PL3628320T3 - Inhibitory acc i ich zastosowania - Google Patents

Inhibitory acc i ich zastosowania

Info

Publication number
PL3628320T3
PL3628320T3 PL19190936.5T PL19190936T PL3628320T3 PL 3628320 T3 PL3628320 T3 PL 3628320T3 PL 19190936 T PL19190936 T PL 19190936T PL 3628320 T3 PL3628320 T3 PL 3628320T3
Authority
PL
Poland
Prior art keywords
acc inhibitors
acc
inhibitors
Prior art date
Application number
PL19190936.5T
Other languages
English (en)
Polish (pl)
Inventor
Geraldine C. Harriman
Craig E. Masse
James Harwood
Sathesh Bhat
Jeremy Robert Greenwood
Original Assignee
Gilead Apollo, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Apollo, Llc filed Critical Gilead Apollo, Llc
Publication of PL3628320T3 publication Critical patent/PL3628320T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL19190936.5T 2011-11-11 2012-11-09 Inhibitory acc i ich zastosowania PL3628320T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161559023P 2011-11-11 2011-11-11
US201261615092P 2012-03-23 2012-03-23
US201261651878P 2012-05-25 2012-05-25
US201261675513P 2012-07-25 2012-07-25

Publications (1)

Publication Number Publication Date
PL3628320T3 true PL3628320T3 (pl) 2022-07-25

Family

ID=48281206

Family Applications (3)

Application Number Title Priority Date Filing Date
PL19190936.5T PL3628320T3 (pl) 2011-11-11 2012-11-09 Inhibitory acc i ich zastosowania
PL17209455T PL3329919T3 (pl) 2011-11-11 2012-11-09 Inhibitory ACC i ich zastosowania
PL12848361T PL2776038T3 (pl) 2011-11-11 2012-11-09 Inhibitory acc i ich zastosowania

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL17209455T PL3329919T3 (pl) 2011-11-11 2012-11-09 Inhibitory ACC i ich zastosowania
PL12848361T PL2776038T3 (pl) 2011-11-11 2012-11-09 Inhibitory acc i ich zastosowania

Country Status (26)

