PL430717A1 - Sproszkowany preparat roślinny, sposób jego otrzymywania, mikrogranulki i tabletki otrzymywane z tego preparatu i sposoby ich wytwarzania - Google Patents

Sproszkowany preparat roślinny, sposób jego otrzymywania, mikrogranulki i tabletki otrzymywane z tego preparatu i sposoby ich wytwarzania

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Publication number
PL430717A1
PL430717A1 PL430717A PL43071719A PL430717A1 PL 430717 A1 PL430717 A1 PL 430717A1 PL 430717 A PL430717 A PL 430717A PL 43071719 A PL43071719 A PL 43071719A PL 430717 A1 PL430717 A1 PL 430717A1
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PL
Poland
Prior art keywords
amount
exceeding
preparations
weight
production
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PL430717A
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English (en)
Inventor
Oleksiy Chystyakov-Malinowski
Józef SMOCZYŃSKI
Original Assignee
Biofiton Spółka Z Ograniczoną Odpowiedzialnością
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Application filed by Biofiton Spółka Z Ograniczoną Odpowiedzialnością filed Critical Biofiton Spółka Z Ograniczoną Odpowiedzialnością
Priority to PL430717A priority Critical patent/PL430717A1/pl
Priority to US17/630,281 priority patent/US12558318B2/en
Priority to PCT/PL2020/050053 priority patent/WO2021020978A1/en
Priority to EP20789705.9A priority patent/EP4003383A1/en
Publication of PL430717A1 publication Critical patent/PL430717A1/pl
Priority to US19/461,824 priority patent/US20260199247A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/533—Leonurus (motherwort)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/577—Malvaceae (Mallow family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/68—Plantaginaceae (Plantain Family)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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    • A61K36/906—Zingiberaceae (Ginger family)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób otrzymywania sproszkowanego preparatu roślinnego, charakteryzującego się tym, że: a) materiał roślinny, korzystnie o zawartości wody od 6% do 8%, zamraża się do temperatury poniżej -90°C, b) zamrożony materiał roślinny mieli się w temperaturze od -150°C do -15°C w młynie wibracyjnym przy częstotliwości powyżej 30 Hz, korzystnie od 35 do 37 Hz, przez czas od 1 do 15 minut, korzystnie od 5 do 10 minut, c) oddziela się frakcję sproszkowanego materiału roślinnego o wielkości ziaren nie przekraczającej 400 µm, korzystnie poniżej 150 µm. Zgłoszenie obejmuje też mikrogranulki składające się ze: sproszkowanego preparatu roślinnego, określonego w zastrz. 5 lub otrzymanego sposobem określonym w zastrz. 1-5, w ilości od 93% wag. do 99% wag. substancji pomocniczej wybranej spośród skrobi lub laktozy, w ilości nie przekraczającej 1% wag., wody w ilości nie przekraczającej 5% wag. oraz karboksymetylocelulozy w ilości nie przekraczającej 1% wagowych oraz tabletkę składającą się ze sproszkowanego preparatu roślinnego, określonego w zastrz. 6 lub otrzymanego sposobem określonym w zastrz. 1-5, w ilości od 93% wag. do 99% wag. substancji pomocniczej, korzystnie wybranej spośród skrobi lub laktozy, w ilości nie przekraczającej 1% wag., wody w ilości nie przekraczającej 5% wag., substancji klejącej, korzystnie karboksymetylocelulozy, w ilości nie przekraczającej 1% wagowych oraz substancji poślizgowej, korzystnie stearynianu wapnia, w ilości nie przekraczającej 1% wagowych.
PL430717A 2019-07-27 2019-07-27 Sproszkowany preparat roślinny, sposób jego otrzymywania, mikrogranulki i tabletki otrzymywane z tego preparatu i sposoby ich wytwarzania PL430717A1 (pl)

Priority Applications (5)

Application Number Priority Date Filing Date Title
PL430717A PL430717A1 (pl) 2019-07-27 2019-07-27 Sproszkowany preparat roślinny, sposób jego otrzymywania, mikrogranulki i tabletki otrzymywane z tego preparatu i sposoby ich wytwarzania
US17/630,281 US12558318B2 (en) 2019-07-27 2020-07-27 Powdered plant preparation, the manner in which it is obtained, microgranules and tablets obtained from that preparation and the ways of producing them
PCT/PL2020/050053 WO2021020978A1 (en) 2019-07-27 2020-07-27 Powdered plant preparation, the manner in which it is obtained, microgranules and tablets obtained from that preparation and the ways of producing them
EP20789705.9A EP4003383A1 (en) 2019-07-27 2020-07-27 Powdered plant preparation, the manner in which it is obtained, microgranules and tablets obtained from that preparation and the ways of producing them
US19/461,824 US20260199247A1 (en) 2019-07-27 2026-01-28 Powdered plant preparation, the manner in which it is obtained, microgranules and tablets obtained from that preparation and the ways of producing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL430717A PL430717A1 (pl) 2019-07-27 2019-07-27 Sproszkowany preparat roślinny, sposób jego otrzymywania, mikrogranulki i tabletki otrzymywane z tego preparatu i sposoby ich wytwarzania

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PL430717A1 true PL430717A1 (pl) 2021-02-08

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US3838825A (en) 1971-12-27 1974-10-01 Kloeckner Humboldt Deutz Ag Vibrating mill with heat insulating grinding chamber
JPS58210023A (ja) 1982-05-31 1983-12-07 Ichikawa Kagaku Kenkyusho:Kk 医薬植物の粉末化方法
US5513809A (en) 1995-07-03 1996-05-07 Tdf, Inc. Cryogenic vibratory mill apparatus
FR2823423B1 (fr) * 2001-04-11 2004-08-27 Bio Serae Laboratoires Preparation a base de cactaceae ayant la propriete de fixer les graisses, et procede d'obtention d'une telle preparation
KR20100005165A (ko) * 2008-07-05 2010-01-14 이창열 검정콩자엽을 초저온액체질소를 이용한 포장위생검정콩자엽 활성미립자의 제조방법.
PL232073B1 (pl) 2015-06-24 2019-05-31 Univ Przyrodniczy W Poznaniu Deser i sposób wytwarzania deserów zawierających w swoim składzie funkcjonalne dodatki pochodzące z owoców róży pomarszczonej
CN109174407A (zh) 2018-08-30 2019-01-11 云南金不换生物科技有限责任公司 超微粉低温研磨技术

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