PL362366A1 - Nowy sposób syntezy przemysłowej tetraestrów kwasu 5-[bis(karboksymetylo)amino]-3-karboksymetylo-4-cyjano-2-tiofenokarboksylowego, sposób wytwarzaniasoli metali dwuwartościowych kwasu ranelowego i ich hydratów oraz nowe związki pośrednie - Google Patents

Nowy sposób syntezy przemysłowej tetraestrów kwasu 5-[bis(karboksymetylo)amino]-3-karboksymetylo-4-cyjano-2-tiofenokarboksylowego, sposób wytwarzaniasoli metali dwuwartościowych kwasu ranelowego i ich hydratów oraz nowe związki pośrednie

Info

Publication number: PL362366A1
Authority: PL; Poland
Prior art keywords: acid; new; phenokarboxylic; karboxymethyl; hydrates
Prior art date: 2002-09-24

Application number

PL03362366A

Other languages

English (en)

Other versions

PL215879B1 (pl

Inventor

Lucile Vaysse-Ludot

Jean-Pierre Lecouve

Pascal Langlois

Original Assignee

Les Laboratoires Servier

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-24

Filing date

2003-09-23

Publication date

2004-04-05

2003-09-23 Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier

2004-04-05 Publication of PL362366A1 publication Critical patent/PL362366A1/pl

2014-02-28 Publication of PL215879B1 publication Critical patent/PL215879B1/pl

Links

238000000034 method Methods 0.000 title 2
239000002253 acid Substances 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
150000002148 esters Chemical class 0.000 title 1
150000004677 hydrates Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
DJSXNILVACEBLP-UHFFFAOYSA-N ranelic acid Chemical class OC(=O)CN(CC(O)=O)C=1SC(C(O)=O)=C(CC(O)=O)C=1C#N DJSXNILVACEBLP-UHFFFAOYSA-N 0.000 title 1
229950003464 ranelic acid Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PL362366A 2002-09-24 2003-09-23 Sposób syntezy przemyslowej tetraestrów kwasu 5-[bis(karboksymetylo)amino]-3-karboksymetylo-4-cyjano-2-tiofenokarboksylowego oraz zwiazek posredni 5-[bis(2-metoksy-2-oksoetylo)amino]-4-cyjano-3-(2-metoksy-2-oksoetylo)-2-tiofenokarboksylan metylu PL215879B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0211765A FR2844797B1 (fr)	2002-09-24	2002-09-24	Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Publications (2)

Publication Number	Publication Date
PL362366A1 true PL362366A1 (pl)	2004-04-05
PL215879B1 PL215879B1 (pl)	2014-02-28

Family

ID=29415191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL362366A PL215879B1 (pl)	2002-09-24	2003-09-23	Sposób syntezy przemyslowej tetraestrów kwasu 5-[bis(karboksymetylo)amino]-3-karboksymetylo-4-cyjano-2-tiofenokarboksylowego oraz zwiazek posredni 5-[bis(2-metoksy-2-oksoetylo)amino]-4-cyjano-3-(2-metoksy-2-oksoetylo)-2-tiofenokarboksylan metylu

Country Status (38)

Country	Link
US (1)	US7091364B2 (pl)
EP (1)	EP1403265B1 (pl)
JP (1)	JP4136866B2 (pl)
KR (1)	KR100551502B1 (pl)
CN (1)	CN1280286C (pl)
AP (1)	AP1972A (pl)
AR (1)	AR041357A1 (pl)
AT (1)	ATE449767T1 (pl)
AU (2)	AU2003248280B2 (pl)
BR (1)	BR0304203A (pl)
CA (1)	CA2442881C (pl)
CY (1)	CY1109831T1 (pl)
DE (1)	DE60330213D1 (pl)
DK (1)	DK1403265T3 (pl)
EA (1)	EA007108B1 (pl)
EC (1)	ECSP055743A (pl)
ES (1)	ES2337348T3 (pl)
FR (1)	FR2844797B1 (pl)
GE (1)	GEP20074139B (pl)
HR (1)	HRP20050361B1 (pl)
IL (1)	IL167315A (pl)
IS (1)	IS2728B (pl)
MA (1)	MA26100A1 (pl)
ME (1)	ME00453B (pl)
MX (1)	MXPA03008647A (pl)
MY (1)	MY134924A (pl)
NO (1)	NO328626B1 (pl)
NZ (1)	NZ528401A (pl)
OA (1)	OA12932A (pl)
PL (1)	PL215879B1 (pl)
PT (1)	PT1403265E (pl)
RS (1)	RS51551B (pl)
SG (1)	SG110069A1 (pl)
SI (1)	SI1403265T1 (pl)
TN (1)	TNSN05088A1 (pl)
UA (1)	UA79157C2 (pl)
WO (1)	WO2004029034A1 (pl)
ZA (1)	ZA200307411B (pl)

