PL423896A1 - Antibacterial ionic liquids with 1-alkyl-1-methyl-4-piperidinolium cation and (S)-mandelate anion, method for obtaining them and the application as antibacterial agents - Google Patents
Antibacterial ionic liquids with 1-alkyl-1-methyl-4-piperidinolium cation and (S)-mandelate anion, method for obtaining them and the application as antibacterial agentsInfo
- Publication number
- PL423896A1 PL423896A1 PL423896A PL42389617A PL423896A1 PL 423896 A1 PL423896 A1 PL 423896A1 PL 423896 A PL423896 A PL 423896A PL 42389617 A PL42389617 A PL 42389617A PL 423896 A1 PL423896 A1 PL 423896A1
- Authority
- PL
- Poland
- Prior art keywords
- alkyl
- application
- antibacterial
- piperidinolium
- methyl
- Prior art date
Links
- 239000002608 ionic liquid Substances 0.000 title abstract 3
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 150000001768 cations Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- -1 (S)-mandelate anion Chemical class 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 229910017053 inorganic salt Inorganic materials 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem zgłoszenia są antybakteryjne ciecze jonowe z kationem 1-alkilo-1-metylo-4-piperydynoliowym i anionem (S)-migdalanowym o wzorze ogólnym 1, w którym R oznacza podstawnik alkilowy o długości od 2 do 16 atomów węgla. Zgłoszenie obejmuje także sposób ich otrzymywania, który polega na tym, że bromek 1-alkilo-1-metylo-4-piperydynoliowy o wzorze ogólnym 2, w którym R oznacza podstawnik alkilowy o długości od 2 do 16 atomów węgla, rozpuszcza się w metanolu, albo etanolu, albo 1-propanolu, albo 2-propanolu, po czym dodaje się sól litową albo potasową albo sodową kwasu (S)-migdałowego w stosunku molowym od 1 do 1,1, w dalszej kolejności układ poddaje się mieszaniu w temperaturze od 15 do 40°C, korzystnie 20°C, w czasie od 20 minut do 1 godziny, korzystnie 30 minut, po czym odsącza się wytrąconą sól nieorganiczną, a następnie z przesączu odparowuje się rozpuszczalnik, a pozostałość suszy. Przedmiotem zgłoszenia jest też zastosowanie cieczy jonowych jako środków antybakteryjnych.The subject of the application are antibacterial ionic liquids with a 1-alkyl-1-methyl-4-piperidinolium cation and a (S) -daldalan anion of general formula 1, wherein R is an alkyl substituent with a length of 2 to 16 carbon atoms. The application also includes a method for their preparation, which consists in the fact that 1-alkyl-1-methyl-4-piperidinolium bromide of general formula 2, wherein R is an alkyl substituent with a length of 2 to 16 carbon atoms, dissolves in methanol, or ethanol or 1-propanol or 2-propanol, followed by the addition of lithium or potassium or sodium salt of (S) -maldic acid in a molar ratio of 1 to 1.1, followed by mixing at a temperature of 15 to 40 ° C, preferably 20 ° C, in 20 minutes to 1 hour, preferably 30 minutes, then the precipitated inorganic salt is filtered off, then the solvent is evaporated from the filtrate and the residue is dried. The subject of the application is also the use of ionic liquids as antibacterial agents.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL423896A PL423896A1 (en) | 2017-12-14 | 2017-12-14 | Antibacterial ionic liquids with 1-alkyl-1-methyl-4-piperidinolium cation and (S)-mandelate anion, method for obtaining them and the application as antibacterial agents |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL423896A PL423896A1 (en) | 2017-12-14 | 2017-12-14 | Antibacterial ionic liquids with 1-alkyl-1-methyl-4-piperidinolium cation and (S)-mandelate anion, method for obtaining them and the application as antibacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL423896A1 true PL423896A1 (en) | 2019-06-17 |
Family
ID=66809769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL423896A PL423896A1 (en) | 2017-12-14 | 2017-12-14 | Antibacterial ionic liquids with 1-alkyl-1-methyl-4-piperidinolium cation and (S)-mandelate anion, method for obtaining them and the application as antibacterial agents |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL423896A1 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL388194A1 (en) * | 2009-06-05 | 2010-12-06 | Instytut Chemii Przemysłowej im. Prof. Ignacego Mościckiego | New ammonium ionic liquids, method for their production and use thereof |
-
2017
- 2017-12-14 PL PL423896A patent/PL423896A1/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL388194A1 (en) * | 2009-06-05 | 2010-12-06 | Instytut Chemii Przemysłowej im. Prof. Ignacego Mościckiego | New ammonium ionic liquids, method for their production and use thereof |
Non-Patent Citations (2)
| Title |
|---|
| A ANNA WISNIEWSKA, SYNTHESIS AND ANTIMICROBIAL PROPERTIES OF NEW MANDELATE IONIC L1QUIDS, 2016 * |
| JAN KOZŁOWSKI, OCENA WPŁYWU MORFOLINIOWYCH CIECZY JONOWYCH NA KONDYCJĘ I AKTYWNOŚĆ ŻEROWANIA ŚLIMAKÓW GASTROPODA: ARIONIDAE NA ROŚLINACH, 2012 * |
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