PL443856A1 - 4-Chloro-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone and method for producing 4-chloro-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone - Google Patents

4-Chloro-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone and method for producing 4-chloro-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone

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Publication number
PL443856A1
PL443856A1 PL443856A PL44385623A PL443856A1 PL 443856 A1 PL443856 A1 PL 443856A1 PL 443856 A PL443856 A PL 443856A PL 44385623 A PL44385623 A PL 44385623A PL 443856 A1 PL443856 A1 PL 443856A1
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Poland
Prior art keywords
chloro
methylglucopyranosyl
dihydrochalcone
formula
producing
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PL443856A
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Polish (pl)
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PL247886B1 (en
Inventor
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
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Uniwersytet Przyrodniczy we Wrocławiu
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Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL443856A priority Critical patent/PL247886B1/en
Publication of PL443856A1 publication Critical patent/PL443856A1/en
Publication of PL247886B1 publication Critical patent/PL247886B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Przedmiotem zgłoszenia jest 4-Chloro-2'-O-β-D-(4"-O-metyloglukopiranozylo)-dihydrochalkon o wzorze 2 oraz sposób wytwarzania 4-chloro-2'-O-β-D-(4"-O-metyloglukopiranozylo)-dihydrochalkonu, który polega na tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 4-chloro-2'-hydroksychalkon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 4-chloro-2'-O-β-D-(4"-O-metyloglukopiranozylo)-dihydrochalkon o wzorze 2 znajduje się we frakcji o pośredniej polarności, w drugim paśmie od linii startu.The subject of the application is 4-Chloro-2'-O-β-D-(4"-O-methylglucopyranosyl)-dihydrochalcone of formula 2 and a method for producing 4-chloro-2'-O-β-D-(4"-O-methylglucopyranosyl)-dihydrochalcone, which consists in introducing the strain Isaria fumosorosea KCH J2 into a substrate suitable for filamentous fungi, then after at least 72 hours a substrate is introduced into the culture, which is 4-chloro-2'-hydroxychalcone of formula 1, dissolved in an organic solvent miscible with water, the transformation is carried out at a temperature of 20 to 30 degrees Celsius, with continuous shaking, for at least 96 hours, after which the product is extracted with an organic solvent immiscible with water and purified chromatographically, wherein 4-Chloro-2'-O-β-D-(4"-O-methylglucopyranosyl)-dihydrochalcone of formula 2 is located in the fraction of intermediate polarity, in the second band from the starting line.

PL443856A 2023-02-22 2023-02-22 4-Chloro-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone and method for producing 4-chloro-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone PL247886B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL443856A PL247886B1 (en) 2023-02-22 2023-02-22 4-Chloro-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone and method for producing 4-chloro-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL443856A PL247886B1 (en) 2023-02-22 2023-02-22 4-Chloro-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone and method for producing 4-chloro-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone

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PL443856A1 true PL443856A1 (en) 2024-08-26
PL247886B1 PL247886B1 (en) 2025-09-15

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PL443856A PL247886B1 (en) 2023-02-22 2023-02-22 4-Chloro-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone and method for producing 4-chloro-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL438351A1 (en) * 2021-07-05 2023-01-09 Wrocław University Of Environmental And Life Sciences 2'-Hydroxy-2-methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone and method for the preparation of 2'-hydroxy-2-methyl-3'-O-β-D- (4''-O-methylglucopyranosyl)-dihydrochalcone
PL438645A1 (en) * 2021-07-30 2023-02-06 Wrocław University Of Environmental And Life Sciences 3-Hydroxy-2-methyl-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone and method for the preparation of 3-hydroxy-2-methyl-2'-O-β-D-(4 ''O-methylglucopyranosyl)-dihydrochalcone

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL438351A1 (en) * 2021-07-05 2023-01-09 Wrocław University Of Environmental And Life Sciences 2'-Hydroxy-2-methyl-3'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone and method for the preparation of 2'-hydroxy-2-methyl-3'-O-β-D- (4''-O-methylglucopyranosyl)-dihydrochalcone
PL438645A1 (en) * 2021-07-30 2023-02-06 Wrocław University Of Environmental And Life Sciences 3-Hydroxy-2-methyl-2'-O-β-D-(4''-O-methylglucopyranosyl)-dihydrochalcone and method for the preparation of 3-hydroxy-2-methyl-2'-O-β-D-(4 ''O-methylglucopyranosyl)-dihydrochalcone

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PL247886B1 (en) 2025-09-15

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