PL373090A1 - 9-alfa-podstawione estratrieny jako estrogeny o selektywnej aktywności - Google Patents

9-alfa-podstawione estratrieny jako estrogeny o selektywnej aktywności

Info

Publication number: PL373090A1
Authority: PL; Poland
Prior art keywords: alpha; selectively active; active estrogen; substituted estratrienes; estratrienes
Prior art date: 2002-06-11

Application number

PL03373090A

Other languages

English (en)

Other versions

PL209910B1 (pl

Inventor

Dirk Kosemund

Gerd Müller

Alexander Hillisch

Karl-Heinrich Fritzemeier

Peter Muhn

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-11

Filing date

2003-06-11

Publication date

2005-08-08

2003-06-11 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

2005-08-08 Publication of PL373090A1 publication Critical patent/PL373090A1/pl

2011-11-30 Publication of PL209910B1 publication Critical patent/PL209910B1/pl

Links

150000002164 estratrienes Chemical class 0.000 title 1
229940011871 estrogen Drugs 0.000 title 1
239000000262 estrogen Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0055—Estrane derivatives not substituted in position 17
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL373090A 2002-06-11 2003-06-11 9-alfa-podstawione pochodne estra -1,3,5 (10) -trienu, kompozycje farmaceutyczne je zawierające oraz ich zastosowanie PL209910B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10226326A DE10226326A1 (de)	2002-06-11	2002-06-11	9-alpha-substiuierte Estratriene als selektiv wirksame Estrogene

Publications (2)

Publication Number	Publication Date
PL373090A1 true PL373090A1 (pl)	2005-08-08
PL209910B1 PL209910B1 (pl)	2011-11-30

Family

ID=29723144

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL373090A PL209910B1 (pl)	2002-06-11	2003-06-11	9-alfa-podstawione pochodne estra -1,3,5 (10) -trienu, kompozycje farmaceutyczne je zawierające oraz ich zastosowanie

Country Status (28)

Country	Link
EP (1)	EP1517914B1 (pl)
JP (1)	JP4615998B2 (pl)
KR (1)	KR101006612B1 (pl)
CN (1)	CN1293090C (pl)
AR (1)	AR040188A1 (pl)
AT (1)	ATE303397T1 (pl)
AU (1)	AU2003242683B9 (pl)
BR (1)	BR0312140A (pl)
CA (1)	CA2486495C (pl)
CR (1)	CR10289A (pl)
CU (1)	CU23414B7 (pl)
DE (2)	DE10226326A1 (pl)
DK (1)	DK1517914T3 (pl)
EA (1)	EA008442B1 (pl)
EC (1)	ECSP055530A (pl)
ES (1)	ES2248770T3 (pl)
HR (1)	HRP20050009B1 (pl)
IL (1)	IL165321A (pl)
MX (1)	MXPA04012491A (pl)
NO (1)	NO329563B1 (pl)
PE (1)	PE20040613A1 (pl)
PL (1)	PL209910B1 (pl)
RS (1)	RS50878B (pl)
TW (1)	TWI286140B (pl)
UA (1)	UA78062C2 (pl)
UY (1)	UY27844A1 (pl)
WO (1)	WO2003104253A2 (pl)
ZA (1)	ZA200500217B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10027887A1 (de)	2000-05-31	2001-12-13	Jenapharm Gmbh	Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
ES2307064T3 (es) *	2003-11-26	2008-11-16	Bayer Schering Pharma Aktiengesellschaft	Prevencion y tratamiento de enfermedades cardiacas hipertensivas por los estrogenos selectivos 8beta-vinil-estra-1,3,5(10)-trien-3,17beta-diol y 17beta-fluor-9alfa-vinil-estra-1,3,5(10)-trien-3,16alfa-diol.
US7534780B2 (en)	2004-05-21	2009-05-19	Bayer Schering Pharma Aktiengesellschaft	Estradiol prodrugs
DE102005057224A1 (de) *	2005-11-29	2007-05-31	Bayer Schering Pharma Ag	Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
AU2009214307A1 (en) *	2008-02-13	2009-08-20	Bayer Intellectual Property Gmbh	Drug delivery system with stabilising effect
EP2143432A1 (en)	2008-07-11	2010-01-13	Bayer Schering Pharma AG	9-alpha estratriene derivatives as ER-beta selective ligands for the prevention and treatment of intestinal cancer
KR20110097779A (ko) *	2008-11-21	2011-08-31	바이엘 파마 악티엔게젤샤프트	약물 전달 시스템
AU2015308987B2 (en)	2014-08-26	2021-02-18	Kaass Discovery As	Methods, agents and compositions for treatment of inflammatory conditions
JP2021535183A (ja) *	2018-09-07	2021-12-16	トラスティーズ・オヴ・ダートマス・カレッジ	Ｃ１９骨格およびステロイドならびにそれらの使用および製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2336432A1 (de) *	1973-07-13	1975-01-30	Schering Ag	3.17.18-trihydroxy-1.3.5(10)-oestratriene
US6154158A (en) *	1998-06-30	2000-11-28	Qualcomm Incorporated	Digital-to-analog converter D.C. offset correction comparing converter input and output signals
DE19906159A1 (de) *	1999-02-09	2000-08-10	Schering Ag	16-Hydroxyestratriene als selektiv wirksame Estrogene
PT1226155E (pt) *	1999-11-02	2007-07-26	Bayer Schering Pharma Ag	18-nor-esteróides como estrogénios selectivamente activos
WO2001077139A1 (de) *	2000-04-12	2001-10-18	Schering Aktiengesellschaft	8.beta.-hydrocarbyl-substituierte estratriene als selektiv wirksame estrogene