Country Link
US (5) US8969557B2 (2)
EP (3) EP2776038B1 (2)
JP (4) JP6114297B2 (2)
KR (3) KR102033806B1 (2)
CN (3) CN106905346B (2)
AU (3) AU2012335088B2 (2)
BR (2) BR122019026836B1 (2)
CA (1) CA2855372C (2)
CL (1) CL2014001241A1 (2)
CY (2) CY1120224T1 (2)
DK (2) DK3329919T3 (2)
EA (2) EA033598B1 (2)
ES (3) ES2912574T3 (2)
HR (2) HRP20180534T1 (2)
HU (2) HUE037444T2 (2)
LT (2) LT3329919T (2)
MX (3) MX370976B (2)
PL (3) PL3628320T3 (2)
PT (2) PT3329919T (2)
RS (1) RS57157B1 (2)
SI (2) SI3329919T1 (2)
SM (1) SMT201800191T1 (2)
TW (4) TWI655193B (2)
UA (2) UA114901C2 (2)
WO (1) WO2013071169A1 (2)
ZA (3) ZA201403633B (2)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI598347B (zh) 2009-07-13 2017-09-11 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
RS57157B1 (sr) 2011-11-11 2018-07-31 Gilead Apollo Llc Acc inhibitori i njihove primene
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
US12226412B2 (en) 2012-05-25 2025-02-18 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
MX2014014323A (es) 2012-05-25 2015-02-12 Janssen R & D Ireland Nucleosidos de espirooxetano de uracilo.
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
MA38260B1 (fr) 2012-12-18 2018-04-30 Almirall Sa Nouveaux dérivés de cyclohexyl et quinuclidinyl carbamate ayant une activité d'agoniste adrénergique beta2 et une activité d'antagoniste muscarinique m3
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
JP6417401B2 (ja) * 2013-05-10 2018-11-07 ギリアド アポロ， エルエルシー Ａｃｃ阻害剤及びその使用
AU2014262547A1 (en) * 2013-05-10 2015-11-26 Gilead Apollo, Llc ACC inhibitors and uses thereof
JP6417402B2 (ja) * 2013-05-10 2018-11-07 ギリアド アポロ， エルエルシー Ａｃｃ阻害剤及びその使用
EP2994139B1 (en) 2013-05-10 2019-04-10 Gilead Apollo, LLC Acc inhibitors and uses thereof
WO2015003881A1 (en) * 2013-07-08 2015-01-15 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2015003879A1 (en) * 2013-07-08 2015-01-15 Syngenta Participations Ag Microbiocidal heterobicylic derivatives
WO2015007453A1 (en) * 2013-07-15 2015-01-22 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2015007451A1 (en) 2013-07-15 2015-01-22 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2015010832A1 (en) * 2013-07-22 2015-01-29 Syngenta Participations Ag Microbiocidal heterocyclic derivatives
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
US20160220557A1 (en) 2013-09-12 2016-08-04 Pfizer Inc. Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris
KR20160065957A (ko) 2013-10-07 2016-06-09 바이엘 파마 악티엔게젤샤프트 시클릭 티에노우라실-카르복스아미드 및 그의 용도
EP3670496A3 (en) 2013-10-17 2020-09-30 Shionogi&Co., Ltd. Acc2 inhibitors
HRP20191679T1 (hr) * 2013-10-30 2019-12-13 Shanghai hengrui pharmaceutical co ltd Derivati pirazolopirimidona ili pirolotriazona, postupak pripreme jednakih i njihove farmaceutske uporabe
BR112016014004B1 (pt) 2013-12-19 2022-11-01 Novartis Ag Compostos para tratamento de doenças parasíticas, seus usos, e composições farmacêuticas
JP6573968B2 (ja) * 2014-08-11 2019-09-11 ハイドラ バイオサイエンシズ インコーポレイテッドＨｙｄｒａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． ＴＲＰＣ５調節因子としての、精神神経障害の処置のためのチエノおよびフロ［２，３−ｄ］ピリミジン−２，４［１Ｈ，３Ｈ］−ジオン誘導体
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
CN105779463B (zh) * 2014-12-25 2019-08-09 深圳华大生命科学研究院 Vps13b基因突变体及其应用
EA201791258A1 (ru) * 2015-01-09 2017-12-29 Джилид Аполло, Ллс Комбинированная терапия с применением ингибитора ацетил-коа-карбоксилазы (acc) для лечения неалкогольной жировой болезни печени
UY36586A (es) 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
WO2016196895A1 (en) * 2015-06-05 2016-12-08 Joslin Diabetes Center, Inc. Methods amd compositions for promoting thermogenic potential
CN105009933B (zh) * 2015-06-10 2018-08-14 邓娟 一种以通风曲方式栽培草菇的工艺
PL3456717T3 (pl) 2015-07-06 2021-10-25 Gilead Sciences, Inc. Pochodna 4,6-diaminochinolino-3-karbonitrylu jako modulator cot (cancer osaka thyroid) do leczenia choroby zapalnej
AR106472A1 (es) * 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
PL3380479T3 (pl) * 2015-11-25 2023-05-08 Gilead Apollo, Llc Triazolowe inhibitory acc i ich zastosowania
AU2016361412A1 (en) * 2015-11-25 2018-05-24 Gilead Apollo, Llc Pyrazole ACC inhibitors and uses thereof
EA201890949A1 (ru) 2015-11-25 2018-12-28 Джилид Аполло, Ллс СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ
BR112018009212B1 (pt) 2015-11-25 2022-06-14 Gilead Apollo, Llc Método para controlar patógenos fúngicos agrícolas