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FR2844795B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
JP4354984B2 (ja) *	2003-05-07	2009-10-28	オステオロジックスエイ／エス	水溶性ストロンチウム塩を用いる軟骨／骨症状の治療
EP2266584B1 (en) *	2003-05-07	2012-09-05	Osteologix A/S	Composition with strontium and vitamin D for the prophylaxis and/or treatment of cartilage and/or bone conditions
US20050085531A1 (en) *	2003-10-03	2005-04-21	Hodge Carl N.	Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
EP1732575B1 (en)	2004-02-26	2010-12-29	Osteologix A/S	Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
EA011814B1 (ru)	2004-06-25	2009-06-30	Стронтин Апс	Композиции, содержащие стронций и витамин d, и их применение
FR2875807B1 (fr) *	2004-09-30	2006-11-17	Servier Lab	Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN100391955C (zh) *	2005-04-30	2008-06-04	河北医科大学	一种雷尼酸锶中间体的合成方法
US20070292535A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating arthritic and or osteoporitic conditions
US20070292529A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating osteoporotic conditions
US20120123131A1 (en) *	2008-08-22	2012-05-17	Koilpillai Joseph Prabahar	Process for the preparation of strontium ranelate
CN101665483B (zh) *	2008-09-01	2013-01-23	河北医科大学	一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011124992A1 (en) *	2010-03-24	2011-10-13	Actavis Group Ptc Ehf	Substantially pure strontium ranelate
CN101812048B (zh) *	2010-04-06	2012-11-14	浙江东亚药业有限公司	雷尼酸锶及其水合物的合成方法
EP2602248A1 (en)	2011-12-05	2013-06-12	University Of Leicester	Novel pyrrole compounds
WO2013113319A1 (en)	2012-01-31	2013-08-08	Pharmathen S.A.	Process for the preparation of strontium ranelate, intermediate or hydrates thereof
EP2756841B1 (en)	2013-01-21	2015-05-13	Galenicum Health S.L.	Pharmaceutical compositions comprising an acid salt
GB201310126D0 (en) *	2013-06-06	2013-07-24	Univ Leicester	Novel pyrrole derivatives

Family Cites Families (7)

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Publication number	Priority date	Publication date	Assignee	Title
DE3624304A1 (de)	1986-07-18	1988-01-28	Bayer Ag	Fungizide verwendung von substituierten thienylaminen
GB8715925D0 (en) *	1987-07-07	1987-08-12	Shell Int Research	Thiapentanamide derivatives
FR2651497B1 (fr) *	1989-09-01	1991-10-25	Adir	Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE19528380A1 (de) *	1995-08-02	1997-02-06	Hoechst Ag	Heterogene Vinylacetat/Ethylen-Dispersion
FR2749759B1 (fr) *	1996-06-17	1999-11-26	Adir	Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
DE19650196A1 (de) *	1996-12-04	1998-06-10	Bayer Ag	Thienylsulfonylamino(thio)carbonylverbindungen
US6835745B2 (en) *	2002-01-15	2004-12-28	Wyeth	Phenyl substituted thiophenes as estrogenic agents

