CN1134539C - 血小板生成素 - Google Patents

血小板生成素 Download PDF

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Publication number
CN1134539C
CN1134539C CNB941947513A CN94194751A CN1134539C CN 1134539 C CN1134539 C CN 1134539C CN B941947513 A CNB941947513 A CN B941947513A CN 94194751 A CN94194751 A CN 94194751A CN 1134539 C CN1134539 C CN 1134539C
Authority
CN
China
Prior art keywords
tpo
mpl
mpl ligand
dna
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB941947513A
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English (en)
Chinese (zh)
Other versions
CN1141061A (zh
Inventor
Mά
D.L.伊顿
F.J.德索瓦热
��Ī������
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CN1141061A publication Critical patent/CN1141061A/zh
Application granted granted Critical
Publication of CN1134539C publication Critical patent/CN1134539C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Vehicle Body Suspensions (AREA)
  • Information Transfer Systems (AREA)
CNB941947513A 1994-01-03 1994-12-28 血小板生成素 Expired - Lifetime CN1134539C (zh)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US08/176,553 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/185,607 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US08/196,689 1994-02-15
US22326394A 1994-04-04 1994-04-04
US08/223,263 1994-04-04
US08/249,376 1994-05-25
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A 1994-12-02 1994-12-02
US08/348,657 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand
US08/348,658 1994-12-02

Publications (2)

Publication Number Publication Date
CN1141061A CN1141061A (zh) 1997-01-22
CN1134539C true CN1134539C (zh) 2004-01-14

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB941947513A Expired - Lifetime CN1134539C (zh) 1994-01-03 1994-12-28 血小板生成素

Country Status (28)

Country Link
EP (1) EP0738323A1 (de)
JP (2) JPH09508262A (de)
CN (1) CN1134539C (de)
AU (1) AU704266B2 (de)
BG (1) BG63639B1 (de)
CA (1) CA2178482C (de)
CZ (1) CZ296130B6 (de)
DK (1) DK149194A (de)
ES (1) ES2114786B1 (de)
FI (1) FI121573B (de)
FR (1) FR2714670B1 (de)
GB (1) GB2285446B (de)
HR (1) HRP941020A2 (de)
HU (1) HUT75657A (de)
IE (1) IE72517B1 (de)
IL (1) IL112184A (de)
IT (1) IT1283770B1 (de)
LU (1) LU88573A1 (de)
LV (1) LV11632B (de)
NL (1) NL9500010A (de)
NO (1) NO326903B1 (de)
NZ (1) NZ278726A (de)
PT (1) PT101627B (de)
RO (1) RO117110B1 (de)
SG (1) SG47030A1 (de)
SI (1) SI9420079A (de)
SK (1) SK282265B6 (de)
WO (1) WO1995018858A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2810503C1 (ru) * 2023-02-13 2023-12-27 Общество С Ограниченной Ответственностью "Герофарм" Тест-система и способы определения биологической активности агонистов рецептора тромбопоэтина человека
EP3255055B1 (de) * 2015-12-21 2024-06-05 BrainOn Inc. Zusammensetzung zur verbesserung des gedächtnisses, der lernfähigkeit und der kognition

