PL361173A1 - 2,2-Dipodstawione 1,3-dioksolany jako środki przeciwkaszlowe - Google Patents

2,2-Dipodstawione 1,3-dioksolany jako środki przeciwkaszlowe

Info

Publication number: PL361173A1
Authority: PL; Poland
Prior art keywords: dioxolanes; disubstituted; antitussive agents; piperazinyl; phenyl
Prior art date: 2000-07-28

Application number

PL01361173A

Other languages

English (en)

Other versions

PL206308B1 (pl

Inventor

Marcello Allegretti

Maria Candida Cesta

Roberto Curti

Luca Nicolini

Original Assignee

Dompe S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-28

Filing date

2001-07-18

Publication date

2004-09-20

2001-07-18 Application filed by Dompe S.P.A. filed Critical Dompe S.P.A.

2004-09-20 Publication of PL361173A1 publication Critical patent/PL361173A1/pl

2010-07-30 Publication of PL206308B1 publication Critical patent/PL206308B1/pl

Links

-1 2,2-disubstituted 1,3-dioxolanes Chemical class 0.000 title abstract 2
239000003434 antitussive agent Substances 0.000 title 1
229940124584 antitussives Drugs 0.000 title 1
PTVWPYVOOKLBCG-UHFFFAOYSA-N 3-(4-phenyl-1-piperazinyl)propane-1,2-diol Chemical compound C1CN(CC(O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-UHFFFAOYSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
PTVWPYVOOKLBCG-ZDUSSCGKSA-N levodropropizine Chemical compound C1CN(C[C@H](O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-ZDUSSCGKSA-N 0.000 abstract 1
229960002265 levodropropizine Drugs 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Holo Graphy (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)
Glass Compositions (AREA)
Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Fats And Perfumes (AREA)
Liquid Crystal Substances (AREA)
Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Secondary Cells (AREA)

PL361173A 2000-07-28 2001-07-18 2,2-dipodstawione 1,3-dioksolany, sposób ich wytwarzania, sposób ich rozdzielania optycznego i ich zastosowanie oraz sposób syntezy lewodropropizyny PL206308B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2000MI001735A IT1318651B1 (it)	2000-07-28	2000-07-28	Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.

Publications (2)

Publication Number	Publication Date
PL361173A1 true PL361173A1 (pl)	2004-09-20
PL206308B1 PL206308B1 (pl)	2010-07-30

Family

ID=11445592

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL361173A PL206308B1 (pl)	2000-07-28	2001-07-18	2,2-dipodstawione 1,3-dioksolany, sposób ich wytwarzania, sposób ich rozdzielania optycznego i ich zastosowanie oraz sposób syntezy lewodropropizyny

Country Status (24)

Country	Link
US (1)	US6916926B2 (pl)
EP (1)	EP1307440B1 (pl)
JP (1)	JP5015403B2 (pl)
KR (1)	KR100788532B1 (pl)
CN (1)	CN1216053C (pl)
AT (1)	ATE290533T1 (pl)
AU (1)	AU2001281992A1 (pl)
BR (1)	BR0112802A (pl)
CZ (1)	CZ301039B6 (pl)
DE (1)	DE60109299T2 (pl)
EE (1)	EE05159B1 (pl)
ES (1)	ES2237589T3 (pl)
HU (1)	HU229801B1 (pl)
IL (2)	IL153502A0 (pl)
IT (1)	IT1318651B1 (pl)
MX (1)	MXPA02012922A (pl)
PL (1)	PL206308B1 (pl)
PT (1)	PT1307440E (pl)
RS (1)	RS50862B (pl)
RU (1)	RU2269522C2 (pl)
SI (1)	SI21041B (pl)
SK (1)	SK286795B6 (pl)
UA (1)	UA73790C2 (pl)
WO (1)	WO2002010150A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1318650B1 (it) *	2000-07-28	2003-08-27	Dompe Spa	1,3-diossolani ad attivita' antitosse.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4049660A (en) *	1971-06-18	1977-09-20	Delalande S.A.	N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics
IT1210639B (it) *	1981-02-25	1989-09-14	Menarini Sas	Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione
IT1203721B (it)	1983-12-29	1989-02-23	Dompe Farmaceutici Spa	Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
SE449516B (sv) *	1984-10-16	1987-05-04	Skf Nova Ab	Klemring med reglerbar halomkrets
IT1254452B (it) *	1992-02-14	1995-09-25	Dompe Farmaceutici Spa	N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
IL111730A (en) *	1993-11-29	1998-12-06	Fujisawa Pharmaceutical Co	Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
DE69722360T2 (de) *	1996-06-29	2003-11-27	Samjin Pharm, Co.	Piperazin-derivate und verfahren zu ihrer herstellung
IT1318650B1 (it) *	2000-07-28	2003-08-27	Dompe Spa	1,3-diossolani ad attivita' antitosse.