2002
- 2002-09-24 FR FR0211765A patent/FR2844797B1/fr not_active Expired - Fee Related
2003
- 2003-09-17 MY MYPI20033533A patent/MY134924A/en unknown
- 2003-09-22 AU AU2003248280A patent/AU2003248280B2/en not_active Ceased
- 2003-09-22 HR HRP20050361AA patent/HRP20050361B1/hr not_active IP Right Cessation
- 2003-09-22 DE DE60330213T patent/DE60330213D1/de not_active Expired - Lifetime
- 2003-09-22 JP JP2003330439A patent/JP4136866B2/ja not_active Expired - Fee Related
- 2003-09-22 ES ES03292318T patent/ES2337348T3/es not_active Expired - Lifetime
- 2003-09-22 GE GEAP20038759A patent/GEP20074139B/en unknown
- 2003-09-22 AP AP2005003255A patent/AP1972A/xx active
- 2003-09-22 AU AU2003299095A patent/AU2003299095A1/en not_active Abandoned
- 2003-09-22 UA UAA200503860A patent/UA79157C2/uk unknown
- 2003-09-22 RS YUP-2005/0241A patent/RS51551B/sr unknown
- 2003-09-22 WO PCT/FR2003/002775 patent/WO2004029034A1/fr not_active Ceased
- 2003-09-22 EP EP03292318A patent/EP1403265B1/fr not_active Expired - Lifetime
- 2003-09-22 OA OA1200500081A patent/OA12932A/en unknown
- 2003-09-22 DK DK03292318.7T patent/DK1403265T3/da active
- 2003-09-22 PT PT03292318T patent/PT1403265E/pt unknown
- 2003-09-22 AT AT03292318T patent/ATE449767T1/de active
- 2003-09-22 ME MEP-2008-687A patent/ME00453B/me unknown
- 2003-09-22 SI SI200331715T patent/SI1403265T1/sl unknown
- 2003-09-23 AR ARP030103455A patent/AR041357A1/es not_active Application Discontinuation
- 2003-09-23 ZA ZA200307411A patent/ZA200307411B/xx unknown
- 2003-09-23 BR BR0304203-0A patent/BR0304203A/pt not_active Application Discontinuation
- 2003-09-23 NO NO20034236A patent/NO328626B1/no not_active IP Right Cessation
- 2003-09-23 CA CA2442881A patent/CA2442881C/fr not_active Expired - Fee Related
- 2003-09-23 EA EA200300927A patent/EA007108B1/ru not_active IP Right Cessation
- 2003-09-23 MX MXPA03008647A patent/MXPA03008647A/es active IP Right Grant
- 2003-09-23 KR KR1020030065784A patent/KR100551502B1/ko not_active Expired - Fee Related
- 2003-09-23 PL PL362366A patent/PL215879B1/pl unknown
- 2003-09-23 NZ NZ528401A patent/NZ528401A/en not_active IP Right Cessation
- 2003-09-24 MA MA27319A patent/MA26100A1/fr unknown
- 2003-09-24 CN CNB031348122A patent/CN1280286C/zh not_active Expired - Fee Related
- 2003-09-24 SG SG200305553A patent/SG110069A1/en unknown
- 2003-09-24 US US10/669,302 patent/US7091364B2/en not_active Expired - Fee Related
2005
- 2005-03-08 IL IL167315A patent/IL167315A/en not_active IP Right Cessation
- 2005-03-23 TN TNP2005000088A patent/TNSN05088A1/fr unknown
- 2005-04-18 IS IS7803A patent/IS2728B/is unknown
- 2005-04-22 EC EC2005005743A patent/ECSP055743A/es unknown
2010
- 2010-01-19 CY CY20101100055T patent/CY1109831T1/el unknown

Also Published As

Publication number	Publication date
PT1403265E (pt)	2009-12-16
AP2005003255A0 (en)	2005-03-31
US7091364B2 (en)	2006-08-15
CN1280286C (zh)	2006-10-18
AU2003299095A1 (en)	2004-04-19
ECSP055743A (es)	2005-07-06
CA2442881A1 (fr)	2004-03-24
MY134924A (en)	2008-01-31
ZA200307411B (en)	2004-07-07
KR100551502B1 (ko)	2006-02-13
DK1403265T3 (da)	2010-04-06
IS2728B (is)	2011-04-15
FR2844797B1 (fr)	2004-10-22
EA007108B1 (ru)	2006-06-30
PL215879B1 (pl)	2014-02-28
WO2004029034A1 (fr)	2004-04-08
HK1061846A1 (en)	2004-10-08
FR2844797A1 (fr)	2004-03-26
AU2003248280A1 (en)	2004-04-08
IS7803A (is)	2005-04-18
EP1403265A1 (fr)	2004-03-31
NO20034236L (no)	2004-03-25
HRP20050361A2 (en)	2005-06-30
ME00453B (me)	2011-10-10
RS51551B (sr)	2011-06-30
ATE449767T1 (de)	2009-12-15
CA2442881C (fr)	2010-06-29
RS20050241A (sr)	2007-06-04
SI1403265T1 (sl)	2010-01-29
NO328626B1 (no)	2010-04-12
JP2004269496A (ja)	2004-09-30
ES2337348T3 (es)	2010-04-23
OA12932A (en)	2006-10-13
SG110069A1 (en)	2005-04-28
JP4136866B2 (ja)	2008-08-20
EP1403265B1 (fr)	2009-11-25
MXPA03008647A (es)	2005-04-19
MA26100A1 (fr)	2004-04-01
TNSN05088A1 (fr)	2007-05-14
KR20040026626A (ko)	2004-03-31
US20040059134A1 (en)	2004-03-25
HRP20050361B1 (hr)	2014-03-14
GEP20074139B (en)	2007-06-25
EA200300927A1 (ru)	2004-04-29
AP1972A (en)	2009-03-12
NZ528401A (en)	2004-05-28
BR0304203A (pt)	2004-08-24
CN1500784A (zh)	2004-06-02
AU2003248280B2 (en)	2009-01-08
AR041357A1 (es)	2005-05-11
DE60330213D1 (de)	2010-01-07
IL167315A (en)	2009-08-03
NO20034236D0 (no)	2003-09-23
UA79157C2 (en)	2007-05-25
CY1109831T1 (el)	2014-09-10

