PL376019A1 - Pochodne pirolidonu jako inhibitory MAOB - Google Patents

Pochodne pirolidonu jako inhibitory MAOB

Info

Publication number
PL376019A1
PL376019A1 PL03376019A PL37601903A PL376019A1 PL 376019 A1 PL376019 A1 PL 376019A1 PL 03376019 A PL03376019 A PL 03376019A PL 37601903 A PL37601903 A PL 37601903A PL 376019 A1 PL376019 A1 PL 376019A1
Authority
PL
Poland
Prior art keywords
pyrrolidone derivatives
maob inhibitors
maob
inhibitors
pyrrolidone
Prior art date
Application number
PL03376019A
Other languages
English (en)
Inventor
Hans Iding
Synese Jolidon
Daniela Krummenacher
Sarmiento Rosa Maria Rodriguez
Andrew William Thomas
Beat Wirz
Wolfgang Wostl
Rene Wyler
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of PL376019A1 publication Critical patent/PL376019A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL03376019A 2002-09-20 2003-09-18 Pochodne pirolidonu jako inhibitory MAOB PL376019A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02021319 2002-09-20

Publications (1)

Publication Number Publication Date
PL376019A1 true PL376019A1 (pl) 2005-12-12

Family

ID=32010924

Family Applications (3)

Application Number Title Priority Date Filing Date
PL03376019A PL376019A1 (pl) 2002-09-20 2003-09-18 Pochodne pirolidonu jako inhibitory MAOB
PL03376018A PL376018A1 (pl) 2002-09-20 2003-09-18 Pochodne eteru 4-pirolidynofenylowo-benzylowego
PL376021A PL216030B1 (pl) 2002-09-20 2003-09-18 Pochodne pirolidonu, srodek farmaceutyczny oraz zastosowanie tych pochodnych

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL03376018A PL376018A1 (pl) 2002-09-20 2003-09-18 Pochodne eteru 4-pirolidynofenylowo-benzylowego
PL376021A PL216030B1 (pl) 2002-09-20 2003-09-18 Pochodne pirolidonu, srodek farmaceutyczny oraz zastosowanie tych pochodnych

Country Status (31)

