutylidSposób wytwarzania kwasu 4-amino-1-hydroksybutylideno-1,1-bisfosfoniowego i jego trójwodnej soli moneno-1,1-bisfosfoniowego i jego trójwodnej soli monosodowejosodowej

Info

Publication number
PL354033A1
PL354033A1 PL00354033A PL35403300A PL354033A1 PL 354033 A1 PL354033 A1 PL 354033A1 PL 00354033 A PL00354033 A PL 00354033A PL 35403300 A PL35403300 A PL 35403300A PL 354033 A1 PL354033 A1 PL 354033A1
Authority
PL
Poland
Prior art keywords
amino
trihydrated
hidroxybutylidene
producing
bisphosphonic acid
Prior art date
Application number
PL00354033A
Other languages
English (en)
Other versions
PL191733B1 (pl
Inventor
Illado JordiBosch Illado Jordi Bosch
Lista EugeniaPagans Lista Eugenia Pagans
Miguel M del CarmenOnrubia Miguel M del Carmen Onrubia
Original Assignee
Medichem S.A.Medichem S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem S.A.Medichem S.A. filed Critical Medichem S.A.Medichem S.A.
Publication of PL354033A1 publication Critical patent/PL354033A1/pl
Publication of PL191733B1 publication Critical patent/PL191733B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL354033A 1999-08-06 2000-07-17 Sposób wytwarzania kwasu 4-amino-1-hydroksybutylideno-1,1-bisfosfonowego i jego trójwodnej soli monosodowej PL191733B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009901806A ES2153794B1 (es) 1999-08-06 1999-08-06 Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PCT/ES2000/000254 WO2001010874A1 (es) 1999-08-06 2000-07-17 Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada

Publications (2)

Publication Number Publication Date
PL354033A1 true PL354033A1 (pl) 2003-12-15
PL191733B1 PL191733B1 (pl) 2006-06-30

Family

ID=8309563

Family Applications (1)

Application Number Title Priority Date Filing Date
PL354033A PL191733B1 (pl) 1999-08-06 2000-07-17 Sposób wytwarzania kwasu 4-amino-1-hydroksybutylideno-1,1-bisfosfonowego i jego trójwodnej soli monosodowej

Country Status (18)

Country Link
US (1) US6573401B1 (pl)
EP (1) EP1205484B1 (pl)
KR (1) KR100688287B1 (pl)
AT (1) ATE238317T1 (pl)
AU (1) AU5987300A (pl)
BR (1) BR0013031A (pl)
CA (1) CA2380841C (pl)
CR (1) CR6575A (pl)
DE (1) DE60002347T2 (pl)
DK (1) DK1205484T3 (pl)
ES (2) ES2153794B1 (pl)
HU (1) HUP0202196A3 (pl)
IL (1) IL148000A (pl)
MX (1) MXPA02001293A (pl)
PL (1) PL191733B1 (pl)
PT (1) PT1205484E (pl)
SI (1) SI1205484T1 (pl)
WO (1) WO2001010874A1 (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100897837B1 (ko) * 2001-12-24 2009-05-15 테바 파마슈티컬 인더스트리즈 리미티드 분말 또는 과립 물질의 압착된 환상체 내에 싸인 활성성분의 코어 정제를 갖는 제형과, 이의 제조 방법 및 툴링
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
KR100681282B1 (ko) * 2002-05-17 2007-02-12 테바 파마슈티컬 인더스트리즈 리미티드 특정 희석제를 사용하는 비스포스폰산 및 그 염의 제조방법
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2005035542A1 (en) * 2003-10-14 2005-04-21 Pliva-Istrazivanje I Razvoj D.O.O. Solid-state form of alendronate sodium and preparation thereof
EP1883644A2 (en) * 2005-05-06 2008-02-06 Medichem, S.A. Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof
WO2006134603A1 (en) 2005-06-13 2006-12-21 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
WO2007132478A2 (en) * 2006-05-11 2007-11-22 Ind-Swift Laboratories Limited Process for the preparation of pure risedronic acid or salts
PL2483283T3 (pl) 2009-10-02 2015-06-30 Monsanto Technology Llc Sposób wytwarzania kwasów aminohydroksydifosfonowych