2000
- 2000-07-28 IT IT2000MI001735A patent/IT1318651B1/it active
2001
- 2001-07-18 BR BR0112802-7A patent/BR0112802A/pt not_active Application Discontinuation
- 2001-07-18 UA UA2003021768A patent/UA73790C2/uk unknown
- 2001-07-18 KR KR1020037000943A patent/KR100788532B1/ko not_active Expired - Fee Related
- 2001-07-18 US US10/312,290 patent/US6916926B2/en not_active Expired - Fee Related
- 2001-07-18 RS YUP-31/03A patent/RS50862B/sr unknown
- 2001-07-18 ES ES01960513T patent/ES2237589T3/es not_active Expired - Lifetime
- 2001-07-18 PT PT01960513T patent/PT1307440E/pt unknown
- 2001-07-18 AU AU2001281992A patent/AU2001281992A1/en not_active Abandoned
- 2001-07-18 SI SI200120037A patent/SI21041B/sl not_active IP Right Cessation
- 2001-07-18 HU HU0301473A patent/HU229801B1/hu not_active IP Right Cessation
- 2001-07-18 SK SK90-2003A patent/SK286795B6/sk not_active IP Right Cessation
- 2001-07-18 EE EEP200300035A patent/EE05159B1/xx not_active IP Right Cessation
- 2001-07-18 PL PL361173A patent/PL206308B1/pl unknown
- 2001-07-18 CN CN018134572A patent/CN1216053C/zh not_active Expired - Fee Related
- 2001-07-18 CZ CZ20030269A patent/CZ301039B6/cs not_active IP Right Cessation
- 2001-07-18 MX MXPA02012922A patent/MXPA02012922A/es active IP Right Grant
- 2001-07-18 AT AT01960513T patent/ATE290533T1/de active
- 2001-07-18 EP EP01960513A patent/EP1307440B1/en not_active Expired - Lifetime
- 2001-07-18 JP JP2002515881A patent/JP5015403B2/ja not_active Expired - Fee Related
- 2001-07-18 RU RU2003105692/04A patent/RU2269522C2/ru not_active IP Right Cessation
- 2001-07-18 DE DE60109299T patent/DE60109299T2/de not_active Expired - Lifetime
- 2001-07-18 WO PCT/EP2001/008305 patent/WO2002010150A1/en not_active Ceased
- 2001-07-18 IL IL15350201A patent/IL153502A0/xx active IP Right Grant
2002
- 2002-12-17 IL IL153502A patent/IL153502A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ301039B6 (cs)	2009-10-21
CN1216053C (zh)	2005-08-24
SK902003A3 (en)	2003-09-11
RU2269522C2 (ru)	2006-02-10
JP2004505074A (ja)	2004-02-19
SK286795B6 (sk)	2009-05-07
ITMI20001735A1 (it)	2002-01-28
KR20030016424A (ko)	2003-02-26
KR100788532B1 (ko)	2007-12-24
UA73790C2 (uk)	2005-09-15
US6916926B2 (en)	2005-07-12
EP1307440A1 (en)	2003-05-07
CZ2003269A3 (cs)	2003-06-18
WO2002010150A1 (en)	2002-02-07
ITMI20001735A0 (it)	2000-07-28
PT1307440E (pt)	2005-05-31
PL206308B1 (pl)	2010-07-30
JP5015403B2 (ja)	2012-08-29
BR0112802A (pt)	2003-07-01
HUP0301473A2 (hu)	2003-08-28
EE05159B1 (et)	2009-04-15
DE60109299T2 (de)	2005-07-21
ES2237589T3 (es)	2005-08-01
RS50862B (sr)	2010-08-31
IL153502A0 (en)	2003-07-06
SI21041A (sl)	2003-04-30
EP1307440B1 (en)	2005-03-09
IL153502A (en)	2006-12-10
SI21041B (en)	2005-08-31
MXPA02012922A (es)	2003-10-06
IT1318651B1 (it)	2003-08-27
YU3103A (sh)	2006-05-25
AU2001281992A1 (en)	2002-02-13
DE60109299D1 (de)	2005-04-14
EE200300035A (et)	2004-10-15
HU229801B1 (en)	2014-07-28
CN1444579A (zh)	2003-09-24
ATE290533T1 (de)	2005-03-15
HK1058798A1 (en)	2004-06-04
US20030176446A1 (en)	2003-09-18