2002
- 2002-06-11 DE DE10226326A patent/DE10226326A1/de not_active Ceased
2003
- 2003-06-10 PE PE2003000575A patent/PE20040613A1/es not_active Application Discontinuation
- 2003-06-11 EA EA200401544A patent/EA008442B1/ru not_active IP Right Cessation
- 2003-06-11 RS YUP-1070/04A patent/RS50878B/sr unknown
- 2003-06-11 MX MXPA04012491A patent/MXPA04012491A/es active IP Right Grant
- 2003-06-11 DE DE50301116T patent/DE50301116D1/de not_active Expired - Lifetime
- 2003-06-11 CN CNB038135027A patent/CN1293090C/zh not_active Expired - Fee Related
- 2003-06-11 WO PCT/EP2003/006172 patent/WO2003104253A2/de not_active Ceased
- 2003-06-11 HR HRP20050009AA patent/HRP20050009B1/hr not_active IP Right Cessation
- 2003-06-11 EP EP03757065A patent/EP1517914B1/de not_active Expired - Lifetime
- 2003-06-11 JP JP2004511321A patent/JP4615998B2/ja not_active Expired - Fee Related
- 2003-06-11 AU AU2003242683A patent/AU2003242683B9/en not_active Ceased
- 2003-06-11 AR ARP030102079A patent/AR040188A1/es active IP Right Grant
- 2003-06-11 BR BR0312140-2A patent/BR0312140A/pt not_active IP Right Cessation
- 2003-06-11 ES ES03757065T patent/ES2248770T3/es not_active Expired - Lifetime
- 2003-06-11 DK DK03757065T patent/DK1517914T3/da active
- 2003-06-11 AT AT03757065T patent/ATE303397T1/de active
- 2003-06-11 KR KR1020047020133A patent/KR101006612B1/ko not_active Expired - Fee Related
- 2003-06-11 CA CA2486495A patent/CA2486495C/en not_active Expired - Fee Related
- 2003-06-11 TW TW092115863A patent/TWI286140B/zh not_active IP Right Cessation
- 2003-06-11 UY UY27844A patent/UY27844A1/es not_active Application Discontinuation
- 2003-06-11 PL PL373090A patent/PL209910B1/pl not_active IP Right Cessation
- 2003-11-06 UA UAA200500212A patent/UA78062C2/uk unknown
2004
- 2004-11-22 IL IL165321A patent/IL165321A/en not_active IP Right Cessation
- 2004-12-10 CU CU20040282A patent/CU23414B7/es not_active IP Right Cessation
2005
- 2005-01-10 EC EC2005005530A patent/ECSP055530A/es unknown
- 2005-01-10 NO NO20050127A patent/NO329563B1/no not_active IP Right Cessation
2006
- 2006-01-10 ZA ZA200500217A patent/ZA200500217B/en unknown
2008
- 2008-09-16 CR CR10289A patent/CR10289A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20050127L (no)	2005-03-11
EP1517914A2 (de)	2005-03-30
ES2248770T3 (es)	2006-03-16
HK1081203A1 (en)	2006-05-12
CU23414B7 (es)	2009-09-08
ZA200500217B (en)	2006-03-29
PE20040613A1 (es)	2004-12-01
MXPA04012491A (es)	2005-06-08
KR20050009745A (ko)	2005-01-25
RS107004A (sr)	2006-10-27
HRP20050009A2 (en)	2005-04-30
IL165321A (en)	2009-08-03
TW200407331A (en)	2004-05-16
ATE303397T1 (de)	2005-09-15
WO2003104253A3 (de)	2004-09-16
CN1659181A (zh)	2005-08-24
HRP20050009B1 (hr)	2013-07-31
CA2486495A1 (en)	2003-12-18
JP4615998B2 (ja)	2011-01-19
CA2486495C (en)	2011-04-19
JP2005533053A (ja)	2005-11-04
ECSP055530A (es)	2005-03-10
DE50301116D1 (de)	2005-10-06
AR040188A1 (es)	2005-03-16
CR10289A (es)	2008-11-26
KR101006612B1 (ko)	2011-01-10
EA008442B1 (ru)	2007-06-29
BR0312140A (pt)	2005-04-05
AU2003242683B9 (en)	2009-08-27
AU2003242683A1 (en)	2003-12-22
UY27844A1 (es)	2003-12-31
DE10226326A1 (de)	2004-01-15
NO20050127D0 (no)	2005-01-10
AU2003242683B2 (en)	2009-07-02
DK1517914T3 (da)	2006-01-16
EA200401544A1 (ru)	2005-06-30
NO329563B1 (no)	2010-11-15
RS50878B (sr)	2010-08-31
CN1293090C (zh)	2007-01-03
EP1517914B1 (de)	2005-08-31
WO2003104253A2 (de)	2003-12-18
TWI286140B (en)	2007-09-01
PL209910B1 (pl)	2011-11-30
UA78062C2 (en)	2007-02-15

