PL358667A1 - Estratrieny podstawione hydrokarbylem w pozycji 8ss do zastosowania jako selektywne estrogeny - Google Patents

Estratrieny podstawione hydrokarbylem w pozycji 8ss do zastosowania jako selektywne estrogeny

Info

Publication number: PL358667A1
Authority: PL; Poland
Prior art keywords: sup; compounds; action; 8beta; 5ht2a
Prior art date: 2000-04-12

Application number

PL01358667A

Other languages

English (en)

Other versions

PL207488B1 (pl

Inventor

Olaf Peters

Alexander Hillisch

Ina Thieme

Walter Elger

Christa Hegele-Hartung

Uwe Kollenkirchen

Karl-Heinrich Fritzemeier

Vladimir Patchev

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-12

Filing date

2001-04-12

Publication date

2004-08-09

2000-04-12 Priority claimed from DE10019167A external-priority patent/DE10019167A1/de

2001-04-12 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

2004-08-09 Publication of PL358667A1 publication Critical patent/PL358667A1/pl

2010-12-31 Publication of PL207488B1 publication Critical patent/PL207488B1/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0062—Estrane derivatives substituted in position 17 alfa not substituted in position 17 beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Pregnancy & Childbirth (AREA)
Toxicology (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL358667A 2000-04-12 2001-04-12 Pochodne estra-1,3,5(10)-trienu podstawione w pozycji 8ß, ich zastosowanie oraz kompozycja farmaceutyczna je zawierająca PL207488B1 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10019167A DE10019167A1 (de)	2000-04-12	2000-04-12	Substituierte Estratriene als selektiv wirksame Estrogene
US20737000P	2000-05-26	2000-05-26
PCT/EP2001/004290 WO2001077139A1 (de)	2000-04-12	2001-04-12	8.beta.-hydrocarbyl-substituierte estratriene als selektiv wirksame estrogene

Publications (2)

Publication Number	Publication Date
PL358667A1 true PL358667A1 (pl)	2004-08-09
PL207488B1 PL207488B1 (pl)	2010-12-31

Family

ID=26005365

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL358667A PL207488B1 (pl)	2000-04-12	2001-04-12	Pochodne estra-1,3,5(10)-trienu podstawione w pozycji 8ß, ich zastosowanie oraz kompozycja farmaceutyczna je zawierająca

Country Status (25)

Country	Link
US (3)	US20040029847A1 (pl)
EP (2)	EP1272505B1 (pl)
JP (2)	JP3828423B2 (pl)
CN (1)	CN100453549C (pl)
AT (2)	ATE363487T1 (pl)
AU (3)	AU2001273945A1 (pl)
BG (1)	BG107173A (pl)
BR (1)	BR0109983A (pl)
CA (1)	CA2406177C (pl)
CZ (1)	CZ20023382A3 (pl)
DE (1)	DE50112561D1 (pl)
DK (2)	DK1272505T3 (pl)
EA (1)	EA006299B1 (pl)
EE (1)	EE200200589A (pl)
ES (2)	ES2245694T3 (pl)
HR (1)	HRP20020892B1 (pl)
HU (1)	HUP0300335A2 (pl)
IL (2)	IL152248A0 (pl)
MX (1)	MXPA02010066A (pl)
NO (2)	NO325337B1 (pl)
NZ (1)	NZ543724A (pl)
PL (1)	PL207488B1 (pl)
PT (1)	PT1272504E (pl)
SK (1)	SK14632002A3 (pl)
WO (2)	WO2001077138A1 (pl)

