PT101627B - Polipeptideo trombopoietina isolado e substancialmente homogeneo, dna que o codifica e metodos recombinantes ou de sintese para a sua preparacao e purificacao - Google Patents

Polipeptideo trombopoietina isolado e substancialmente homogeneo, dna que o codifica e metodos recombinantes ou de sintese para a sua preparacao e purificacao Download PDF

Info

Publication number: PT101627B
Authority: PT; Portugal
Prior art keywords: polypeptide; seq; mpl; mpl ligand; dna
Prior art date: 1994-01-03

Application number

PT101627A

Other languages

English (en)

Portuguese (pt)

Other versions

PT101627A (pt

Inventor

Dan L Eaton

Frederic J De Sauvage

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-03

Filing date

1994-12-30

Publication date

1996-11-29

1994-02-15 Priority claimed from US08/196,689 external-priority patent/US8357513B1/en

1994-05-25 Priority claimed from US08/249,376 external-priority patent/US8192955B1/en

1994-12-02 Priority claimed from US08/348,657 external-priority patent/US6660256B1/en

1994-12-30 Application filed by Genentech Inc filed Critical Genentech Inc

1995-11-30 Publication of PT101627A publication Critical patent/PT101627A/pt

1996-11-29 Publication of PT101627B publication Critical patent/PT101627B/pt

Links

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FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
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239000007929 subcutaneous injection Substances 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
RINCXYDBBGOEEQ-UHFFFAOYSA-N succinic anhydride Chemical class O=C1CCC(=O)O1 RINCXYDBBGOEEQ-UHFFFAOYSA-N 0.000 description 1
229940124530 sulfonamide Drugs 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
239000013589 supplement Substances 0.000 description 1
230000000153 supplemental effect Effects 0.000 description 1
238000004114 suspension culture Methods 0.000 description 1
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208000024891 symptom Diseases 0.000 description 1
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235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
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ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
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RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
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FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
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VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
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OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Vehicle Body Suspensions (AREA)
Information Transfer Systems (AREA)

PT101627A 1994-01-03 1994-12-30 Polipeptideo trombopoietina isolado e substancialmente homogeneo, dna que o codifica e metodos recombinantes ou de sintese para a sua preparacao e purificacao PT101627B (pt)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US17655394A	1994-01-03	1994-01-03
US18560794A	1994-01-21	1994-01-21
US08/196,689 US8357513B1 (en)	1994-01-03	1994-02-15	Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A	1994-04-04	1994-04-04
US08/249,376 US8192955B1 (en)	1994-01-03	1994-05-25	Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A	1994-12-02	1994-12-02
US08/348,657 US6660256B1 (en)	1994-01-03	1994-12-02	Porcine mpl ligand

Publications (2)

Publication Number	Publication Date
PT101627A PT101627A (pt)	1995-11-30
PT101627B true PT101627B (pt)	1996-11-29

Family

ID=27569151

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT101627A PT101627B (pt)	1994-01-03	1994-12-30	Polipeptideo trombopoietina isolado e substancialmente homogeneo, dna que o codifica e metodos recombinantes ou de sintese para a sua preparacao e purificacao

Country Status (28)

Country	Link
EP (1)	EP0738323A1 (de)
JP (2)	JPH09508262A (de)
CN (1)	CN1134539C (de)
AU (1)	AU704266B2 (de)
BG (1)	BG63639B1 (de)
CA (1)	CA2178482C (de)
CZ (1)	CZ296130B6 (de)
DK (1)	DK149194A (de)
ES (1)	ES2114786B1 (de)
FI (1)	FI121573B (de)
FR (1)	FR2714670B1 (de)
GB (1)	GB2285446B (de)
HR (1)	HRP941020A2 (de)
HU (1)	HUT75657A (de)
IE (1)	IE72517B1 (de)
IL (1)	IL112184A (de)
IT (1)	IT1283770B1 (de)
LU (1)	LU88573A1 (de)
LV (1)	LV11632B (de)
NL (1)	NL9500010A (de)
NO (1)	NO326903B1 (de)
NZ (1)	NZ278726A (de)
PT (1)	PT101627B (de)
RO (1)	RO117110B1 (de)
SG (1)	SG47030A1 (de)
SI (1)	SI9420079A (de)
SK (1)	SK282265B6 (de)
WO (1)	WO1995018858A1 (de)