Legal Events

Date	Code	Title	Description
2014-05-30	RECP	Rectifications of patent specification

Publication	Publication Date	Title
PL362366A1 (pl)	2004-04-05	Nowy sposób syntezy przemysłowej tetraestrów kwasu 5-[bis(karboksymetylo)amino]-3-karboksymetylo-4-cyjano-2-tiofenokarboksylowego, sposób wytwarzaniasoli metali dwuwartościowych kwasu ranelowego i ich hydratów oraz nowe związki pośrednie
DK1488790T3 (da)	2014-10-13	Fast præparat indeholdende en enkeltkrystalform A af etthiazolcarboxylsyrederivat
GEP20074135B (en)	2007-06-25	Process for the synthesis of (is)-4,5-dimethoxy-1-(methylaminomethyl)- benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
NO20050118D0 (no)	2005-01-10	Substituerte fenylsulfonamidinhibitorer av beta-amyolid produksjon
EE200300343A (et)	2003-10-15	Pantoteenhappe võimendatud produktsiooni meetod
MX2008010884A (es)	2008-09-03	Acidos 4-fenil-tiazol-5-carboxilicos y amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1.
HUP0400053A3 (en)	2006-01-30	New process for synthesis of 4-phenylbutyric acid
PL362367A1 (pl)	2004-04-05	Nowy sposób syntezy przemysłowej diestru metylowego kwasu 5-amino-3-karboksymetylo-4-cyjano-2-tiofenokarboksylowego, sposób syntezy kwasu ranelowego,soli metali dwuwartościowych kwasu ranelowego i ich hydratów oraz nowe związki pośrednie
GB2400100B (en)	2006-04-12	Metabolites of (3-{[4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid
IL172167A0 (en)	2009-02-11	Pharmaceutically useful salts of carboxylic acid derivatives
MXPA05010398A (es)	2005-11-04	Nuevo metodo para la sintesis del acido (2s)-indolin-2-carboxilico y aplicacion de mismo en la sintesis del perindopril.
ITMI20002188A0 (it)	2000-10-10	Sintesi dell'acido r(+) -lipoico
ZA200605067B (en)	2007-10-31	Production of dihydronepetalactone by reduction of nepetalic acid
AU2003300106A1 (en)	2004-08-10	2-'5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl!- carboxylic acid derivatives as factor viia inhibitors
WO2007057265A3 (de)	2008-12-24	Triazinverbindungen mit aminogruppen- und carboxygruppen-haltigen substituenten
PL371427A1 (pl)	2005-06-13	Nowe zastosowania podstawionych kwasów aminoalkanofosfonowych
AU2003221495A1 (en)	2003-10-08	Production of carboxylic acid amides
IL207995A0 (en)	2010-12-30	Novel method for the production of sulphonylpyrroles as hdac inhibitors
SI1511741T1 (sl)	2013-02-28	Esterski derivativi dekahidroizokinolin-3-karboksilne kisline kot analgetiki
WO2004078107A3 (fr)	2004-10-21	Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
AU2003231527A8 (en)	2003-10-27	Novel derivatives of carnosic acid
PL1718593T3 (pl)	2007-12-31	Stereoselektywna synteza 4, 4-dipodstawionych kwasów cykloheksanopropanowych
AU2003285325A1 (en)	2004-06-18	Oral compositions comprising salts of alkyl hydroxybenzoates
AU2003255540A1 (en)	2004-03-11	Process for manufacture of carboxylic acid salts
TW200718425A (en)	2007-05-16	Intestinal polyp inhibitor