PL445157A1 - Method of producing 4'-O-β-D-(4'''-O-methylglucopyranosyl)xanthohumol - Google Patents

Method of producing 4'-O-β-D-(4'''-O-methylglucopyranosyl)xanthohumol

Info

Publication number
PL445157A1
PL445157A1 PL445157A PL44515723A PL445157A1 PL 445157 A1 PL445157 A1 PL 445157A1 PL 445157 A PL445157 A PL 445157A PL 44515723 A PL44515723 A PL 44515723A PL 445157 A1 PL445157 A1 PL 445157A1
Authority
PL
Poland
Prior art keywords
xanthohumol
methylglucopyranosyl
producing
hours
organic solvent
Prior art date
Application number
PL445157A
Other languages
Polish (pl)
Inventor
Tomasz Tronina
Daniel Radosław Łój
Agnieszka Bartmańska
Jarosław Popłoński
Ewa Huszcza
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL445157A priority Critical patent/PL445157A1/en
Publication of PL445157A1 publication Critical patent/PL445157A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób wytwarzania 4'-O-β-D-(4"'-O-metyloglukopiranozylo)-ksantohumolu charakteryzujący się tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCh J2, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest ksantohumol o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 24 godziny, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie.The subject of the application is a method for producing 4'-O-β-D-(4"'-O-methylglucopyranosyl)-xanthohumol characterized in that the strain Isaria fumosorosea KCh J2 is introduced into a medium suitable for filamentous fungi, then after at least 72 hours a substrate, which is xanthohumol of formula 1, dissolved in an organic solvent miscible with water, is introduced into the culture, the transformation is carried out at a temperature of 20 to 30 degrees Celsius, with continuous shaking, for at least 24 hours, after which the product is extracted with an organic solvent immiscible with water and purified chromatographically.

PL445157A 2023-06-07 2023-06-07 Method of producing 4'-O-β-D-(4'''-O-methylglucopyranosyl)xanthohumol PL445157A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL445157A PL445157A1 (en) 2023-06-07 2023-06-07 Method of producing 4'-O-β-D-(4'''-O-methylglucopyranosyl)xanthohumol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL445157A PL445157A1 (en) 2023-06-07 2023-06-07 Method of producing 4'-O-β-D-(4'''-O-methylglucopyranosyl)xanthohumol

Publications (1)

Publication Number Publication Date
PL445157A1 true PL445157A1 (en) 2024-12-09

Family

ID=93799857

Family Applications (1)

Application Number Title Priority Date Filing Date
PL445157A PL445157A1 (en) 2023-06-07 2023-06-07 Method of producing 4'-O-β-D-(4'''-O-methylglucopyranosyl)xanthohumol

Country Status (1)

Country Link
PL (1) PL445157A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL210084B1 (en) * 2008-06-16 2011-12-30 Univ Przyrodniczy We Wrocławiu The manner of production of 4'-O- -D-glucosylo-2'-4-dihydroxy-6'-metoxy-3'-prenylochalcone

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL210084B1 (en) * 2008-06-16 2011-12-30 Univ Przyrodniczy We Wrocławiu The manner of production of 4'-O- -D-glucosylo-2'-4-dihydroxy-6'-metoxy-3'-prenylochalcone

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HUSZCZA E, BARTMAŃSKA A, TRONINA T., GLYCOSYLATION OF XANTHOHUMOL BY FUNGI. Z NATURFORSCH C J BIOSCI. 2008 JUL-AUG;63(7-8):557-60. DOI:10.1515/ZNC-2008-7-815. *
TOMASZ TRONINA, AGNIESZKA BARTMAŃSKA, MAGDALENA MILCZAREK, JOANNA WIETRZYK, JAROSŁAW POPŁOŃSKI, EDWARD RÓJ, EWA HUSZCZA, ANTIOXIDANT AND ANTIPROLIFERATIVE ACTIVITY OF GLYCOSIDES OBTAINED BY BIOTRANSFORMATION OF XANTHOHUMOL, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, VOLUME 23, ISSUE 7, 2013, PAGES 1957-1960, HTTPS://DOI.ORG/10.1016/J.BMCL.2013.02.031. *

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