JP7071917B2 (ja) 2015-12-09 2022-05-19 カデント セラピューティクス，インコーポレーテッド ヘテロ芳香族ｎｍｄａ受容体モジュレーターおよびその使用
EP4006038A1 (en) * 2015-12-09 2022-06-01 Cadent Therapeutics, Inc. Thienopyrimidinone nmda receptor modulators and uses thereof
WO2017147161A1 (en) * 2016-02-23 2017-08-31 Raju Mohan Treatment of dermatological disorders or conditions
SG11201807077RA (en) * 2016-03-02 2018-09-27 Gilead Apollo Llc Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
CN107286174B (zh) * 2016-04-11 2020-08-18 上海勋和医药科技有限公司 取代2,4-(1h,3h)嘧啶二酮作为parp抑制剂及其应用
CN107629071B (zh) * 2016-07-19 2019-12-27 上海勋和医药科技有限公司 取代2，4-（1h,3h）嘧啶二酮作为parp抑制剂及其应用
WO2018041771A1 (de) 2016-09-02 2018-03-08 Bayer Pharma Aktiengesellschaft (1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung
CA3037642A1 (en) 2016-09-23 2018-03-29 Bayer Aktiengesellschaft N 3 -cyclically substituted thienouraciles and use thereof
US11274107B2 (en) 2016-12-22 2022-03-15 Cadent Therapeutics, Inc. NMDA receptor modulators and uses thereof
EP3571205B1 (en) * 2017-01-22 2023-08-30 Sunshine Lake Pharma Co., Ltd. Thienopyrimidine derivative and use thereof in medicine
WO2018161008A1 (en) * 2017-03-03 2018-09-07 Gilead Apollo, Llc Processes for the preparation of fungicidal compounds
CN110382503B (zh) * 2017-03-03 2022-07-19 吉利德科学公司 制备acc抑制剂及其固体形式的方法
CN110431143B (zh) * 2017-03-24 2022-08-12 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物及其制备方法和用途
US11142531B2 (en) 2017-03-24 2021-10-12 Zhejiang Hisun Pharmaceutical Co., Ltd. Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof
JP2020512342A (ja) 2017-03-28 2020-04-23 ギリアード サイエンシーズ， インコーポレイテッド 肝疾患を処置する方法
SI4122464T1 (sl) * 2017-03-28 2024-07-31 Gilead Sciences, Inc. Terapevtske kombinacije za zdravljenje bolezni jeter
CA3055076C (en) 2017-03-31 2022-02-22 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat cervical cancer
JP2020516627A (ja) 2017-04-12 2020-06-11 ギリアード サイエンシーズ， インコーポレイテッド 肝疾患を処置する方法
CN107151251A (zh) * 2017-05-10 2017-09-12 江苏开元药业有限公司 一种acc抑制剂药物关键中间体的制备方法
US10495648B2 (en) 2017-06-13 2019-12-03 Gilead Sciences, Inc. Methods of treating liver fibrosis
CN110709402B (zh) * 2017-06-15 2022-05-10 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途
CN111201234A (zh) * 2017-07-17 2020-05-26 南京瑞捷医药科技有限公司 新型化合物及其作为acc抑制剂的用途
TW201910338A (zh) * 2017-07-26 2019-03-16 大陸商南京聖和藥業股份有限公司 作為acc抑制劑的化合物及其應用
AU2018305633B2 (en) * 2017-07-28 2022-11-24 Jiangsu Hengrui Medicine Co., Ltd. Method for preparing pyrimidone heteroaryl derivative and intermediate of pyrimidone heteroaryl derivative
WO2019031384A1 (ja) * 2017-08-07 2019-02-14 日本曹達株式会社 １，３，５，６－テトラ置換チエノ［２，３－ｄ］ピリミジン－２，４（１Ｈ，３Ｈ）ジオン化合物および農園芸用殺菌剤
KR20190036705A (ko) 2017-09-28 2019-04-05 한미약품 주식회사 (2r)-2-(2-메톡시페닐)-2-(옥산-4-일옥시)에탄-1-올 화합물의 신규 제조방법 및 이에 사용되는 중간체
US10980810B2 (en) 2017-10-06 2021-04-20 Gilead Sciences, Inc. Combination therapy comprising an ACC inhibitor
WO2019072478A1 (en) 2017-10-10 2019-04-18 Galderma Research & Development SPECIFIC ACETYL-COA CARBOXYLASE INHIBITORS FOR USE IN THE TREATMENT AND / OR PREVENTION OF ACNE
EP3710599B1 (en) 2017-11-13 2024-07-17 Gilead Sciences, Inc. Method for staging liver fibrosis in nash patients
CN108129251A (zh) * 2017-12-22 2018-06-08 上海应用技术大学 一种2-乙基苯乙烯的合成工艺
EP3805230B1 (en) * 2018-06-05 2024-08-07 Medshine Discovery Inc. Thieno[2,3-c]pyridazin-4(1h)-one derivative and application thereof
AR115905A1 (es) 2018-08-03 2021-03-10 Cadent Therapeutics Inc 5-(3-cloro-4-fluorofenil)-7-ciclopropil-3-(2-(3-fluoro-3-metilazetidin-1-il)-2-oxoetil)-3,7-dihidro-4h-pirrolo[2,3-d]pirimidin-4-ona como modulador de los receptores de nmda
CN110950884B (zh) * 2018-09-27 2024-03-26 上海翰森生物医药科技有限公司 含二并环类衍生物抑制剂、其制备方法和应用
US20220041616A1 (en) * 2018-11-20 2022-02-10 The National Institutes of Pharmaceutical R&D Co., Ltd. Spiro compound and medical uses thereof
FI3897589T3 (fi) 2018-12-19 2026-01-13 Corcept Therapeutics Inc Farmaseuttisia formulaatioita, jotka sisältävät relakorilanttia, heteroaryyliketonifusoitua atsekaliiniyhdistettä
WO2020132046A1 (en) 2018-12-19 2020-06-25 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
EP3669652A1 (en) * 2018-12-21 2020-06-24 Bayer AG Active compound combination
PT3911647T (pt) 2019-01-15 2024-03-04 Gilead Sciences Inc Composto de isoxazole como agonista de fxr e composições farmacêuticas que o contenham
CN111484504B (zh) * 2019-01-25 2024-05-10 南京圣和药业股份有限公司 Acc抑制剂的光学异构体及其应用