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DE10027887A1 (de)	2000-05-31	2001-12-13	Jenapharm Gmbh	Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE10039199A1 (de) *	2000-08-10	2002-02-21	Schering Ag	Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen
GB0020498D0 (en)	2000-08-18	2000-10-11	Sterix Ltd	Compound
DE10151363A1 (de) *	2001-10-17	2003-05-08	Schering Ag	Somatotrope Therapie
DE10226326A1 (de) *	2002-06-11	2004-01-15	Schering Ag	9-alpha-substiuierte Estratriene als selektiv wirksame Estrogene
EP1468690B1 (en) *	2003-03-27	2008-10-08	Pantarhei Bioscience B.V.	Use of estrogens for the treatment of infertility in male mammals
DE10318896A1 (de) *	2003-04-22	2004-11-25	Schering Ag	8beta-Vinyl-11beta-(omega-substituierte)alkyl-estra-1,3,5(10)-triene
PT1689410E (pt) *	2003-11-26	2008-08-18	Bayer Schering Pharma Ag	Prevenção e tratamento de doenças cardíacas hipertensivas pelos estrogénios selectivos 8beta-vinil-estra-1,3,5(10)-trieno-3,17beta-diol e 17beta-fluoro-9alfa-vinil-estra-1,3,5(10)-trieno-3,16alfa-diol
US7534780B2 (en)	2004-05-21	2009-05-19	Bayer Schering Pharma Aktiengesellschaft	Estradiol prodrugs
DE102005057224A1 (de) *	2005-11-29	2007-05-31	Bayer Schering Pharma Ag	Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE102005057225A1 (de) *	2005-11-29	2007-05-31	Bayer Schering Pharma Ag	Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
EP2014672A1 (en) *	2007-07-12	2009-01-14	Bayer Schering Pharma Aktiengesellschaft	8-beta-substituted estratrienes as selectively active estrogens
US20110052699A1 (en) *	2008-02-13	2011-03-03	Adrian Funke	Drug delivery system with stabilising effect
EP2249803A2 (en) *	2008-02-13	2010-11-17	Bayer Schering Pharma Aktiengesellschaft	Estradiol-containing drug delivery system
EP2143432A1 (en)	2008-07-11	2010-01-13	Bayer Schering Pharma AG	9-alpha estratriene derivatives as ER-beta selective ligands for the prevention and treatment of intestinal cancer
JP2012509286A (ja) *	2008-11-21	2012-04-19	バイエルファーマアクチエンゲゼルシャフト	薬物送達システム
RS62297B1 (sr)	2011-11-23	2021-09-30	Therapeuticsmd Inc	Prirodne kombinovane hormonske supstitucione formulacije i terapije
US9301920B2 (en)	2012-06-18	2016-04-05	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
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US10806697B2 (en)	2012-12-21	2020-10-20	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en)	2012-06-18	2015-07-16	Therapeuticsmd, Inc.	Progesterone formulations having a desirable pk profile
US10806740B2 (en)	2012-06-18	2020-10-20	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US10471072B2 (en)	2012-12-21	2019-11-12	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en)	2012-12-21	2020-02-25	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en)	2012-12-21	2022-02-15	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en)	2012-12-21	2020-01-21	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
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DE69702450T2 (de) *	1996-05-01	2001-03-08	The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer	21-substituierte progesteron derivate als antigestagene
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SK14632002A3 (sk) *	2000-04-12	2003-03-04	Schering Aktiengesellschaft	Substituované estratriény a ich použitie ako selektívne účinných estrogénov
DE10019167A1 (de) *	2000-04-12	2001-10-18	Schering Ag	Substituierte Estratriene als selektiv wirksame Estrogene
DE10318896A1 (de) *	2003-04-22	2004-11-25	Schering Ag	8beta-Vinyl-11beta-(omega-substituierte)alkyl-estra-1,3,5(10)-triene

