PL424963A1 - Crystalline form of the complex of dihydrate triaquabis(1,3-dimethylxanthine)copper(II) and method for producing it - Google Patents
Crystalline form of the complex of dihydrate triaquabis(1,3-dimethylxanthine)copper(II) and method for producing itInfo
- Publication number
- PL424963A1 PL424963A1 PL424963A PL42496318A PL424963A1 PL 424963 A1 PL424963 A1 PL 424963A1 PL 424963 A PL424963 A PL 424963A PL 42496318 A PL42496318 A PL 42496318A PL 424963 A1 PL424963 A1 PL 424963A1
- Authority
- PL
- Poland
- Prior art keywords
- dimethylxanthine
- copper
- crystalline form
- dihydrate
- complex
- Prior art date
Links
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 title abstract 3
- 229960000278 theophylline Drugs 0.000 title abstract 2
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 title 1
- 150000004683 dihydrates Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 (1.3-dimethylxanthine) copper (II) dihydrate Chemical compound 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Zgłoszenie dotyczy krystalicznej formy kompleksu dihydrat triakwabis(1.3-dimetyloksantyno)miedź(II) o wzorze 1, znajdującej zastosowanie jako składnik leku o wolnym uwalnianiu i kontrolowanym stężeniu teofiliny. Zgłoszenie obejmuje również sposób wytwarzania krystalicznej formy kompleksu dihydrat triakwabis(1.3-dimetyloksantyno)miedź(II) o wzorze 1, który charakteryzuje się tym, że jedną część molową uwodnionej soli octanu miedzi(II), rozpuszcza się w wodzie i poddaje się reakcji z dwiema częściami molowymi wodnego roztworu 1.3-dimetyloksantyny z dodatkiem 80% stężonego kwasu octowego. Po minimum 14 dniach otrzymuje się krystaliczną formę dihydrat triakwabis(1.3-dimetyloksantyno)miedź(II) o wzorze 1.The application relates to the crystalline form of the triacquisbis (1.3-dimethylxanthine) copper (II) dihydrate complex of formula 1, which is used as a component of a slow release drug and a controlled concentration of theophylline. The application also includes a process for producing the crystalline form of the triacquisbis (1.3-dimethylxanthine) copper (II) dihydrate complex, which is characterized in that one molar part of the hydrated salt of copper (II) acetate is dissolved in water and reacted with two mole parts of aqueous 1.3-dimethylxanthine with 80% concentrated acetic acid. After a minimum of 14 days, the crystalline form triacquisbis (1.3-dimethylxanthine) copper (II) dihydrate is obtained with formula (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL424963A PL239998B1 (en) | 2018-03-21 | 2018-03-21 | Crystalline form of the complex of dihydrate triaquabis(1,3-dimethylxanthine)copper(II) and method for producing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL424963A PL239998B1 (en) | 2018-03-21 | 2018-03-21 | Crystalline form of the complex of dihydrate triaquabis(1,3-dimethylxanthine)copper(II) and method for producing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL424963A1 true PL424963A1 (en) | 2018-11-05 |
| PL239998B1 PL239998B1 (en) | 2022-02-07 |
Family
ID=63998350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL424963A PL239998B1 (en) | 2018-03-21 | 2018-03-21 | Crystalline form of the complex of dihydrate triaquabis(1,3-dimethylxanthine)copper(II) and method for producing it |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL239998B1 (en) |
-
2018
- 2018-03-21 PL PL424963A patent/PL239998B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL239998B1 (en) | 2022-02-07 |
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