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SK100896A3 (en) *	1994-02-14	1997-10-08	Zymogenetics Inc	Hematopoietic protein and materials and methods for making it
US5795569A (en) *	1994-03-31	1998-08-18	Amgen Inc.	Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
CN1229385C (zh) *	1994-03-31	2005-11-30	安姆根有限公司	刺激巨核细胞生长和分化的组合物及方法
US5986049A (en) *	1994-12-30	1999-11-16	Zymogenetics, Inc.	Purified thrombopoietin and method of making it
TW387940B (en) *	1995-01-17	2000-04-21	Kirin Brewery	Anti-tpo monodonal antibody
JPH11500308A (ja)	1995-02-03	1999-01-12	ジー．ディー．サールアンドカンパニー	新規ｃ−ＭＰＬリガンド
US5989538A (en) *	1995-02-15	1999-11-23	Amgen Inc.	Mpl ligand analogs
US5696250A (en) *	1995-02-15	1997-12-09	Amgen Inc.	DNA encoding megakaryocyte growth and development factor analogs
CN1161468C (zh) *	1995-02-15	2004-08-11	安姆根有限公司	Mpl配体类似物
TW434021B (en) *	1995-03-15	2001-05-16	Kirin Brewery	Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
TW434020B (en) *	1995-03-15	2001-05-16	Kirin Brewery	Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
ZA964382B (en) *	1995-06-06	1997-12-01	Genentech Inc	Lymphotoxin and thrombopoietin for use in the treatment of cancer.
TR199701526T1 (xx) *	1995-06-07	1998-03-21	Glaxo Group Limited	Bir trombopoietin resept�r�ne ba�lanan peptitler ve bile�ikler.
US5869451A (en) *	1995-06-07	1999-02-09	Glaxo Group Limited	Peptides and compounds that bind to a receptor
US6251864B1 (en)	1995-06-07	2001-06-26	Glaxo Group Limited	Peptides and compounds that bind to a receptor
TW497972B (en) *	1995-06-08	2002-08-11	Kirin Brewery	Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) *	1995-10-05	2000-05-23	G.D. Searle & Co.	Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) *	1996-01-24	2000-02-29	Biophage, Inc.	Methods of generating novel peptides
US5879673A (en) *	1996-01-25	1999-03-09	Genentech, Inc.	Administration of thrombopoietin on a single day only
US7091311B2 (en)	1996-06-07	2006-08-15	Smithkline Beecham Corporation	Peptides and compounds that bind to a receptor
EP0920511A1 (de) *	1996-08-13	1999-06-09	ZymoGenetics	Expressionsvektoren, zellen und verfahren zur herstellung von thrombopietin polypeptide
AU7589898A (en) *	1997-05-21	1998-12-11	Genentech Inc.	Novel administration of thrombopoietin
US5980893A (en) *	1997-07-17	1999-11-09	Beth Israel Deaconess Medical Center, Inc.	Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en)	1997-08-25	2002-01-29	Genentech, Inc.	Agonist antibodies
US20030228666A1 (en)	1998-06-30	2003-12-11	Daewoong Pharmaceutical Co., Ltd.	Novel human thrombopoietin mutein
KR20000006549A (ko) *	1998-06-30	2000-01-25	윤재승	생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US6660843B1 (en)	1998-10-23	2003-12-09	Amgen Inc.	Modified peptides as therapeutic agents
PT1783222E (pt)	1998-10-23	2012-07-26	Kirin Amgen Inc	Péptidos diméricos de trombopoietina que simulam a ligação ao receptor mpl e têm actividade trombopoiética
CY2010012I2 (el) *	2000-05-25	2020-05-29	Novartis Ag	Μιμητικα θρομβοποιητινης
UY26317A1 (es) *	2000-08-30	2000-10-31	Alfonso Cayota Carlos Pritsch	Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
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1994
- 1994-12-21 SG SG1996003050A patent/SG47030A1/en unknown
- 1994-12-21 GB GB9425831A patent/GB2285446B/en not_active Expired - Lifetime
- 1994-12-27 HR HR08/348,658A patent/HRP941020A2/hr not_active Application Discontinuation
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- 1994-12-28 JP JP7518499A patent/JPH09508262A/ja active Pending
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1995
- 1995-01-02 FR FR9500007A patent/FR2714670B1/fr not_active Expired - Lifetime
- 1995-01-02 IT IT95TO000002A patent/IT1283770B1/it active IP Right Grant
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1996
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Also Published As

