PL439097A1 - Method of preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone - Google Patents

Method of preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

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Publication number
PL439097A1
PL439097A1 PL439097A PL43909721A PL439097A1 PL 439097 A1 PL439097 A1 PL 439097A1 PL 439097 A PL439097 A PL 439097A PL 43909721 A PL43909721 A PL 43909721A PL 439097 A1 PL439097 A1 PL 439097A1
Authority
PL
Poland
Prior art keywords
methylglucopyranosyl
flavanone
methylene
hours
formula
Prior art date
Application number
PL439097A
Other languages
Polish (pl)
Other versions
PL244830B1 (en
Inventor
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL439097A priority Critical patent/PL244830B1/en
Publication of PL439097A1 publication Critical patent/PL439097A1/en
Publication of PL244830B1 publication Critical patent/PL244830B1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób wytwarzania 4'-metyleno-O-β-D-(4"-O-metyloglukopiranozylo)-flawanonu, który polega na tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria farinosa KCH J2.6, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 4'-metyloflawanon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 4'metyleno-O-β-D-(4"-O-metyloglukopiranozylo)-flawanon o wzorze 2 znajduje się we frakcji o pośredniej polarności, w drugim paśmie od linii startu.The subject of the application is a method of producing 4'-methylene-O-β-D-(4"-O-methylglucopyranosyl)-flavanone, which consists in introducing the strain Isaria farinosa KCH J2.6 into a substrate suitable for filamentous fungi, then after at least 72 hours, the substrate, which is 4'-methylflavanone of the formula 1, dissolved in an organic solvent miscible with water, is introduced into the culture, the transformation is carried out at a temperature of 20 to 30 degrees Celsius, with constant shaking, at least 96 hours, after which the product is extracted with a water-immiscible organic solvent and purified by chromatography, the 4'-methylene-O-β-D-(4"-O-methylglucopyranosyl)-flavanone of formula 2 being in the intermediate polarity fraction, in the second lane from the starting line.

PL439097A 2021-09-30 2021-09-30 Method for producing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone PL244830B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL439097A PL244830B1 (en) 2021-09-30 2021-09-30 Method for producing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL439097A PL244830B1 (en) 2021-09-30 2021-09-30 Method for producing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

Publications (2)

Publication Number Publication Date
PL439097A1 true PL439097A1 (en) 2023-04-03
PL244830B1 PL244830B1 (en) 2024-03-11

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ID=85783967

Family Applications (1)

Application Number Title Priority Date Filing Date
PL439097A PL244830B1 (en) 2021-09-30 2021-09-30 Method for producing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

Country Status (1)

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PL (1) PL244830B1 (en)

Also Published As

Publication number Publication date
PL244830B1 (en) 2024-03-11

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