JP7789561B2 (ja) 2019-02-22 2025-12-22 コーセプト セラピューティクス， インコーポレイテッド レラコリラント、ヘテロアリール－ケトン縮合アザデカリングルココルチコイド受容体調節物質の治療用途
JP7697885B2 (ja) 2019-03-11 2025-06-24 ギリアード サイエンシーズ， インコーポレイテッド 化合物の製剤およびそれらの使用
CN111747916A (zh) * 2019-03-27 2020-10-09 尚科生物医药（上海）有限公司 (r)-2-(2-甲氧基苯基)-2-(四氢吡喃-4-氧基)乙-1-醇的制备方法
CN109810085B (zh) * 2019-04-19 2019-07-19 上海皓元生物医药科技有限公司 Acc抑制剂及其中间体的制备方法
CN111850061B (zh) * 2019-04-30 2022-12-09 浙江工业大学 一种井冈羟胺a酯化物的制备方法
CN110343650B (zh) * 2019-05-28 2020-12-29 浙江工业大学 一种产两性霉素b的重组结节链霉菌及其应用
TWI770527B (zh) 2019-06-14 2022-07-11 美商基利科學股份有限公司 Cot 調節劑及其使用方法
WO2020255946A1 (ja) * 2019-06-17 2020-12-24 日本曹達株式会社 ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物及び農園芸用殺菌剤
EP3995498A4 (en) 2019-07-02 2023-03-01 Sunshine Lake Pharma Co., Ltd. THIENOPYRIMIDI DERIVATIVES WITH STEREO CONFIGURATION AND THEIR USE IN MEDICINE
AR119594A1 (es) * 2019-08-09 2021-12-29 Gilead Sciences Inc Derivados de tienopirimidina como inhibidores acc y usos de los mismos
JP2022548617A (ja) 2019-09-19 2022-11-21 ノバルティス アーゲー Ｆｘｒアゴニストを含む処置
CN112574253B (zh) * 2019-09-29 2021-08-27 上海喀露蓝科技有限公司 磷酸或磷酸酯类衍生物、其制备方法及其在医药上的用途
CN110746439B (zh) * 2019-10-18 2020-10-30 南京瑞捷医药科技有限公司 一种噻吩并嘧啶二酮化合物的制备方法
CN114585610A (zh) 2019-10-28 2022-06-03 日本曹达株式会社 2,6-二氧代-3,6-二氢嘧啶化合物以及农业园艺用杀菌剂、杀线虫剂、及医疗用·动物用抗真菌剂
CN112778325A (zh) * 2019-11-07 2021-05-11 南京瑞捷医药科技有限公司 一种acc抑制剂及其用途
EP4058144A1 (en) 2019-11-15 2022-09-21 Gilead Sciences, Inc. Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof
CN114787166B (zh) 2019-12-05 2023-09-19 漳州片仔癀药业股份有限公司 噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用
US11578081B1 (en) 2019-12-05 2023-02-14 Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd. Crystal form as inhibitor of ACC1 and ACC2, and preparation method therefor and use thereof
WO2021112213A1 (ja) * 2019-12-05 2021-06-10 日本曹達株式会社 ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物、及びそれを含有する農園芸用殺菌剤又は医療用・動物用抗真菌剤
PH12022551430A1 (en) 2019-12-11 2023-11-20 Corcept Therapeutics Inc Methods of treating antipsychotic-induced weight gain with miricorilant
CA3175541A1 (en) 2020-03-30 2021-10-07 Gilead Sciences, Inc. Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound
JP7446475B2 (ja) 2020-04-02 2024-03-08 ギリアード サイエンシーズ， インコーポレイテッド Ｃｏｔ阻害剤化合物を調製するためのプロセス
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
CN111513022B (zh) * 2020-05-08 2021-11-12 武汉市农业科学院 一种低皮脂率的小体型肉鸭的选育方法
EP4154880A4 (en) 2020-05-21 2024-06-05 Shionogi & Co., Ltd Pharmaceutical for treating fatty liver diseases
US11285145B2 (en) 2020-05-27 2022-03-29 Corcept Therapeutics Incorporated Concomitant administration of glucocorticoid receptor modulator relacorilant and paclitaxel, a dual substrate of CYP2C8 and CYP3A4
EP4161936A1 (en) 2020-06-03 2023-04-12 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
TWI843503B (zh) 2020-06-03 2024-05-21 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
CN113968871A (zh) * 2020-07-25 2022-01-25 南京圣和药业股份有限公司 苯基取代类acc抑制剂的晶型
CN113967213A (zh) * 2020-07-25 2022-01-25 南京圣和药业股份有限公司 一种包含苯基取代类acc抑制剂的组合物及其用途
CN111888349B (zh) * 2020-07-29 2021-10-22 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 印楝素在制备促进缺血超长随意皮瓣存活药物的作用
WO2022134033A1 (en) 2020-12-25 2022-06-30 Corcept Therapeutics Incorporated Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
WO2022166761A1 (zh) * 2021-02-07 2022-08-11 正大天晴药业集团股份有限公司 噻吩并嘧啶衍生物
WO2022192428A1 (en) 2021-03-11 2022-09-15 Gilead Sciences, Inc. Glp-1r modulating compounds
EP4681774A3 (en) 2021-03-29 2026-03-25 Gilead Sciences, Inc. Khk inhibitors
WO2022230804A1 (ja) 2021-04-28 2022-11-03 日本曹達株式会社 農園芸用殺菌性組成物
WO2022240879A1 (en) 2021-05-11 2022-11-17 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
KR20240007233A (ko) 2021-05-13 2024-01-16 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도
TW202345826A (zh) 2021-06-04 2023-12-01 美商基利科學股份有限公司 治療nash之方法
TW202311256A (zh) 2021-06-18 2023-03-16 美商基利科學股份有限公司 用於治療ｆｘｒ誘發之搔癢之ｉｌ－３１調節劑
JPWO2023090411A1 (2) 2021-11-19 2023-05-25
JPWO2023106175A1 (2) * 2021-12-08 2023-06-15
WO2023107938A1 (en) 2021-12-08 2023-06-15 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
WO2024031089A1 (en) 2022-08-05 2024-02-08 Gilead Sciences, Inc. Sars-cov2 main protease inhibitors
IL319657A (en) 2022-10-06 2025-05-01 Corcept Therapeutics Inc Glucocorticoid receptor modulator formulations
WO2024092195A1 (en) 2022-10-28 2024-05-02 Corcept Therapeutics Incorporated Treatments for amyotrophic lateral sclerosis using dazucorilant