2001
- 2001-04-12 SK SK1463-2002A patent/SK14632002A3/sk unknown
- 2001-04-12 AT AT01931609T patent/ATE363487T1/de active
- 2001-04-12 ES ES01940331T patent/ES2245694T3/es not_active Expired - Lifetime
- 2001-04-12 JP JP2001575608A patent/JP3828423B2/ja not_active Expired - Lifetime
- 2001-04-12 MX MXPA02010066A patent/MXPA02010066A/es active IP Right Grant
- 2001-04-12 EP EP01940331A patent/EP1272505B1/de not_active Expired - Lifetime
- 2001-04-12 IL IL15224801A patent/IL152248A0/xx active IP Right Grant
- 2001-04-12 DK DK01940331T patent/DK1272505T3/da active
- 2001-04-12 DK DK01931609T patent/DK1272504T3/da active
- 2001-04-12 NZ NZ543724A patent/NZ543724A/en unknown
- 2001-04-12 PT PT01931609T patent/PT1272504E/pt unknown
- 2001-04-12 US US10/257,287 patent/US20040029847A1/en not_active Abandoned
- 2001-04-12 AU AU2001273945A patent/AU2001273945A1/en not_active Abandoned
- 2001-04-12 BR BR0109983-3A patent/BR0109983A/pt not_active IP Right Cessation
- 2001-04-12 EE EEP200200589A patent/EE200200589A/xx unknown
- 2001-04-12 HR HR20020892A patent/HRP20020892B1/xx not_active IP Right Cessation
- 2001-04-12 PL PL358667A patent/PL207488B1/pl not_active IP Right Cessation
- 2001-04-12 US US10/257,288 patent/US7378404B2/en not_active Expired - Fee Related
- 2001-04-12 ES ES01931609T patent/ES2287127T3/es not_active Expired - Lifetime
- 2001-04-12 HU HU0300335A patent/HUP0300335A2/hu unknown
- 2001-04-12 AU AU5834101A patent/AU5834101A/xx active Pending
- 2001-04-12 CA CA2406177A patent/CA2406177C/en not_active Expired - Fee Related
- 2001-04-12 AU AU2001258341A patent/AU2001258341B2/en not_active Ceased
- 2001-04-12 AT AT01940331T patent/ATE302790T1/de not_active IP Right Cessation
- 2001-04-12 DE DE50112561T patent/DE50112561D1/de not_active Expired - Lifetime
- 2001-04-12 CZ CZ20023382A patent/CZ20023382A3/cs unknown
- 2001-04-12 EA EA200201052A patent/EA006299B1/ru not_active IP Right Cessation
- 2001-04-12 CN CNB018107745A patent/CN100453549C/zh not_active Expired - Fee Related
- 2001-04-12 WO PCT/EP2001/004289 patent/WO2001077138A1/de not_active Ceased
- 2001-04-12 WO PCT/EP2001/004290 patent/WO2001077139A1/de not_active Ceased
- 2001-04-12 EP EP01931609A patent/EP1272504B1/de not_active Expired - Lifetime
2002
- 2002-10-08 BG BG107173A patent/BG107173A/bg unknown
- 2002-10-10 IL IL152248A patent/IL152248A/en not_active IP Right Cessation
- 2002-10-11 NO NO20024908A patent/NO325337B1/no unknown
- 2002-10-11 NO NO20024907A patent/NO20024907L/no not_active Application Discontinuation
2008
- 2008-03-11 US US12/045,979 patent/US20080182829A1/en not_active Abandoned
- 2008-06-25 JP JP2008166585A patent/JP2008280355A/ja active Pending