Publication number	Publication date
BG63639B1 (bg)	2002-07-31
CZ192296A3 (en)	1997-05-14
ITTO950002A0 (it)	1995-01-02
IL112184A0 (en)	1995-03-15
CN1134539C (zh)	2004-01-14
CN1141061A (zh)	1997-01-22
WO1995018858A1 (en)	1995-07-13
ITTO950002A1 (it)	1996-07-02
FI962723A0 (fi)	1996-07-02
IE72517B1 (en)	1997-04-23
IT1283770B1 (it)	1998-04-30
RO117110B1 (ro)	2001-10-30
JPH10113186A (ja)	1998-05-06
SK282265B6 (sk)	2001-12-03
GB2285446B (en)	1999-07-28
DK149194A (da)	1995-07-04
IE950002A1 (en)	1995-07-12
NO962783D0 (no)	1996-07-02
ES2114786A1 (es)	1998-06-01
SK87596A3 (en)	1997-11-05
CZ296130B6 (cs)	2006-01-11
LU88573A1 (de)	1995-06-01
JPH09508262A (ja)	1997-08-26
SG47030A1 (en)	1998-03-20
EP0738323A1 (de)	1996-10-23
ES2114786B1 (es)	1999-01-01
FR2714670B1 (fr)	1997-01-10
NO326903B1 (no)	2009-03-16
AU1514695A (en)	1995-08-01
FI121573B (fi)	2011-01-14
NO962783L (no)	1996-09-03
BG100693A (en)	1998-01-30
GB2285446A (en)	1995-07-12
HRP941020A2 (en)	1997-04-30
GB9425831D0 (en)	1995-02-22
SI9420079A (en)	1997-02-28
HUT75657A (en)	1997-05-28
IL112184A (en)	2004-07-25
LV11632A (lv)	1996-12-20
HU9601805D0 (en)	1996-08-28
AU704266B2 (en)	1999-04-15
FR2714670A1 (fr)	1995-07-07
CA2178482A1 (en)	1995-07-13
NL9500010A (nl)	1995-08-01
CA2178482C (en)	2012-01-03
NZ278726A (en)	1998-06-26
PT101627A (pt)	1995-11-30
FI962723L (fi)	1996-09-03
LV11632B (en)	1997-04-20

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Publication	Publication Date	Title
PT101627B (pt)	1996-11-29	Polipeptideo trombopoietina isolado e substancialmente homogeneo, dna que o codifica e metodos recombinantes ou de sintese para a sua preparacao e purificacao
US5830647A (en)	1998-11-03	Hybridization and amplification of nucleic acids encoding mpl ligand
RU2245365C2 (ru)	2005-01-27	Тромбопоэтин
US8192955B1 (en)	2012-06-05	Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
DE19500030A1 (de)	1995-07-06	Thrombopoietin
US8278099B1 (en)	2012-10-02	Monoclonal antibody to human thrombopoietin
AU749175B2 (en)	2002-06-20	Thrombopoietin
US8147844B1 (en)	2012-04-03	Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand
KR100607613B1 (ko)	2007-03-02	트롬보포이에틴
KR20040065249A (ko)	2004-07-21	트롬보포이에틴
US8241900B1 (en)	2012-08-14	mpl ligand
US6660256B1 (en)	2003-12-09	Porcine mpl ligand
AU782245B2 (en)	2005-07-14	Thrombopoietin
US8399250B1 (en)	2013-03-19	Anti-mpl ligand (thromobpoietin) antibodies
IL161813A (en)	2008-07-08	CHIMERIC POLYPEPTIDES COMPRISING A HETEROLOGOUS POLYPEPTIDE AND A FRAGMENT OF A mpl LIGAND
SA95150635B1 (ar)	2006-05-27	ثرومبوبواييتين thrombopoietin (عامل مولد للصفائح الدموية )