Publication	Publication Date	Title
EA200300459A1 (ru)	2003-10-30	Новые, применяемые в качестве медикаментов антихолинергические средства, а также способ их получения
MX9603050A (es)	1997-03-29	Derivados de la 1-h-3-aril-pirrolidin-2,4-diona como agentes pesticidas.
DE69527072D1 (de)	2002-07-18	Endothelin antagoniste
NO870241D0 (no)	1987-01-20	Hypoglykemiske tiazolidindioner.
ATE502932T1 (de)	2011-04-15	Makrocyclische analoga und verfahren zu ihrer verwendung und herstellung
DK0565549T3 (da)	1995-07-03	Anvendelse af 1,3-oxathiolannucleosidanaloger til fremstilling af et præparat til behandling af hepatitis B
FI922806A0 (fi)	1992-06-17	Substituerade 4-fenyl-4 -piperidinkarboxamider med baode lokalbedoevande och smaertstillande effekt samt foerfaranden foer deras framstaellning.
ATE212860T1 (de)	2002-02-15	Eine neuartige medizinische verwendung eines 5ht 3-antagonisten
ATE419228T1 (de)	2009-01-15	Herstellung von fluoromethyl-2,2,2-trifluoro-1- (trifluoromethyl)ethylether
AU4600200A (en)	2000-11-21	Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof
TR200402546T4 (tr)	2004-12-21	Taksan türevleri hazırlamak için işlem.
BR0114380A (pt)	2003-12-30	Derivados-1-aminobutan-3-ol-substituìdos
DE50101861D1 (de)	2004-05-06	Tocotrienolchinon- zyklisierungsprodukte mit antihypercholesterin wirkung
IL153502A0 (en)	2003-07-06	2,2-disubstituted 1,3-dioxolanes as antitussive agents
IL140151A0 (en)	2002-02-10	Hyperforin derivatives, the use thereof and formulations containing them
EA200201003A1 (ru)	2003-02-27	Аморфная модификация торасемида
IL153515A0 (en)	2003-07-06	1,3-dioxolanes with antitussive activity
IT1255461B (it)	1995-11-02	Eteri di imidazoli ad attivita' a ii antagonista
DE60111634D1 (de)	2005-07-28	Verfahren zur herstellung von thiazolidinedion-derivaten und zwischenprodukte
EA200200741A1 (ru)	2002-12-26	Способ получения эфиров арилиминометилкарбаминовой кислоты
EA200200090A1 (ru)	2002-06-27	Способ получения замещенных бензизотиазоловых соединений
ATE98628T1 (de)	1994-01-15	2-amino-7-hydroxytetralin-ether.
IT9020200A0 (it)	1990-05-03	Procedimento per la fabbricazione di spazzole, nonche' macchina per la fabbricazione di spazzole per l'esecuzione del procedimento
UY26638A1 (es)	2001-10-25	Nuevos derivados de piperazina