PL439737A1 - Method for producing 4',5,7-trihydroxy-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone - Google Patents

Method for producing 4',5,7-trihydroxy-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone

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Publication number
PL439737A1
PL439737A1 PL439737A PL43973721A PL439737A1 PL 439737 A1 PL439737 A1 PL 439737A1 PL 439737 A PL439737 A PL 439737A PL 43973721 A PL43973721 A PL 43973721A PL 439737 A1 PL439737 A1 PL 439737A1
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PL
Poland
Prior art keywords
methylglucopyranosyl
flavone
trihydroxy
formula
hours
Prior art date
Application number
PL439737A
Other languages
Polish (pl)
Other versions
PL247590B1 (en
Inventor
Monika Dymarska
Edyta Kostrzewa-Susłow
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
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Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL439737A priority Critical patent/PL247590B1/en
Publication of PL439737A1 publication Critical patent/PL439737A1/en
Publication of PL247590B1 publication Critical patent/PL247590B1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób wytwarzania 4',5,7-trihydroksy-3-O-β-D-(4"-O-metyloglukopiranozylo)-flawonu o wzorze 2, charakteryzujący się tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat którym jest 3,4',5,7-tetrahydroksyflawon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 4',5,7-trihydroksy-3-O-β-D-(4"-O-metyloglukopiranozylo)-flawon o wzorze 2 znajduje się we frakcji o najwyższej polarności.The subject of the application is a method for the production of 4',5,7-trihydroxy-3-O-β-D-(4"-O-methylglucopyranosyl)-flavone of formula 2, characterized in that a strain of Isaria fumosorosea KCH J2, then, after at least 72 hours, a substrate is added to the culture, which is 3,4',5,7-tetrahydroxyflavone of the formula 1, dissolved in an organic solvent miscible with water, the transformation is carried out at a temperature of 20 to 30 degrees Celsius under continuous shaking for at least 96 hours, after which the product is extracted with a water-immiscible organic solvent and purified by chromatography, whereby 4',5,7-trihydroxy-3-O-β-D-(4" -O-methylglucopyranosyl)-flavone of formula 2 is found in the fraction with the highest polarity.

PL439737A 2021-12-03 2021-12-03 Method for producing 4',5,7-trihydroxy-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone PL247590B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL439737A PL247590B1 (en) 2021-12-03 2021-12-03 Method for producing 4',5,7-trihydroxy-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL439737A PL247590B1 (en) 2021-12-03 2021-12-03 Method for producing 4',5,7-trihydroxy-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Publications (2)

Publication Number Publication Date
PL439737A1 true PL439737A1 (en) 2023-06-05
PL247590B1 PL247590B1 (en) 2025-07-28

Family

ID=86701145

Family Applications (1)

Application Number Title Priority Date Filing Date
PL439737A PL247590B1 (en) 2021-12-03 2021-12-03 Method for producing 4',5,7-trihydroxy-3-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Country Status (1)

Country Link
PL (1) PL247590B1 (en)

Also Published As

Publication number Publication date
PL247590B1 (en) 2025-07-28

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