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060084A (en) 1961-06-09 1962-10-23 Du Pont Improved homogeneous, readily dispersed, pesticidal concentrate
US3299566A (en) 1964-06-01 1967-01-24 Olin Mathieson Water soluble film containing agricultural chemicals
US3325503A (en) 1965-02-18 1967-06-13 Diamond Alkali Co Polychloro derivatives of mono- and dicyano pyridines and a method for their preparation
US3296272A (en) 1965-04-01 1967-01-03 Dow Chemical Co Sulfinyl- and sulfonylpyridines
US4144050A (en) 1969-02-05 1979-03-13 Hoechst Aktiengesellschaft Micro granules for pesticides and process for their manufacture
US3920442A (en) 1972-09-18 1975-11-18 Du Pont Water-dispersible pesticide aggregates
US4172714A (en) 1976-12-20 1979-10-30 E. I. Du Pont De Nemours And Company Dry compactible, swellable herbicidal compositions and pellets produced therefrom
GB2095558B (en) 1981-03-30 1984-10-24 Avon Packers Ltd Formulation of agricultural chemicals
DE3338292A1 (de) 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
CA1249832A (en) 1984-02-03 1989-02-07 Shionogi & Co., Ltd. Azolyl cycloalkanol derivatives and agricultural fungicides
US5304732A (en) 1984-03-06 1994-04-19 Mgi Pharma, Inc. Herbicide resistance in plants
BR8600161A (pt) 1985-01-18 1986-09-23 Plant Genetic Systems Nv Gene quimerico,vetores de plasmidio hibrido,intermediario,processo para controlar insetos em agricultura ou horticultura,composicao inseticida,processo para transformar celulas de plantas para expressar uma toxina de polipeptideo produzida por bacillus thuringiensis,planta,semente de planta,cultura de celulas e plasmidio
DE3545319A1 (de) 1985-12-20 1987-06-25 Basf Ag Acrylsaeureester und fungizide, die diese verbindungen enthalten
ATE57390T1 (de) 1986-03-11 1990-10-15 Plant Genetic Systems Nv Durch gentechnologie erhaltene und gegen glutaminsynthetase-inhibitoren resistente pflanzenzellen.
US4670560A (en) 1986-04-28 1987-06-02 Ortho Pharmaceutical Corporation Thienopyrimidine-2,4-dione derivatives and intermediates thereof
CN1050538A (zh) 1986-05-02 1991-04-10 施托福化学公司 杀真菌性吡啶基亚胺组合物及杀真菌方法
ES2011602T3 (es) 1986-08-12 1994-07-16 Mitsubishi Chem Ind Derivados de piridinacarboxamida y su uso como fungicidas.
FR2629098B1 (fr) 1988-03-23 1990-08-10 Rhone Poulenc Agrochimie Gene chimerique de resistance herbicide
US5180587A (en) 1988-06-28 1993-01-19 E. I. Du Pont De Nemours And Company Tablet formulations of pesticides
EP0374753A3 (de) 1988-12-19 1991-05-29 American Cyanamid Company Insektizide Toxine, Gene, die diese Toxine kodieren, Antikörper, die sie binden, sowie transgene Pflanzenzellen und transgene Pflanzen, die diese Toxine exprimieren
JPH02225485A (ja) * 1989-02-27 1990-09-07 Taiho Yakuhin Kogyo Kk チエノピリミジン―３―酢酸誘導体
EP0392225B1 (en) 1989-03-24 2003-05-28 Syngenta Participations AG Disease-resistant transgenic plants
DK0777964T3 (da) 1989-08-30 2002-03-11 Kynoch Agrochemicals Proprieta Fremgangsmåde til fremstilling af et doseringssystem
EP0427529B1 (en) 1989-11-07 1995-04-19 Pioneer Hi-Bred International, Inc. Larvicidal lectins and plant insect resistance based thereon
AU628229B2 (en) 1989-11-10 1992-09-10 Agro-Kanesho Co. Ltd. Hexahydrotriazine compounds and insecticides
PL167613B1 (pl) 1990-03-12 1995-09-30 Du Pont Granulowana kompozycja rozpuszczalna lub dyspergowalna w wodzie PL
CA2083948C (en) 1990-06-25 2001-05-15 Ganesh M. Kishore Glyphosate tolerant plants
DE69122201T2 (de) 1990-10-11 1997-02-06 Sumitomo Chemical Co Pestizide Zusammensetzung
JP2828186B2 (ja) 1991-09-13 1998-11-25 宇部興産株式会社 アクリレート系化合物、その製法及び殺菌剤
UA48104C2 (uk) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
DE4322211A1 (de) 1993-07-03 1995-01-12 Basf Ag Wäßrige, mehrphasige, stabile Fertigformulierung für Pflanzenschutz-Wirkstoffe und Verfahren zu ihrer Herstellung
TW276256B (2) * 1993-08-26 1996-05-21 Takeda Pharm Industry Co Ltd
JP3811196B2 (ja) * 1993-08-26 2006-08-16 武田薬品工業株式会社 エンドセリン拮抗剤、チエノピリミジン誘導体およびその製造法
US5530195A (en) 1994-06-10 1996-06-25 Ciba-Geigy Corporation Bacillus thuringiensis gene encoding a toxin active against insects
JPH09110873A (ja) * 1995-08-17 1997-04-28 Takeda Chem Ind Ltd チエノピリミジン誘導体、その製造法および用途
EP0846119B1 (en) 1995-08-17 2002-11-13 Takeda Chemical Industries, Ltd. Thienopyrimidine derivatives, their production and use as endothelin antagonists
US5773704A (en) 1996-04-29 1998-06-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Herbicide resistant rice
JP2007302703A (ja) * 1996-04-30 2007-11-22 Takeda Chem Ind Ltd 医薬組成物