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
GB2248061A (en) * 1990-09-18 1992-03-25 Merck & Co Inc Amino-hydroxy-alkylidene bis phosphonic acids
US5039819A (en) 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
TW257765B (pl) 1993-08-25 1995-09-21 Merck & Co Inc
US5510517A (en) 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
EP1169326B1 (en) * 1999-02-17 2004-07-14 Teva Pharmaceutical Industries Ltd. Process for preparing alendronic acid

Also Published As

Publication number Publication date
SI1205484T1 (en) 2003-12-31
AU5987300A (en) 2001-03-05
BR0013031A (pt) 2002-04-16
DE60002347T2 (de) 2004-02-12
EP1205484A1 (en) 2002-05-15
EP1205484B1 (en) 2003-04-23
DE60002347D1 (de) 2003-05-28
ATE238317T1 (de) 2003-05-15
PT1205484E (pt) 2003-08-29
MXPA02001293A (es) 2002-07-22
CR6575A (es) 2002-08-16
DK1205484T3 (da) 2003-08-11
CA2380841C (en) 2009-09-15
KR100688287B1 (ko) 2007-02-28
IL148000A0 (en) 2002-09-12
HUP0202196A2 (en) 2002-10-28
PL191733B1 (pl) 2006-06-30
WO2001010874A1 (es) 2001-02-15
ES2153794A1 (es) 2001-03-01
ES2153794B1 (es) 2001-10-16
HUP0202196A3 (en) 2002-12-28
ES2194753T3 (es) 2003-12-01
IL148000A (en) 2005-12-18
US6573401B1 (en) 2003-06-03
KR20020024320A (ko) 2002-03-29
CA2380841A1 (en) 2001-02-15

Similar Documents

Publication Publication Date Title
PL354033A1 (pl) Sposób wytwarzania kwasu 4-amino-1-hydroksybutylidSposób wytwarzania kwasu 4-amino-1-hydroksybutylideno-1,1-bisfosfoniowego i jego trójwodnej soli moneno-1,1-bisfosfoniowego i jego trójwodnej soli monosodowejosodowej
AU2266899A (en) Method for producing dialkylphosphinic acids
EP1055677A3 (de) Verfahren zur Herstellung von Phosphinsäureestern
AU642264B2 (en) Improved process for preparing 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid (ABP) or salts thereof
AU625704C (en) 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof, compositions and uses therefor and processes of preparation.
MXPA03005885A (es) Procedimiento para fabricar maleato de amlodipina.
CA2223287A1 (en) Process for preparing n-phosphonomethyliminodiacetic acid
AU5788000A (en) Process for producing particles of amine reaction product
EP1164127A4 (en) PROCESS FOR PRODUCTION OF ONIUM SALT DERIVATIVE AND NEW ONIUM SALT DERIVATIVE
ES2138539A1 (es) "fabricacion de acido 3-amino-1-hidroxipropano-1,1-difosfonico".
EP0358022A3 (en) Process for the continuous preparation of 2-phosphonobutane-1,2,4-tricarboxylic acid and its alkali salts
FR2780968B1 (fr) Procede de preparation de l'acide hydroxymethylthiobutyrique
AU6578400A (en) Novel method for preparing benzoperhydroisoindole compounds
AU5987400A (en) Venlafaxine production process
PL311002A1 (en) Method of obtaining aminomethanophosphonic acid
AU1876688A (en) Process for synthesis of aminomethylene phosphonoalkylphosphinates
HUP0204173A2 (hu) Eljárás konjugált linolénsav előállítására
ATE258547T1 (de) Verfahren zur herstellung von 2-hydroxy-6- trifluormethylpyridin
EP1211239A4 (en) PROCESSES FOR THE PREPARATION OF 2,3-DIHYDROAZEPINE COMPOUNDS
WO2005086961A3 (en) Improved preparation of halohydroccarbyl phosphonic acid diestres
AU5681100A (en) Method for producing 4,6-dichloropyrimidine
AU6530796A (en) Process for producing carbamoylmethylurea derivatives

Legal Events

Date Code Title Description
LAPS Decisions on the lapse of the protection rights

Effective date: 20100717