PL428569A1 - Flavanone analog and method of its preparation - Google Patents
Flavanone analog and method of its preparationInfo
- Publication number
- PL428569A1 PL428569A1 PL428569A PL42856919A PL428569A1 PL 428569 A1 PL428569 A1 PL 428569A1 PL 428569 A PL428569 A PL 428569A PL 42856919 A PL42856919 A PL 42856919A PL 428569 A1 PL428569 A1 PL 428569A1
- Authority
- PL
- Poland
- Prior art keywords
- flavanone
- analog
- preparation
- precipitate
- ethanol
- Prior art date
Links
- ZONYXWQDUYMKFB-UHFFFAOYSA-N SJ000286395 Natural products O1C2=CC=CC=C2C(=O)CC1C1=CC=CC=C1 ZONYXWQDUYMKFB-UHFFFAOYSA-N 0.000 title abstract 3
- 229930003949 flavanone Natural products 0.000 title abstract 3
- 150000002207 flavanone derivatives Chemical class 0.000 title abstract 3
- 235000011981 flavanones Nutrition 0.000 title abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- 239000002244 precipitate Substances 0.000 abstract 2
- VKUGVGABPFGOCN-PTGBLXJZSA-N C1(=CC=CC=C1)C1OC2=CC=CC=C2\C(\C1)=N\NC(C1=CC=NC=C1)=O Chemical compound C1(=CC=CC=C1)C1OC2=CC=CC=C2\C(\C1)=N\NC(C1=CC=NC=C1)=O VKUGVGABPFGOCN-PTGBLXJZSA-N 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 229960003350 isoniazid Drugs 0.000 abstract 1
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem wynalazku jest analog flawanonu, o nazwie chemicznej (E)-N'-(2-fenylochroman-4-ylideno)izonikotynohydrazyd, o przedstawionym wzorze. Analog ten otrzymuje się w reakcji flawanonu z izoniazydem w środowisku bezwodnego etanolu w obecności stężonego kwasu siarkowego (VI) w temperaturze 60°C w czasie 24 godzin, po czym mieszaninę reakcyjną z wytrąconym osadem pozostawia się do wystudzenia, a następnie wytrącony osad produktu sączy się pod próżnią i przemywa etanolem i destylowaną wodą.The invention relates to a flavanone analog having the chemical name (E) -N '- (2-phenylchroman-4-ylidene) isonicotinohydrazide having the formula shown. This analogue is obtained by reacting flavanone with isoniazid in anhydrous ethanol in the presence of concentrated sulfuric acid (VI) at a temperature of 60 ° C for 24 hours, then the reaction mixture with a precipitate is allowed to cool, and then the precipitate of the product is filtered off. under vacuum and washed with ethanol and distilled water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL428569A PL238431B1 (en) | 2019-01-14 | 2019-01-14 | Flavanone analog and method of its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL428569A PL238431B1 (en) | 2019-01-14 | 2019-01-14 | Flavanone analog and method of its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL428569A1 true PL428569A1 (en) | 2020-07-27 |
| PL238431B1 PL238431B1 (en) | 2021-08-23 |
Family
ID=71733860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL428569A PL238431B1 (en) | 2019-01-14 | 2019-01-14 | Flavanone analog and method of its preparation |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL238431B1 (en) |
-
2019
- 2019-01-14 PL PL428569A patent/PL238431B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL238431B1 (en) | 2021-08-23 |
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