AU2407997A (en) 1996-04-30 1997-11-19 Takeda Chemical Industries Ltd. Combined use of gnrh agonist and antagonist
DE69736841T2 (de) 1996-07-17 2007-02-01 Michigan State University, East Lansing Imidazolinon-herbizid-resistente zuckerrüben-pflanzen
US5773702A (en) 1996-07-17 1998-06-30 Board Of Trustees Operating Michigan State University Imidazolinone herbicide resistant sugar beet plants
DE19650197A1 (de) 1996-12-04 1998-06-10 Bayer Ag 3-Thiocarbamoylpyrazol-Derivate
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6984644B2 (en) * 1997-05-28 2006-01-10 Astrazeneca Ab Treatment of skin disorders using thieno[2,3-D]pyrimidinediones
SE9702001D0 (sv) * 1997-05-28 1997-05-28 Astra Pharma Prod Novel compounds
PL193553B1 (pl) 1997-09-18 2007-02-28 Basf Ag Pochodne benzamidoksymu, benzamidoksymy, zastosowanie pochodnych benzamidoksymu i środek grzybobójczy
DE19750012A1 (de) 1997-11-12 1999-05-20 Bayer Ag Isothiazolcarbonsäureamide
BR9813376A (pt) 1997-12-04 2001-06-19 Dow Agrosciences Llc Composição fungicidas e métodos e compostos para a preparação das mesmas
DE19754082A1 (de) * 1997-12-05 1999-06-10 Knoll Ag Methode zur Bekämpfung der Fettleibigkeit
US6348643B1 (en) 1998-10-29 2002-02-19 American Cyanamid Company DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use
US6576631B1 (en) 1998-11-17 2003-06-10 Kumiai Chemical Industry Co., Ltd. Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural bactericides
IT1303800B1 (it) 1998-11-30 2001-02-23 Isagro Ricerca Srl Composti dipeptidici aventi elevata attivita' fungicida e loroutilizzo agronomico.
JP3417862B2 (ja) 1999-02-02 2003-06-16 新東工業株式会社 酸化チタン光触媒高担持シリカゲルおよびその製造方法
AU770077B2 (en) 1999-03-11 2004-02-12 Dow Agrosciences Llc Heterocyclic substituted isoxazolidines and their use as fungicides
CA2369981A1 (en) 1999-04-09 2000-10-19 Cell Therapeutics, Inc. Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same
US6586617B1 (en) 1999-04-28 2003-07-01 Sumitomo Chemical Takeda Agro Company, Limited Sulfonamide derivatives
UA73307C2 (uk) 1999-08-05 2005-07-15 Куміаі Кемікал Індастрі Ко., Лтд. Похідна карбамату і фунгіцид сільськогосподарського/садівницького призначення
DE10021412A1 (de) 1999-12-13 2001-06-21 Bayer Ag Fungizide Wirkstoffkombinationen
WO2001054501A2 (en) 2000-01-25 2001-08-02 Syngenta Participations Ag Herbicidal composition
US6376548B1 (en) 2000-01-28 2002-04-23 Rohm And Haas Company Enhanced propertied pesticides
IL167958A (en) 2000-02-04 2010-11-30 Sumitomo Chemical Co 2-thio 3-hydroxypyridine derivatives
BR0110410A (pt) 2000-04-28 2003-07-01 Basf Ag Uso do gene ahas 2 mutante x112 de milho e herbicidas de imidazolinona para seleção de mudas transgênicas de monocotiledÈneas de milho, arroz e trigo resistentes aos herbicidas de imidazolinona
AU2001285900B2 (en) 2000-08-25 2005-02-17 Syngenta Participations Ag Novel insecticidal toxins derived from bacillus thuringiensis insecticidal crystal proteins
EP1322614A2 (en) 2000-09-18 2003-07-02 E. I. du Pont de Nemours and Company Pyridinyl amides and imides for use as fungicides
US6815556B2 (en) 2000-11-17 2004-11-09 Dow Agrosciences Llc Compounds having fungicidal activity and processes to make and use same
EP1370562A1 (en) * 2001-02-14 2003-12-17 Warner-Lambert Company LLC Thieno[2,3-d]pyrimidindione derivatives as matrix metalloproteinase inhibitors
JP5034142B2 (ja) 2001-04-20 2012-09-26 住友化学株式会社 植物病害防除剤組成物
DE10136065A1 (de) 2001-07-25 2003-02-13 Bayer Cropscience Ag Pyrazolylcarboxanilide
AR037228A1 (es) 2001-07-30 2004-11-03 Dow Agrosciences Llc Compuestos del acido 6-(aril o heteroaril)-4-aminopicolinico, composicion herbicida que los comprende y metodo para controlar vegetacion no deseada
FR2828196A1 (fr) 2001-08-03 2003-02-07 Aventis Cropscience Sa Derives de chromone a action fongicide, procede de preparation et application dans le domaine de l'agriculture
AU2002319037B2 (en) 2001-08-09 2008-05-29 University Of Saskatchewan Wheat plants having increased resistance to imidazolinone herbicides
WO2003014356A1 (en) 2001-08-09 2003-02-20 University Of Saskatchewan Wheat plants having increased resistance to imidazolinone herbicides
ES2417012T3 (es) 2001-08-09 2013-08-05 Northwest Plant Breeding Co. Plantas de trigo que exhiben resistencia aumentada a los herbicidas de imidazolinona
US7655658B2 (en) * 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
CN1543455B (zh) 2001-08-17 2012-07-11 三井化学Agro株式会社 3-苯氧基-4-哒嗪醇衍生物以及含有它的除草剂组合物