Legal Events

Date	Code	Title	Description
2015-09-30	LAPS	Decisions on the lapse of the protection rights	Effective date: 20140611

Publication	Publication Date	Title
AU2003266227A8 (en)	2003-12-22	Crossmember
ZA200602339B (en)	2007-08-29	HRT Formulations
IL175843A0 (en)	2006-10-05	Hrt formulations
PL370457A1 (pl)	2005-05-30	Nowe kortykosteroidy
ZA200507351B (en)	2008-04-30	Steroid spirolactonization
EP1625143A4 (en)	2009-09-30	ÖSTRATRIENDERIVATE
DK1517914T3 (da)	2006-01-16	9-alpha-substituerede estratriener som selektivt virksomme östrogener
GB2398992B (en)	2006-06-28	Underwear
SI1517914T1 (sl)	2006-02-28	9-alfa-substituirani estratrieni kot selektivno ucinkoviti estrogeni
IL165321A0 (en)	2006-01-15	9-alpha-substituted estratrienes as selectively active estrogen
TW560398U (en)	2003-11-01	Improved structure for scissors
GB0312262D0 (en)	2003-07-02	An undergarment
GB2390533B (en)	2006-04-05	Undergarment
AU2003246936A1 (en)	2004-02-02	Improved bib
IL173608A0 (en)	2006-07-05	15-d-homosteroids having an androgenic effect
GB0203608D0 (en)	2002-04-03	Improved undergarment
GB0330045D0 (en)	2004-02-04	An envelope
ZA200609275B (en)	2009-08-26	D-homo-17-chloro-16(17)en steroids
GB0215011D0 (en)	2002-08-07	Easy squeezy
ZA200602305B (en)	2009-09-30	Δ15-D-Homosteroids having an androgenic effect
CA94412S (en)	2002-01-18	Envelope
HU0200217V0 (en)	2002-10-28	Construction for newspaper
TW580978U (en)	2004-03-21	Improved structure for scissors
SI1539184T1 (sl)	2007-04-30	Rezim nadomestitve estrogena
AU153205S (en)	2003-10-07	Envelope