Also Published As

Publication number	Publication date
NZ543724A (en)	2007-07-27
HUP0300335A2 (hu)	2003-07-28
EP1272505A1 (de)	2003-01-08
PT1272504E (pt)	2007-08-29
DE50112561D1 (de)	2007-07-12
BR0109983A (pt)	2003-02-25
CZ20023382A3 (cs)	2003-02-12
MXPA02010066A (es)	2003-06-04
JP3828423B2 (ja)	2006-10-04
CA2406177A1 (en)	2001-10-18
HK1057219A1 (zh)	2004-03-19
EP1272504A1 (de)	2003-01-08
NO20024908L (no)	2002-11-13
NO20024907D0 (no)	2002-10-11
IL152248A0 (en)	2003-05-29
NO325337B1 (no)	2008-03-31
AU2001273945A1 (en)	2001-10-23
HRP20020892B1 (en)	2011-08-31
CA2406177C (en)	2010-06-22
ATE363487T1 (de)	2007-06-15
US20030176405A1 (en)	2003-09-18
NO20024907L (no)	2002-12-05
PL207488B1 (pl)	2010-12-31
ES2245694T3 (es)	2006-01-16
EE200200589A (et)	2004-04-15
WO2001077139A1 (de)	2001-10-18
AU5834101A (en)	2001-10-23
ATE302790T1 (de)	2005-09-15
EA200201052A1 (ru)	2003-04-24
US20080182829A1 (en)	2008-07-31
EP1272504B1 (de)	2007-05-30
AU2001258341B2 (en)	2007-03-15
BG107173A (bg)	2003-05-30
DK1272504T3 (da)	2007-10-01
IL152248A (en)	2008-06-05
SK14632002A3 (sk)	2003-03-04
JP2008280355A (ja)	2008-11-20
US20040029847A1 (en)	2004-02-12
EA006299B1 (ru)	2005-10-27
WO2001077138A1 (de)	2001-10-18
JP2003530403A (ja)	2003-10-14
CN100453549C (zh)	2009-01-21
EP1272505B1 (de)	2005-08-24
ES2287127T3 (es)	2007-12-16
US7378404B2 (en)	2008-05-27
DK1272505T3 (da)	2005-11-07
HRP20020892A2 (en)	2005-02-28
CN1433424A (zh)	2003-07-30
NO20024908D0 (no)	2002-10-11

Legal Events

Date	Code	Title	Description
2014-06-30	LAPS	Decisions on the lapse of the protection rights	Effective date: 20130412

Publication	Publication Date	Title
AU5834101A (en)	2001-10-23	8ss-hydrocarbyl-substituted estratrienes for use as selective estrogens
ES2258005T3 (es)	2006-08-16	Ent-esteroides como estrogenos de accion selectiva.
HUP0302093A3 (en)	2010-03-29	Use of conjugated estrogens and medroxyprogesterone acetate for producing pharmaceutical compositions for hormone replacement therapy
EA200100108A1 (ru)	2001-12-24	Применение биогенных сульфаматов эстрогенов для гормонзаместительной терапии
CN1156998A (zh)	1997-08-13	雌-1，3，5(10)-三烯衍生物，其制备方法及含有这些化合物的药物组合物
RU97104120A (ru)	1999-04-20	Фармацевтические композиции, содержащие производные эстра-1,3,5(10)-триена
YU57201A (sh)	2005-06-10	16-hidroksiestratrieni kao selektivno aktivni estrogeni
AU4246501A (en)	2001-09-24	4-fluoroalkyl-2h-benzopyrans with anti-estrogenic activity
ES2286042T3 (es)	2007-12-01	18-nor-esteroides como estrogenos eficaces selectivamente.
KR101006612B1 (ko)	2011-01-10	선택적 활성 에스트로겐으로서의 9-ａｌｐｈａ-치환에스트라트리엔
HU230920B1 (hu)	2019-03-28	Depresszió kezelésére szolgáló androgén gyógyászati készítmények
ES2300431T3 (es)	2008-06-16	Esteroides androgenos halogenados en posicion 11 y sustituidos en posicion 7.
YU77302A (sh)	2005-11-28	8beta-hidrokarbil-supstituisani estratrieni kao selektivno delotvorni estrogeni
UA99918C2 (ru)	2012-10-25	8-бета-замещенные эстратриены как селективно активные эстрогены
ES2260294T3 (es)	2006-11-01	17-metilen-esteroides halogenados en posicion 4, procedimientos para su preparacion y composiciones que contienen estos compuestos.