US7230167B2 (en) 2001-08-31 2007-06-12 Syngenta Participations Ag Modified Cry3A toxins and nucleic acid sequences coding therefor
AR037856A1 (es) 2001-12-17 2004-12-09 Syngenta Participations Ag Evento de maiz
AU2002354251A1 (en) 2001-12-21 2003-07-09 Nissan Chemical Industries, Ltd. Bactericidal composition
TWI327462B (en) 2002-01-18 2010-07-21 Sumitomo Chemical Co Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same
DE10204390A1 (de) 2002-02-04 2003-08-14 Bayer Cropscience Ag Disubstituierte Thiazolylcarboxanilide
CN1642599A (zh) * 2002-02-27 2005-07-20 辉瑞产品公司 Acc抑制剂
KR100818540B1 (ko) 2002-03-05 2008-04-01 신젠타 파티서페이션즈 아게 Ｏ-사이클로프로필-카복스아닐리드 및 이를 포함하는 살진균 조성물
EP1551218B1 (en) 2002-07-10 2017-05-17 The Department of Agriculture, Western Australia Wheat plants having increased resistance to imidazolinone herbicides
AU2003253165A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Pyrimidine fused bicyclic metalloproteinase inhibitors
GB0227966D0 (en) 2002-11-29 2003-01-08 Syngenta Participations Ag Organic Compounds
WO2004060058A2 (en) * 2003-01-06 2004-07-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Herbicides inhibiting the action of plant acetyl-coa carboxylase for use as pesticides.
EP1591446B1 (en) * 2003-01-29 2013-03-06 Takeda Pharmaceutical Company Limited Thienopyrimidine compounds and use thereof
WO2004083193A1 (ja) 2003-03-17 2004-09-30 Sumitomo Chemical Company, Limited アミド化合物およびこれを含有する殺菌剤組成物
PL1633875T3 (pl) 2003-05-28 2012-12-31 Basf Se Rośliny pszenicy o zwiększonej tolerancji na herbicydy imidazolinonowe
MXPA06002155A (es) 2003-08-29 2007-01-25 Inst Nac De Technologia Agrope Plantas de arroz que tienen una tolerancia incrementada a los herbicidas de imidazolinona.
TWI355894B (en) 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
US9487519B2 (en) 2004-03-10 2016-11-08 Basf Se 5,6-Dialkyl-7-aminotriazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds
EA009883B1 (ru) 2004-03-10 2008-04-28 Басф Акциенгезельшафт 5, 6-диалкил-7-амино-триазолопиримидины, способ их получения и их применение для борьбы с патогенными растениями, а также содержащие их средства
CA2564813A1 (en) 2004-06-03 2005-12-22 E.I. Du Pont De Nemours And Company Fungicidal mixtures of amidinylphenyl compounds
JP2008502625A (ja) 2004-06-18 2008-01-31 ビーエーエスエフ　アクチェンゲゼルシャフト Ｎ−（オルト−フェニル）−１−メチル−３−トリフルオロメチルピラゾール−４−カルボキシアニリドおよびそれらの殺菌剤としての使用
US20080108686A1 (en) 2004-06-18 2008-05-08 Basf Aktiengesellschaft N-(Ortho-Phenyl)-1-Methyl-3-Difluoromethylpyrazole-4-Carboxanilides And Their Use As Fungicides
US7947691B2 (en) 2004-07-21 2011-05-24 Athersys, Inc. Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof
GB0418048D0 (en) 2004-08-12 2004-09-15 Syngenta Participations Ag Method for protecting useful plants or plant propagation material
DE502006001074D1 (de) 2005-02-16 2008-08-21 Basf Se 5-alkoxyalkyl-6-alkyl-7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
DE102005007160A1 (de) 2005-02-16 2006-08-24 Basf Ag Pyrazolcarbonsäureanilide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen
DE102005009458A1 (de) 2005-03-02 2006-09-07 Bayer Cropscience Ag Pyrazolylcarboxanilide
MY143535A (en) 2006-01-13 2011-05-31 Dow Agrosciences Llc 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides
EP1983832A2 (en) 2006-02-09 2008-10-29 Syngeta Participations AG A method of protecting a plant propagation material, a plant, and/or plant organs
CA2644996A1 (en) 2006-03-02 2007-09-13 Cv Therapeutics, Inc. A2a adenosine receptor antagonists
JPWO2008143262A1 (ja) 2007-05-21 2010-08-12 武田薬品工業株式会社 複素環化合物およびその用途
WO2010050445A1 (ja) * 2008-10-27 2010-05-06 武田薬品工業株式会社 二環性化合物
DK2519527T3 (da) * 2009-12-29 2014-01-27 Poxel Thieno[2,3-b]pyridindion-aktivatorer af ampk og terapeutiske anvendelser deraf
RS57157B1 (sr) * 2011-11-11 2018-07-31 Gilead Apollo Llc Acc inhibitori i njihove primene
JP6417401B2 (ja) * 2013-05-10 2018-11-07 ギリアド アポロ， エルエルシー Ａｃｃ阻害剤及びその使用
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
BR112018009212B1 (pt) 2015-11-25 2022-06-14 Gilead Apollo, Llc Método para controlar patógenos fúngicos agrícolas
EA201890949A1 (ru) 2015-11-25 2018-12-28 Джилид Аполло, Ллс СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ
AU2016361412A1 (en) 2015-11-25 2018-05-24 Gilead Apollo, Llc Pyrazole ACC inhibitors and uses thereof
PL3380479T3 (pl) 2015-11-25 2023-05-08 Gilead Apollo, Llc Triazolowe inhibitory acc i ich zastosowania
SG11201807077RA (en) 2016-03-02 2018-09-27 Gilead Apollo Llc Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof