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US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5733761A (en) 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
SK100896A3 (en) * 1994-02-14 1997-10-08 Zymogenetics Inc Hematopoietic protein and materials and methods for making it
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
CN1229385C (zh) * 1994-03-31 2005-11-30 安姆根有限公司 刺激巨核细胞生长和分化的组合物及方法
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
JPH11500308A (ja) 1995-02-03 1999-01-12 ジー．ディー．サール アンド カンパニー 新規ｃ−ＭＰＬリガンド
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
CN1161468C (zh) * 1995-02-15 2004-08-11 安姆根有限公司 Mpl配体类似物
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
TR199701526T1 (xx) * 1995-06-07 1998-03-21 Glaxo Group Limited Bir trombopoietin resept�r�ne ba�lanan peptitler ve bile�ikler.
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
EP0920511A1 (de) * 1996-08-13 1999-06-09 ZymoGenetics Expressionsvektoren, zellen und verfahren zur herstellung von thrombopietin polypeptide
AU7589898A (en) * 1997-05-21 1998-12-11 Genentech Inc. Novel administration of thrombopoietin
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
PT1783222E (pt) 1998-10-23 2012-07-26 Kirin Amgen Inc Péptidos diméricos de trombopoietina que simulam a ligação ao receptor mpl e têm actividade trombopoiética
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US20050177884A1 (en) 2001-11-15 2005-08-11 Kirin Beer Kabushiki Kaisha Chimeric nonhuman animal
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
KR20050093759A (ko) 2002-09-18 2005-09-23 오르토-맥네일 파마슈티칼, 인코퍼레이티드 혈소판 및 조혈 줄기세포의 생산을 증가시키는 방법
US7576056B2 (en) 2003-08-28 2009-08-18 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
US20090170727A1 (en) * 2004-05-18 2009-07-02 Intrexon Corporation Methods for dynamic vector assembly of dna cloning vector plasmids
WO2006010057A2 (en) 2004-07-08 2006-01-26 Amgen Inc. Therapeutic peptides
EA011879B1 (ru) 2004-09-24 2009-06-30 Эмджин Инк. МОЛЕКУЛЫ С МОДИФИЦИРОВАННЫМ Fc ФРАГМЕНТОМ
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
AU2007278748B2 (en) 2006-07-24 2013-08-15 The University Of Queensland Method of producing a population of cells
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
EP2162540A2 (de) 2007-05-22 2010-03-17 Amgen Inc. Zusammensetzungen und verfahren zur herstellung biologisch aktiver fusionsproteine
WO2010085086A2 (ko) 2009-01-20 2010-07-29 한올바이오파마 주식회사 변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
CA3177929A1 (en) 2012-12-21 2014-06-26 Astellas Institute For Regenerative Medicine Methods for production of platelets from pluripotent stem cells and compositions thereof
CN103555760B (zh) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 一种重组人血小板生成素的制备方法及其制剂
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
US20230212565A1 (en) * 2019-09-20 2023-07-06 Ractigen Therapeutics Nucleic acid molecule for treating thrombocytopenia and application thereof
WO2021123832A1 (en) 2019-12-20 2021-06-24 Instil Bio (Uk) Limited Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof
CN118086536A (zh) * 2024-04-23 2024-05-28 佛山科学技术学院 一种通过snp标记改善黄牛血小板生成素分泌的方法及其应用

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3255055B1 (de) * 2015-12-21 2024-06-05 BrainOn Inc. Zusammensetzung zur verbesserung des gedächtnisses, der lernfähigkeit und der kognition
RU2810503C1 (ru) * 2023-02-13 2023-12-27 Общество С Ограниченной Ответственностью "Герофарм" Тест-система и способы определения биологической активности агонистов рецептора тромбопоэтина человека

Also Published As

Publication number Publication date
BG63639B1 (bg) 2002-07-31
CZ192296A3 (en) 1997-05-14
ITTO950002A0 (it) 1995-01-02
IL112184A0 (en) 1995-03-15
CN1141061A (zh) 1997-01-22
WO1995018858A1 (en) 1995-07-13
ITTO950002A1 (it) 1996-07-02
FI962723A0 (fi) 1996-07-02
IE72517B1 (en) 1997-04-23
IT1283770B1 (it) 1998-04-30
RO117110B1 (ro) 2001-10-30
JPH10113186A (ja) 1998-05-06
SK282265B6 (sk) 2001-12-03
GB2285446B (en) 1999-07-28
DK149194A (da) 1995-07-04
IE950002A1 (en) 1995-07-12
NO962783D0 (no) 1996-07-02
ES2114786A1 (es) 1998-06-01
SK87596A3 (en) 1997-11-05
CZ296130B6 (cs) 2006-01-11
LU88573A1 (de) 1995-06-01
JPH09508262A (ja) 1997-08-26
SG47030A1 (en) 1998-03-20
EP0738323A1 (de) 1996-10-23
ES2114786B1 (es) 1999-01-01
FR2714670B1 (fr) 1997-01-10
NO326903B1 (no) 2009-03-16
AU1514695A (en) 1995-08-01
FI121573B (fi) 2011-01-14
NO962783L (no) 1996-09-03
BG100693A (en) 1998-01-30
GB2285446A (en) 1995-07-12
HRP941020A2 (en) 1997-04-30
GB9425831D0 (en) 1995-02-22
SI9420079A (en) 1997-02-28
HUT75657A (en) 1997-05-28
IL112184A (en) 2004-07-25
LV11632A (lv) 1996-12-20
HU9601805D0 (en) 1996-08-28
AU704266B2 (en) 1999-04-15
FR2714670A1 (fr) 1995-07-07
CA2178482A1 (en) 1995-07-13
PT101627B (pt) 1996-11-29
NL9500010A (nl) 1995-08-01
CA2178482C (en) 2012-01-03
NZ278726A (en) 1998-06-26
PT101627A (pt) 1995-11-30
FI962723L (fi) 1996-09-03
LV11632B (en) 1997-04-20

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Expiration termination date: 20141228

Granted publication date: 20040114