PL377232A1 - Nowy proces syntezy kwasu (2S, 3aS, 7aS)-perhydroindolo-2- karboksylowego i jego estrów oraz zastosowanie w syntezie perindoprylu - Google Patents
Nowy proces syntezy kwasu (2S, 3aS, 7aS)-perhydroindolo-2- karboksylowego i jego estrów oraz zastosowanie w syntezie perindopryluInfo
- Publication number
- PL377232A1 PL377232A1 PL377232A PL37723204A PL377232A1 PL 377232 A1 PL377232 A1 PL 377232A1 PL 377232 A PL377232 A PL 377232A PL 37723204 A PL37723204 A PL 37723204A PL 377232 A1 PL377232 A1 PL 377232A1
- Authority
- PL
- Poland
- Prior art keywords
- perhydroindole
- synthesising
- esters
- carboxylic acid
- novel method
- Prior art date
Links
- CQYBNXGHMBNGCG-FXQIFTODSA-N (2s,3as,7as)-2,3,3a,4,5,6,7,7a-octahydro-1h-indol-1-ium-2-carboxylate Chemical compound C1CCC[C@@H]2[NH2+][C@H](C(=O)[O-])C[C@@H]21 CQYBNXGHMBNGCG-FXQIFTODSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title 1
- 229960002582 perindopril Drugs 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03290487A EP1338591B1 (fr) | 2003-02-28 | 2003-02-28 | Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL377232A1 true PL377232A1 (pl) | 2006-01-23 |
| PL219733B1 PL219733B1 (pl) | 2015-07-31 |
Family
ID=27635945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL377232A PL219733B1 (pl) | 2003-02-28 | 2004-02-27 | Sposób otrzymywania kwasu (2S, 3aS, 7aS)-perhydroindolo-2- karboksylowego |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7157484B2 (pl) |
| EP (1) | EP1338591B1 (pl) |
| JP (1) | JP4563371B2 (pl) |
| CN (1) | CN100364974C (pl) |
| AR (1) | AR043411A1 (pl) |
| AT (1) | ATE307801T1 (pl) |
| AU (1) | AU2004218200B2 (pl) |
| DE (1) | DE60301980T2 (pl) |
| DK (1) | DK1338591T3 (pl) |
| EA (1) | EA007948B1 (pl) |
| ES (1) | ES2250847T3 (pl) |
| MY (1) | MY135169A (pl) |
| NZ (1) | NZ541422A (pl) |
| PL (1) | PL219733B1 (pl) |
| SI (1) | SI1338591T1 (pl) |
| WO (1) | WO2004078707A2 (pl) |
| ZA (1) | ZA200505779B (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004099138A2 (en) * | 2003-05-12 | 2004-11-18 | Cipla Limited | Process for the preparation of perindopril |
| LT1729739T (lt) * | 2004-03-29 | 2016-11-10 | Les Laboratoires Servier | Kietos farmacinės kompozicijos gamybos būdas |
| SI21800A (sl) | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| ATE515496T1 (de) * | 2004-12-28 | 2011-07-15 | Dsm Ip Assets Bv | Verfahren zur herstellung von enantiomerenangereicherter indolin-2-carbonsäure |
| CN100391945C (zh) * | 2005-05-31 | 2008-06-04 | 浙江大学 | 一种s-(-)-吲哚啉-2-羧酸的合成方法 |
| CN116120195B (zh) * | 2022-12-29 | 2025-02-25 | 长兴宜生药物科技有限公司 | 一种催化制备培哚普利中间体的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE55867B1 (en) * | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| NL1008302C2 (nl) * | 1998-02-13 | 1999-08-16 | Dsm Nv | Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan. |
| FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
| ATE305939T1 (de) * | 2003-02-28 | 2005-10-15 | Servier Lab | Verfahren zur synthese von (2s,3as,7as)-1-((s)- |
-
2003
- 2003-02-28 DE DE60301980T patent/DE60301980T2/de not_active Expired - Lifetime
- 2003-02-28 ES ES03290487T patent/ES2250847T3/es not_active Expired - Lifetime
- 2003-02-28 EP EP03290487A patent/EP1338591B1/fr not_active Expired - Lifetime
- 2003-02-28 SI SI200330107T patent/SI1338591T1/sl unknown
- 2003-02-28 DK DK03290487T patent/DK1338591T3/da active
- 2003-02-28 AT AT03290487T patent/ATE307801T1/de active
-
2004
- 2004-02-27 NZ NZ541422A patent/NZ541422A/en not_active IP Right Cessation
- 2004-02-27 CN CNB2004800054078A patent/CN100364974C/zh not_active Expired - Fee Related
- 2004-02-27 PL PL377232A patent/PL219733B1/pl unknown
- 2004-02-27 US US10/546,967 patent/US7157484B2/en not_active Expired - Fee Related
- 2004-02-27 WO PCT/FR2004/000444 patent/WO2004078707A2/fr not_active Ceased
- 2004-02-27 EA EA200501256A patent/EA007948B1/ru not_active IP Right Cessation
- 2004-02-27 AR ARP040100611A patent/AR043411A1/es not_active Application Discontinuation
- 2004-02-27 AU AU2004218200A patent/AU2004218200B2/en not_active Ceased
- 2004-02-27 MY MYPI20040683A patent/MY135169A/en unknown
- 2004-02-27 JP JP2006500161A patent/JP4563371B2/ja not_active Expired - Fee Related
- 2004-02-27 ZA ZA200505779A patent/ZA200505779B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7157484B2 (en) | 2007-01-02 |
| MY135169A (en) | 2008-02-29 |
| WO2004078707A3 (fr) | 2004-10-14 |
| EA200501256A1 (ru) | 2006-04-28 |
| WO2004078707A2 (fr) | 2004-09-16 |
| US20060167273A1 (en) | 2006-07-27 |
| SI1338591T1 (sl) | 2006-02-28 |
| ZA200505779B (en) | 2006-09-27 |
| AU2004218200B2 (en) | 2009-07-30 |
| EP1338591A1 (fr) | 2003-08-27 |
| DE60301980D1 (de) | 2005-12-01 |
| EP1338591B1 (fr) | 2005-10-26 |
| CN100364974C (zh) | 2008-01-30 |
| DE60301980T2 (de) | 2006-07-27 |
| ATE307801T1 (de) | 2005-11-15 |
| PL219733B1 (pl) | 2015-07-31 |
| JP4563371B2 (ja) | 2010-10-13 |
| CN1753869A (zh) | 2006-03-29 |
| NZ541422A (en) | 2008-03-28 |
| AU2004218200A1 (en) | 2004-09-16 |
| ES2250847T3 (es) | 2006-04-16 |
| AR043411A1 (es) | 2005-07-27 |
| EA007948B1 (ru) | 2007-02-27 |
| JP2006519175A (ja) | 2006-08-24 |
| DK1338591T3 (da) | 2006-01-23 |
| HK1086262A1 (en) | 2006-09-15 |
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