PL374266A1 - Rekombinowane polipeptydy - Google Patents

Rekombinowane polipeptydy

Info

Publication number
PL374266A1
PL374266A1 PL02374266A PL37426602A PL374266A1 PL 374266 A1 PL374266 A1 PL 374266A1 PL 02374266 A PL02374266 A PL 02374266A PL 37426602 A PL37426602 A PL 37426602A PL 374266 A1 PL374266 A1 PL 374266A1
Authority
PL
Poland
Prior art keywords
polypeptides
recombinant polypeptides
inducing
domain
trimers
Prior art date
Application number
PL02374266A
Other languages
English (en)
Other versions
PL208287B1 (pl
Inventor
Pranhitha Reddy
Original Assignee
Immunex Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corporation filed Critical Immunex Corporation
Publication of PL374266A1 publication Critical patent/PL374266A1/pl
Publication of PL208287B1 publication Critical patent/PL208287B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL374266A 2001-12-21 2002-12-20 Polipeptyd fuzyjny, sposób jego wytwarzania oraz kodujący go kwas nukleinowy, komórka gospodarza, rekombinowany wektor oraz sposób jego konstruowania PL208287B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34331501P 2001-12-21 2001-12-21

Publications (2)

Publication Number Publication Date
PL374266A1 true PL374266A1 (pl) 2005-10-03
PL208287B1 PL208287B1 (pl) 2011-04-29

Family

ID=23345581

Family Applications (1)

Application Number Title Priority Date Filing Date
PL374266A PL208287B1 (pl) 2001-12-21 2002-12-20 Polipeptyd fuzyjny, sposób jego wytwarzania oraz kodujący go kwas nukleinowy, komórka gospodarza, rekombinowany wektor oraz sposób jego konstruowania

Country Status (11)

Country Link
US (1) US7238499B2 (pl)
EP (1) EP1463755B1 (pl)
JP (1) JP4660092B2 (pl)
AT (1) ATE399180T1 (pl)
AU (1) AU2002359780B2 (pl)
CA (1) CA2470564C (pl)
DE (1) DE60227285D1 (pl)
ES (1) ES2309224T3 (pl)
MX (1) MXPA04005909A (pl)
PL (1) PL208287B1 (pl)
WO (1) WO2003060072A2 (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030095967A1 (en) * 1999-01-25 2003-05-22 Mackay Fabienne BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
US20050100548A1 (en) * 2001-07-24 2005-05-12 Biogen Idec Ma Inc. BAFF, inhibitors thereof and their use in the modulation of B-cell response
US20080267965A1 (en) * 2002-02-21 2008-10-30 Kalled Susan L Use of Bcma as an Immunoregulatory Agent
EP1558640B1 (en) * 2002-10-29 2011-04-13 Anaphore, Inc. Trimeric binding proteins for trimeric cytokines
EP2332563A3 (en) 2004-10-13 2013-03-13 The Washington University Use of BAFF to treat sepsis
CA2596276A1 (en) * 2005-01-28 2006-08-03 Biogen Idec Ma Inc. Use of baff to treat th2-mediated conditions
AU2011265482B2 (en) * 2005-05-06 2013-08-29 Providence Health & Services - Oregon Trimeric OX40L-immunoglobulin fusion protein and methods of use
ES2605380T3 (es) * 2005-05-06 2017-03-14 Providence Health & Services - Oregon Proteina de fusión OX40-inmunoglobulina trimérica y métodos de uso
ES2657801T3 (es) 2007-07-10 2018-03-06 Apogenix Ag Proteínas de fusión de colectina de la superfamilia de TNF
PT2214701T (pt) * 2007-11-01 2016-11-02 Univ Guelph Composições e métodos de potenciar respostas imunes a eimeria
AU2009308707A1 (en) * 2008-10-31 2010-05-06 Biogen Idec Ma Inc. LIGHT targeting molecules and uses thereof
WO2013166290A1 (en) 2012-05-04 2013-11-07 Abbvie Biotherapeutics Inc. P21 biomarker assay
WO2013177386A1 (en) 2012-05-24 2013-11-28 Abbvie Biotherapeutics Inc. Biomarkers for predicting response to tweak receptor (tweakr) agonist therapy
EP2956165B1 (en) 2013-02-14 2019-09-11 The Board of Trustees of the University of Arkansas Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection
CN105142653B (zh) 2013-03-15 2019-11-15 阿肯色大学评议会 增强对肠病原体免疫应答的组合物和方法
AU2015243562B2 (en) * 2014-04-07 2019-02-28 Lokon Pharma Ab New medical agents and uses thereof
AR108688A1 (es) 2016-05-03 2018-09-19 Univ Arkansas Vector de vacuna de levadura que incluye polipéptidos inmunoestimuladores y antigénicos, métodos para su uso
CA3022636A1 (en) * 2016-05-13 2017-11-16 Medimmune, Llc Cd40l-fc fusion polypeptides and methods of use thereof
MX2021012471A (es) 2019-04-11 2022-01-04 Univ Arkansas Aptameros de adn especificos de cd40 como adyuvantes de vacunas.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962406A (en) * 1991-10-25 1999-10-05 Immunex Corporation Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same
US5716805A (en) * 1991-10-25 1998-02-10 Immunex Corporation Methods of preparing soluble, oligomeric proteins
ATE240394T1 (de) * 1992-10-23 2003-05-15 Immunex Corp Methoden zur herstellung löslicher, oligomerer proteine
GB9409768D0 (en) * 1994-05-16 1994-07-06 Medical Res Council Trimerising polypeptides
US7056695B2 (en) * 2000-03-02 2006-06-06 Xencor TNF-α variants

