NO20022021L - Indeno-, nafto- og benzocyklohepta-dihydrotiazolderivater, fremstilling av de samme og deres anvendelse somanoreksilegemidler - Google Patents
Indeno-, nafto- og benzocyklohepta-dihydrotiazolderivater, fremstilling av de samme og deres anvendelse somanoreksilegemidlerInfo
- Publication number
- NO20022021L NO20022021L NO20022021A NO20022021A NO20022021L NO 20022021 L NO20022021 L NO 20022021L NO 20022021 A NO20022021 A NO 20022021A NO 20022021 A NO20022021 A NO 20022021A NO 20022021 L NO20022021 L NO 20022021L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- replaced
- preparation
- dihydrotiazole
- benzocyclohepta
- Prior art date
Links
- 239000002830 appetite depressant Substances 0.000 title abstract 2
- 101150065749 Churc1 gene Proteins 0.000 abstract 13
- 102100038239 Protein Churchill Human genes 0.000 abstract 13
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 abstract 12
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Oppfinnelsen vedrører en forbindelse med formel (I). Y er en direkte binding, -CH-, -CH-CH-; X representerer CHCH(CH); CH(CH), CH(CH), CH(CH); R4 representerer (C-C)-cykloalkyl, hvori ett eller flere hydrogener kan substitueres i alkylgruppene med fluor eller et hydrogen kan erstattes med OH, OC(0)CH, OC(0)H, 0-CH-Ph eller 0-(C,-C)-alkyl;. (CH)-A-Rg, hvori n = 1 - 6, idet gruppen -CH-0-CH-fenyl, hvori fenyl er usubstituert, er utelatt; (CH)-B-R, hvori r = 1 - 6; A er O, S, SO, S0; B er NH, N-(C-C)-alkyl, NCHO, N(CO-CH); R8 representerer (C-C)-alkyl, (C-C)-cykloalkyl, idet i alkylgruppene ett eller flere hydrogener kan være erstattet med fluor eller et hydrogen kan være erstattet med OH, OC(0)CH, OC(0)H, 0-CH-Ph eller O-(C|-C)-alkyl; (CH)-aryl, hvor m = 0 - 6 og aryl er fenyl, naftyl, bifenyl, tienyl eller pyridyl og aryldelen kan være erstattet opp til to ganger og hvori gruppene Ri, R'i, Rog Rhar de angitte betydninger. Oppfinnelsen vedrører også fysiologisk tålbare salter av forbindelsene og fremgangsmåte for fremstilling av forbindelsene. Forbindelsene ifølge oppfinnelsen er f.eks. egnet for anvendelse som anorektiske midler.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19953205 | 1999-11-05 | ||
| DE2000113306 DE10013306A1 (de) | 2000-03-17 | 2000-03-17 | Polycyclische, in 2-Stellung mit substituierten Alkylresten versehene Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP2000/010396 WO2001032638A1 (de) | 1999-11-05 | 2000-10-21 | Indeno-, naphtho- und benzocyclohepta-dihydrothiazol derivate, deren herstellung und deren verwendung als anorektische arzneimittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20022021L true NO20022021L (no) | 2002-04-29 |
| NO20022021D0 NO20022021D0 (no) | 2002-04-29 |
| NO322309B1 NO322309B1 (no) | 2006-09-11 |
Family
ID=26004890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20022021A NO322309B1 (no) | 1999-11-05 | 2002-04-29 | Indenotiazolforbindelser, legemiddel som inneholder slike forbindelser, fremgangsmate for deres fremstilling og deres anvendelse som anoreksimidler. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6387935B1 (no) |
| EP (1) | EP1230230B1 (no) |
| JP (1) | JP2003524632A (no) |
| KR (1) | KR20020047331A (no) |
| CN (1) | CN1176080C (no) |
| AR (1) | AR026338A1 (no) |
| AT (1) | ATE250045T1 (no) |
| AU (1) | AU777569B2 (no) |
| BR (1) | BR0015322A (no) |
| CA (1) | CA2389703A1 (no) |
| CZ (1) | CZ20021528A3 (no) |
| DE (1) | DE50003761D1 (no) |
| DK (1) | DK1230230T3 (no) |
| EE (1) | EE200200235A (no) |
| ES (1) | ES2206320T3 (no) |
| HR (1) | HRP20020379A2 (no) |
| HU (1) | HUP0203290A3 (no) |
| IL (1) | IL149400A0 (no) |
| MX (1) | MXPA02003477A (no) |
| NO (1) | NO322309B1 (no) |
| NZ (1) | NZ518751A (no) |
| PL (1) | PL354533A1 (no) |
| PT (1) | PT1230230E (no) |
| SK (1) | SK6132002A3 (no) |
| WO (1) | WO2001032638A1 (no) |
| YU (1) | YU29602A (no) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| MX2009013293A (es) | 2007-06-04 | 2010-02-15 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| CA2730603C (en) | 2008-07-16 | 2019-09-24 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2348857B1 (en) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| JP5557845B2 (ja) | 2008-10-31 | 2014-07-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体 |
| AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| MX348131B (es) | 2011-02-25 | 2017-05-26 | Merck Sharp & Dohme | Novedosos derivados de azabencimidazol ciclico utiles como agentes antidiabeticos. |
| CA3100941C (en) | 2011-03-01 | 2024-03-05 | Synergy Pharmaceuticals Inc. | Process of preparing guanylate cyclase c agonists |
| WO2014022528A1 (en) | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| WO2014130608A1 (en) | 2013-02-22 | 2014-08-28 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| JP2016514670A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト |
| EA201592263A1 (ru) | 2013-06-05 | 2016-05-31 | Синерджи Фармасьютикалз, Инк. | Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| EP3558298B1 (en) | 2016-12-20 | 2026-03-11 | Merck Sharp & Dohme LLC | Antidiabetic spirochroman compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3507868A (en) * | 1968-10-21 | 1970-04-21 | Sandoz Ag | Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines |
| DE2640358A1 (de) * | 1976-09-08 | 1978-03-16 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| DE19831878C2 (de) * | 1998-07-17 | 2001-05-17 | Aventis Pharma Gmbh | Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE19844547C2 (de) * | 1998-09-29 | 2002-11-07 | Aventis Pharma Gmbh | Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE19908539A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
-
2000
- 2000-10-21 BR BR0015322-2A patent/BR0015322A/pt not_active IP Right Cessation
- 2000-10-21 JP JP2001534789A patent/JP2003524632A/ja not_active Withdrawn
- 2000-10-21 PT PT00974437T patent/PT1230230E/pt unknown
- 2000-10-21 AT AT00974437T patent/ATE250045T1/de not_active IP Right Cessation
- 2000-10-21 PL PL00354533A patent/PL354533A1/xx not_active Application Discontinuation
- 2000-10-21 SK SK613-2002A patent/SK6132002A3/sk unknown
- 2000-10-21 MX MXPA02003477A patent/MXPA02003477A/es active IP Right Grant
- 2000-10-21 CA CA002389703A patent/CA2389703A1/en not_active Abandoned
- 2000-10-21 KR KR1020027005768A patent/KR20020047331A/ko not_active Ceased
- 2000-10-21 AU AU12746/01A patent/AU777569B2/en not_active Ceased
- 2000-10-21 EP EP00974437A patent/EP1230230B1/de not_active Expired - Lifetime
- 2000-10-21 CN CNB008148899A patent/CN1176080C/zh not_active Expired - Fee Related
- 2000-10-21 HR HR20020379A patent/HRP20020379A2/hr not_active Application Discontinuation
- 2000-10-21 DK DK00974437T patent/DK1230230T3/da active
- 2000-10-21 ES ES00974437T patent/ES2206320T3/es not_active Expired - Lifetime
- 2000-10-21 IL IL14940000A patent/IL149400A0/xx unknown
- 2000-10-21 DE DE50003761T patent/DE50003761D1/de not_active Expired - Lifetime
- 2000-10-21 NZ NZ518751A patent/NZ518751A/en unknown
- 2000-10-21 HU HU0203290A patent/HUP0203290A3/hu unknown
- 2000-10-21 YU YU29602A patent/YU29602A/sh unknown
- 2000-10-21 WO PCT/EP2000/010396 patent/WO2001032638A1/de not_active Ceased
- 2000-10-21 CZ CZ20021528A patent/CZ20021528A3/cs unknown
- 2000-10-21 EE EEP200200235A patent/EE200200235A/xx unknown
- 2000-11-02 AR ARP000105782A patent/AR026338A1/es unknown
- 2000-11-06 US US09/706,351 patent/US6387935B1/en not_active Expired - Lifetime
-
2002
- 2002-04-29 NO NO20022021A patent/NO322309B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2389703A1 (en) | 2001-05-10 |
| HUP0203290A3 (en) | 2004-12-28 |
| BR0015322A (pt) | 2002-07-09 |
| WO2001032638A1 (de) | 2001-05-10 |
| PT1230230E (pt) | 2003-12-31 |
| NZ518751A (en) | 2004-06-25 |
| HRP20020379A2 (en) | 2004-02-29 |
| DK1230230T3 (da) | 2003-12-15 |
| EE200200235A (et) | 2003-06-16 |
| MXPA02003477A (es) | 2002-08-20 |
| AR026338A1 (es) | 2003-02-05 |
| NO322309B1 (no) | 2006-09-11 |
| ES2206320T3 (es) | 2004-05-16 |
| EP1230230B1 (de) | 2003-09-17 |
| CN1384827A (zh) | 2002-12-11 |
| DE50003761D1 (de) | 2003-10-23 |
| YU29602A (sh) | 2006-01-16 |
| JP2003524632A (ja) | 2003-08-19 |
| CN1176080C (zh) | 2004-11-17 |
| NO20022021D0 (no) | 2002-04-29 |
| US6387935B1 (en) | 2002-05-14 |
| PL354533A1 (en) | 2004-01-26 |
| HK1050524A1 (en) | 2003-06-27 |
| IL149400A0 (en) | 2002-11-10 |
| SK6132002A3 (en) | 2002-11-06 |
| EP1230230A1 (de) | 2002-08-14 |
| ATE250045T1 (de) | 2003-10-15 |
| CZ20021528A3 (cs) | 2002-07-17 |
| AU777569B2 (en) | 2004-10-21 |
| HUP0203290A2 (hu) | 2003-01-28 |
| AU1274601A (en) | 2001-05-14 |
| KR20020047331A (ko) | 2002-06-21 |
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