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AU2019253834B2 (en) 2021-04-29
EP3628320B1 (en) 2022-03-16
ZA201704192B (en) 2021-10-27
TWI701253B (zh) 2020-08-11
CY1120224T1 (el) 2018-12-12
KR20140106554A (ko) 2014-09-03
US10472374B2 (en) 2019-11-12
JP6276442B2 (ja) 2018-02-07
US9453026B2 (en) 2016-09-27
KR102060290B1 (ko) 2019-12-27
HUE047049T2 (hu) 2020-04-28
AU2012335088A1 (en) 2014-05-29
NZ723933A (en) 2018-03-23
US20130123231A1 (en) 2013-05-16
JP2018052989A (ja) 2018-04-05
WO2013071169A1 (en) 2013-05-16
MX370976B (es) 2020-01-10
SMT201800191T1 (it) 2018-05-02
EP2776038A4 (en) 2015-04-01
EA201490826A1 (ru) 2015-01-30
SI2776038T1 (en) 2018-06-29
SI3329919T1 (sl) 2020-02-28
MX344490B (es) 2016-12-16
CN106905346B (zh) 2019-05-28
EP3329919A8 (en) 2020-10-07
CN104105485A (zh) 2014-10-15
CN109970760B (zh) 2022-04-26
US20190016732A1 (en) 2019-01-17
HRP20192202T1 (hr) 2020-03-06
MX2014005693A (es) 2014-11-26
DK2776038T3 (en) 2018-04-23
KR102172902B1 (ko) 2020-11-02
CN109970760A (zh) 2019-07-05
ZA201403633B (en) 2021-10-27
KR102033806B1 (ko) 2019-10-17
AU2019253834A1 (en) 2019-11-14
NZ624819A (en) 2016-10-28
RS57157B1 (sr) 2018-07-31
HK1201207A1 (en) 2015-08-28
TW201831492A (zh) 2018-09-01
AU2017265088B2 (en) 2019-08-08
HUE037444T2 (hu) 2018-09-28
TWI582095B (zh) 2017-05-11
CN104105485B (zh) 2017-04-12
CN106905346A (zh) 2017-06-30
JP2017114910A (ja) 2017-06-29
EA033598B1 (ru) 2019-11-07
PL3329919T3 (pl) 2020-05-18
TWI655193B (zh) 2019-04-01
EP3628320A1 (en) 2020-04-01
JP6114297B2 (ja) 2017-04-12
AU2012335088B2 (en) 2017-08-24
HRP20180534T1 (hr) 2018-05-04
EP2776038B1 (en) 2018-01-10
ES2767956T3 (es) 2020-06-19
JP2014533281A (ja) 2014-12-11
DK3329919T3 (da) 2019-12-09
EA201692104A1 (ru) 2017-08-31
TW201720831A (zh) 2017-06-16
BR112014011351B1 (pt) 2021-02-17
US8969557B2 (en) 2015-03-03
CA2855372C (en) 2022-03-22
CA2855372A1 (en) 2013-05-16
EP2776038A1 (en) 2014-09-17
JP6756014B2 (ja) 2020-09-16
CL2014001241A1 (es) 2014-11-28
TW201930310A (zh) 2019-08-01
PT2776038T (pt) 2018-04-18
BR112014011351A2 (pt) 2017-06-06
TW201350489A (zh) 2013-12-16
ZA201704173B (en) 2021-08-25
US20150203510A1 (en) 2015-07-23
LT2776038T (lt) 2018-04-25
ES2665580T3 (es) 2018-04-26
JP2019147847A (ja) 2019-09-05
LT3329919T (lt) 2020-02-10
MX2020000331A (es) 2022-03-16
TWI612050B (zh) 2018-01-21
KR20190041027A (ko) 2019-04-19
US20160297834A1 (en) 2016-10-13
CY1122657T1 (el) 2021-03-12
NZ738735A (en) 2019-08-30
KR20190143473A (ko) 2019-12-30
PL2776038T3 (pl) 2018-06-29
MX390746B (es) 2025-03-21
UA114901C2 (uk) 2017-08-28
BR122019026836B1 (pt) 2021-02-23
ES2912574T3 (es) 2022-05-26

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