Also Published As

Publication number Publication date
PL208287B1 (pl) 2011-04-29
EP1463755B1 (en) 2008-06-25
DE60227285D1 (de) 2008-08-07
US7238499B2 (en) 2007-07-03
EP1463755A4 (en) 2005-11-09
JP4660092B2 (ja) 2011-03-30
AU2002359780B2 (en) 2009-08-13
CA2470564C (en) 2011-02-22
ES2309224T3 (es) 2008-12-16
EP1463755A2 (en) 2004-10-06
US20030119149A1 (en) 2003-06-26
WO2003060072A3 (en) 2004-01-15
JP2005514061A (ja) 2005-05-19
MXPA04005909A (es) 2005-05-17
WO2003060072A2 (en) 2003-07-24
ATE399180T1 (de) 2008-07-15
AU2002359780A1 (en) 2003-07-30
CA2470564A1 (en) 2003-07-24

Similar Documents

Publication Publication Date Title
EP1463755A4 (en) RECOMBINANT POLYPEPTIDE
IL158751A0 (en) Recombinant fusion proteins and the trimers thereof
BR0012759A (pt) Neurotoxinas recombinantes ativáveis
MXPA02006888A (es) Flavivirus recombinantes y metodos para utilizar los mismos.
ATE454393T1 (de) Egvii-endoglucanase und dafür codierende nukleinsäuren
DE69435049D1 (de) Chimäre proteine zur vermeidung der komplementaktivierung
ATE292685T1 (de) Herstellung und verwendung von rekombinanten influenza a virus m2 konstruktionen und impstoffe
IL157414A0 (en) Fusion protein for the secretion of a protein of interest into the supernatant of the bacterial culture
ATE433491T1 (de) Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential
DK244289D0 (da) Fibronectinbindende protein, dets anvendelse og fremstilling samt midler til brug ved fremstillingen
WO2002062296A3 (en) Methods and compositions useful for stimulating an immune response
WO2003031598A3 (en) Nucleic acid and amino acid sequences encoding high-level expressor factor viii polypeptides and methods of use
WO2002070549A3 (en) Chimeric polypeptides of serum albumin and uses related thereto
WO2002070665A8 (en) Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen
MXPA03000427A (es) Preparacion de una proteina recombinante en una celula huesped procariotica.
AU1717402A (en) Glucuronyl c5-epimerase, dna encoding the same and uses thereof
AU4333793A (en) Modified kluyveromyces yeasts, their preparation and use
DE69631127D1 (en) Glykosyltransferase expression in aspergillus
WO2002038769A3 (de) Für expression in eukaryonten optimierte hpv 16-l1 und hpv 16-l2 kodierende dna-sequenzen
EP0832972A3 (en) Cloning, expression and production of tasty peptides
ATE487735T1 (de) Säugetier milchwachstumsfaktor
EP1111058A4 (en) NOVEL GENE OF HUMAN LYSOZYME, ITS ENCODING POLYPEPTIDE AND THEIR PREPARATION METHOD
WO2002059317A3 (en) Cub domain protein zcub3 and materials and methods for making it
WO2002033081A3 (en) Veterinary immunisation vectors comprising nucleic acid sequences encoding variants of non-human c3d polypeptides
AU2002341202A1 (en) Recombinant fusion proteins and the trimers thereof

Legal Events

Date Code Title Description
RECP Rectifications of patent specification