Country Link
US (4) US7151111B2 (pl)
EP (3) EP1542971A1 (pl)
JP (3) JP4335142B2 (pl)
KR (3) KR100676015B1 (pl)
CN (3) CN100503562C (pl)
AR (3) AR041298A1 (pl)
AT (2) ATE459601T1 (pl)
AU (3) AU2003273901B2 (pl)
BR (4) BRPI0314631B1 (pl)
CA (3) CA2498335A1 (pl)
CY (1) CY1110745T1 (pl)
DE (2) DE60331559D1 (pl)
DK (1) DK1542970T3 (pl)
ES (2) ES2338646T3 (pl)
GT (3) GT200300205A (pl)
HR (3) HRP20050262A2 (pl)
JO (2) JO2605B1 (pl)
MX (3) MXPA05002880A (pl)
MY (3) MY134480A (pl)
NO (3) NO330012B1 (pl)
NZ (3) NZ538046A (pl)
PA (3) PA8583001A1 (pl)
PE (3) PE20050077A1 (pl)
PL (3) PL376019A1 (pl)
PT (1) PT1542970E (pl)
RU (3) RU2336268C2 (pl)
SI (1) SI1542970T1 (pl)
TW (3) TWI286132B (pl)
UY (3) UY27990A1 (pl)
WO (3) WO2004026826A1 (pl)
ZA (3) ZA200501137B (pl)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8583001A1 (es) * 2002-09-20 2004-04-23 Hoffmann La Roche Derivados de 4-pirrolidino-fenil-bencil eter como inhibidores de mao-b
GB0314373D0 (en) 2003-06-19 2003-07-23 Glaxo Group Ltd Chemical compounds
KR100845366B1 (ko) * 2004-08-02 2008-07-09 에프. 호프만-라 로슈 아게 모노아민 산화효소 ｂ 억제제로서 벤질옥시 유도체
AU2005268894B2 (en) * 2004-08-02 2010-12-16 F. Hoffmann-La Roche Ag Benzyloxy derivatives as MAOB inhibitors
CA2598762A1 (en) 2005-02-25 2006-08-31 F. Hoffmann-La Roche Ag Tablets with improved drug substance dispersibility
US7501528B2 (en) * 2005-03-15 2009-03-10 Hoffmann-La Roche Inc. Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives
CN101142181B (zh) * 2005-03-15 2011-05-04 弗·哈夫曼-拉罗切有限公司 对映异构纯的4-吡咯烷子基苯基苄基醚衍生物的制备方法
TW200730494A (en) 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
EP1943216B1 (en) * 2005-10-10 2010-06-30 Glaxo Group Limited Prolinamide derivatives as sodium channel modulators
EP2171478A4 (en) * 2007-03-30 2013-01-30 Univ California IN VIVO IMAGING METHOD FOR SULPHOTRANSFERASES
KR101220182B1 (ko) 2009-02-25 2013-01-11 에스케이바이오팜 주식회사 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CZ304053B6 (cs) * 2011-08-22 2013-09-04 Farmak, A. S. Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
KR102018284B1 (ko) * 2013-02-28 2019-09-05 삼성디스플레이 주식회사 박막 트랜지스터 어레이 기판 및 이를 포함하는 유기 발광 표시 장치
NZ711598A (en) 2013-03-14 2016-09-30 Dart Neuroscience Cayman Ltd Substituted naphthyridine and quinoline compounds as mao inhibitors
CZ305213B6 (cs) 2013-04-29 2015-06-10 Farmak, A. S. Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
WO2015063001A1 (en) 2013-10-29 2015-05-07 F. Hoffmann-La Roche Ag Crystalline forms of a pyrrolidone derivative useful in the treatment of alzheimer's disease and preparation thereof
WO2016102967A1 (en) 2014-12-23 2016-06-30 Convergence Pharmaceuticals Limited Process for preparing alpha-carboxamide pyrrolidine derivatives
WO2016156124A1 (en) 2015-03-27 2016-10-06 F. Hoffmann-La Roche Ag Pharmaceutical formulation comprising sembragiline
EP3689870B1 (en) 2017-09-27 2022-07-13 Kagoshima University Analgesic drug using pac1 receptor antagonistic drug
EP3691634A4 (en) 2017-10-05 2021-03-31 Biogen Inc. PROCESS FOR THE PREPARATION OF PYRROLIDINE ALPHA-CARBOXAMIDE DERIVATIVES
CN108299272B (zh) * 2018-01-31 2019-10-18 福州大学 一种合成1-氯-2,2,2-三氟亚乙基取代咯酮化合物的方法
CA3092747A1 (en) * 2018-03-08 2019-09-12 Sunshine Lake Pharma Co., Ltd. Pyrrolidineamide derivatives and uses thereof
WO2020175134A1 (ja) 2019-02-27 2020-09-03 国立大学法人鹿児島大学 Ｐａｃ１受容体拮抗薬を用いた鎮痒薬
WO2021225161A1 (ja) 2020-05-08 2021-11-11 国立大学法人鹿児島大学 Ｐａｃ１受容体拮抗薬を用いた抗うつ・抗不安薬
CN112851561A (zh) * 2021-01-29 2021-05-28 南京艾美斐生物医药科技有限公司 一种nr6a1蛋白受体抑制剂及其制备和应用
WO2022268520A1 (de) 2021-06-21 2022-12-29 Bayer Aktiengesellschaft Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen.

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
FR2500831A1 (fr) 1981-02-27 1982-09-03 Delalande Sa Nouvelles n-aryl-oxazolidinones et -pyrrolidinones
DK0393607T3 (da) 1989-04-19 1996-03-18 Otsuka Pharma Co Ltd Phenylcarboxylsyrederivater med en heteroring
NZ291508A (en) * 1994-08-30 1999-07-29 Sankyo Co Isoxazoles; preparation and medicaments
US5679715A (en) 1995-06-07 1997-10-21 Harris; Richard Y. Method for treating multiple sclerosis
CA2244253C (en) 1996-03-15 2002-11-12 Somerset Pharmaceuticals, Inc. Method for preventing and treating peripheral neuropathy by administering selegiline
US5683404A (en) * 1996-06-05 1997-11-04 Metagen, Llc Clamp and method for its use
DE19841895A1 (de) 1998-09-11 2000-03-23 Degussa Neues Verfahren zur Herstellung von 3-Amino-2-oxo-pyrrolidinen, neue Zwischenprodukte und deren Verwendung
EP1165546A2 (en) * 1999-04-02 2002-01-02 Du Pont Pharmaceuticals Company Novel lactam inhibitors of matrix metalloproteinases, tnf-alpha, and aggrecanase
WO2001034172A2 (en) 1999-11-05 2001-05-17 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome
CN1222254C (zh) * 2000-02-10 2005-10-12 波滕西亚医疗公司 用无线能量源进行尿失禁治疗
EP1255513B1 (en) * 2000-02-14 2005-05-25 Potencia Medical AG Penile prosthesis
PA8583001A1 (es) * 2002-09-20 2004-04-23 Hoffmann La Roche Derivados de 4-pirrolidino-fenil-bencil eter como inhibidores de mao-b
US20040267292A1 (en) * 2003-06-27 2004-12-30 Byrum Randal T. Implantable band with transverse attachment mechanism
US20040267291A1 (en) * 2003-06-27 2004-12-30 Byrum Randal T. Implantable band with non-mechanical attachment mechanism

