PL377337A1 - Humanizowane przeciwciało (H14.18) z mysiego przeciwciała 14.18 wiążące GD2 oraz jego połączenie z IL-2 - Google Patents

Humanizowane przeciwciało (H14.18) z mysiego przeciwciała 14.18 wiążące GD2 oraz jego połączenie z IL-2

Info

Publication number
PL377337A1
PL377337A1 PL377337A PL37733703A PL377337A1 PL 377337 A1 PL377337 A1 PL 377337A1 PL 377337 A PL377337 A PL 377337A PL 37733703 A PL37733703 A PL 37733703A PL 377337 A1 PL377337 A1 PL 377337A1
Authority
PL
Poland
Prior art keywords
antibody
fusion
mouse
antibodies
binding
Prior art date
Application number
PL377337A
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English (en)
Other versions
PL211180B1 (pl
Inventor
Stephen D. Gillies
Kin-Ming Lo
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL377337A1 publication Critical patent/PL377337A1/pl
Publication of PL211180B1 publication Critical patent/PL211180B1/pl

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/461Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/467Igs with modifications in the FR-residues only
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL377337A 2002-12-17 2003-12-16 Białko fuzyjne typu przeciwciało-IL2, wektor zawierający sekwencję kwasów nukleinowych kodujących takie białko, kompozycja farmaceutyczna zawierająca takie białko fuzyjne oraz jego zastosowania do wytwarzania leków PL211180B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43394502P 2002-12-17 2002-12-17

Publications (2)

Publication Number Publication Date
PL377337A1 true PL377337A1 (pl) 2006-01-23
PL211180B1 PL211180B1 (pl) 2012-04-30

Family

ID=32595250

Family Applications (1)

Application Number Title Priority Date Filing Date
PL377337A PL211180B1 (pl) 2002-12-17 2003-12-16 Białko fuzyjne typu przeciwciało-IL2, wektor zawierający sekwencję kwasów nukleinowych kodujących takie białko, kompozycja farmaceutyczna zawierająca takie białko fuzyjne oraz jego zastosowania do wytwarzania leków

Country Status (18)

Country Link
US (3) US7169904B2 (pl)
EP (1) EP1572748B1 (pl)
JP (1) JP4494977B2 (pl)
KR (1) KR101086660B1 (pl)
CN (1) CN100432105C (pl)
AT (1) ATE471946T1 (pl)
AU (1) AU2003298187B2 (pl)
BR (1) BRPI0317376B8 (pl)
CA (1) CA2510180C (pl)
DE (1) DE60333121D1 (pl)
DK (1) DK1572748T3 (pl)
ES (1) ES2346205T3 (pl)
MX (1) MXPA05006384A (pl)
PL (1) PL211180B1 (pl)
PT (1) PT1572748E (pl)
RU (1) RU2366664C2 (pl)
WO (1) WO2004055056A1 (pl)
ZA (1) ZA200505681B (pl)

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US8470991B2 (en) 2013-06-25
EP1572748B1 (en) 2010-06-23
US7767405B2 (en) 2010-08-03
MXPA05006384A (es) 2005-08-29
KR20050085775A (ko) 2005-08-29
BRPI0317376B8 (pt) 2021-05-25
RU2366664C2 (ru) 2009-09-10
US20070059282A1 (en) 2007-03-15
RU2005119305A (ru) 2006-01-20
AU2003298187B2 (en) 2010-09-16
BR0317376A (pt) 2005-11-16
US7169904B2 (en) 2007-01-30
CA2510180A1 (en) 2004-07-01
WO2004055056A1 (en) 2004-07-01
BRPI0317376B1 (pt) 2019-12-03
EP1572748A1 (en) 2005-09-14
JP4494977B2 (ja) 2010-06-30
ES2346205T3 (es) 2010-10-13
CN100432105C (zh) 2008-11-12
CN1726227A (zh) 2006-01-25
JP2006521085A (ja) 2006-09-21
PL211180B1 (pl) 2012-04-30
PT1572748E (pt) 2010-09-28
ATE471946T1 (de) 2010-07-15
AU2003298187A1 (en) 2004-07-09
KR101086660B1 (ko) 2011-11-24

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