Also Published As

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KR100681586B1 (ko) 2007-02-09
DK1542970T3 (da) 2010-08-02
AR041297A1 (es) 2005-05-11
EP1542969A1 (en) 2005-06-22
CN1681779A (zh) 2005-10-12
GT200300204A (es) 2004-04-29
HK1083498A1 (zh) 2006-07-07
PE20050077A1 (es) 2005-03-01
NZ538046A (en) 2007-08-31
TWI286132B (en) 2007-09-01
KR20050057456A (ko) 2005-06-16
JO2604B1 (en) 2011-11-01
CA2498785C (en) 2011-07-26
RU2005111968A (ru) 2006-11-10
MY133332A (en) 2007-11-30
JO2605B1 (en) 2011-11-01
EP1542969B1 (en) 2010-03-03
EP1542970A1 (en) 2005-06-22
CN100383118C (zh) 2008-04-23
CA2496756A1 (en) 2004-04-01
BR0314299A (pt) 2005-12-13
HRP20050263A2 (en) 2006-12-31
GT200300206A (es) 2004-04-29
CA2496756C (en) 2012-01-10
AU2003267381A1 (en) 2004-04-08
UY27993A1 (es) 2004-03-31
US7151111B2 (en) 2006-12-19
JP2006503834A (ja) 2006-02-02
MY135696A (en) 2008-06-30
AU2003270213A1 (en) 2004-04-08
US20040106650A1 (en) 2004-06-03
PA8583501A1 (es) 2004-04-23
HK1084383A1 (en) 2006-07-28
ES2338646T3 (es) 2010-05-11
ATE459601T1 (de) 2010-03-15
AU2003273901A1 (en) 2004-04-08
EP1542971A1 (en) 2005-06-22
HK1083499A1 (zh) 2006-07-07
US20040116707A1 (en) 2004-06-17
BR0314314A (pt) 2005-07-26
HRP20050263B1 (hr) 2013-09-30
SI1542970T1 (sl) 2010-08-31
PE20050079A1 (es) 2005-03-01
NO330012B1 (no) 2011-02-07
BR0314631A (pt) 2005-08-02
EP1542970B1 (en) 2010-06-30
TW200413350A (en) 2004-08-01
CN100400509C (zh) 2008-07-09
JP2006503833A (ja) 2006-02-02
CY1110745T1 (el) 2015-06-10
NO329754B1 (no) 2010-12-13
ZA200501557B (en) 2005-09-08
HRP20050262A2 (en) 2006-06-30
AU2003273901B2 (en) 2008-07-10
PA8583601A1 (es) 2004-09-16
US20040097578A1 (en) 2004-05-20
DE60333202D1 (de) 2010-08-12
AR041298A1 (es) 2005-05-11
US7122562B2 (en) 2006-10-17
BRPI0314631B1 (pt) 2018-04-17
US7235581B2 (en) 2007-06-26
KR20050057466A (ko) 2005-06-16
JP4335142B2 (ja) 2009-09-30
RU2005111969A (ru) 2006-01-20
KR100676014B1 (ko) 2007-01-30
DE60331559D1 (de) 2010-04-15
MY134480A (en) 2007-12-31
PE20050078A1 (es) 2005-02-28
US20060122235A1 (en) 2006-06-08
WO2004026826A1 (en) 2004-04-01
ZA200501137B (en) 2006-12-27
GT200300205A (es) 2004-04-29
NZ538048A (en) 2007-05-31
TW200408624A (en) 2004-06-01
RU2323209C2 (ru) 2008-04-27
WO2004026825A1 (en) 2004-04-01
MXPA05002881A (es) 2005-05-27
PL216030B1 (pl) 2014-02-28
JP4335140B2 (ja) 2009-09-30
PL376021A1 (pl) 2005-12-12
RU2336267C2 (ru) 2008-10-20
ZA200501311B (en) 2006-10-25
HRP20050261A2 (en) 2006-05-31
PL376018A1 (pl) 2005-12-12
CA2498785A1 (en) 2004-04-01
RU2336268C2 (ru) 2008-10-20
CA2498335A1 (en) 2004-04-01
AU2003270213B8 (en) 2009-03-05
WO2004026827A1 (en) 2004-04-01
NO20050665L (no) 2005-04-18
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